Reconstitution of self-tolerance after hematopoietic stem cell transplantation

Immunologic Research

Volumn 47, Issue 1-3, 2010, Pages 143-152

  Hess, Allan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Allogeneic graft versus host disease; Autologous graft versus host disease; Hematopoietic stem cell transplantation; Regulatory T cells

Indexed keywords

CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGEN SPECIFICITY; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL COMMUNICATION; CELL SURFACE; DISEASE EXACERBATION; EPITHELIUM CELL; GENE EXPRESSION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; THYMUS; ALLOTRANSPLANTATION; ANIMAL; AUTOTRANSPLANTATION; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY;

ANIMALS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 77953958821     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8145-2     Document Type: Review

References (59)

1. JH Kersey D Weisdorf ME Nesbit TW LeBien WG Woods PB McGlave T Kim DA Vallera AI Goldman B Bostrom D Hurd NKC Ramsay 1987 Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia N Engl J Med 317 461 467 3302708 (Pubitemid 17135960)
2. PL Weiden N Flournoy ED Thomas R Prentice A Fefer CD Buckner R Storb 1979 Anti-leukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts N Engl J Med 300 1068 1073 34792
3. RJ Jones RF Ambinder S Piantadosi GW Santos 1991 Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation Blood 77 649 653 1991174
4. MM Horowitz RP Gale PM Sondel JM Goldman J Kersey H-J Kolb AA Rimm O Ringden C Rozman B Speck RL Truitt FE Zwaan 1990 Graft-versus-leukemia reactions after bone marrow transplantation Blood 75 555 562 2297567 (Pubitemid 20069191)
5. Petersdorf EW. Hematopoietic cell transplantation from unrelated donors. In: Blume KG, Forman SJ, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation. Malden: Blackwell; 2004. p. 1132-49.
6. WD Shlomchik MS Coizens CB Tang, et al. 1999 Prevention of graft-versus-host disease by inactivation of host antigen-presenting cells Science 285 412 415 10.1126/science.285.5426.412 10411505 (Pubitemid 29343964)
7. CC Matte J Liu BE Anderson, et al. 2004 Donor APC's are required for maximal GVHD but not for GVL Nat Med 10 987 992 10.1038/nm1089 15286785 (Pubitemid 39273741)
8. PP Reddy 2003 Pathophysiology of acute graft-versus-host disease Hematol Oncol 21 149 161 10.1002/hon.716 14735553 (Pubitemid 38146266)
9. Ferrara LM, Antin J. The pathophysiology of graft-versus-host disease. In: Blume KG, Forman SJ, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation. Malden: Blackwell; 2004. p. 353-68.
10. RE Billingham 1966-67 The biology of graft-versus-host reactions Harvey Lect 62 21 35
11. J Gluckman A Devergie J Sohier JH Sauret 1980 Graft-versus-host reactions in recipients of syngeneic bone marrow Lancet 1 253 256 6101698
12. J Rappeport E Reinherz M Mihm, et al. 1979 Acute graft-versus-host reactions in recipients of bone marrow transplantation from identical twin donors Lancet 2 717 720 10.1016/S0140-6736(79)90644-5 90805
13. AF Hood GB Vogelsang LP Black, et al. 1987 Acute graft-versus-host disease: development following autologous and syngeneic bone marrow transplantation Arch Derm 123 745 751 10.1001/archderm.123.6.745 3555353 (Pubitemid 17076166)
14. SW Thien JM Goldman DG Galton 1981 Acute "graft-versus-host disease" after autografting for chronic granulocytic leukemia in transplantation Ann Intern Med 94 210 216
15. AD Hess CJ Thoburn 1997 Immunobiology and immunotherapeutic implications of syngeneic/autologous graft-vs-host disease Immunol Rev 157 111 123 10.1111/j.1600-065X.1997.tb00977.x 9255625 (Pubitemid 27303124)
16. GA Hollander B Widmer SJ Burakoff 1994 Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft-versus-host disease J Immunol 152 1609 1617 7907102
17. E Tivol R Komorowkski WR Drobyski 2005 Emergent autoimmunity in graft-versus-host disease Blood 105 4885 4891 10.1182/blood-2004-12-4980 15746077 (Pubitemid 40807318)
18. T Teshima P Reddy C Liu D Williams KR Cooke JL Ferrara 2003 Impaired negative selection causes autoimmune graft-versus-host disease Blood 102 429 435 10.1182/blood-2003-01-0266 12663438 (Pubitemid 36841956)
