Naegleria fowleri induces MUC5AC and proinflammatory cytokines in human epithelial cells via ROS production and EGFR activation

Microbiology

Volumn 155, Issue 11, 2009, Pages 3739-3747

  Cervantes Sandoval, Isaac ^a,b   Serrano Luna, José de Jesús ^a   Meza Cervantes, Patricia ^a   Arroyo, Rossana ^a   Tsutsumi, Víctor ^a   Shibayama, Mineko ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLOROFLUORESCEIN; DICHLOROFLUORESCEIN DIACETATE; EOTAXIN; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 8; MUCIN 5AC; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CRIBRIFORM PLATE; DISEASE SEVERITY; EPITHELIUM CELL; FLUORESCENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MALE; MOUSE; MUCUS SECRETION; NAEGLERIA FOWLERI; NONHUMAN; OLFACTORY EPITHELIUM; OXIDATION; PLATE COUNT; PRIMARY AMEBIC MENINGOENCEPHALITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; TROPHOZOITE;

ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM PROTOZOAL INFECTIONS; DIMETHYL SULFOXIDE; EPITHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1BETA; INTERLEUKIN-8; MALE; MICE; MICE, INBRED BALB C; MUCIN 5AC; NAEGLERIA FOWLERI; NEUTROPHILS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TROPHOZOITES; TYRPHOSTINS;

NAEGLERIA FOWLERI;

EID: 70450246884     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.030635-0     Document Type: Article

References (31)

