Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons

Physiological Research

Volumn 59, Issue 2, 2010, Pages 289-298

  Neacsu, C ^a   Ciobanu, C ^a   Barbu, I ^a   Toader, O ^a   Szegli, G ^b   Kerek, F ^c   Babes, A ^a  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b CANTACUZINO INSTITUTE   (Romania)

^c DoNatur GmbH   (Germany)

Author keywords

Capsaicin; DRG; Pain; Plant extract; TRP channels

Indexed keywords

ACID; ACROLEIN; BIOLOGICAL PRODUCT; CALCIUM; CAPSAICIN; CINNAMALDEHYDE; DRUG DERIVATIVE; MCS 18; MCS-18; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HEAT; METABOLISM; PAIN; PATCH CLAMP; RAT; SENSORY RECEPTOR; SPINAL GANGLION; VERATRUM;

ACIDS; ACROLEIN; ANIMALS; BIOLOGICAL PRODUCTS; CALCIUM; CAPSAICIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HELLEBORUS; HOT TEMPERATURE; MEMBRANE POTENTIALS; PAIN; PATCH-CLAMP TECHNIQUES; RATS; SENSORY RECEPTOR CELLS; TRPV CATION CHANNELS;

EID: 77953917862     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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