Emergent autoimmunity in graft-versus-host disease

Blood

Volumn 105, Issue 12, 2005, Pages 4885-4891

  Tivol, Elizabeth ^a   Komorowski, Richard ^a   Drobyski, William R ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Bone Marrow Transplant Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE COURSE; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; ISOGRAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 20444362731     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-12-4980     Document Type: Article

References (47)

1. Ferrara JLM, Deeg HJ, Burakoff S. Graft versus host disease. New York: Marcell Dekker, 1997.
2. Reddy P. Pathophysiology of acute graft-versus-host disease. Hematol Oncol. 2003;21:149-161.
3. Higman MA, Vogelsang GB. Chronic graft versus host disease. Br J Haematol. 2004;125:435-454.
4. Rouquette-Gally AM, Boyeldieu D, Prost AC, Gluckman E. Autoimmunity after allogeneic bone marrow transplantation. A study of 53 long-term-surviving patients. Transplantation. 1988;46:238-240.
5. Rouquette-Gally AM, Boyeldieu D, Gluckman E, Abuaf N, Combrisson A. Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with Sjogren syndrome and scleroderma. Br J Haematol. 1987;66:45-47.
6. Sherer Y, Shoenfeld Y. Autoimmune diseases and autoimmunity post-bone marrow transplantation. Bone Marrow Transplant. 1998;22:873-881.
7. Parkman R. Is chronic graft versus host disease an autoimmune disease? Curr Opin Immunol. 1993;5:800-803.
8. + cytotoxic T cells in chronic graft-versus-host disease. Bone Marrow Transplant. 1994;14:525-533.
9. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
10. + T cells to elicit hepatic graft-versus-host disease. J Immunol. 2002;169:7111-7118.
11. Horowitz J, Kaye J, Katz ME, Janeway C. Ability of fixed B-lymphoma cells to present foreign protein antigen fragments and allogeneic MHC molecules to a cloned helper-T-cell line. Cell Immunol. 1987;109:429-436
12. Benichou G, Takizawa AP, Olson CA, McMillan M, Sercarz EE. Donor major histocompatibility complex class I peptides are presented by recipient MHC molecules during graft rejection. J Exp Med. 1992;175:305-308.
13. Liu Z, Braunstein NS, Suciu-Foca N. T cell recognition of allopeptides in context of syngeneic MHC. J Immunol. 1992;148:35-40.
14. Matte CC, Liu J, Andersen BE, et al. Donor APCs are required for maximal GVHD but not for GVL. Nat Med. 2004;10:987-992.
15. Drobyski WR, Komorowski R., Logan B, Gendelman M. Role of the passive apoptotic pathway in graft versus host disease. J Immunol. 2002;169:1626-1633.
16. Auffermann-Gretzinger S, Losses IS, Vayntrub TA, et al. Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients. Blood. 2002;99:1442-1448.
17. Clark FJ, Freeman L, Dzionek A, et al. Origin and subset distribution of peripheral blood dendritic cells in patients with chronic graft-versus-host disease. Transplantation. 2003;75:221-225.
18. Grebe SC, Streilein JW. Graft versus host reactions: a review. Adv Immunol. 1976;22:119-221.
19. Brochu S, Rioux-Masse B, Roy J, Roy DC, Perreault C. Massive activation-induced cell death of alloreactive T cells with apoptosis of bystander postthymic T cells prevents immune reconstitution in mice with graft-versus-host disease. Blood. 1999;94:390-400.
20. Hebib NC, Deas O, Rouleau M. Peripheral blood T cells generated after allogeneic bone marrow transplantation: lower levels of bcl-2 protein and enhanced sensitivity to spontaneous and CD95-mediated apoptosis in vitro. Abrogation of the apoptotic phenotype correlates with the recovery of normal naive/primed T cell profiles. Blood. 1999;94:1803-1813.
21. Lin M, Tseng L, Frangoul H, et al. Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. Blood. 2000;95:3832-3839.
22. Bellone M, Iezzi G, Rovere P, et al. Processing of engulfed apoptotic bodies yields T cell epitopes. J Immunol. 1997;159:5391-5399.
23. Albert M, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Science. 1998;392:86-89.
24. Rovere P, Vallinoto C, Bondanza A, et al. Cutting edge: bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol. 1998;161:4467-4471.
25. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol. 1994;152:3685-3692.
26. Mevorach D, Zhou J, Song X, Elkon K. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med. 1998;188:387-392.
27. Fukushi N, Arase H, Wang B, et al. Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of self-tolerance. Proc Natl Acad Sci U S A. 1990;87:6301-6305.
28. Desbarats J, Lapp WS. Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions. J Exp Med. 1993;178:805-814.
29. Hollander GA, Widmer B, Burakoff SJ. Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease. J Immunol. 1994;152:1609-1617.
30. Van den Brink MRM, Moore E, Ferrara JLM, Burakoff SJ. Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity. Transplantation. 2000;69:446-449.
31. Parkman R. Clonal analysis of murine graft-vs-host disease, I: phenotypic and functional analysis of T lymphocyte clones. J Immunol. 1986;136:3543-3548.
32. DeClerck Y, Draper V, Parkman R. Clonal analysis of murine graft-vs-host disease, II: leukokines that stimulate fibroblast proliferation and collagen synthesis in graft-vs. host disease. J Immunol. 1986;136:3549-3552.
33. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993;75:203-205.
34. + T cells induce or protect chronic intestinal inflammation in C.B-17 scid mice. Int Immunol. 1993;5:1461-1471.
35. + T cells. J Exp Med. 1993;178:237-244.
36. Strober W, Fuss I, Blumberg R. The immunology of mucosal models of inflammation. Ann Rev Immunol. 2002;20:485-549.
37. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med. 1994;179:589-600.
38. Miura Y, Thobum CJ, Bright EC, et al. Association of Foxp3 regulatory gene expression with graft versus host disease. Blood. 2004;104:2187-2193.
39. Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest. 2004;114:979-987.
40. + regulator T cells in autoimmune polyglandular syndrome type II. J Exp Med. 2004;199:1285-1291.
41. + T regulatory cells. J Exp Med. 2004;199:323-335.
42. Suzuki H, Kundig TM, Furlonger C, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science. 1995;268:1472-1476.
43. Grossman WJ, Verbsky JW, Yang L, et al. Dysregulated myelopoiesis in mice lacking Jak3. Blood. 1999;94:932-939.
44. Fukushi N, Arase H, Wang B, et al. Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of self-tolerance. Proc Natl Acad Sci U S A. 1990;87:6301-6305.
45. Desbarats J, Lapp WS. Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions. J Exp Med. 1993;178:805-814.
46. Hollander GA, Widmer B, Burakoff SJ. Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease. J Immunol. 1994;152:1609-1617.
47. Teshima T, Reddy P, Liu C, William D, Cooke KR, Ferrara JL. Impaired thymic negative selection causes autoimmune graft versus host disease. Blood. 2003;102:429-435.