Regulation of neutrophil elastase-induced muc5ac expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells

Journal of Investigative Medicine

Volumn 58, Issue 5, 2010, Pages 730-736

  Li, Qi ^a   Zhou, Xiangdong ^a   Yu, Hongmei ^a   Nie, Xiaohong ^a   Xu, Xiaoyan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Mucous hypersecretion; Nuclear factor erythroid 2 related factor 2; Reactive oxygen species

Indexed keywords

LEUKOCYTE ELASTASE; MUCIN 5AC; REACTIVE OXYGEN METABOLITE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SMALL INTERFERING RNA; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUTROPHIL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; WESTERN BLOTTING;

EID: 77954389712     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/jim.0b013e3181d88fde     Document Type: Article

References (52)

1. Voynow JA, Young LR, Wang Y, et al. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol Lung. 1999;276:L835-L843.
2. Voynow JA, Fischer BM, Malarkey DE, et al. Neutrophil elastase induces mucus cell metaplasis in mouse lung. Am J Physiol Lung Cell Mol Physiol. 2004;287:L1293-L1302.
3. Koo JS, Kim YD, Jetten AM, et al. Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist. Exp Lung Res. 2002;28:315-332.
4. Fischer B, Voynow J. Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. Chest. 2000; 117:317S-320S.
5. McCubrey JA, Lahair MM, Franklin RA. Reactive oxygen speciesYinduced activation of the MAPK kinase signaling. Antioxid Redox Signal. 2006;8:1775-1789.
6. Nadel JA. Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir Res. 2001;2:85-89.
7. Kohri K, Ueki IF, Nadel JA. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol. 2002;283:L531-L540.
8. Burgel PR, Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax. 2004;59:992-996.
9. Kuwahara I, Lillehoj EP, Koga T, et al. The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription. Am J Respir Cell Mol Biol. 2007;37:691-698.
10. Azad N, Rojanasakul Y, Vallyathan V. Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev. 2008;11:1-15.
11. Dong CC, Yin XJ, Ma JY, et al. Effects of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats. Toxicol Sci. 2005;88:202-212.
12. Fubini B, Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med. 2003;34:1507-1516.
13. Afonso V, Champy R, Mitrovic D, et al. Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine. 2007; 74:324-329.
14. Ishii T, Itoh K, Takahashi S, et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000;275:16023-16029.
15. Choi AMK, Alam J. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol. 1996;15:9-19.
16. Ryter SW, Choi AM. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxid Redox Signal. 2005;7:80-91.
17. Maines MD. The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517-547.
18. Lee JM, Li J, Johnson DA, et al. Nrf2, a multi-organ protector? FASEB J. 2005;19:1061-1066.
19. He X, Kan H, Cai L, et al. Nrf2 is critical in defense against high glucoseYinduced oxidative damage in cardiomyocytes. J Mol Cell Cardiol. 2009;46:47-58.
20. Cho HY, Reddy SP, Kleeberger SR. Nrf2 defends the lung from oxidative stress. Antioxid Redox Signal. 2006;8:76-87.
21. Ishii Y, Itoh K, Morishima Y, et al. Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J Immunol. 2005;175:6968-6975.
22. van der Toorn M, Rezayat D, Kauffman HF, et al. Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009;297:L109-L114.
23. Franck T, Kohnen S, de la Rebière G, et al. Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl- phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase. Vet Immunol Immunopathol. 2009;130:243-250.
24. Sarir H, Mortaz E, Janse WT, et al. IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha. Biochem Pharmacol. 2010;79:698-705.
25. Takeyama K, Dabbagh K, Jeong SJ, et al. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000;164:1545-1552.
26. Cervantes-Sandoval I, Serrano-Luna Jde J, Meza-Cervantez P, et al. Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation. Microbiology. 2009;155:3739-3747.
