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Volumn 183, Issue 9, 2009, Pages 5756-5767

Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADAP PROTEIN; ADAPTOR PROTEIN; CHEMOKINE RECEPTOR CXCR4; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PHOSPHOPROTEIN; PROTEIN SH2; RAC PROTEIN; RAP1 PROTEIN; RIAM PROTEIN; SKAP55 PROTEIN; SLP76 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 77954162555     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900649     Document Type: Article
Times cited : (27)

References (59)
  • 1
    • 33244490746 scopus 로고    scopus 로고
    • SLP76 and SLP65: Complex regulation of signalling in lymphocytes and beyond
    • Koretzky, G. A., F. Abtahian, and M. A. Silverman. 2006. SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nat. Rev. Immunol. 6: 67-78.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 67-78
    • Koretzky, G.A.1    Abtahian, F.2    Silverman, M.A.3
  • 2
    • 0343181431 scopus 로고    scopus 로고
    • The hematopoietic- Specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
    • Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic- specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9: 67-75.
    • (1999) Curr. Biol. , vol.9 , pp. 67-75
    • Liu, S.K.1    Fang, N.2    Koretzky, G.A.3    McGlade, C.J.4
  • 3
    • 0032541062 scopus 로고    scopus 로고
    • Uncoupling of nonreceptor tyrosine kinases from PLC-γ 1 in an SLP-76-deficient T cell
    • Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science 281: 413-416. (Pubitemid 128665444)
    • (1998) Science , vol.281 , Issue.5375 , pp. 413-416
    • Yablonski, D.1    Kuhne, M.R.2    Kadlecek, T.3    Weiss, A.4
  • 4
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: A molecular machine controlling T cell activation
    • DOI 10.1126/science.285.5425.221
    • Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285: 221-227. (Pubitemid 29329988)
    • (1999) Science , vol.285 , Issue.5425 , pp. 221-227
    • Grakoui, A.1    Bromley, S.K.2    Sumen, C.3    Davis, M.M.4    Shaw, A.S.5    Allen, P.M.6    Dustin, M.L.7
  • 5
    • 4644323006 scopus 로고    scopus 로고
    • A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo
    • Gunzer, M., C. Weishaupt, A. Hillmer, Y. Basoglu, P. Friedl, K. E. Dittmar, W. Kolanus, G. Varga, and S. Grabbe. 2004. A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood 104: 2801-2809.
    • (2004) Blood , vol.104 , pp. 2801-2809
    • Gunzer, M.1    Weishaupt, C.2    Hillmer, A.3    Basoglu, Y.4    Friedl, P.5    Dittmar, K.E.6    Kolanus, W.7    Varga, G.8    Grabbe, S.9
  • 6
    • 21844450244 scopus 로고    scopus 로고
    • Intracellular signalling controlling integrin activation in lymphocytes
    • Kinashi, T. 2005. Intracellular signalling controlling integrin activation in lymphocytes. Nat. Rev. Immunol. 5: 546-559.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 546-559
    • Kinashi, T.1
  • 7
    • 0042681786 scopus 로고    scopus 로고
    • Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
    • Kim, M., C. V. Carman, and T. A. Springer. 2003. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301: 1720-1725.
    • (2003) Science , vol.301 , pp. 1720-1725
    • Kim, M.1    Carman, C.V.2    Springer, T.A.3
  • 8
    • 34548259213 scopus 로고    scopus 로고
    • WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse
    • Nolz, J. C., R. B. Medeiros, J. S. Mitchell, P. Zhu, B. D. Freedman, Y. Shimizu, and D. D. Billadeau. 2007. WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol. Cell. Biol. 27: 5986-6000.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 5986-6000
    • Nolz, J.C.1    Medeiros, R.B.2    Mitchell, J.S.3    Zhu, P.4    Freedman, B.D.5    Shimizu, Y.6    Billadeau, D.D.7
  • 9
    • 52249086931 scopus 로고    scopus 로고
    • The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- And CrkL-C3G-mediated activation of Rap1
    • Nolz, J. C., L. P. Nacusi, C. M. Segovis, R. B. Medeiros, J. S. Mitchell, Y. Shimizu, and D. D. Billadeau. 2008. The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J. Cell Biol. 182: 1231-1244.
