Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes

Experimental Dermatology

Volumn 19, Issue 6, 2010, Pages 493-500

  Ayli, Elias E ^a   Dugas Breit, Susanne ^a   Li, Weijie ^a   Marshall, Christine ^a   Zhao, Liang ^a   Meulener, Marc ^a   Griffin, Thomas ^a   Gelfand, Joel M ^a   Seykora, John T ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Curcumin; Keratinocytes; MAP kinases; P53; UVB

Indexed keywords

ACETYLCYSTEINE; CURCUMIN; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; PROTEIN P53; SERINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TETRAHYDROCURCUMIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KERATINOCYTE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION;

ACETYLCYSTEINE; CELL DIVISION; CELL PROLIFERATION; CELLS, CULTURED; CURCUMIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GLUTATHIONE; HUMANS; IMIDAZOLES; INTERPHASE; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 77954038091     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01081.x     Document Type: Article

References (50)

1. Tilak J C, Banerjee M, Mohan H, Devasagayam T P. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res 2004, 18:798-804.
2. Aggarwal B B, Kumar A, Bharti A C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003, 23:363-398.
3. Huang M T, Newmark H L, Frenkel K. Inhibitory effects of curcumin on tumorigenesis in mice. J Cell Biochem Suppl 1997, 27:26-34.
4. Choudhuri T, Pal S, Das T, Sa G. Curcumin selectively induces apoptosis in deregulated cyclin D1 expressed cells at G2 phase of cell cycle in a p53-dependent manner. J Biol Chem 2005, 280:20059-20068. Feb 28: [Epub ahead of print]
5. Joe B, Lokesh B R. Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 1997, 32:1173-1180.
6. Korutla L, Cheung J Y, Mendelsohn J, Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine kinase phosphorylation by curcumin. Carcinogenesis 1995, 16:1741-1745.
7. Xu Y X, Pindolia K R, Janakiraman N, Noth C J, Chapman R A, Gautam S C. Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells. Exp Hematol 1997, 25:413-422.
8. White E L, Ross L J, Schmid S M, Kelloff G J, Steele V E, Hill D L. Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells. Oncol Rep 1998, 5:507-512.
9. Surh Y J. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002, 40:1091-1097.
10. Squamous Cell Carcinoma. 2008, " , " April
11. Czarnecki D, Meehan C J, Bruce F, Culjak G. The majority of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg 2002, 6:207-209.
12. Einspahr J, Alberts D S, Aickin M. Expression of p53 protein in actinic keratosis, adjacent, normal-appearing, and non-sun-exposed human skin. Cancer Epidemiol Biomarkers Prev 1997, 6:583-587.
13. Ziegler A, Jonason A S, Leffell D J. Sunburn and p53 in the onset of skin cancer. Nature 1994, 372:773-776.
14. Nindl I, Gottschling M, Krawtchenko N. Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis. Br J Dermatol 2007, 156(Suppl 3):34-39.
15. Rehman I, Takata M, Wu Y Y, Rees J L. Genetic change in actinic keratoses. Oncogene 1996, 12:2483-2490.
16. Tang X, Zhu Y, Han L. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest 2007, 117:3753-3764.
17. Khavari T A, Rinn J. Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle 2007, 6:2928-2931.
18. Li W, Marshall C, Mei L. Srcasm Modulates EGF and Src-kinase Signaling in Keratinocytes. J Biol Chem 2005, 280:6036-6046.
19. Peus D, Vasa R A, Beyerle A, Meves A, Krautmacher C, Pittelkow M R. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 1999, 112:751-756.
20. Li W, Marshall C, Mei L, Gelfand J, Seykora J T. Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation. J Biol Chem 2007, 282:1161-1169.
21. Liu E, Wu J, Cao W. Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J Neurooncol 2007, 85:263-270.
22. Park C, Kim G Y, Kim G D, Choi B T, Park Y M, Choi Y H. Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep 2006, 15:1225-1231.
23. Park M J, Kim E H, Park I C. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol 2002, 21:379-383.
24. Zheng M, Ekmekcioglu S, Walch E T, Tang C H, Grimm E A. Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. Melanoma Res 2004, 14:165-171.
25. Kwon Y K, Jun J M, Shin S W, Cho J W, Suh S I. Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells. Int J Oncol 2005, 26:1597-1603.
26. Moragoda L, Jaszewski R, Majumdar A P. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 2001, 21:873-878.
27. Bourcier C, Jacquel A, Hess J. p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res 2006, 66:2700-2707.
28. Eckert R L, Crish J F, Efimova T, Balasubramanian S. Antioxidants regulate normal human keratinocyte differentiation. Biochem Pharmacol 2004, 68:1125-1131.
29. Pol A, Bergers M, Schalkwijk J. Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human keratinocytes, using a simple 96-well-plate assay. In Vitro Cell Dev Biol Anim 2003, 39:36-42.
30. Chouinard N, Valerie K, Rouabhia M, Huot J. UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. Biochem J 2002, 365:133-145.
31. Zeigler M E, Krause S, Karmiol S, Varani J. Growth factor-induced epidermal invasion of the dermis in human skin organ culture: dermal invasion correlated with epithelial cell motility. Invasion Metastasis 1996, 16:3-10.
32. Dujic J, Kippenberger S, Hoffmann S. Low Concentrations of Curcumin Induce Growth Arrest and Apoptosis in Skin Keratinocytes Only in Combination with UVA or Visible Light. J Invest Dermatol 2007, 127:1992-2000.
33. Wilhelm D, Bender K, Knebel A, Angel P. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol 1997, 17:4792-4800.
34. Awasthi S, Pandya U, Singhal S S. Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chem Biol Interact 2000, 128:19-38.
35. Oetari S, Sudibyo M, Commandeur J N, Samhoedi R, Vermeulen N P. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol 1996, 51:39-45.
36. Bean L J, Stark G R. Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV. Oncogene 2001, 20:1076-1084.
37. Kapoor M, Hamm R, Yan W, Taya Y, Lozano G. Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation. Oncogene 2000, 19:358-364.
38. el-Deiry W S, Tokino T, Velculescu V E. WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
39. Gao M, Zhou H, Li X. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol 2009, 104:236-240.
40. Siwak D R, Shishodia S, Aggarwal B B, Kurzrock R. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 2005, 104:879-890.
41. Roberts P J, Der C J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26:3291-3310.
42. Aggarwal B B, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol 2007, 73:1024-1032.
43. Marks R, Rennie G, Selwood T S. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988, 1:795-797.
44. Shieh S Y, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997, 91:325-334.
45. Lee Y S, Sohn K C, Kim K H. Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte. Exp Dermatol 2009, 18:50-56.
46. Uddin S, Sassano A, Deb D K. Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem 2002, 277:14408-14416.
47. Kurd S, Smith N, VanVoorhees A. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: a prospective clinical trial. J Am Acad Dermatol 2008, 58:625-631.
48. Shenouda N S, Zhou C, Browning J D. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 2004, 49:200-208.
49. Chen H, Zhang Z S, Zhang Y L, Zhou D Y. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 1999, 19:3675-3680.
50. Balasubramanian S, Eckert R L. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol Chem 2007, 282:6707-6715.