19. R Parkman 1993 Is chronic graft-versus-host disease an autoimmune disease? Curr Opin Immunol 5 800 803 10.1016/0952-7915(93)90140-N 8240743 (Pubitemid 23300141)
20. M Yamamoto K Sugihara F Ohtsuki, et al. 1994 Generation of self HLA-DR specific CD3+ CD4-CD8+ cytotoxic T cells in chronic graft-versus-host disease Bone Marrow Transpl 14 525 533
21. MK Jenkins RH Schwartz DM Pardoll 1988 Effects of CsA on T cell development and clonal deletion Science 241 1655 1659 10.1126/science.3262237 3262237
22. A Glazier PJ Tutschka ER Farmer GW Santos 1983 GVHD in CsA treated rats after syngeneic and autologous bone marrow reconstitution J Exp Med 158 1 12 10.1084/jem.158.1.1 6345713
23. AC Fischer WE Beschorner AD Hess 1989 Requirements for the induction and adoptive transfer of syngeneic GVHD J Exp Med 169 1031 1038 10.1084/jem.169.3. 1031 2647891 (Pubitemid 19085838)
24. RJ Jones AD Hess RB Mann, et al. 1989 Induction of graft-versus-host disease after autologous bone marrow transplantation Lancet 1 754 7 10.1016/S0140-6736(89)92575-0 2564566
25. R Sorokin H Kimura K Schroeder DB Wilson 1986 Cyclosporine-induced autoimmunity: conditions for expressing disease, requirement for an intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats J Exp Med 164 1615 1626 10.1084/jem.164.5.1615 3490534 (Pubitemid 17184192)
26. AD Hess CJ Thoburn L Horwitz 1998 Promiscuous recognition of major histocompatibility complex class II determinants in Cyclosporine-induced syngeneic graft-vs-host disease Transplantation 65 785 792 10.1097/00007890- 199803270-00004 9539089 (Pubitemid 28160669)
27. W Chen C Thoburn AD Hess 1998 Characterization of the pathogenic autoreactive T cells in Cyclosporine-induced syngeneic graft-vs-host disease J Immunol 161 7040 7046 9862741
28. AD Hess CJ Thoburn W Chen EC Bright 2003 Unexpected T-cell diversity in syngeneic graft-versus-host disease revealed by interaction with peptide-loaded soluble MHC class II molecules Transplantation 75 1361 1367 10.1097/01.TP. 0000063691.54928.CF 12717231 (Pubitemid 36513049)
29. AD Hess EC Bright C Thoburn, et al. 1997 Specificity of effector T lymphocytes in autologous graft-vs-host disease: role of the major histocompatibility complex class II invariant chain peptide Blood 89 2203 2209 9058745
30. CJ Thoburn Y Miura EC Bright AD Hess 2004 Functional divergence of antigen-specific T-lymphocyte responses in syngeneic graft-versus-host disease Biol Blood Marrow Transplant 10 591 603 10.1016/j.bbmt.2004.05.003 15319771 (Pubitemid 39157826)
31. AD Hess CJ Thoburn W Chen LR Horwitz 2000 Complexity of effector mechanisms in syngeneic graft-vs-host disease Biol Blood Marrow Transplant 6 13 24 10.1016/S1083-8791(00)70048-6 10707995
32. Sykes M. Mechanisms of tolerance. In: Blume KG, Forman SJ, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation. Malden: Blackwell; 2004. p. 300-23.
33. AD Hess AC Fischer L Horwitz EC Bright MK Laulis 1994 Characterization of peripheral autoregulatory mechanisms that prevent development of Cyclosporine-induced syngeneic graft-vs-host disease J Immunol 153 400 411 8207251
34. PA Taylor RJ Noelle BR Blazar 2001 CD4+ CD25+ immune regulatory cells are required for induction of tolerance to alloantigen via co-stimulatory blockade J Exp Med 193 1311 1318 10.1084/jem.193.11.1311 11390438 (Pubitemid 32524781)
35. PJ Tutschka AD Hess WE Beschorner GW Santos 1981 Suppressor cells in the transplantation tolerance. I. Suppressor cells in the mechanism of tolerance in radiation chimeras Transplantation 32 203 209 10.1097/00007890-198109000-00005 6456580
36. PJ Tutschka AD Hess WE Beschorner GW Santos 1982 Suppressor cells in transplantation tolerance. III. The role of antigen in the maintenance of transplantation tolerance Transplantation 33 510 514 10.1097/00007890-198205000- 00009 6211807
37. PJ Tutschka P Ki WE Beschorner, et al. 1985 Suppressor cells in transplantation tolerance. II. Maturation of suppressor cells in the bone marrow chimera Transplantation 32 321 329 10.1097/00007890-198110000-00012
