메뉴 건너뛰기




Volumn 83, Issue 3-4, 2010, Pages 103-107

The molecular pathology of schizophrenia-Focus on histone and DNA modifications

Author keywords

Core histone; CpG methylation; Development; Lysine methylation; Nucleosome; Prefrontal cortex; Psychosis; Transcriptional repression

Indexed keywords

DNA; HISTONE; RNA;

EID: 77954141232     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.08.018     Document Type: Review
Times cited : (35)

References (83)
  • 1
    • 20144373163 scopus 로고    scopus 로고
    • Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
    • Abdolmaleky H.M., et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 134B(1):60-66.
    • (2005) Am. J. Med. Genet. B: Neuropsychiatr. Genet. , vol.134 B , Issue.1 , pp. 60-66
    • Abdolmaleky, H.M.1
  • 2
    • 84934443799 scopus 로고    scopus 로고
    • Epigenetic alterations of the dopaminergic system in major psychiatric disorders
    • Abdolmaleky H.M., et al. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods Mol. Biol. 2008, 448:187-212.
    • (2008) Methods Mol. Biol. , vol.448 , pp. 187-212
    • Abdolmaleky, H.M.1
  • 3
    • 33750244045 scopus 로고    scopus 로고
    • Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    • Abdolmaleky H.M., et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet. 2006, 15(21):3132-3145.
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.21 , pp. 3132-3145
    • Abdolmaleky, H.M.1
  • 4
    • 22244471085 scopus 로고    scopus 로고
    • Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope
    • Abdolmaleky H.M., Thiagalingam S., Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am. J. Pharmacogenomics 2005, 5(3):149-160.
    • (2005) Am. J. Pharmacogenomics , vol.5 , Issue.3 , pp. 149-160
    • Abdolmaleky, H.M.1    Thiagalingam, S.2    Wilcox, M.3
  • 5
    • 38649124003 scopus 로고    scopus 로고
    • Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    • Abel T., Zukin R.S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 2008, 8(1):57-64.
    • (2008) Curr. Opin. Pharmacol. , vol.8 , Issue.1 , pp. 57-64
    • Abel, T.1    Zukin, R.S.2
  • 6
    • 21244501298 scopus 로고    scopus 로고
    • GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
    • Addington A.M., et al. GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss. Mol. Psychiatry 2005, 10(6):581-588.
    • (2005) Mol. Psychiatry , vol.10 , Issue.6 , pp. 581-588
    • Addington, A.M.1
  • 7
    • 58149316420 scopus 로고    scopus 로고
    • Epigenetic regulation in human brain-focus on histone lysine methylation
    • Akbarian S., Huang H.S. Epigenetic regulation in human brain-focus on histone lysine methylation. Biol. Psychiatry 2009, 65(3):198-203.
    • (2009) Biol. Psychiatry , vol.65 , Issue.3 , pp. 198-203
    • Akbarian, S.1    Huang, H.S.2
  • 8
    • 33747872904 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    • Akbarian S., Huang H.S. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res. Rev. 2006, 52(2):293-304.
    • (2006) Brain Res. Rev. , vol.52 , Issue.2 , pp. 293-304
    • Akbarian, S.1    Huang, H.S.2
  • 9
    • 23744449082 scopus 로고    scopus 로고
    • Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia
    • Akbarian S., et al. Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch. Gen. Psychiatry 2005, 62(8):829-840.
    • (2005) Arch. Gen. Psychiatry , vol.62 , Issue.8 , pp. 829-840
    • Akbarian, S.1
  • 10
    • 36049028058 scopus 로고    scopus 로고
    • New nomenclature for chromatin-modifying enzymes
    • Allis C.D., et al. New nomenclature for chromatin-modifying enzymes. Cell 2007, 131(4):633-636.
    • (2007) Cell , vol.131 , Issue.4 , pp. 633-636
    • Allis, C.D.1
  • 11
    • 39749136603 scopus 로고    scopus 로고
    • The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues
    • Al-Mahdawi S., et al. The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues. Hum. Mol. Genet. 2008, 17(5):735-746.
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.5 , pp. 735-746
    • Al-Mahdawi, S.1
  • 12
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A., et al. High-resolution profiling of histone methylations in the human genome. Cell 2007, 129(4):823-837.
