Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides

Human and Experimental Toxicology

Volumn 23, Issue 12, 2004, Pages 565-569

  Pajoumand, Abdolkarim ^a   Shadńia, Shahin ^a,b   Rezaie, Ali ^b   Abdi, Mahboobeh ^b   Abdollahi, Mohammad ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Human; Magnesium; Organophosphorus; Pesticide; Poisoning

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; INSECTICIDE; MAGNESIUM SULFATE; MUSCARINIC RECEPTOR BLOCKING AGENT; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME; PRALIDOXIME;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG INDICATION; FEMALE; HOSPITALIZATION; HUMAN; HYDROLYSIS; INTOXICATION; IRAN; MALE; MORTALITY; PESTICIDE SPRAYING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; SINGLE BLIND PROCEDURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ATROPINE; CHOLINESTERASE REACTIVATORS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INSECTICIDES; MAGNESIUM SULFATE; MALE; MIDDLE AGED; MUSCARINIC ANTAGONISTS; OBIDOXIME CHLORIDE; PHOSPHORIC ACID ESTERS; PRALIDOXIME COMPOUNDS; SINGLE-BLIND METHOD;

EID: 11844251346     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht489oa     Document Type: Article

References (36)

1. Haddad LM, Shannon MW, Winchester JF. Clinical management of poisoning and drug overdose. Philadelphia, Pennsylvania: WB Saunders Co., 1998: 836-45.
2. Eddleston M, Karalliedde L, Buckley N, Fernando R, Hutchinson G, Isbister G et al. Pesticide poisoning in the developing world - a minimum pesticides list. Lancet 2002; 12: 1163-67.
3. Murray D, Wesseling C, Keifer M, Corriols M, Henao S. Surveillance of pesticide related illness in the developing world: putting the data to work. Int J Occup Environ Health 2002; 8: 243-48.
4. Senanayake N, Petris H. Mortality due to poisoning in a developing agricultural country. Trends over 20 years. Hum Exp Toxicol 1995; 14: 808-11.
5. Thomas M, Anandan S, Kuruvilla PJ, Singh PR, David S. Profile of hospital admission following acute poisoning-experiences from major teaching hospital in south India. Adverse Drug React Toxicol Rev 2000; 19: 313-17.
6. Khan MM, Reza H. The pattern of suicide in Pakistan. Crisis 2000; 21: 31-35.
7. Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T. A retrospective study of poisoning in Tehran. J Toxicol Clin Toxicol 1997; 35: 387-93.
8. Abdollahi M, Jalali N, Jafari AA. Organophosphate-induced chronic toxicity in occupationally exposed workers. Med J IR Irn 1995; 9: 221-25.
9. Abdollahi M, Kebriaeezadeh A, Akhgari M, Pirdehghan F, Janat B, Jalali N. Cholinesterase levels in saliva, plasma and erythrocytes of Iranian population. Toxicol Lett 1995; 78 (Suppl 1): 15.
10. Abdollahi M, Balali M, Akhgari M, Jannat B, Kebriaeezadeh A, Nikfar S. A survey of cholinesterase activity in healthy and organophosphate-exposed populations. Irn J Med Sci 1996; 21: 63-66.
11. Jalali N, Pajoumand A, Abdollahi M, Shadnia Sh, Pakravan N. Pesticides poisoning: one-year report of Loghman-Hakim Hospital Poison Center. Prog Med Res 2003; 1: 1-9.
12. Jeyaratnama J. Acute pesticide poisoning: a major global health problem. World Health Statistic Quarterly 1990; 43: 139-44.
13. Selden BS, Curry SC. Prolonged succinylcholine-induced paralysis in organophosphate insecticide poisoning. Ann Emerg Med 1987; 16: 215-17.
14. Tafuri J, Roberts J. Organophosphate poisoning. Ann Emerg Med 1987; 16: 193-202.
15. Abdollahi M, Jafari A, Jalali N, Balai MM, Kebriaeezadeh A, Nikfar S. A new approach to the efficacy of oximes in the management of acute organophosphate poisoning. Irn J Med Sci 1995; 20: 105-109.