    • (2008) J. Cell Biol. , vol.182 , pp. 1231-1244
    • Nolz, J.C.1    Nacusi, L.P.2    Segovis, C.M.3    Medeiros, R.B.4    Mitchell, J.S.5    Shimizu, Y.6    Billadeau, D.D.7
  • 11
    • 0036009116 scopus 로고    scopus 로고
    • Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
    • Sebzda, E., M. Bracke, T. Tugal, N. Hogg, and D. A. Cantrell. 2002. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat. Immunol. 3: 251-258.
    • (2002) Nat. Immunol. , vol.3 , pp. 251-258
    • Sebzda, E.1    Bracke, M.2    Tugal, T.3    Hogg, N.4    Cantrell, D.A.5
  • 13
    • 1642482866 scopus 로고    scopus 로고
    • Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-γ1
    • Katagiri, K., M. Shimonaka, and T. Kinashi. 2004. Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-γ1. J. Biol. Chem. 279: 11875-11881.
    • (2004) J. Biol. Chem. , vol.279 , pp. 11875-11881
    • Katagiri, K.1    Shimonaka, M.2    Kinashi, T.3
  • 14
    • 33747623042 scopus 로고    scopus 로고
    • Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
    • Katagiri, K., M. Imamura, and T. Kinashi. 2006. Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat. Immunol. 7: 919-928.
    • (2006) Nat. Immunol. , vol.7 , pp. 919-928
    • Katagiri, K.1    Imamura, M.2    Kinashi, T.3
  • 18
    • 34748849183 scopus 로고    scopus 로고
    • Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
    • Wang, H., H. Liu, Y. Lu, M. Lovatt, B. Wei, and C. E. Rudd. 2007. Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol. Cell. Biol. 27: 6863-6875.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 6863-6875
    • Wang, H.1    Liu, H.2    Lu, Y.3    Lovatt, M.4    Wei, B.5    Rudd, C.E.6
  • 19
    • 49249112051 scopus 로고    scopus 로고
    • Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
    • Bezman, N. A., L. Lian, C. S. Abrams, L. F. Brass, M. L. Kahn, M. S. Jordan, and G. A. Koretzky. 2008. Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J. Exp. Med. 205: 1775-1788.
    • (2008) J. Exp. Med. , vol.205 , pp. 1775-1788
    • Bezman, N.A.1    Lian, L.2    Abrams, C.S.3    Brass, L.F.4    Kahn, M.L.5    Jordan, M.S.6    Koretzky, G.A.7
  • 21
    • 34347337643 scopus 로고    scopus 로고
    • RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    • Menasche, G., S. Kliche, E. J. Chen, T. E. Stradal, B. Schraven, and G. Koretzky. 2007. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol. Cell. Biol. 27: 4070-4081.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4070-4081
    • Menasche, G.1    Kliche, S.2    Chen, E.J.3    Stradal, T.E.4    Schraven, B.5    Koretzky, G.6
  • 22
    • 35348909616 scopus 로고    scopus 로고
    • In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP- 76/Gads interaction
    • Jordan, M. S., J. S. Maltzman, S. Kliche, J. Shabason, J. E. Smith, A. Obstfeld, B. Schraven, and G. A. Koretzky. 2007. In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP- 76/Gads interaction. Eur. J. Immunol. 37: 2961-2972.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 2961-2972
    • Jordan, M.S.1    Maltzman, J.S.2    Kliche, S.3    Shabason, J.4    Smith, J.E.5    Obstfeld, A.6    Schraven, B.7    Koretzky, G.A.8
  • 23
    • 7244221321 scopus 로고    scopus 로고
    • ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation
    • Wang, H., F. E. McCann, J. D. Gordan, X. Wu, M. Raab, T. H. Malik, D. M. Davis, and C. E. Rudd. 2004. ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. J. Exp. Med. 200: 1063-1074.