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1
  • 13
    • 58549086951 scopus 로고    scopus 로고
    • Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
    • Benes F.M., et al. Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(52):20935-20940.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.52 , pp. 20935-20940
    • Benes, F.M.1
  • 14
    • 64349095390 scopus 로고    scopus 로고
    • An operational definition of epigenetics
    • Berger S.L., et al. An operational definition of epigenetics. Genes Dev. 2009, 23(7):781-783.
    • (2009) Genes Dev. , vol.23 , Issue.7 , pp. 781-783
    • Berger, S.L.1
  • 15
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger S.L. The complex language of chromatin regulation during transcription. Nature 2007, 447(7143):407-412.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 407-412
    • Berger, S.L.1
  • 16
    • 74049085933 scopus 로고    scopus 로고
    • The genetics of schizophrenia, Neuroscience doi:10.10.16/j.neuroscience.2009.04.038.
    • A. Bertolino, G. Blasi, The genetics of schizophrenia, Neuroscience (2009) doi:10.10.16/j.neuroscience.2009.04.038.
    • (2009)
    • Bertolino, A.1    Blasi, G.2
  • 17
    • 33847026146 scopus 로고    scopus 로고
    • Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    • Bollati V., et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res. 2007, 67(3):876-880.
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 876-880
    • Bollati, V.1
  • 18
    • 56649099232 scopus 로고    scopus 로고
    • Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients
    • Bullock W.M., et al. Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. Am. J. Psychiatry 2008, 165(12):1594-1603.
    • (2008) Am. J. Psychiatry , vol.165 , Issue.12 , pp. 1594-1603
    • Bullock, W.M.1
  • 19
    • 14544303760 scopus 로고    scopus 로고
    • Structure and dynamic properties of nucleosome core particles
    • Chakravarthy S., et al. Structure and dynamic properties of nucleosome core particles. FEBS Lett. 2005, 579(4):895-898.
    • (2005) FEBS Lett. , vol.579 , Issue.4 , pp. 895-898
    • Chakravarthy, S.1
  • 20
    • 38949120504 scopus 로고    scopus 로고
    • Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex
    • Cheng M.C., et al. Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex. Int. J. Neuropsychopharmacol. 2008, 11(2):207-216.
    • (2008) Int. J. Neuropsychopharmacol. , vol.11 , Issue.2 , pp. 207-216
    • Cheng, M.C.1
  • 21
    • 47149112211 scopus 로고    scopus 로고
    • DNA methylation changes in schizophrenia and bipolar disorder
    • Connor C.M., Akbarian S. DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics 2008, 3(2):55-58.
    • (2008) Epigenetics , vol.3 , Issue.2 , pp. 55-58
    • Connor, C.M.1    Akbarian, S.2
  • 22
    • 70349576823 scopus 로고    scopus 로고
    • Searching for the true genetic vulnerability for schizophrenia
    • Delisi L.E. Searching for the true genetic vulnerability for schizophrenia. Genome Med. 2009, 1(1):14.
    • (2009) Genome Med. , vol.1 , Issue.1 , pp. 14
    • Delisi, L.E.1
  • 23
    • 26944468327 scopus 로고    scopus 로고
    • Comparisons of brain, uterus, and liver mRNA expression for cytochrome p450s, DNA methyltransferase-1, and catechol-o-methyltransferase in prepubertal female Sprague-Dawley rats exposed to a mixture of aryl hydrocarbon receptor agonists
    • Desaulniers D., et al. Comparisons of brain, uterus, and liver mRNA expression for cytochrome p450s, DNA methyltransferase-1, and catechol-o-methyltransferase in prepubertal female Sprague-Dawley rats exposed to a mixture of aryl hydrocarbon receptor agonists. Toxicol. Sci. 2005, 86(1):175-184.
    • (2005) Toxicol. Sci. , vol.86 , Issue.1 , pp. 175-184
    • Desaulniers, D.1
  • 24
    • 2342471419 scopus 로고    scopus 로고
    • GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
    • Dracheva S., et al. GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia. J. Neurosci. Res. 2004, 76(4):581-592.
    • (2004) J. Neurosci. Res. , vol.76 , Issue.4 , pp. 581-592
    • Dracheva, S.1
  • 25
    • 0034193368 scopus 로고    scopus 로고
    • DNA methyltransferase contributes to delayed ischemic brain injury
    • Endres M., et al. DNA methyltransferase contributes to delayed ischemic brain injury. J. Neurosci. 2000, 20(9):3175-3181.
