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Volumn 22, Issue 4, 2010, Pages 237-244

Interplay between CD45RA+ regulatory T cells and TNF-α in the regulation of human Th17 differentiation

Author keywords

Th17; TNF ; Treg

Indexed keywords

ALPHA INTERFERON; CD45RA ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 22; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

EID: 77954051914     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp130     Document Type: Article
Times cited : (10)

References (55)
  • 1
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: the long and winding road
    • McGeachy, M. J. and Cua, D. J. 2008. Th17 cell differentiation: the long and winding road. Immunity 28:445.
    • (2008) Immunity , vol.28 , pp. 445
    • McGeachy, M.J.1    Cua, D.J.2
  • 2
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: an updated view of their molecular identity and genetic programming
    • Dong, C. 2008. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8:337.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 337
    • Dong, C.1
  • 3
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann, P., Eder, R., Boeld, T. J. et al. 2006. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108:4260.
    • (2006) Blood , vol.108 , pp. 4260
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 4
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara, M., Yoshioka, Y., Kitoh, A. et al. 2009. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30:899.
    • (2009) Immunity , vol.30 , pp. 899
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 5
    • 44449171488 scopus 로고    scopus 로고
    • Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
    • Venken, K., Hellings, N., Broekmans, T., Hensen, K., Rummens, J. L. and Stinissen, P. 2008. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 180:6411.
    • (2008) J. Immunol. , vol.180 , pp. 6411
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.L.5    Stinissen, P.6
  • 6
    • 40549138745 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    • Nistala, K., Moncrieffe, H., Newton, K. R., Varsani, H., Hunter, P. and Wedderburn, L. R. 2008. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58:875.
    • (2008) Arthritis Rheum. , vol.58 , pp. 875
    • Nistala, K.1    Moncrieffe, H.2    Newton, K.R.3    Varsani, H.4    Hunter, P.5    Wedderburn, L.R.6
  • 8
    • 55849126729 scopus 로고    scopus 로고
    • Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
    • Michel, L., Berthelot, L., Pettre, S. et al. 2008. Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J. Clin. Invest. 118:3411.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3411
    • Michel, L.1    Berthelot, L.2    Pettre, S.3
  • 9
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W. et al. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235.
    • (2006) Nature , vol.441 , pp. 235
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 10
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan, P. R., Harrington, L. E., O'Quinn, D. B. et al. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231.
    • (2006) Nature , vol.441 , pp. 231
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 11
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    • Yang, L., Anderson, D. E., Baecher-Allan, C. et al. 2008. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454:350.
    • (2008) Nature , vol.454 , pp. 350
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3
  • 12
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn, T., Bettelli, E., Gao, W. et al. 2007. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484.
    • (2007) Nature , vol.448 , pp. 484
    • Korn, T.1    Bettelli, E.2    Gao, W.3
  • 13
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. and Sallusto, F. 2007. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8:942.
    • (2007) Nat. Immunol. , vol.8 , pp. 942
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 14
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson, N. J., Boniface, K., Chan, J. R. et al. 2007. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8:950.
    • (2007) Nat. Immunol. , vol.8 , pp. 950
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 15
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat
    • Manel, N., Unutmaz, D. and Littman, D. R. 2008. The differentiation of human T(H)-17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9:641.
    • (2008) Nat. Immunol. , vol.9 , pp. 641
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 16
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe, E., Servant, N., Zollinger, R. et al. 2008. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 9:650.
    • (2008) Nat. Immunol. , vol.9 , pp. 650
    • Volpe, E.1    Servant, N.2    Zollinger, R.3
  • 17
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence, A., Tato, C. M., Davidson, T. S. et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371.
    • (2007) Immunity , vol.26 , pp. 371
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3
  • 18
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng, Y., Danilenko, D. M., Valdez, P. et al. 2007. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445:648.
    • (2007) Nature , vol.445 , pp. 648
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3
  • 19
    • 60549095448 scopus 로고    scopus 로고
    • Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    • Veldhoen, M., Hirota, K., Christensen, J., O'Garra, A. and Stockinger, B. 2009. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J. Exp. Med. 206:43.
    • (2009) J. Exp. Med. , vol.206 , pp. 43
    • Veldhoen, M.1    Hirota, K.2    Christensen, J.3    O'Garra, A.4    Stockinger, B.5