27. Brownlee IA, Knight J, Dettmar PW, et al. Action of reactive oxygen species on colonic mucus secretions. Free Radic Biol Med. 2007;43: 800-808.
28. He X, Ma Q. NRF2 cysteine residues are critical for oxidant/ electrophile-sensing, Kelch-like ECH-associated protein-1Ydependent ubiquitination-proteasomal degradation, and transcription activation. Mol Pharmacol. 2009;76:1265-1278.
29. Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 2006;38:769-789.
30. Cho HY, Jedlicka AE, Reddy SP, et al. Role of Nrf2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol. 2002;26: 175-182.
31. Cho HY, Reddy SP, Yamamoto M, et al. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J. 2004;18:1258-1260.
32. Papaiahgari S, Yerrapureddy A, Reddy SR, et al. Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 2007;176:1222-1235.
33. Goven D, Boutten A, Leoon-Malas V, et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax. 2008;63:916-924.
34. Rangsamy T, Cho CY, Thimmulappa RK, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smokeYinduced emphysema in mice. J Clin Invest. 2004;114:1248-1259.
35. Iizuka T, Ishii Y, Itoh K, et al. Nrf2-deficient mice are highly susceptible to cigarette smokeYinduced emphysema. Genes Cells. 2005;10: 1113-1125.
36. Singh A, Rangasamy T, Thimmulappa RK, et al. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol. 2006;35:639-650.
37. Ma Q, Battelli L, Hubbs AF. Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am J Pathol. 2006;168:1960-1974.
38. Yoh K, Itoh K, Enomoto A, et al. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int. 2001;60:1343-1353.
39. Grobmyer SR, Barie PS, Nathan CF, et al. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit Care Med. 2000; 28:1276-1282.
40. Rogan MP, Geraghty P, Greene CM, et al. Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res. 2006;7:29.
41. van Wetering S, van der Linden AC, van Sterkenburg MA, et al. Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. Am J Physiol Lung Cell Mol Physiol. 2000;278: L51-L58.
42. Kouchi I, Yasuoka S, Ueda Y, et al. Analysis of secretory leukocyte protease inhibitor (SLPI) in bronchial secretions from patients with hypersecretory respiratory diseases. Tokushima J Exp Med. 1993;40: 95-107.
43. Mulligan MS, Desrochers PE, Chinnaiyan AM, et al. In vivo suppression of immune complexYinduced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2. Proc Natl Acad Sci U S A. 1993;90:11523-11527.
44. Vogelmeier C, Hubbard RC, Fells GA, et al. Anti-neutrophil elasatse defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor. J Clin Invest. 1991;87: 482-488.
45. Lucey EC, Stone PJ, Ciccolella DE, et al. Recombinant human secretory leukocyte-protease inhibitor: in vitro properties, and amelioration of human neutrophil elastaseYinduced emphysema and secretory cell metaplasia in the hamster. J Lab Clin Med. 1990;115:224-232.
46. Rudolphus A, Stolk J, Dijkman JH, et al. Inhibition of lipopolysaccharide-induced pulmonary emphysema by intratracheally instilled recombinant secretory leukocyte proteinase inhibitor. Am Rev Respir Dis. 1993;147:442-447. (Pubitemid 23044922)
47. Yang J, Zhu J, Ding A. Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function. Biochim Biophys Acta. 2005;1745:310-317.
48. Abbinante-Nissen JM, Simpson LG, Leikanf GD. Neutrophil elastase increases secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am J Physiol. 1993;265:286-292.
49. Saitoh H, Masuda T, Shimura S, et al. Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands. Am J Physiol Lung Cell Mol Physiol. 2001;280:L79-L87.
50. Moreau T, Baranger K, Dadé S, et al. Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor(SLPI), two serine protease inhibitors of the chelonianin family. Biochimie. 2008;90:284-295.
51. Van Wetering S, Van der Linden AC, Van Sterkenburg MA, et al. Regulation of secretory leukocyte proteinase inhibitor(SLPI) production by human bronchial epithelial cells: increase of cell-associated SLPI by neutrophil elastase. J Invest Med. 2000;48:359-366.
52. Zheng S, Byrd AS, Fisher BM, et al. Regulation of MUC5AC expression by NAD(P)H:quinine oxidoreductase 1. Free Radic Biol Med. 2007; 42:1398-1408.