Pharmacological agents in the prophylaxis/treatment of organophosphorous pesticide intoxication

Indian Journal of Experimental Biology

Volumn 48, Issue 7, 2010, Pages 642-650

  Husain, Kazim ^a   Ansari, Rais A ^b   Ferder, Leon ^a  

^a PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^b NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

Antidote; OPIDN; Organophosphorus pesticide; Prophylatic agents

Indexed keywords

ANTIDOTE; ORGANOPHOSPHORUS COMPOUND; PESTICIDE;

HUMAN; INTOXICATION; REVIEW; DRUG THERAPY; ORGANOPHOSPHATE POISONING;

ANTIDOTES; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; PESTICIDES; POISONING; ORGANOPHOSPHATE POISONING;

ANIMALIA;

EID: 77954291440     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (90)

1. Karalliedde L, Eddleston M & Murray V, The global picture of organophosphate insecticide poisoning, in London: eds. Organophosphates and health, edited by Karalliedde L, Feldman F, Henry J, Marrs T, (Imperial College Press), 2001,431.
2. Kwong T C, Organophosphate pesticides: biochemistry and clinical toxicology, Ther Drug Monit, 24 (2002) 144.
3. Eddleston M, Patterns and problems of deliberate self-poisoning in the developing world, QJM, 93 (2000) 715.
4. Konradsen F, van der Hoek W, Cole D C, Hutchinson G, Daisley H, Singh S, & Eddleston M, Reducing acute poisoning in developing countries-options for restricting the availability of pesticides, Toxicology, 192 (2003) 249.
5. Mileson B E, Chambers J E, Chen W L, Dettbarn W, Ehrich M, Eldefrawi A T, Gaylor D W, Hamernik K, Hodgson E, Karczmar A G, Padilla S, Pope C N, Richardson R J, Saunders D R, Sheets L P, Sultatos L G & Wallace K B, Common mechanism of toxicity: a case study of organophosphorus pesticides, Toxicol Sci, 41 (1998) 8.
6. Pope C, Karanth S & Liu J, Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action, Environ Toxicol Pharmacol, 19 (2005) 433.
7. Thiermann H, Szinicz L, Eyer P, Zilker T & Worek F, Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning, Chem Biol Interact, 157-158 (2005) 345.
8. Zilker T, Medical management of incidents with chemical warfare agents, Toxicology, 214 (2005) 221.
9. Ballantyne B & Marrs T C, Overview of the biological and clinical aspects of organophosphates and carbamates, in Clinical and experimental toxicology of organophosphates and carbamates. edited by Ballantyne B, Marrs TC, (Oxford Press; Butterworth-Heinemann), 1992, 3.
10. Bismuth C, Inns R H & Marrs T C, Efficacy, toxicity and clinical use of oximes in anticholinesterase poisoning, in Clinical and experimental toxicology of organophosphates and carbamates edited by Ballantyne B, Marrs TC, (Butterworth-Heinemann, Oxford) 1992, 555.
11. Namba T & Hiraki K, PAM (pyridine-2-aldoxime methiodide) therapy for alkyl-phosphate poisoning, J Am MedAssoc, 166 (1958) 1834.
12. Luettringhaus A & Hagedorn I, Quaternary hydroxyiminomethylpyridinium salts. The dischloride of bis-(4-hydroxyiminomethyl-1 -pyridinium-methyl)-ether (lueh6), a new reactivator of acetylcholinesterase inhibited by organic phosphoric acid esters, Arzneimittelforschung, 14 (1964) 1.
13. Hagedorn I, Gundel W H & Schoene K, Reactivation of phosphorylated acetylcholine esterase with oximes: contribution to the study of the reaction course, Arzneimittelforschung, 19 (1969) 603.
14. Loffler M, Quartare Salze von Pyridin 2,4-dialdoxim als. Gegenmittel fur Organophosphat-Vergiftungen (dissertation), Freiburg, University of Freiburg, Germany, 1986.
15. Shih T M, Skovira J W, O'Donnell J C, & McDonough J H, Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication, J Mol Neurosci, (2009) Aug 13.
16. Husain K & Ansari R A, Effectiveness of certain drugs in acute malathion intoxication in rats, Ecotoxicol Environ Safety, 19(1990)271.
17. Srivastava A K & Malik J K, Therapeutic efficacy of oxime reactivators in fenitrothion toxicity in buffalo calves (Bubalus bubalis), Ada Vet Hung, 49 (2001) 229.
18. Kassa J & Cabal J, A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods, Toxicology, 132 (1999) 111.
