Analysis of 55 autoimmune disease and type II diabetes loci: Further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3–q14.1

Genes and Immunity

Volumn 10, Issue , 2009, Pages S95-S120

  Cooper, J D ^a   Walker, N M ^a   Healy, B C ^a   Smyth, D J ^a   Downes, K ^a   Todd, J A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Autoimmune disease; SNPs; T1DGC; Type I diabetes; Type II diabetes

Indexed keywords

ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 12; CHROMOSOME 4; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM;

AUTOIMMUNE DISEASES; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 4; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 75649122271     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2009.98     Document Type: Article

References (10)

1. Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008; 359: 2767–2777.
2. Fung EYMG, Smyth DJ, Howson JMM, Cooper JD, Walker NM, Stevens H et al. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun 2009; 10: 188–191.
3. Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J MolMed 2003; 81: 455–470.
4. Cooper JD, Walker NM, Smyth DJ, Downes K, Healy BC, Todd JA and the Type I Diabetes Genetics Consortium. Follow-up of SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 2009; 10(Suppl 1): S85–S94.
5. Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857–864.
6. Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S et al. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 2008; 57: 2693–2697.
7. Raj SM, Howson JMM, Walker NM, Cooper JD, Smyth DJ, Field SF et al. Type 1 diabetes is genetically distinct from type 2 diabetes. Diabetologia 2009; 52: 2109–2116.
8. Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JH, Walker NM et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 2007; 56: 2616–2621.
9. Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008; 40: 1216–1223.
10. Clayton D, Leung HT. An R package for analysis of wholegenome association studies. Hum Hered 2007; 64: 45–51.