  • 20
    • 34249079176 scopus 로고    scopus 로고
    • Surface phenotype and antigenic specificity of human interleukin 17producing T helper memory cells
    • Acosta-Rodriguez, E. V., Rivino, L., Geginat, J. et al. 2007. Surface phenotype and antigenic specificity of human interleukin 17producing T helper memory cells. Nat. Immunol. 8:639.
    • (2007) Nat. Immunol. , vol.8 , pp. 639
    • Acosta-Rodriguez, E.V.1    Rivino, L.2    Geginat, J.3
  • 21
    • 55749116154 scopus 로고    scopus 로고
    • Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
    • Chizzolini, C., Chicheportiche, R., Alvarez, M. et al. 2008. Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion. Blood 112:3696.
    • (2008) Blood , vol.112 , pp. 3696
    • Chizzolini, C.1    Chicheportiche, R.2    Alvarez, M.3
  • 22
    • 41549158609 scopus 로고    scopus 로고
    • Cytokines as therapeutic targets: advances and limitations
    • Scheinecker, C., Redlich, K. and Smolen, J. S. 2008. Cytokines as therapeutic targets: advances and limitations. Immunity 28:440.
    • (2008) Immunity , vol.28 , pp. 440
    • Scheinecker, C.1    Redlich, K.2    Smolen, J.S.3
  • 24
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNFalpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    • Nadkarni, S., Mauri, C. and Ehrenstein, M. R. 2007. Anti-TNFalpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J. Exp. Med. 204:33.
    • (2007) J. Exp. Med. , vol.204 , pp. 33
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 25
    • 38949155203 scopus 로고    scopus 로고
    • Regulation of IL-17 production in human lymphocytes
    • Chen, Z. and O'Shea, J. J. 2008. Regulation of IL-17 production in human lymphocytes. Cytokine 41:71.
    • (2008) Cytokine , vol.41 , pp. 71
    • Chen, Z.1    O'Shea, J.J.2
  • 26
    • 0034652002 scopus 로고    scopus 로고
    • CD47 engagement inhibits cytokine production and maturation of human dendritic cells
    • Demeure, C. E., Tanaka, H., Mateo, V., Rubio, M., Delespesse, G. and Sarfati, M. 2000. CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J. Immunol. 164:2193.
    • (2000) J. Immunol. , vol.164 , pp. 2193
    • Demeure, C.E.1    Tanaka, H.2    Mateo, V.3    Rubio, M.4    Delespesse, G.5    Sarfati, M.6
  • 28
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • Ziolkowska, M., Koc, A., Luszczykiewicz, G. et al. 2000. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol. 164:2832.
    • (2000) J. Immunol. , vol.164 , pp. 2832
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3
  • 29
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes, I. B. and Schett, G. 2007. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7:429.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 429
    • McInnes, I.B.1    Schett, G.2
  • 30
    • 35348948374 scopus 로고    scopus 로고
    • Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    • van Beelen, A. J., Zelinkova, Z., Taanman-Kueter, E. W. et al. 2007. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27:660.
    • (2007) Immunity , vol.27 , pp. 660
    • van Beelen, A.J.1    Zelinkova, Z.2    Taanman-Kueter, E.W.3
  • 31
    • 26844503161 scopus 로고    scopus 로고
    • Paradoxical antiinflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells
    • Zakharova, M. and Ziegler, H. K. 2005. Paradoxical antiinflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. J. Immunol. 175:5024.
    • (2005) J. Immunol. , vol.175 , pp. 5024
    • Zakharova, M.1    Ziegler, H.K.2
  • 32
    • 58149166804 scopus 로고    scopus 로고
    • Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    • Notley, C. A., Inglis, J. J., Alzabin, S., McCann, F. E., McNamee, K. E. and Williams, R. O. 2008. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J. Exp. Med. 205:2491.
    • (2008) J. Exp. Med. , vol.205 , pp. 2491
    • Notley, C.A.1    Inglis, J.J.2    Alzabin, S.3    McCann, F.E.4    McNamee, K.E.5    Williams, R.O.6
  • 33
    • 40449141770 scopus 로고    scopus 로고
    • Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
    • Singh, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N. and Farber, J. M. 2008. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 180:214.
    • (2008) J. Immunol. , vol.180 , pp. 214
    • Singh, S.P.1    Zhang, H.H.2    Foley, J.F.3    Hedrick, M.N.4    Farber, J.M.5
  • 34
    • 70449704670 scopus 로고    scopus 로고
    • Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    • Bradshaw, E. M., Raddassi, K., Elyaman, W. et al. 2009. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J. Immunol. 183:4432.
    • (2009) J. Immunol. , vol.183 , pp. 4432
    • Bradshaw, E.M.1    Raddassi, K.2    Elyaman, W.3
  • 35
    • 45149118823 scopus 로고    scopus 로고
    • Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
    • Gerosa, F., Baldani-Guerra, B., Lyakh, L. A. et al. 2008. Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J. Exp. Med. 205:1447.
    • (2008) J. Exp. Med. , vol.205 , pp. 1447
    • Gerosa, F.1    Baldani-Guerra, B.2    Lyakh, L.A.3
  • 36
    • 40749159713 scopus 로고    scopus 로고
    • Distinct, specific IL-17and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response
    • Scriba, T. J., Kalsdorf, B., Abrahams, D. A. et al. 2008. Distinct, specific IL-17and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J. Immunol. 180:1962.
    • (2008) J. Immunol. , vol.180 , pp. 1962
    • Scriba, T.J.1    Kalsdorf, B.2    Abrahams, D.A.3
  • 37
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng, Y., Valdez, P. A., Danilenko, D. M. et al. 2008. Interleukin22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14:282.
    • (2008) Nat. Med. , vol.14 , pp. 282
