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Volumn 700, Issue 1-2, 2010, Pages 71-79

Whole cell-ELISA to measure the γH2AX response of six aneugens and eight DNA-damaging chemicals

Author keywords

H2AX; Aneugen; ELISA; Genotoxicity

Indexed keywords

ANEUGEN; ANTIBODY; BIOLOGICAL MARKER; CH 3310395; CISPLATIN; DEMECOLCINE; DOUBLE STRANDED DNA; ETHYLNITRONITROSOGUANIDINE; ETOPOSIDE; FLUOROURACIL; GRISEOFULVIN; HISTONE H2AX; HISTONE H2AX GAMMA; IRINOTECAN; MESYLIC ACID METHYL ESTER; METHOTREXATE; MITOMYCIN C; PACLITAXEL; TANESPIMYCIN; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 77953915626     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.05.009     Document Type: Article
Times cited : (43)

References (49)
  • 1
    • 36949030242 scopus 로고    scopus 로고
    • DNA double-strand breaks: their cellular and clinical impact?
    • Jeggo P.A., Löbrich M. DNA double-strand breaks: their cellular and clinical impact?. Oncogene 2007, 26:7717-7719.
    • (2007) Oncogene , vol.26 , pp. 7717-7719
    • Jeggo, P.A.1    Löbrich, M.2
  • 3
    • 55249116558 scopus 로고    scopus 로고
    • γH2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner A., Wu W., Staudt C., Iliakis G. γH2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008, 36:5678-5694.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5678-5694
    • Kinner, A.1    Wu, W.2    Staudt, C.3    Iliakis, G.4
  • 4
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 1999, 146:905-915.
    • (1999) J. Cell Biol. , vol.146 , pp. 905-915
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 5
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses
    • Rothkamm K., Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:5057-5062.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Löbrich, M.2
  • 6
    • 13744258586 scopus 로고    scopus 로고
    • The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase β defective mammalian cells
    • Pascucci B., Russo M.T., Crescenzi M., Bignami M., Dogliotti E. The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase β defective mammalian cells. Nucleic Acids Res. 2005, 33:280-288.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 280-288
    • Pascucci, B.1    Russo, M.T.2    Crescenzi, M.3    Bignami, M.4    Dogliotti, E.5
  • 7
    • 36148951013 scopus 로고    scopus 로고
    • H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase
    • Hanasoge S., Ljungman M. H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase. Carcinogenesis 2007, 28:2298-2304.
    • (2007) Carcinogenesis , vol.28 , pp. 2298-2304
    • Hanasoge, S.1    Ljungman, M.2
  • 10
    • 26444553297 scopus 로고    scopus 로고
    • Does γH2AX foci formation depend on the presence of DNA double strand breaks?
    • Takahashi A., Ohnishi T. Does γH2AX foci formation depend on the presence of DNA double strand breaks?. Cancer Lett. 2005, 229:171-179.
    • (2005) Cancer Lett. , vol.229 , pp. 171-179
    • Takahashi, A.1    Ohnishi, T.2
  • 11
    • 33645979960 scopus 로고    scopus 로고
    • DNA damage evaluated by γH2AX foci formation by a selective group of chemical/physical stressors
    • Zhou C., Li Z., Diao H., Yu Y., Zhu W., Dai Y., Chen F.F., Yang J. DNA damage evaluated by γH2AX foci formation by a selective group of chemical/physical stressors. Mutat. Res. 2006, 604:8-18.
    • (2006) Mutat. Res. , vol.604 , pp. 8-18
    • Zhou, C.1    Li, Z.2    Diao, H.3    Yu, Y.4    Zhu, W.5    Dai, Y.6    Chen, F.F.7    Yang, J.8
  • 12
    • 49049086680 scopus 로고    scopus 로고
    • Two structurally distinct inhibitors of glycogen synthase kinase 3 induced centromere positive micronuclei in human lymphoblastoid TK6 cells
    • Mishima M., Tanaka K., Takeiri A., Harada A., Kubo C., Sone S., Nishimura Y., Tachibana Y., Okazaki M. Two structurally distinct inhibitors of glycogen synthase kinase 3 induced centromere positive micronuclei in human lymphoblastoid TK6 cells. Mutat. Res. 2008, 643:29-35.
    • (2008) Mutat. Res. , vol.643 , pp. 29-35
    • Mishima, M.1    Tanaka, K.2    Takeiri, A.3    Harada, A.4    Kubo, C.5    Sone, S.6    Nishimura, Y.7    Tachibana, Y.8    Okazaki, M.9
  • 13
    • 33746045662 scopus 로고    scopus 로고
    • 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation
    • Niikura Y., Ohta S., Vandenbeldt K.J., Abdulle R., McEwen B.F., Kitagawa K. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene 2006, 25:4133-4146.
    • (2006) Oncogene , vol.25 , pp. 4133-4146
    • Niikura, Y.1    Ohta, S.2    Vandenbeldt, K.J.3    Abdulle, R.4    McEwen, B.F.5    Kitagawa, K.6
  • 14
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
    • Kirkland D, Aardema M., Henderson L., Müller L. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat. Res. 2005, 584:1-256.
    • (2005) Mutat. Res. , vol.584 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3    Müller, L.4
  • 15
    • 0023855146 scopus 로고
    • A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures
    • Ishidate M., Harnois M.C., Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res. 1988, 195:151-213.
    • (1988) Mutat. Res. , vol.195 , pp. 151-213
    • Ishidate, M.1    Harnois, M.C.2    Sofuni, T.3
  • 16
    • 0026445710 scopus 로고
    • Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test
    • Matsuoka A., Yamazaki N., Suzuki T., Hayashi M., Sofuni T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat. Res. 1993, 272:223-236.
    • (1993) Mutat. Res. , vol.272 , pp. 223-236
    • Matsuoka, A.1    Yamazaki, N.2    Suzuki, T.3    Hayashi, M.4    Sofuni, T.5
  • 18
    • 77953912884 scopus 로고    scopus 로고
    • National toxicology program, NTP website at .
    • National toxicology program, NTP website at http://ntp-server.niehs.nih.gov/.
  • 19
    • 0025360399 scopus 로고
    • Induction of micronucleated and binucleate cells in Chinese hamster ovary (CHO) cells by cis-diamminedichloroplatinum (II): a morphological and morphometric study
    • Rodilla V., Pellicer J.A., Pertusa J., Mothersill C. Induction of micronucleated and binucleate cells in Chinese hamster ovary (CHO) cells by cis-diamminedichloroplatinum (II): a morphological and morphometric study. Mutat. Res. 1990, 241:115-124.
    • (1990) Mutat. Res. , vol.241 , pp. 115-124
    • Rodilla, V.1    Pellicer, J.A.2    Pertusa, J.3    Mothersill, C.4
  • 20
    • 77953916011 scopus 로고
    • Mutagenicity studies of CPT-11, a new anticancer drug
    • Japanese
    • Shimada H., Hattori C., Sato T., Ebine Y. Mutagenicity studies of CPT-11, a new anticancer drug. Clin. Rep. 1990, 24:7357-7366. Japanese.
    • (1990) Clin. Rep. , vol.24 , pp. 7357-7366
    • Shimada, H.1    Hattori, C.2    Sato, T.3    Ebine, Y.4
  • 22
    • 0022515776 scopus 로고
    • Mutagenicity tests of etoposide and teniposide
    • Nakanomyo H., Hiraoka M., Shiraya M. Mutagenicity tests of etoposide and teniposide. J. Toxicol. Sci. 1986, 11(Suppl. 1):301-310.
    • (1986) J. Toxicol. Sci. , vol.11 , Issue.SUPPL. 1 , pp. 301-310
    • Nakanomyo, H.1    Hiraoka, M.2    Shiraya, M.3
  • 23
    • 0023251854 scopus 로고
    • Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems
    • Gupta R.S., Bromke A., Bryant D.W., Gupta R., Singh B., McCalla D.R. Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems. Mutagenesis 1987, 2:179-186.
    • (1987) Mutagenesis , vol.2 , pp. 179-186
    • Gupta, R.S.1    Bromke, A.2    Bryant, D.W.3    Gupta, R.4    Singh, B.5    McCalla, D.R.6
  • 24
    • 0028343989 scopus 로고
    • Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells
    • Suzuki H, Nakane S. Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells. Biol. Pharm. Bull. 1994, 17:222-226.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 222-226
    • Suzuki, H.1    Nakane, S.2
  • 25
    • 0030748287 scopus 로고    scopus 로고
    • Comparative induction of micronuclei in repair-deficient and -proficient Chinese hamster cell lines following clastogen or aneugen exposures
    • Hermine T., Jones N.J., Parry J.M. Comparative induction of micronuclei in repair-deficient and -proficient Chinese hamster cell lines following clastogen or aneugen exposures. Mutat. Res. 1997, 392:151-163.
    • (1997) Mutat. Res. , vol.392 , pp. 151-163
    • Hermine, T.1    Jones, N.J.2    Parry, J.M.3
  • 26
    • 0032472887 scopus 로고    scopus 로고
    • Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells
    • Keshava C., Keshava N., Whong W.Z., Nath J., Ong T.M. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat. Res. 1998, 397:221-228.
    • (1998) Mutat. Res. , vol.397 , pp. 221-228
    • Keshava, C.1    Keshava, N.2    Whong, W.Z.3    Nath, J.4    Ong, T.M.5
