MCS-18, a novel natural product isolated from Helleborus purpurascens, inhibits dendritic cell activation and prevents autoimmunity as shown in vivo using the EAE model

Immunobiology

Volumn 212, Issue 9-10, 2008, Pages 839-853

  Horstmann, Brigitte ^a   Zinser, Elisabeth ^a   Turza, Nadine ^a   Kerek, Franz ^b   Steinkasserer, Alexander ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b DoNatur GmbH   (Germany)

Author keywords

Autoimmunity; DC migration; Dendritic cell; Experimental autoimmune encephalomyelitis; T cells

Indexed keywords

B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; HELLEBORUS PURPURASCENS EXTRACT; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MCS 18; NATURAL PRODUCT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNITY; BRAIN PROTECTION; CELL ACTIVATION; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENCY; FEMALE; HELLEBORUS PURPURASCENS; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PARALYSIS; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; VERATRUM;

EID: 37049007431     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2007.09.016     Document Type: Article

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