    • (2000) J. Neurosci. , vol.20 , Issue.9 , pp. 3175-3181
    • Endres, M.1
  • 26
    • 9244249796 scopus 로고    scopus 로고
    • GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and Reelin proteins in cerebellum
    • Fatemi S.H., et al. GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and Reelin proteins in cerebellum. Schizophr. Res. 2005, 72(2-3):109-122.
    • (2005) Schizophr. Res. , vol.72 , Issue.2-3 , pp. 109-122
    • Fatemi, S.H.1
  • 27
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(30):10604-10609.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.30 , pp. 10604-10609
    • Fraga, M.F.1
  • 28
    • 67349238734 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and candidate gene expression: an in vivo and in vitro approach to studying chromatin remodeling in a clinical population
    • Gavin D.P., et al. Histone deacetylase inhibitors and candidate gene expression: an in vivo and in vitro approach to studying chromatin remodeling in a clinical population. J. Psychiatr. Res. 2009, 43(9):870-876.
    • (2009) J. Psychiatr. Res. , vol.43 , Issue.9 , pp. 870-876
    • Gavin, D.P.1
  • 29
    • 47249107242 scopus 로고    scopus 로고
    • Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects
    • Gavin D.P., et al. Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophr. Res. 2008, 103(1-3):330-332.
    • (2008) Schizophr. Res. , vol.103 , Issue.1-3 , pp. 330-332
    • Gavin, D.P.1
  • 30
    • 21544433777 scopus 로고    scopus 로고
    • Reelin promoter hypermethylation in schizophrenia
    • Grayson D.R., et al. Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(26):9341-9346.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.26 , pp. 9341-9346
    • Grayson, D.R.1
  • 31
    • 59349098142 scopus 로고    scopus 로고
    • Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
    • Guidotti A., et al. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol. Sci. 2009, 30(2):55-60.
    • (2009) Trends Pharmacol. Sci. , vol.30 , Issue.2 , pp. 55-60
    • Guidotti, A.1
  • 32
    • 0033759439 scopus 로고    scopus 로고
    • Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    • Guidotti A., et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 2000, 57(11):1061-1069.
    • (2000) Arch. Gen. Psychiatry , vol.57 , Issue.11 , pp. 1061-1069
    • Guidotti, A.1
  • 33
    • 62249133709 scopus 로고    scopus 로고
    • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    • Guttman M., et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009, 458(7235):223-227.
    • (2009) Nature , vol.458 , Issue.7235 , pp. 223-227
    • Guttman, M.1
  • 34
    • 43349105701 scopus 로고    scopus 로고
    • Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
    • Hashimoto T., et al. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am. J. Psychiatry 2008, 165(4):479-489.
    • (2008) Am. J. Psychiatry , vol.165 , Issue.4 , pp. 479-489
    • Hashimoto, T.1
  • 35
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman N.D., et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 2007, 39(3):311-318.
    • (2007) Nat. Genet. , vol.39 , Issue.3 , pp. 311-318
    • Heintzman, N.D.1
  • 36
    • 38649094308 scopus 로고    scopus 로고
    • GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    • Huang H.S., Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS ONE 2007, 2(8):e809.
    • (2007) PLoS ONE , vol.2 , Issue.8
    • Huang, H.S.1    Akbarian, S.2
  • 37
    • 33747186161 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation in postmortem brain
    • Huang H.S., et al. Chromatin immunoprecipitation in postmortem brain. J. Neurosci. Methods 2006, 156(1-2):284-292.
    • (2006) J. Neurosci. Methods , vol.156 , Issue.1-2 , pp. 284-292
    • Huang, H.S.1
  • 38
    • 35448944724 scopus 로고    scopus 로고
    • Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters
    • Huang H.S., et al. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J. Neurosci. 2007, 27(42):11254-11262.
    • (2007) J. Neurosci. , vol.27 , Issue.42 , pp. 11254-11262
    • Huang, H.S.1
  • 39
    • 20044389866 scopus 로고    scopus 로고
    • DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    • Iwamoto K., et al. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J. Neurosci. 2005, 25(22):5376-5381.
    • (2005) J. Neurosci. , vol.25 , Issue.22 , pp. 5376-5381
    • Iwamoto, K.1
  • 40
    • 0036960243 scopus 로고    scopus 로고
    • The changing concept of epigenetics
    • Jablonka E., Lamb M.J. The changing concept of epigenetics. Ann. N. Y. Acad. Sci. 2002, 981:82-96.
    • (2002) Ann. N. Y. Acad. Sci. , vol.981 , pp. 82-96
    • Jablonka, E.1    Lamb, M.J.2
  • 41
    • 58149347147 scopus 로고    scopus 로고
    • Epigenetics in the nervous system
    • Jiang Y., et al. Epigenetics in the nervous system. J. Neurosci. 2008, 28(46):11753-11759.