    • Zheng, Y.1    Valdez, P.A.2    Danilenko, D.M.3
  • 38
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame, H., Kakuta, S., Nagai, T. et al. 2009. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30:108.
    • (2009) Immunity , vol.30 , pp. 108
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3
  • 39
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto, K., Ogawa, A., Mizoguchi, E. et al. 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118:534.
    • (2008) J. Clin. Invest. , vol.118 , pp. 534
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3
  • 40
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17producing T cells
    • Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17producing T cells. Immunity 24:179.
    • (2006) Immunity , vol.24 , pp. 179
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 41
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: regulatory T cells induce CD4+CD25-Foxp3T cells or are selfinduced to become Th17 cells in the absence of exogenous TGFbeta
    • Xu, L., Kitani, A., Fuss, I. and Strober, W. 2007. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3T cells or are selfinduced to become Th17 cells in the absence of exogenous TGFbeta. J. Immunol. 178:6725.
    • (2007) J. Immunol. , vol.178 , pp. 6725
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 42
    • 36749081557 scopus 로고    scopus 로고
    • Optimal induction of T helper 17 cells in humans requires Tcell receptor ligation in the context of Toll-like receptor-activated monocytes
    • Evans, H. G., Suddason, T., Jackson, I., Taams, L. S. and Lord, G. M. 2007. Optimal induction of T helper 17 cells in humans requires Tcell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl Acad. Sci. USA 104:17034.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 17034
    • Evans, H.G.1    Suddason, T.2    Jackson, I.3    Taams, L.S.4    Lord, G.M.5
  • 43
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen, H. J., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. and Joosten, I. 2008. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 112:2340.
    • (2008) Blood , vol.112 , pp. 2340
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 44
    • 63849183918 scopus 로고    scopus 로고
    • Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    • Voo, K. S., Wang, Y. H., Santori, F. R. et al. 2009. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc. Natl Acad. Sci. USA 106:4793.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 4793
    • Voo, K.S.1    Wang, Y.H.2    Santori, F.R.3
  • 45
    • 60549094470 scopus 로고    scopus 로고
    • TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    • Santarlasci, V., Maggi, L., Capone, M. et al. 2009. TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur. J. Immunol. 39:207.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 207
    • Santarlasci, V.1    Maggi, L.2    Capone, M.3
  • 46
    • 34250864955 scopus 로고    scopus 로고
    • Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    • Chen, X., Baumel, M., Mannel, D. N., Howard, O. M. and Oppenheim, J. J. 2007. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J. Immunol. 179:154.
    • (2007) J. Immunol. , vol.179 , pp. 154
    • Chen, X.1    Baumel, M.2    Mannel, D.N.3    Howard, O.M.4    Oppenheim, J.J.5
  • 47
    • 70349668946 scopus 로고    scopus 로고
    • The tumorpromoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans
    • Charles, K. A., Kulbe, H., Soper, R. et al. 2009. The tumorpromoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J. Clin. Invest. 119:3011.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3011
    • Charles, K.A.1    Kulbe, H.2    Soper, R.3
  • 48
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • Smith, A. M., Rahman, F. Z., Hayee, B. et al. 2009. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J. Exp. Med. 206:1883.
    • (2009) J. Exp. Med. , vol.206 , pp. 1883
    • Smith, A.M.1    Rahman, F.Z.2    Hayee, B.3
  • 50
    • 40649108353 scopus 로고    scopus 로고
    • New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept
    • Song, I. H., Appel, H., Haibel, H. et al. 2008. New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept. J. Rheumatol. 35:532.
    • (2008) J. Rheumatol. , vol.35 , pp. 532
    • Song, I.H.1    Appel, H.2    Haibel, H.3
  • 52
    • 0023904746 scopus 로고
    • Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
    • Selmaj, K. W. and Raine, C. S. 1988. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:339.
    • (1988) Ann. Neurol. , vol.23 , pp. 339
    • Selmaj, K.W.1    Raine, C.S.2
  • 53
    • 0025092159 scopus 로고
    • Proliferation of astrocytes in vitro in response to cytokines A primary role for tumor necrosis factor
    • Selmaj, K. W., Farooq, M., Norton, W. T., Raine, C. S. and Brosnan, C. F. 1990. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J. Immunol. 144:129.
    • (1990) J. Immunol. , vol.144 , pp. 129
    • Selmaj, K.W.1    Farooq, M.2    Norton, W.T.3    Raine, C.S.4    Brosnan, C.F.5
  • 54
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: results of a randomized, placebocontrolled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • TNF neutralization in MS: results of a randomized, placebocontrolled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology. 53:457.
    • Neurology , vol.53 , pp. 457
  • 55
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17producing T cells that mediate autoimmune encephalomyelitis
    • Sutton, C., Brereton, C., Keogh, B., Mills, K. H. and Lavelle, E. C. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203:1685.
    • (2006) J. Exp. Med. , vol.203 , pp. 1685
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.