The tubulin-bound structure of the antimitotic drug tubulysin

Angewandte Chemie - International Edition

Volumn 49, Issue 28, 2010, Pages 4809-4812

  Kubicek, Karel ^b,d   Grimm, S Kaspar ^b   Orts, Julien ^a   Sasse, Florenz ^c   Carlomagno, Teresa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Conformation analysis; Cytotoxicity; Microtubules; NMR spectroscopy; Tubulysin

Indexed keywords

BIOACTIVE CONFORMATION; BOUND STRUCTURE; CONFORMATION ANALYSIS; EPOTHILONE A; MICROTUBULES; NMR SPECTROSCOPY; SOLUTION STRUCTURES;

BINDING ENERGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CYTOTOXICITY;

ANTIMITOTIC AGENT; OLIGOPEPTIDE; TUBULIN; PROTEIN BINDING;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANTIMITOTIC AGENTS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 77953989187     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200906828     Document Type: Article

References (26)

1. F. Sasse, H. Steinmetz, J. Heil, G. Höfle, J. Antibiot. 2000, 53, 879-885.
2. M. W. Khalil, F. Sasse, H. Lunsdorf, Y. A. Elnakady, ChemBioChem 2006, 7, 678-683.
3. H. Steinmetz, N. Glaser, E. Herdtweck, F. Sasse, H. Reichenbach, G. Höfle, Angew. Chem. 2004, 116, 4996-5000;
4. Angew. Chem. Int. Ed. 2004, 43, 4888-4892.
5. R. B. Ravelli, B. Gigant, P. A. Curmi, I. Jourdain, S. Lachkar, A. Sobel, M. Knossow, Nature 2004, 428, 198-202.
6. B. Gigant, C. Wang, R. B. Ravelli, F. Roussi, M. O. Steinmetz, P. A. Curmi, A. Sobel, M. Knossow, Nature 2005, 435, 519-522.
7. a) R. Bai, G. R. Pettit, E. Hamel, J. Biol. Chem. 1990, 265, 17141-17149;
8. b) R. Bai, M. C. Roach, S. K. Jayaram, J. Barkoczy, G. R. Pettit, R. F. Luduena, E. Hamel, Biochem. Pharmacol. 1993, 45, 1503-1515;
9. c) R. Bai, N. A. Durso, D. L. Sackett, E. Hamel, Biochemistry 1999, 38, 14302-14310.
10. E. Nogales, S. G. Wolf, K. H. Downing, Nature 1998, 393, 191.
11. J. H. Nettles, H. L. Li, B. Cornett, J. M. Krahn, J. P. Snyder, K. H. Downing, Science 2004, 305, 866-869.
12. T. Carlomagno, M. J. J. Blommers, J. Meiler, W. Jahnke, T. Schupp, F. Petersen, D. Schinzer, K. H. Altmann, C. Griesinger, Angew. Chem. 2003, 115, 2619-2621;
13. Angew. Chem. Int. Ed. 2003, 42, 2515-2517.
14. Z. Wang, P. A. McPherson, B. S. Raccor, R. Balachandran, G. Zhu, B. W. Day, A. Vogt, P. Wipf, Chem. Biol. Drug Des 2007, 70, 75-86.
15. A. W. Patterson, H. M. Peltier, F. Sasse, J. A. Ellman, Chem. Eur. J. 2007, 13, 9534-9541.
16. V. M. Sánchez-Pedregal, M. Reese, J. Meiler, M. J. J. Blommers, C. Griesinger, T. Carlomagno, Angew. Chem. 2005, 117, 4244-4247;
17. Angew. Chem. Int. Ed. 2005, 44, 4172-4175.
18. M. Reese, V. M. Sánchez-Pedregal, K. Kubicek, J. Meiler, M. J. J. Blommers, C. Griesinger, T. Carlomagno, Angew. Chem. 2007, 119, 1896-1900;
19. Angew. Chem. Int. Ed. 2007, 46, 1864-1868.
20. a) R. M. Buey, E. Calvo, I. Barasoain, O. Pineda, M. C. Edler, R. Matesanz, G. Cerezo, C. D. Vanderwal, B. W. Day, E. J. Sorensen, J. A. López, J. M. Andreu, E. Hamel, J. F. Díaz, Nat. Chem. Biol. 2007, 3, 117-125;
21. b) J. F. Diaz, I. Barasoain, A. A. Souto, F. Amat-Guerri, J. M. Andreu, J. Biol. Chem, 2005, 280, 3928-3937.
22. A. Cormier, M. Marchand, R. B. G. Ravelli, M. Knossow, B. Gigant, EMBO Rep. 2008, 9, 1101-1106.
23. V. M. Sánchez-Pedregal, K. Kubicek, J. Meiler, I. Lyothier, I. Paterson, T. Carlomagno, Angew. Chem. 2006, 118, 7548-7554;
24. Angew. Chem. Int. Ed. 2006, 45, 7388-7394.
25. F. Delaglio, S. Grzesiek, G. W. Vuister, G. Zhu, J. Pfeifer, A. Bax, J. Biomol. NMR 1995, 6, 277-293.
26. C. D. Schwieters, J. J. Kuszewski, N. Tjandra, G. M. Clore, J. Magn. Reson. 2003, 160, 65-73.