    • (2008) J. Neurosci. , vol.28 , Issue.46 , pp. 11753-11759
    • Jiang, Y.1
  • 42
    • 43549109877 scopus 로고    scopus 로고
    • Isolation of neuronal chromatin from brain tissue
    • Jiang Y., et al. Isolation of neuronal chromatin from brain tissue. BMC Neurosci. 2008, 9:42.
    • (2008) BMC Neurosci. , vol.9 , pp. 42
    • Jiang, Y.1
  • 43
    • 33847095134 scopus 로고    scopus 로고
    • Complex disease, gender and epigenetics
    • Kaminsky Z., Wang S.C., Petronis A. Complex disease, gender and epigenetics. Ann. Med. 2006, 38(8):530-544.
    • (2006) Ann. Med. , vol.38 , Issue.8 , pp. 530-544
    • Kaminsky, Z.1    Wang, S.C.2    Petronis, A.3
  • 44
    • 59249107052 scopus 로고    scopus 로고
    • DNA methylation profiles in monozygotic and dizygotic twins
    • Kaminsky Z.A., et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet. 2009, 41(2):240-245.
    • (2009) Nat. Genet. , vol.41 , Issue.2 , pp. 240-245
    • Kaminsky, Z.A.1
  • 45
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: the mark and its mediators
    • Klose R.J., Bird A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 2006, 31(2):89-97.
    • (2006) Trends Biochem. Sci. , vol.31 , Issue.2 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 46
    • 34347346108 scopus 로고    scopus 로고
    • Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?
    • Klose R.J., et al. Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?. Mol. Cell. Biol. 2007, 27(11):3951-3961.
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.11 , pp. 3951-3961
    • Klose, R.J.1
  • 47
    • 0036532202 scopus 로고    scopus 로고
    • Histone methylation in transcriptional control
    • Kouzarides T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 2002, 12(2):198-209.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , Issue.2 , pp. 198-209
    • Kouzarides, T.1
  • 48
    • 13244276460 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory formation
    • Levenson J.M., Sweatt J.D. Epigenetic mechanisms in memory formation. Nat. Rev. Neurosci. 2005, 6(2):108-118.
    • (2005) Nat. Rev. Neurosci. , vol.6 , Issue.2 , pp. 108-118
    • Levenson, J.M.1    Sweatt, J.D.2
  • 49
    • 16344372645 scopus 로고    scopus 로고
    • Cortical inhibitory neurons and schizophrenia
    • Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005, 6(4):312-324.
    • (2005) Nat. Rev. Neurosci. , vol.6 , Issue.4 , pp. 312-324
    • Lewis, D.A.1    Hashimoto, T.2    Volk, D.W.3
  • 50
    • 20244366232 scopus 로고    scopus 로고
    • Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia
    • Lundorf M.D., et al. Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 135B(1):94-101.
    • (2005) Am. J. Med. Genet. B: Neuropsychiatr. Genet. , vol.135 B , Issue.1 , pp. 94-101
    • Lundorf, M.D.1
  • 51
    • 51649107515 scopus 로고    scopus 로고
    • Schizophrenia: incriminating genomic evidence
    • Lupski J.R. Schizophrenia: incriminating genomic evidence. Nature 2008, 455(7210):178-179.
    • (2008) Nature , vol.455 , Issue.7210 , pp. 178-179
    • Lupski, J.R.1
  • 52
    • 1242306276 scopus 로고    scopus 로고
    • Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice
    • Marutha Ravindran C.R., Ticku M.K. Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice. Brain Res. Mol. Brain Res. 2004, 121(1-2):19-27.
    • (2004) Brain Res. Mol. Brain Res. , vol.121 , Issue.1-2 , pp. 19-27
    • Marutha Ravindran, C.R.1    Ticku, M.K.2
  • 53
    • 80055106172 scopus 로고    scopus 로고
    • A chromatin assay for human brain tissue
    • Matevossian A., Akbarian S. A chromatin assay for human brain tissue. J. Vis. Exp. 2008, (13).
    • (2008) J. Vis. Exp. , Issue.13
    • Matevossian, A.1    Akbarian, S.2
  • 54
    • 80055115383 scopus 로고    scopus 로고
    • Neuronal nuclei isolation from human postmortem brain tissue
    • Matevossian A., Akbarian S. Neuronal nuclei isolation from human postmortem brain tissue. J. Vis. Exp. 2008, (20).