38. AD Hess CJ Thoburn 2006 Immune tolerance to self-MHC class II antigens after bone marrow transplantation: regulatory role of CD4+ CD25+ Foxp3+ T cells Biol Blood Marrow Transplant 12 518 529 10.1016/j.bbmt.2006.01.007 16635787 (Pubitemid 43956367)
39. DY Wu I Goldschneider 1999 Cyclosporin-induced autologous graft-vs-host disease: a prototypical model of autoimmunity and active (dominant) tolerance coordinately expressed induced by recent thymic emigrants J Immunol 162 6926 6933 10352315
40. KJ Wood S Sakaguchi 2003 Regulatory T cells in transplantation tolerance Nature Rev 3 199 210
41. P Hoffmann J Ermann J Edinger, et al. 2002 Donor type CD4+ CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation J Exp Med 196 389 399 10.1084/jem.20020399 12163567 (Pubitemid 34875667)
42. O Joffre N Gorssee P Romagnoli, et al. 2004 Induction of antigen-specific tolerance to bone marrow allografts with CD4+ CD25+ T lymphocytes Blood 103 4216 4221 10.1182/blood-2004-01-0005 14976053 (Pubitemid 38685366)
43. S Jiang RI Lechler 2003 Regulatory T cells in the control of transplantation tolerance and autoimmunity Am J Transpl 3 516 524 10.1034/j.1600-6143.2003.00124.x (Pubitemid 36612834)
44. S Sakaguchi 2004 Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses Ann Rev Immunol 22 531 562 10.1146/annurev.immunol.21.120601.141122 (Pubitemid 38680433)
45. MS Jordan A Boesteanu AJ Reed, et al. 2001 Thymic selection of CD4+ CD25+ regulatory T cells induced by an agonistic self-peptide Nat Immunol 2 301 306 10.1038/86302 11276200 (Pubitemid 33706340)
46. SJ Bensinger A Bandeira MS Jordan, et al. 2001 Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+ CD25+ immunoregulatory T cells J Exp Med 194 427 438 10.1084/jem.194.4.427 11514600 (Pubitemid 32835039)
47. N Watanabe Y Hong-Wang HK Lee, et al. 2005 Hassal's corpuscles instruct dendritic cells to induce CD4+ CD25+ regulatory T cells in human thymus Nature 436 1181 1185 10.1038/nature03886 16121185 (Pubitemid 41232298)
48. CA Piccirillo AM Thornton 2004 Cornerstone of peripheral tolerance: naturally occurring CD4+ CD25+ regulatory T cells Trends Immunol 25 374 380 10.1016/j.it.2004.04.009 15207505 (Pubitemid 38780954)
49. S Read F Powrie 2001 CD4+ regulatory T cells Curr Opin Immunol 13 644 649 10.1016/S0952-7915(01)00273-4 11677084 (Pubitemid 33000156)
50. E Shevach 2000 Regulatory T cells in autoimmunity Ann Rev Immunol 18 423 449 10.1146/annurev.immunol.18.1.423 (Pubitemid 30365387)
51. PA Taylor A Panoskaltsis-Mortari JM Swedin, et al. 2004 L-selectin-hi but not the L-selectin-lo CD4+ 25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection Blood 104 3804 3812 10.1182/blood-2004-05-1850 15292057 (Pubitemid 39564461)
52. Z Fehervari S Sakaguchi 2004 Control of Foxp3+ CD25+ CD4+ regulatory cell activation and function by dendritic cells Inter Immunol 16 1769 1780 10.1093/intimm/dxh178 (Pubitemid 40003865)
53. S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science 299 1057 1061 10.1126/science.1079490 12522256 (Pubitemid 36222930)
54. R Khattri T Cox SA Yasayko F Ramsdell 2003 An essential role for Scurfin in CD4+ CD25+ T regulatory cells Nat Immunol 4 337 342 10.1038/ni909 12612581 (Pubitemid 36432315)
55. JD Fontenot AY Rudensky 2005 A well adapted regulatory contrivance: regulatory T cell development and the forkhead family of transcription factor Foxp3 Nat Immunol 6 331 337 10.1038/ni1179 15785758 (Pubitemid 41716769)
56. Y Miura CJ Thoburn EC Bright, et al. 2004 Association of Foxp3 regulatory gene expression with graft-versus-host disease Blood 104 2187 2193 10.1182/blood-2004-03-1040 15172973 (Pubitemid 39297878)
57. JW Liu ZR Liu P Witkowski, et al. 2004 Rat CD8+ Foxp3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection Transpl Immunol 13 239 247 10.1016/j.trim.2004.10.006 15589736 (Pubitemid 39602590)
58. Zorn E, Kim HT, Lee SJ, et al. Reduced frequency of Foxp3+ CD4+ CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood. 2005. Online 21 June 2005.
59. AP Rapoport EA Stadtmauer N Aqui D Vogl A Chew, et al. 2009 Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of costimulated autologous T cells Clin Cancer Res 15 4499 4507 10.1158/1078-0432.CCR-09-0418 19509133