19. Kassa J, Karasova J, Musilek K, Kuca K & Bajgar J, An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoime, HI-6) in cyclosporine-poisoned rats and mice, Clin Toxicol (Phila), 47 (2009) 72.
20. Kuca K, Bartosova L, Jun D, Patocka J, Cabal J, Kassa J & Kunesova G, New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 149 (2005) 75.
21. Husain K, Sikder A K, Raza S K, Das Gupta S & Jaiswal D K, Reactivation of acetylcholinesterase activity by two new oximes in DFP intoxicated mice, Curr Sci, 59 (1990)1338.
22. Sikder A K, Pandey K S, Jaiswal D K, Dube S N, Deo Kumar, Husain K, Bhattacharya R & Gas Gupta S, The 3,3-Bis pyridinium mono oximes as antidote against organophosphorus intoxication, J Pharm Pharmacol, 44 (1992)1057.
23. Katrolia S P, Sikder A K, Acharya J, Sikder N, Jaiswal D K, Bhattacharya R, Husain K, Dube S N, Kumar D & Das Gupta S, Antidotal efficacy of 1-alkyl pyridinium oximes in sarin intoxication, Pharmacol Commun, 4 (1994) 317.
24. Kusic R, Jovanovic D, Randjelovic S, Joksovic D, Todorovic V, Boskovic B, Jokanovic M & Vojvodic V, HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides, Hum Exp Toxicol, 10 (1991) 113.
25. Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Felgenhauer N & Zilker T, Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients, Hum Exp Toxicol, 16(1997)473.
26. Thiermann H, Szinicz L, Eyer F, Worek F, Eyer P, Felgenhauer N & Zilker T, Modern strategies in therapy of organophosphate poisoning, Toxicol Lett, 107 (1999) 233.
27. Reiner E, Inhibition of acetylcholinesterase by 4,4'-bipyridin and its effect upon phosphorylation of the enzyme, Croat Chem Acta, 59 (1986) 925.
28. Clement J G, Toxicology and pharmacology of bispyridium oximes-insight into the mechanism of action vs Soman poisoning in vivo, Fundam Appl Toxicol, 1 (1981) 193.
29. Busker R W, Zijlstra J J, van der Wiel H J, Melchers B P & van Helden H P, Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat, Toxicology, 69 (1991)331.
30. Melchers B P, Van der Laaken A L, & Van Helden H P, On the mechanism whereby HI-6 improves neuromuscular function after oxime-resistant acetylcholinesterase inhibition and subsequent impairment of neuromuscular transmission, Eur J Pharmacol, 200 (1991) 331.
31. van Helden H P, de Lange J, Busker R W & Melchers B P, Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation, Arch Toxicol, 65(1991)586.
32. Becker G, Kawan A & Szinicz L, Direct reaction of oximes 50 with sarin, soman, or tabun in vitro, Arch Toxicol, 71 (1997) 714.
33. Primozic I, Odzak R, Tomic S, Simeon-Rudolf V & Reiner E, Pyridinium, imidazolium, and quinucludinium oximes: 51 synthesis, interaction with native and phosphylated cholinesterases, and antidotes against organophosphorus compound, J Med Chem Def 2 (2004) 1.
34. Inns R H & Marrs T C, Prophylaxis against anticholinesterse poisoning, in: Ballantyne B, Clinical and experimental toxicology of organophosphates and carbamates edited by Ballantyne B and Marrs TC, (Butterworth-Heinemann, Oxford); 1992, 602.
35. de Jong L P & Ceulen D I, Anticholinesterase activity and rate of decomposition of some phosphylated oximes, Biochem Pharmacol, 27 (1978) 857.
36. Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R & Eyer P, Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning, Hum Exp Toxicol, 16 (1997) 466.
37. Erdmann W D, Zech R, Franke P & Bosse I, On the problem of the therapeutic effectiveness of esterase reactivators in dimethoate poisoning, Arzneimittelforschung, 16 (1966) 492.
38. Maxwell D M, Saxena A, Gordon R K & Doctor B P, Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases, Chem Biol Interact, 119 (1999) 419.
39. Lipp J A, Effect of diazepam upon soman-induced seizure activity and convulsions, Electroencephalogr Clin Neurophysiol, 32 (1972) 557.
40. Sellström Å, Anticonvulsants in anticholinesterase poisoning, in Clinical and experimental toxicology of organophosphates and carbamates, edited by Ballantyne B, Marrs T C, (Butterworth-Heinemann, Oxford) 1992, 578.
41. McDonough J H Jr, Jaax N K, Crowley R A, Mays M Z & Modrow H E, Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology, FundamAppl Toxicol, 13 (1989) 256.