    • (2008) J. Vis. Exp. , Issue.20
    • Matevossian, A.1    Akbarian, S.2
  • 55
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan P.O., et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 2009, 12(3):342-348.
    • (2009) Nat. Neurosci. , vol.12 , Issue.3 , pp. 342-348
    • McGowan, P.O.1
  • 56
    • 47749133462 scopus 로고    scopus 로고
    • Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    • McGowan P.O., et al. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS ONE 2008, 3(5):e2085.
    • (2008) PLoS ONE , vol.3 , Issue.5
    • McGowan, P.O.1
  • 57
    • 67349117808 scopus 로고    scopus 로고
    • Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia
    • Mellios N., et al. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol. Psychiatry 2008, 65(12):1006-1014.
    • (2008) Biol. Psychiatry , vol.65 , Issue.12 , pp. 1006-1014
    • Mellios, N.1
  • 58
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • Mill J., et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am. J. Hum. Genet. 2008, 82(3):696-711.
    • (2008) Am. J. Hum. Genet. , vol.82 , Issue.3 , pp. 696-711
    • Mill, J.1
  • 59
    • 58149280236 scopus 로고    scopus 로고
    • Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission
    • Monteggia L.M., Kavalali E.T. Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission. Biol. Psychiatry 2009, 65(3):204-210.
    • (2009) Biol. Psychiatry , vol.65 , Issue.3 , pp. 204-210
    • Monteggia, L.M.1    Kavalali, E.T.2
  • 60
    • 33847197088 scopus 로고    scopus 로고
    • Methamphetamine alters expression of DNA methyltransferase 1 mRNA in rat brain
    • Numachi Y., et al. Methamphetamine alters expression of DNA methyltransferase 1 mRNA in rat brain. Neurosci. Lett. 2007, 414(3):213-217.
    • (2007) Neurosci. Lett. , vol.414 , Issue.3 , pp. 213-217
    • Numachi, Y.1
  • 61
    • 10444280129 scopus 로고    scopus 로고
    • Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain
    • Numachi Y., et al. Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain. Ann. N. Y. Acad. Sci. 2004, 1025:102-109.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1025 , pp. 102-109
    • Numachi, Y.1
  • 63
    • 0033751356 scopus 로고    scopus 로고
    • Effects of environmental enrichment on gene expression in the brain
    • Rampon C., et al. Effects of environmental enrichment on gene expression in the brain. Proc. Natl. Acad. Sci. U.S.A. 2000, 97(23):12880-12884.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , Issue.23 , pp. 12880-12884
    • Rampon, C.1
  • 64
    • 34047274419 scopus 로고    scopus 로고
    • Global patterns of histone modifications
    • Rando O.J. Global patterns of histone modifications. Curr. Opin. Genet. Dev. 2007, 17(2):94-99.
    • (2007) Curr. Opin. Genet. Dev. , vol.17 , Issue.2 , pp. 94-99
    • Rando, O.J.1
  • 65
    • 18444385647 scopus 로고    scopus 로고
    • The neurodevelopmental model of schizophrenia: update 2005
    • Rapoport J.L., et al. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 2005, 10(5):434-449.
    • (2005) Mol. Psychiatry , vol.10 , Issue.5 , pp. 434-449
    • Rapoport, J.L.1
  • 66
    • 51649107017 scopus 로고    scopus 로고
    • Rare chromosomal deletions and duplications increase risk of schizophrenia
    • International Schizophrenia Consortium
    • Stone J.L., et al. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008, 455(7210):237-241. International Schizophrenia Consortium.
    • (2008) Nature , vol.455 , Issue.7210 , pp. 237-241
    • Stone, J.L.1
  • 67
    • 33744831161 scopus 로고    scopus 로고
    • Structure of the '30nm' chromatin fibre: a key role for the linker histone
    • Robinson P.J., Rhodes D. Structure of the '30nm' chromatin fibre: a key role for the linker histone. Curr. Opin. Struct. Biol. 2006, 16(3):336-343.
    • (2006) Curr. Opin. Struct. Biol. , vol.16 , Issue.3 , pp. 336-343
    • Robinson, P.J.1    Rhodes, D.2
  • 68
    • 38949195955 scopus 로고    scopus 로고
    • Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    • Salnikow K., Zhitkovich A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem. Res. Toxicol. 2008, 21(1):28-44.
