Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis

Tissue Antigens

Volumn 76, Issue 2, 2010, Pages 110-118

  Greer, K A ^a   Wong, A K ^b   Liu, H ^b   Famula, T R ^b   Pedersen, N C ^b   Ruhe, A ^b   Wallace, M ^c   Neff, M W ^b  

^a INDIANA UNIVERSITY EAST   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

acute multiple sclerosis; atypical multiple sclerosis; dog leukocyte antigen; dog leukocyte antigen class II; multiple sclerosis; necrotizing meningoencephalitis; Pug Dog encephalitis

Indexed keywords

LEUKOCYTE ANTIGEN;

ALLELE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; DISEASE COURSE; DOG; EXON; FEMALE; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; HAPLOTYPE; HOMOZYGOSITY; INFLAMMATION; MALE; MARKER GENE; MENINGOENCEPHALITIS; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ALLELES; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA PRIMERS; DOG DISEASES; DOGS; EXONS; FEMALE; GENE FREQUENCY; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MALE; MENINGOENCEPHALITIS; MICROSATELLITE REPEATS; MULTIPLE SCLEROSIS; SPECIES SPECIFICITY;

CANIS FAMILIARIS;

EID: 77954339796     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01484.x     Document Type: Article

References (63)

1. Cordy DR, Holliday TA. A necrotizing meningoencephalitis of pug dogs. Vet Pathol 1989 : 26 : 191 194.
2. Higgins RJ, Dickinson PJ, Kube SA et al. Necrotizing meningoencephalitis in five Chihuahua dogs. Vet Pathol 2008 : 45 : 336 346.
3. Stallis IH, Chadwick B, Dayrell-Hart B et al. Necrotizing meningoencephalitis of Maltese dogs. Vet Path 1995 : 32 : 230 235.
4. Aresu L, D'Angelo A, Zanatta R, Valenza F, Capucchio MT. Canine necrotizing encephalitis associated with anti-glomerular basement membrane glomerulonephritis. J Comp Pathol 2007 : 136 : 279 282.
5. Tibold A, Fatzer R, Jaggy A, Zurbriggen A, Vandevelde JM. Necrotizing encephalitis in Yorkshire terriers. J Small Anim Pract 1993 : 34 : 623 628.
6. Cantile C, Chianini F, Arispici M, Fatzer R. Necrotizing meningoencephalitis associatedwith cortical hippocampal hamartia in a Pekingese dog. Vet Pathol 2001 : 38 : 119 122.
7. Timmann D, Konar M, Howard J, Vandevelde M. Necrotising encephalitis in a French bulldog. J Small Anim Pract 2007 : 48 : 339 342.
8. Talarico LR, Schatzberg SJ. Idiopathic granulomatous and necrotising inflammatory disorders of the canine central nervous system: a review and future perspectives. J Small Anim Pract 2010 : 51 : 138 149.
9. Cordy DR. Canine granulomatous meningoencephalomyelitis. Vet Path 1979 : 16 : 325 333.
10. Higgins RJ, LeCouteur RA. GME, NME, and breed specific encephalitis and allied disorders: variations of the same theme or different diseases? Proceedings of the 20th Annual Symposium of the European College of Veterinary Neurology, Bern, Switzerland, 2007, 35 7.
11. Porter BF, Ambrus A, Storts RW. Immunohistochemical evaluation of mx protein expression in canine encephalitides. Vet Path 2006 : 43 : 981 987.
12. Schatzberg SJ, Haley NJ, Barr SC et al. Polymerase chain reaction screening for DNA viruses in paraffin-embedded brains from dogs with necrotizing meningoencephalitis, necrotizing leukoencephalitis, and granulomatous meningoencephalitis. J Vet Intern Med 2005 : 19 : 553 559.
13. Levine JM, Fosgate GT, Porter B et al. Epidemiology of necrotizing meningoencephalitis in Pug dogs. J Vet Intern Med 2008 : 22 : 961 968.
14. Uchida K, Hasegawa T, Ikeda M et al. Detection of an autoantibody from Pug dogs with necrotizing encephalitis (Pug dog encephalitis). Vet Path 1999 : 36 : 301 307.