42. Guidotti A, Toffano G & Costa E, An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain, Nature, 275 (1978) 553.
43. Costa E & Guidotti A, Molecular mechanisms in the receptor action of benzodiazepines, Annu Rev Pharmacol Toxicol, 19 (1979)531.
44. Matsumoto K & Fukuda H, Stimulatory and protective 61 effects of benzodiazepines on GABA receptors labeled with [3H] muscimol, Life sci, 30 (1982) 935.
45. Skerritt J H, Willow M & Johnston G A, Diazepam enhancement of low affinity GABA binding to rat brain 62 membranes, Neurosci Lett, 29 (1982) 63.
46. Shih T M, Cholinergic actions of diazepam and atropine sulfate in soman poisoning, Brain Res Bull, 26 (1991) 565.
47. McDonough J H Jr, Zoeffel L D, McMonagle J, Copeland T 63 L, Smith C D & Shih T M, Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs, Epilepsy Res, 38 (2000) 1.
48. Marrs T C, Diazepam in the treatment of organophosphorusester pesticide poisoning, Toxicol Rev, 22 (2003) 75.
49. Sivilotti M I, Bird S B, Lo J C & Dickson E W, Multiple centrally acting antidotes against severe organophosphate toxicity, Acad Emerg Med, 206 (2006) 359.
50. Stefanovic D, Antonilevic B, Bokonjic D, Stojiljkovic M P, Milovanovic Z A & Nedeljkovic M, Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos, Basic Clin Pharmacol Toxicol, 98 (2006) 173.
51. Dekundy A, Kaminski R M, Zielinska E, & Turski W A, NMDA antagonist exert distinct effects in experimental organophosphate or carbamate poisoning in mice, Toxiol Appl Pharmacol, 219 (2007) 114.
52. Yurumez Y, Cemek M, Yavuz Y, & Birdane Y O, Buyukokuroglu ME, Beneficial effect of N-acetylcysteine against organophosphate toxicity in mice, Biol Pharm Bull, 30 (2007) 490.
53. Buyukokuroglu M E, Cemek M, Yurumez Y, Yavuz Y & Asian A, Antioxidative role of melatonin in organophosphate toxicity in rats, Cell Biol Toxicol, 24 (2008) 151.
54. Yurumez Y, Ikizceli I, Sozuer E M, Soyuer I, Yavuz Y, Avsarogullari L, & Durukan P, Effect of interleukin-10 on tissue damage caused by organophosphate poisoning, Basic Clin Pharmacol Toxicol, 100 (2007) 323.
55. Kalkan S, Ergur B U, Akgun A, Kaplan Y C, Kinay A O & Tuncok Y, Efficacy of an adenosine Al receptor agonist against compared with atropine and pralidoime in a rat model of organophosphate poisoning, Hum Exp Toxicol, 24 (2005) 369.
56. Pibiri F, Kozikowski A P, Pinna G, Auta J, Kadriu B, Costa E & Guidotti A, The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice, PNAS, 105 (2008) 14169.
57. Kventsel I, Berkovitch M, Reiss A, Bulkowstein M & Kozer E, Scopolamine treatment for severe extra-pyramida signs following organophosphate (chloropyrifos) ingestion, Clin Toxicol, (Phila) 43 (2005) 877.
58. Perera P M, Jayamanna S F, Hettiarachchi R, Abesinghe C, Karunatilake H, Dawson AH & Buckley N A, A phase II clinical Trial to assess the safety of clonidine in acute organophosphate pesticide poisoning, Trails, 10 (2009) 73.
59. Pajoumand A, Shadnia S, Rezaie A, Abdi M & Abdollahi M, Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides, Hum Exp Toxicol, 23 (2004) 565.
60. Saxena A, Sun W, Luo C, Myers T M, Koplovitz I, Lenz D E & Doctor B P, Bioscavenger for protection from toxicity of organophosphorus compounds, J Mol Neurosci, 30 (2006) 145.
61. Broomfield C A, Maxwell D M, Solana R P, Castro C A, Finger AV & Lenz D E, Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates, J Pharmacol Exp Ther, 259 (1991) 633.
62. Guven M, Sungur M, Sungur M & Eser B, The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning, Hum Exp Toxicol, 23 (2004) 365.
63. Aurbek N, Thiermann H, Eyer F, Eyer P & Worek F, Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis, Toxicology, 259 (2009)133.
64. Yang C C, & Deng J F, Intermediate syndrome following organophosphate insecticide poisoning, J Chin Med Assoc, 70 (2007) 467.
65. Sudakin D L, Mullins M E, Horowitz B Z, Abshier V & Letzig L, Intermediate syndrome after malathion ingestion despite continuous infusion of pralidoxime, J Toxicol Clin Toxicol, 38 (2000) 47.