    • (2008) Chem. Res. Toxicol. , vol.21 , Issue.1 , pp. 28-44
    • Salnikow, K.1    Zhitkovich, A.2
  • 69
    • 55849115277 scopus 로고    scopus 로고
    • Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    • Satta R., et al. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(42):16356-16361.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.42 , pp. 16356-16361
    • Satta, R.1
  • 70
    • 77956650846 scopus 로고    scopus 로고
    • Nicotinic cholinergic mechanisms in the regulation of brain DNAmethyltransferase I (DNMT1) expression
    • Maloku E., et al. Nicotinic cholinergic mechanisms in the regulation of brain DNAmethyltransferase I (DNMT1) expression. European Psychiatry 2007, 22(Suppl 1):S88.
    • (2007) European Psychiatry , vol.22 , Issue.SUPPL 1
    • Maloku, E.1
  • 71
    • 57849140661 scopus 로고    scopus 로고
    • Divergent transcription from active promoters
    • Seila A.C., et al. Divergent transcription from active promoters. Science 2008, 322(5909):1849-1851.
    • (2008) Science , vol.322 , Issue.5909 , pp. 1849-1851
    • Seila, A.C.1
  • 72
    • 33845873321 scopus 로고    scopus 로고
    • Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats
    • Shimabukuro M., et al. Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats. Behav. Brain Funct. 2006, 2:37.
    • (2006) Behav. Brain Funct. , vol.2 , pp. 37
    • Shimabukuro, M.1
  • 73
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • Siegmund K.D., et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS ONE 2007, 2(9):e895.
    • (2007) PLoS ONE , vol.2 , Issue.9
    • Siegmund, K.D.1
  • 74
    • 58149166880 scopus 로고    scopus 로고
    • The year in human and medical genetics. Highlights of 2007-2008
    • Smith M. The year in human and medical genetics. Highlights of 2007-2008. Ann. N. Y. Acad. Sci. 2009, 1151:1-21.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1151 , pp. 1-21
    • Smith, M.1
  • 75
    • 22244460464 scopus 로고    scopus 로고
    • Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain
    • Stadler F., et al. Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J. Neurochem. 2005, 94(2):324-336.
    • (2005) J. Neurochem. , vol.94 , Issue.2 , pp. 324-336
    • Stadler, F.1
  • 76
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki M.M., Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 2008, 9(6):465-476.
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 77
    • 58149308474 scopus 로고    scopus 로고
    • Experience-dependent epigenetic modifications in the central nervous system
    • Sweatt J.D. Experience-dependent epigenetic modifications in the central nervous system. Biol. Psychiatry 2009, 65(3):191-197.
    • (2009) Biol. Psychiatry , vol.65 , Issue.3 , pp. 191-197
    • Sweatt, J.D.1
  • 78
    • 34249279202 scopus 로고    scopus 로고
    • Epigenetic aberration of the human REELIN gene in psychiatric disorders
    • 593-600
    • Tamura Y., et al. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol. Psychiatry 2007, 12(6). pp. 519, 593-600.
    • (2007) Mol. Psychiatry , vol.12 , Issue.6 , pp. 519
    • Tamura, Y.1
  • 79
    • 38949150121 scopus 로고    scopus 로고
    • Methylation status of the reelin promoter region in the brain of schizophrenic patients
    • Tochigi M., et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol. Psychiatry 2008, 63(5):530-533.
    • (2008) Biol. Psychiatry , vol.63 , Issue.5 , pp. 530-533
    • Tochigi, M.1
  • 80
    • 34247509796 scopus 로고    scopus 로고
    • Epigenetic regulation in psychiatric disorders
    • Tsankova N., et al. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 2007, 8(5):355-367.
    • (2007) Nat. Rev. Neurosci. , vol.8 , Issue.5 , pp. 355-367
    • Tsankova, N.1
  • 81
    • 0347719319 scopus 로고    scopus 로고
    • DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains
    • Veldic M., et al. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc. Natl. Acad. Sci. U.S.A. 2004, 101(1):348-353.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.1 , pp. 348-353
    • Veldic, M.1
  • 82
    • 13844321733 scopus 로고    scopus 로고
    • In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
    • Veldic M., et al. In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(6):2152-2157.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.6 , pp. 2152-2157
    • Veldic, M.1
  • 83
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver I.C., et al. Epigenetic programming by maternal behavior. Nat. Neurosci. 2004, 7(8):847-854.
    • (2004) Nat. Neurosci. , vol.7 , Issue.8 , pp. 847-854
    • Weaver, I.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.