16. Cherian AM, Peter JV, Samuel J, Jaydevan R, Peter S, Joel S et al. Effectiveness of pralidoxime in the treatment of organophosphorus poisoning: a randomized, double blind placebo controlled clinical trial. J Assoc Physicians India 1997; 45: 22-24.
17. De Silva HJ, Wijewickrema R, Senanayake N. Does pralidoxime affect outcome of management in acute organophosphorus poisoning? Lancet 1992; 339: 1136-38.
18. Sivagnanam S. Potential therapeutic agents in the management of organophosphorus poisoning. Crit Care 2002; 6: 260-61.
19. Sungur M, Guven M. Intensive care management of organophosphate insecticide poisoning. Crit Care 2001; 5: 211-15.
20. Rossic J. Partial antagonism by cholinesterase reactivators of the effects of organophosphate compounds on shuttle-box avoidance. Arch Int Pharmacodyn 1970; 183: 139-47.
21. Sanderson DM. Treatment of poisoning by anticholinesterase insecticides in the rat. J Pharm Pharmacol 1961; 13: 435-39.
22. Du Toit PW, Muller FO, Nan Tonder MW. Experience with intensive care management of organophosphate insecticide poisoning. SA Med Tydskrif 1981; 60: 227-29.
23. Petroianu G, Toomes LM, Petroianu A, Bergler W, Rufer R. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs. J Appl Toxicol 1998; 18: 293-98.
24. Buccafusco JJ, Aronstam RS. Clonidine protection from the toxicity of soman, an organophosphate acetylcholinesterase inhibitor, in the mouse. J Pharmacol Exp Ther 1986; 239: 43-47.
25. Richard CD, Luke Y, Kathrene MH, Edwin KK. Organophosphate insecticides. The 5-Minute Toxicology Consult. Philadelphia: CT Lippincott Williams & Wilkins, 2000.
26. Durham WF, Hayes WJ, Jr. Organic phosphorus poisoning and its therapy: With special reference to modes of action and compounds that reactivate inhibited cholinesterase. Arch Environ Health 1962; 5: 21-47.
27. Medicis JJ, Stork CM, Howland MA, Hoffman RS, Goldfrank LR. Pharmacokinetics following a loading plus a continuous infusion of pralidoxime compared with the traditional short infusion regimen in human volunteers. J Toxicol Clin Toxicol 1996; 34: 289-95.
28. Petroianu G, Ruefer R. Beta-blockade or magnesium in organophosphorus insecticide poisoning (OPIP). Anaesth Intensive Care 1992; 20: 538-39.
29. Fetcher A. Suspected dimethoate toxicity in cattle. Mod Vet Pract 1984; 65: 283-85.
30. Singh G, Avasthi G, Khurana D, Whig J, Mahajan R. Neurophysiological monitoring of pharmacological manipulation in acute organophosphate (OP) poisoning: the effects of pralidoxime, magnesium sulphate and pancuronium. Electroencephalogr Clin Neurophysiol 1998; 107: 140-48.
31. Del Castillo J, Katz B. Action, and spontaneous release, of acetylcholine at an inexcitable nerve-muscle junction. J Physiol 1954; 126: 27P.
32. Kiss Z, Fazekas T. Organophosphates and torsade de pointes ventricular tachycardia. J Roy Soc Med 1983; 76: 983-84.
33. Abraham S, Oz N, Sahar R, Kadar T. OTC prolongation and cardiac lesions following acute organophosphate poisoning in rats. Proc West Pharmacol Soc 2001; 44: 185-86.
34. Saadeh AM, Farsakh NA, al-Ali MK. Cardiac manifestations of acute carbamate and organophosphate poisoning. Heart 1997; 77: 461-64.
35. Chuang FR, Jang SW, Lin JL, Chern MS, Chen JB, Hsu KT. OTc prolongation indicates a poor prognosis in patients with organophosphate poisoning. Am J Emerg Med 1996; 14: 451-53.
36. Cunningham FG, McDonald PC, Gant NF, Leveno KJ, Gulstrap LC. Hypertensive disorders in pregnancy. Williams obstetrics, 19th edition. London: Prentice Hall, 1993: 763-818.