66. Johnson M K, Organophosphorus esters causing delayed 81 neurotoxic effects: mechanism of action and structure activity studies, Arch Toxicol, 34 (1975) 259.
67. Lotti M & Moretto A, Organophosphate-induced delayed polyneuropathy, Toxicol Rev, 24 (2005) 37.
68. Johnson M K, Organophosphates and delayed neuropathy-is NTE alive and well? Toxicol Appl Pharmacol, 102 (1990) 385.
69. Husain K, Neurotoxicesterase, Asia Pacific J Pharmacol, 9 (1994)119.
70. Husain K, Peripheral biochemical marker of organophosphate induced delayed neurotoxicity, Biochem Int, 24(1991)1051.
71. Lotti M, Moretto A, Zoppellari R, Dainese R, Rizzuto N, & Barusco G, Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy, Arch Toxicol, 59 (1986) 176.
72. Kwong, Tai C, Organophosphate pesticides: biochemistry 85 and clinical toxicology, Therapeutic Drug Monitoring, 24 (2002)144.
73. Wilson B W, Hooper M, Chow E, Higgins R J & Knaak J B, Antidotes and neuropathic potential of isofenphos, Bull Environ Contam Toxicol, 33 (1984) 386.
74. Piao F Y, Xie X K, Yamamoto H & Kitabatake M, Effect of phenylmethylsulfonyl fluoride administration prior to and following leptophos administration on electrolyte concentration and enzyme activity in hen serum, Environ Health Prev Med, 1 (1996) 44.
75. Songa F, Yanb Y, Zhaoa X, Doua D, Zhanga C & Xie K, Phenylmethylsulfonyl fluoride protects against the degradation 8 8 of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy, Toxicology, 262 (2009) 258.
76. El-Fawal H, Jortner B S & Ehrich M, Effect of verapamil on organophosphorus induced delayed neuropathy in hens, Toxicol Appl pharmacol, 97 (1989) 500.
77. El-Fawal H, Correli I, Gay I & Ehrich M, Proreas activity in brain, nerve and muscle of hens given neupathy inducing 90 organophosphates and a calcium channel blocker, Toxicol Appl Pharmacol, 103 (1990)133.
78. Berry M M, Troske B K, Tanaka D J & Bursian S J, The effect of a ganglioside mixture on the development of TOCP- induced delayed neurotoxicity, Toxicologist, 6 (1986) 219.
79. 12 on Organophosphorus Compound-Induced Delayed Neurotoxicity, J Occupational Health, 46 (2004) 359.
80. Husain K, Pant S C, Singh R & Das Gupta S, Partial protection by dexamethasone against Mipafox induced delayed neurotoxicity in hens, Asia Pacific J Pharmacol, 9 (1994)7.
81. Ehrich M & Gross W B, Effect of corticosterone on toxicity of malathion and TOCP in hens, Neurobehav Toxicol Teratol, 4 (1982) 789.
82. Ehrich M, Jortner B S & Gross W B, Absence of protective effect of corticostrerone on DNF-induced delayed neurotoxicity in chickens, Neurotoxicology, 6 (1985) 86.
83. Willems J L, De Bisschop H C, Verstraete A G, Declerck C, Christiaens Y, Vanscheeuwyck P, Buylaert W A, Vogelaers D & Colardyn F, Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate, Arch Toxicol, 67(1993)79.
84. Balali-Mood M, & Shariat M, Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes, J Physiol Paris, 92 (1998)375.
85. Samuel J, Thomas K, Jeyaseelan L, Peter J V & Cherian A M, Incidence of intermediate syndrome in organophosphorus poisoning, J Assoc Physic India, 43(1995)321.
86. Samuel J, Peter J V, Thomas K, Jeyaseelan L & Cherian A M, Evaluation of two treatment regimens of pralidoxime (lg single bolus dose vs. 12g infusion) in the management of organophosphorus poisoning, J Assoc Physic India, 44 (1996)529.
87. Cherian A M, Peter J V & Samuel J, Effectiveness of P2AM (PAM-pralidoxime) in the treatment of organophosphorus poisoning. A randomized, double-blind, placebo-controlled trial, J Assoc Physic India, 45 (1997) 22.
88. Abdollahi M, Jafari A & Jalali N, A new approach to the efficacy of oximes in the management of acute organophosphate poisoning, Iranian J Med Sci, 20 (1995)105.
89. Eddleston M, Szinicz L, Eyer P & Buckley N, Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials, QJM, 95 (2002)275.
90. Eddleston M, Eyer P, Worek F, Juszczak E, Alder N, Mohamed M, Senarathna L, Hittarage A, Azher S, Jeganatahn K, Jayamanne S, Meyer L V, Dawson A H, Sheriff MH R & Buckley N A, Pralidoime in acute organophosphorus insecticide poisoning-A randomized controlled trial, PLoS Medicine, 6 (2009) 1.