15. Matsuki N, Fujiwara K, Tamahara S et al. Prevalence of autoantibody in cerebrospinal fluids from dogs with various CNS diseases. J Vet Med Sci 2004 : 66 : 295 297.
16. Toda Y, Matsuki N, Shibuya M et al. Glial fibrillary acidic protein (GFAP) and anti-GFAP autoantibody in canine necrotizing meningoencephalitis. Vet Rec 2007 : 161 : 261 264.
17. Fujiwara K, Matsuki M, Shibuya M et al. Autoantibodies against glial fibrillary acidic protein in canine sera. Vet Rec 2008 : 162 : 592 593.
18. Matsuki N, Takahashi M, Yaegashi M et al. Serial examinations of anti-GFAP autoantibodies in cerebrospinal fluids in canine necrotizing meningoencephalitis. J Vet Med Sci 2009 : 71 : 99 100.
19. Greer KA, Schatzberg SJ, Porter BF et al. Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. Res Vet Sci 2009 : 86 : 438 442.
20. Sambrook J, Fritsch EE, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
21. Irion DN, Schaffer AL, Famula TR et al. Analysis of genetic variation in 28 dog breed populations with 100 microsatellite markers. J Hered 2003 : 94 : 81 7.
22. Wong AK, Ruhe AL, Dumont BL et al. A comprehensive linkage map of the dog genome. Genetics : 2010 : 184 : 595 605.
23. Wong AK, Neff MW. DOGSET: pre-designed primer sets for fine-scale mapping and DNA sequence interrogation in the dog. Anim Genet 2009 : 40 : 569 571.
24. Brownstein MJ, Carpten JD, Smith JR. Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. BioTechniques 1996 : 20 : 1004 1006.
25. Oetting WE, Lee HK, Flanders DJ et al. Linkage analysis with multiplexed short tandem repeat polymorphisms using infrared fluorescence and M13 tailed primers. Genomics 1995 : 30 : 450 458.
26. Doerge RW, Churchill GA. Permutation tests for multiple loci affecting a quantitative character. Genetics 1996 : 142 : 285 294.
27. Kennedy LJ, Barnes A, Happ GM et al. Evidence for extensive DLA polymorphism in different dog populations. Tissue Antigens 2002 : 60 : 43 52.
28. Kennedy LJ, Barnes A, Short A et al. Canine DLA diversity: 1. New alleles andhaplotypes. Tissue Antigens 2007 : 69 (Suppl 1) : 272 288.
29. Angles JM, Famula TR, Pedersen NC. Uveodermatologic (VKH-like) syndrome inAmerican Akita dogs is associated with an increased frequency of DQA*00201. Tissue Antigens 2005 : 66 : 656 665.
30. Kennedy LJ, Barnes A, Ollier WER, Day MJ. Association of a common dog leucocyte antigen class II haplotype with canine primary immune-mediated haemolytic anemia. Tissue Antigens 2006 : 68 : 502 508.
31. Ollier WER, Kennedy LJ, Thomson W et al. Dog MHC alleles containing the "humanRA shared epitope" confer susceptibility to canine rheumatoid arthritis. Immunogenetics 2001 : 53 : 669 673.
32. Kennedy LJ, Quarmby S, Happ GM et al. Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens 2006 : 68 : 82 6.
33. Kennedy LJ, Davison J, Barnes A et al. Identification of susceptibility and protectivemajor histocompatibility complex haplotypes in canine diabetes mellitus. Tissue Antigens 2006 : 68 : 467 476.
34. Barnes A, O'Neill T, Kennedy LJ et al. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens 2009 : 73 : 218 224.
35. Wilbe M, Jokinen P, Hermanrud C et al. MHC class II polymorphism is associated with a canine SLE-related disease complex. Immunogenetics 2009 : 61 : 557 564.
36. Svejgaard A. MHC and disease association, Chapter 37. In: Weir's Handbook of Experimental Immunology, 5th edn.
37. De Jager PL, Chibnik LB, Cui J et al Steering committee of the BENEFIT study; Steering committee of the BEYOND study; Steering committee of the LTF study; Steering committee of the CCR1 study, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 2009 : 8 : 1111 1119.