    • (2004) J. Exp. Med. , vol.200 , pp. 1063-1074
    • Wang, H.1    McCann, F.E.2    Gordan, J.D.3    Wu, X.4    Raab, M.5    Malik, T.H.6    Davis, D.M.7    Rudd, C.E.8
  • 24
    • 0141678842 scopus 로고    scopus 로고
    • Chemokines in the systemic organization of immunity
    • Campbell, D. J., C. H. Kim, and E. C. Butcher. 2003. Chemokines in the systemic organization of immunity. Immunol. Rev. 195: 58-71.
    • (2003) Immunol. Rev. , vol.195 , pp. 58-71
    • Campbell, D.J.1    Kim, C.H.2    Butcher, E.C.3
  • 25
    • 22244438250 scopus 로고    scopus 로고
    • A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
    • Smith, A., Y. R. Carrasco, P. Stanley, N. Kieffer, F. D. Batista, and N. Hogg. 2005. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J. Cell Biol. 170: 141-151.
    • (2005) J. Cell Biol. , vol.170 , pp. 141-151
    • Smith, A.1    Carrasco, Y.R.2    Stanley, P.3    Kieffer, N.4    Batista, F.D.5    Hogg, N.6
  • 26
    • 36349034646 scopus 로고    scopus 로고
    • Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion
    • Ghandour, H., X. Cullere, A. Alvarez, F. W. Luscinskas, and T. N. Mayadas. 2007. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 110: 3682-3690.
    • (2007) Blood , vol.110 , pp. 3682-3690
    • Ghandour, H.1    Cullere, X.2    Alvarez, A.3    Luscinskas, F.W.4    Mayadas, T.N.5
  • 27
    • 0038561221 scopus 로고    scopus 로고
    • Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    • Shimonaka, M., K. Katagiri, T. Nakayama, N. Fujita, T. Tsuruo, O. Yoshie, and T. Kinashi. 2003. Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J. Cell Biol. 161: 417-427.
    • (2003) J. Cell Biol. , vol.161 , pp. 417-427
    • Shimonaka, M.1    Katagiri, K.2    Nakayama, T.3    Fujita, N.4    Tsuruo, T.5    Yoshie, O.6    Kinashi, T.7
  • 28
    • 65649126736 scopus 로고    scopus 로고
    • Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
    • Katagiri, K., T. Katakai, Y. Ebisuno, Y. Ueda, T. Okada, and T. Kinashi. 2009. Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J. 28: 1319-1331.
    • (2009) EMBO J. , vol.28 , pp. 1319-1331
    • Katagiri, K.1    Katakai, T.2    Ebisuno, Y.3    Ueda, Y.4    Okada, T.5    Kinashi, T.6
  • 30
    • 35648963605 scopus 로고    scopus 로고
    • Characterization of interactions of adapter protein RAPL/ Nore1B with RAP GTPases and their role in T cell migration
    • Miertzschke, M., P. Stanley, T. D. Bunney, F. Rodrigues-Lima, N. Hogg, and M. Katan. 2007. Characterization of interactions of adapter protein RAPL/ Nore1B with RAP GTPases and their role in T cell migration. J. Biol. Chem. 282: 30629-30642.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30629-30642
    • Miertzschke, M.1    Stanley, P.2    Bunney, T.D.3    Rodrigues-Lima, F.4    Hogg, N.5    Katan, M.6
  • 32
    • 18844449626 scopus 로고    scopus 로고
    • Vav-family proteins in T-cell signalling
    • Tybulewicz, V. L. 2005. Vav-family proteins in T-cell signalling. Curr. Opin. Immunol. 17: 267-274.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 267-274
    • Tybulewicz, V.L.1
  • 34
    • 33846626054 scopus 로고    scopus 로고
    • Regulation of T-cell activation by the cytoskeleton
    • Billadeau, D. D., J. C. Nolz, and T. S. Gomez. 2007. Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7: 131-143.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 131-143
    • Billadeau, D.D.1    Nolz, J.C.2    Gomez, T.S.3
  • 37
    • 11844291360 scopus 로고    scopus 로고
    • PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/ VASP proteins
    • Jenzora, A., B. Behrendt, J. V. Small, J. Wehland, and T. E. Stradal. 2005. PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/ VASP proteins. FEBS Lett. 579: 455-463.