1. Carter, R. F. (1970). Description of a Naegleria sp. isolated from two cases of primary amoebic meningo-encephalitis, and of the experimental pathological changes induced by it. J Pathol 100, 217-244.
2. Cervantes-Sandoval, I., Serrano-Luna, J. J., García-Latorre, E., Tsutsumi, V. & Shibayama, M. (2008a). Characterization of brain inflammation during primary amoebic meningoencephalitis. Parasitol Int 57, 307-313.
3. Cervantes-Sandoval, I., Serrano Luna, J. J., García-Latorre, E., Tsutsumi, V. & Shibayama, M. (2008b). Mucins in host defence against Naegleria fowleri and mucinolytic activity as a possible means of evasion. Microbiology 154, 3895-3904.
4. Cursons, R. T., Brown, T. J., Keys, E. A., Moriarty, K. M. & Till, D. (1980). Immunity to pathogenic free-living amoebae: role of cell-mediated immunity. Infect Immun 29, 408-410.
5. Edwards, J. H., Griffiths, A. J. & Mullins, J. (1976). Protozoa as sources of antigen in 'humidifier fever'. Nature 264, 438-439.
6. Ferrante, A. (1989). Augmentation of the neutrophil response to the Naegleria fowleri by tumor necrosis factor alpha. Infect Immun 57, 3110-3115.
7. Ferrante, A. & Mocatta, T. J. (1984). Human neutrophils require activation by mononuclear leucocytes conditioned medium to kill the pathogenic free-living amoeba, Naegleria fowleri. Clin Exp Immunol 56, 559-566.
8. Ferrante, A., Carter, R. F., Lopez, A. F., Rowan-Kelly, B., Hill, N. L. & Vadas, M. A. (1988). Depression of immunity to Naegleria fowleri in mice by selective depletion of neutrophils with a monoclonal antibody. Infect Immun 56, 2286-2291.
9. Ferrante, A., Hill, N. L., Goh, D. H. & Kumaritilake, L. (1989). Altered neutrophils in mice immune to experimental Naegleria amoebic meningoencephalitis. Immunol Lett 22, 301-305.
10. Hsu, H. Y. & Wen, M. H. (2002). Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 277, 22131-22139.
11. Ibelgaufts, H. (1995). Cytokines Dictionary. Wenheim, Germany: Wiley-VCH.
12. Jarolim, K. L., McCosh, J. K., Howard, M. J. & John, D. T. (2000). A light microscopy study of the migration of N. fowleri from the nasal submucosa to the central nervous system during the early stage of primary amebic meningoencephalitis in mice. J Parasitol 86, 50-55.
13. Jarolim, K. L., McCosh, J. K. & Howard, M. J. (2002). The role of blood vessels and lungs in the dissemination of Naegleria fowleri following intranasal inoculation in mice. Folia Parasitol (Praha) 49, 183-188.
14. John, D. T. & Nussbaum, S. L. (1983). Naegleria fowleri infection acquired by mice through swimming in amebae-contaminated water. J Parasitol 69, 871-874.
15. Kim, S. H., Smith, C. J. & Van Eldik, L. J. (2004). Importance of MAPK pathways for microglial proinflammatory cytokine IL-1β production. Neurobiol Aging 25, 431-439.
16. Kim, S., Schein, A. J. & Nadel, J. A. (2005). E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 289, L1049-L1060.
17. Marciano-Cabral, F. & Cabral, G. A. (2007). The immune response to Naegleria fowleri amoeba and pathogenesis of infection. FEMS Immunol Med Microbiol 51, 243-259.
18. Nakanaga, T., Nadel, J. A., Ueki, I. F., Koff, J. L. & Shao, M. X. (2007). Regulation of interleukin 8 via an airway epithelial signaling cascade. Am J Physiol Lung Cell Mol Physiol 292, L1289-L1296.
19. Rojas-Hernández, S., Jarillo-Luna, A., Rodríguez-Monroy, M., Moreno-Fierros, L. & Campos-Rodríguez, R. (2004). Immunohistochemical characterization of the initial stages of Naegleria fowleri meningoencephalitis in mice. Parasitol Res 94, 31-36.
20. Rose, M. C., Nickola, T. J. & Voynow, J. A. (2001). Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am J Respir Cell Mol Biol 25, 533-537.
21. Rowan-Kelly, B., Ferrante, A. & Thong, Y. H. (1980). Activation of complement by Naegleria. Trans R Soc Trop Med Hyg 74, 333-336.
22. Schuster, F. L. & Visvesvara, G. S. (2004). Free-living amoeba as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 34, 1001-1027.
23. Serrano-Luna, J., Cervantes-Sandoval, I., Tsutsumi, V. & Shibayama, M. (2007). Biochemical comparison of proteases from pathogenic Naegleria fowleri and non-pathogenic Naegleria gruberi. J Eukaryot Microbiol 54, 411-417.
24. Shao, M. X. & Nadel, J. A. (2005). Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNFα-converting enzyme. J Immunol 175, 4009-4016.
25. Shao, M. X., Ueki, I. F. & Nadel, J. A. (2003). Tumor necrosis factor α-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A 100, 11618-11623.
26. Shimizu, T., Shimizu, S., Hattori, R. & Majima, Y. (2003). A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats. J Allergy Clin Immunol 112, 119-125.
27. Smirnova, M. G., Guo, L., Birchall, J. P. & Pearson, J. P. (2003). LPS upregulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cell Immunol 221, 42-49.
28. Takeyama, K., Dabbagh, K., Lee, H. M., Agustí, C., Lausier, J. A., Ueki, I. F., Grattan, K. M. & Nadel, J. A. (1999). Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A 96, 3081-3086.
29. Takeyama, K., Dabbagh, K., Shim, J. J., Dao-Pick, T., Ueki, I. F. & Nadel, J. A. (2000). Oxidative stress causes mucin synthesis via transcription of epidermal growth factor receptor: role of neutrophils. J Immunol 164, 1546-1552.
30. Teruya, H., Higa, F., Akamine, M., Ishikawa, C., Okudaira, T., Tomimori, K., Mukaida, N., Tateyama, M., Heuner, K. & other authors (2007). Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells. BMC Microbiol 7, 102.
31. Thong, Y. H., Carter, R. F., Ferrante, A. & Kowan-Kelly, B. (1983). Site of expression of immunity to Naegleria fowleri in immunized mice. Parasite Immunol 5, 67-76.