38. Angles JM, Kennedy LJ, Pedersen NC. Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds. Tissue Antigens 2005 : 66 : 173 184.
39. Bannasch DL, Bannach MJ, Ryun JR, Famula TR, Pedersen NC. Y chromosome haplotype analysis in purebred dogs. Mamm Genome 2005 : 16 : 273 280.
40. Pedersen NC. A review of immunologic diseases of the dog. Vet Immun Immunopath 1999 : 69 : 251 342.
41. Capello E, Mancardi GL. Marburg type and Balò's concentric sclerosis: rare and acute variants of multiple sclerosis. Neurol Sci 2004 : 25 (Suppl 4) : S361 3.
42. Hazin R, Khan F, Bhatti MT. Neuromyelitis optica: current concepts and prospects for future management. Curr Opin Opthalmol 2009 : 20 : 434 439.
43. Young NP, Weinshenker BG, Lucchinetti CF. Acute disseminated encephalomyelitis: current understanding and controversies. Semin Neurol 2008 : 28 : 84 94.
44. Gallucci M, Caulo M, Cerone G, Maschocchi C. Acquired inflammatory white matter disease. Child Nerv Syst 2001 : 17 : 202 210.
45. Brown MG, Kirby S, Skedgel C et al. How effective are disease-modifying drugs in delaying progression in relapsing-onset MS? Neurology 2007 : 69 : 1498 1507.
46. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis ofdemyelination. Ann Neurol 2000 : 47 : 707 717.
47. Esiri MM. MS: is it one disease? Int MS J 2009 : 16 : 39 41.
48. Barnett MH, Parratt JD, Pollard JD, Prineas JW. MS: is it one disease? Int MS J 2009 : 16 : 57 65.
49. Barnett MH, Parratt JD, Cho ES, Prineas JW. Immunoglobulins and complement in postmortem multiple sclerosis tissue. Ann Neurol 2009 : 65 : 32 46.
50. Hu W, Lucchinetti CF. The pathological spectrum of CNS inflammatory demyelinating diseases. Semin Immunopathol 2009 (Epub ahead of print).
51. Barnett MH, Henderson AP, Prineas JW. The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion. Mult Scler 2006 : 12 : 121 132.
52. Magaña SM, Pittock SJ, Lennon VA, Keegan BM, Weinshenker BG, Lucchinetti CF. Neuromyelitis optica IgG serostatus in fulminant central nervous system inflammatorydemyelinating disease. Arch Neurol 2009 : 66 : 964 966.
53. Wegner C. Pathological differences in acute inflammatory demyelinating diseases of the central nervous system. Int MS J 2005 : 12 : 13 9, 12.
54. Oksenberg JR, Barcellos LF, Cree BA et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet 2004 : 74 : 160 167.
55. Giordano M, D'Alfonso S, Momigliano-Richiardi P. Genetics of multiple sclerosis: linkage and association studies. Am J Pharmacogenom 2002 : 2 : 37 58.
56. Lincoln MR, Ramagopalan SV, Chao MJ et al. Epistasis among HLA-DRB1, HLADQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A 2009 : 106 : 7542 7547.
57. Kennedy LJ, Barnes A, Happ GM et al. Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs. Tissue Antigens 2002 : 59 : 194 204.
58. Svejgaard A. The immunogenetics of multiple sclerosis. Immunogenetics 2008 : 60 : 275 286.
59. Ramagopalan SV, Morris AP, Dyment DA et al. The inheritance of resistance alleles in multiple sclerosis. PLoS Genet 2007 : 3 : 1607 1613.
60. Dyment DA, Herrera BM, Cader MZ et al. Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet 2005 : 14 : 2019 2026.
61. Callier SJ, Briggs F, Cree BA et al. Uncoupling the roles of HLA-DRB1 and HLADRB5 genes in multiple sclerosis. J Immunol 2008 : 181 : 5473 5480.
62. Storch MK, Bauer J, Linington C et al. Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility (MHC) haplotype-related. J Neuropathol Exp Neurol 2008 : 65 : 1137 1142.
63. Sawcer S. The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 2008 : 131 : 3118 3131.