    • (2005) FEBS Lett. , vol.579 , pp. 455-463
    • Jenzora, A.1    Behrendt, B.2    Small, J.V.3    Wehland, J.4    Stradal, T.E.5
  • 38
    • 0021678703 scopus 로고
    • Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line
    • Weiss, A., and J. D. Stobo. 1984. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J. Exp. Med. 160: 1284-1299.
    • (1984) J. Exp. Med. , vol.160 , pp. 1284-1299
    • Weiss, A.1    Stobo, J.D.2
  • 39
    • 0030002904 scopus 로고    scopus 로고
    • Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor- Mediated interleukin 2 production
    • Motto, D. G., S. E. Ross, J. Wu, L. R. Hendricks-Taylor, and G. A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor- mediated interleukin 2 production. J. Exp. Med. 183: 1937-1943.
    • (1996) J. Exp. Med. , vol.183 , pp. 1937-1943
    • Motto, D.G.1    Ross, S.E.2    Wu, J.3    Hendricks-Taylor, L.R.4    Koretzky, G.A.5
  • 40
    • 0032475935 scopus 로고    scopus 로고
    • Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130
    • Marie-Cardine, A., L. R. Hendricks-Taylor, N. J. Boerth, H. Zhao, B. Schraven, and G. A. Koretzky. 1998. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. J. Biol. Chem. 273: 25789-25795.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25789-25795
    • Marie-Cardine, A.1    Hendricks-Taylor, L.R.2    Boerth, N.J.3    Zhao, H.4    Schraven, B.5    Koretzky, G.A.6
  • 41
    • 0030959305 scopus 로고    scopus 로고
    • Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
    • Musci, M. A., L. R. Hendricks-Taylor, D. G. Motto, M. Paskind, J. Kamens, C. W. Turck, and G. A. Koretzky. 1997. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272: 11674-11677.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11674-11677
    • Musci, M.A.1    Hendricks-Taylor, L.R.2    Motto, D.G.3    Paskind, M.4    Kamens, J.5    Turck, C.W.6    Koretzky, G.A.7
  • 44
    • 36248950704 scopus 로고    scopus 로고
    • Immature hematopoietic cells display selective requirements for adhesion- And degranulation-promoting adaptor protein in development and homeostasis
    • Dluzniewska, J., L. Zou, I. R. Harmon, M. T. Ellingson, and E. J. Peterson. 2007. Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostasis. Eur. J. Immunol. 37: 3208-3219.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3208-3219
    • Dluzniewska, J.1    Zou, L.2    Harmon, I.R.3    Ellingson, M.T.4    Peterson, E.J.5
  • 45
    • 0346244001 scopus 로고    scopus 로고
    • Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events
    • Krutzik, P. O., and G. P. Nolan. 2003. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 55: 61-70.
    • (2003) Cytometry A , vol.55 , pp. 61-70
    • Krutzik, P.O.1    Nolan, G.P.2
  • 46
    • 36549072872 scopus 로고    scopus 로고
    • Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrix
    • Reichardt, P., F. Gunzer, and M. Gunzer. 2007. Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrix. Methods Mol. Biol. 380: 253-269.
    • (2007) Methods Mol. Biol. , vol.380 , pp. 253-269
    • Reichardt, P.1    Gunzer, F.2    Gunzer, M.3
  • 47
    • 0033731119 scopus 로고    scopus 로고
    • Integrin cytoplasmic domain-binding proteins
    • Liu, S., D. A. Calderwood, and M. H. Ginsberg. 2000. Integrin cytoplasmic domain-binding proteins. J. Cell Sci. 113: 3563-3571.
    • (2000) J. Cell Sci. , vol.113 , pp. 3563-3571
    • Liu, S.1    Calderwood, D.A.2    Ginsberg, M.H.3
  • 50
    • 0034326619 scopus 로고    scopus 로고
    • 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity
    • 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity. J. Immunol. 165: 4941-4949.
    • (2000) J. Immunol. , vol.165 , pp. 4941-4949
    • Epler, J.A.1    Liu, R.2    Chung, H.3    Ottoson, N.C.4    Shimizu, Y.5
  • 51
    • 44649191160 scopus 로고    scopus 로고
    • T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76
    • Nguyen, K., N. R. Sylvain, and S. C. Bunnell. 2008. T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28: 810-821.
    • (2008) Immunity , vol.28 , pp. 810-821
    • Nguyen, K.1    Sylvain, N.R.2    Bunnell, S.C.3
  • 52
    • 0032211713 scopus 로고    scopus 로고
    • Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
    • Bubeck Wardenburg, J., R. Pappu, J. Y. Bu, B. Mayer, J. Chernoff, D. Straus, and A. C. Chan. 1998. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 9: 607-616. (Pubitemid 28557589)
    • (1998) Immunity , vol.9 , Issue.5 , pp. 607-616
    • Bubeck Wardenburg, J.1    Pappu, R.2    Bu, J.-Y.3    Mayer, B.4    Chernoff, J.5    Straus, D.6    Chan, A.C.7
  • 53
  • 54
    • 0035254857 scopus 로고    scopus 로고
    • A PAK1- PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT
    • Ku, G. M., D. Yablonski, E. Manser, L. Lim, and A. Weiss. 2001. A PAK1- PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 20: 457-465.
    • (2001) EMBO J. , vol.20 , pp. 457-465
    • Ku, G.M.1    Yablonski, D.2    Manser, E.3    Lim, L.4    Weiss, A.5
  • 55
    • 42949101287 scopus 로고    scopus 로고
    • Phospholipase Cγ1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion
    • Peak, J. C., N. P. Jones, S. Hobbs, M. Katan, and S. A. Eccles. 2008. Phospholipase Cγ1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion. Oncogene 27: 2823-2832.
    • (2008) Oncogene , vol.27 , pp. 2823-2832
    • Peak, J.C.1    Jones, N.P.2    Hobbs, S.3    Katan, M.4    Eccles, S.A.5
  • 56
    • 0035339837 scopus 로고    scopus 로고
    • ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κB activation in response to engagement of CD3 and CD28
    • Herndon, T. M., X. C. Shan, G. C. Tsokos, and R. L. Wange. 2001. ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κB activation in response to engagement of CD3 and CD28. J. Immunol. 166: 5654-5664.
    • (2001) J. Immunol. , vol.166 , pp. 5654-5664
    • Herndon, T.M.1    Shan, X.C.2    Tsokos, G.C.3    Wange, R.L.4
  • 58
    • 37749006707 scopus 로고    scopus 로고
    • Intracellular mediators of CXCR4-dependent signaling in T cells
    • Patrussi, L., and C. T. Baldari. 2008. Intracellular mediators of CXCR4-dependent signaling in T cells. Immunol. Lett. 115: 75-82.
    • (2008) Immunol. Lett. , vol.115 , pp. 75-82
    • Patrussi, L.1    Baldari, C.T.2


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