  • 27
    • 0030591652 scopus 로고    scopus 로고
    • Genetic toxicology of mitotic spindle inhibitors used as anticancer drugs
    • Kirsch-Volders M., Parry E.M. Genetic toxicology of mitotic spindle inhibitors used as anticancer drugs. Mutat. Res. 1996, 355:103-128.
    • (1996) Mutat. Res. , vol.355 , pp. 103-128
    • Kirsch-Volders, M.1    Parry, E.M.2
  • 28
    • 0021875089 scopus 로고
    • Triple short-term tests with bacteria and drosophila for assessment of mutagenicity of antineoplastics
    • Sakamoto Y., Fujikawa K., Nagayabu O., Yamamoto K.S., Samejima K. Triple short-term tests with bacteria and drosophila for assessment of mutagenicity of antineoplastics. Takeda Kenkyusho Ho 1985, 44:96-116.
    • (1985) Takeda Kenkyusho Ho , vol.44 , pp. 96-116
    • Sakamoto, Y.1    Fujikawa, K.2    Nagayabu, O.3    Yamamoto, K.S.4    Samejima, K.5
  • 31
    • 0024501284 scopus 로고
    • Rapid fluorescence-based assay for radiosensitivity and chemosensitivity testing in mammalian cells in vitro
    • Begg A.C., Mooren E. Rapid fluorescence-based assay for radiosensitivity and chemosensitivity testing in mammalian cells in vitro. Cancer Res. 1989, 49:565-569.
    • (1989) Cancer Res. , vol.49 , pp. 565-569
    • Begg, A.C.1    Mooren, E.2
  • 32
    • 26044460461 scopus 로고    scopus 로고
    • The use of receiver operating characteristic curves in biomedical informatics
    • Lasko T.A., Bhagwat J.G., Zou K.H., Ohno-Machado L. The use of receiver operating characteristic curves in biomedical informatics. J. Biomed. Inform. 2005, 38:404-415.
    • (2005) J. Biomed. Inform. , vol.38 , pp. 404-415
    • Lasko, T.A.1    Bhagwat, J.G.2    Zou, K.H.3    Ohno-Machado, L.4
  • 33
    • 33846913205 scopus 로고    scopus 로고
    • Short-term culture and γH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes
    • Hamasaki K., Imai K., Nakachi K., Takahashi N., Kodama Y., Kusunoki Y. Short-term culture and γH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes. Environ. Mol. Mutagen. 2007, 48:38-47.
    • (2007) Environ. Mol. Mutagen. , vol.48 , pp. 38-47
    • Hamasaki, K.1    Imai, K.2    Nakachi, K.3    Takahashi, N.4    Kodama, Y.5    Kusunoki, Y.6
  • 34
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou E.P., Nieves-Neira W., Boon C., Pommier Y., Bonner W.M. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 2000, 275:9390-9395.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 35
    • 67649313760 scopus 로고    scopus 로고
    • The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases
    • Solier S., Pommier Y. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell Cycle 2009, 8:1853-1859.
    • (2009) Cell Cycle , vol.8 , pp. 1853-1859
    • Solier, S.1    Pommier, Y.2
  • 36
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 38
    • 0023655202 scopus 로고
    • Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
    • Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Ayusawa D., Seno T., Garrett C., Wataya Y. Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 1987, 262:8235-8241.
    • (1987) J. Biol. Chem. , vol.262 , pp. 8235-8241
    • Yoshioka, A.1    Tanaka, S.2    Hiraoka, O.3    Koyama, Y.4    Hirota, Y.5    Ayusawa, D.6    Seno, T.7    Garrett, C.8    Wataya, Y.9
  • 39
    • 33746460874 scopus 로고    scopus 로고
    • Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines
    • Oka H., Ikeda K., Yoshimura H., Ohuchida A., Honma M. Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines. Mutat. Res. 2006, 606:52-60.
    • (2006) Mutat. Res. , vol.606 , pp. 52-60
    • Oka, H.1    Ikeda, K.2    Yoshimura, H.3    Ohuchida, A.4    Honma, M.5
  • 40
    • 33745862394 scopus 로고    scopus 로고
    • SFTG, international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study
    • Lorge E., Thybaud V., Aardema M.J., Oliver J., Wakata A., Lorenzon G., Marzin D. SFTG, international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study. Mutat. Res. 2006, 607:13-36.
    • (2006) Mutat. Res. , vol.607 , pp. 13-36
    • Lorge, E.1    Thybaud, V.2    Aardema, M.J.3    Oliver, J.4    Wakata, A.5    Lorenzon, G.6    Marzin, D.7
  • 41
    • 0024503805 scopus 로고
    • Complementation of a methotrexate uptake defect in Chinese hamster ovary cells by DNA-mediated gene transfer
    • Underhill T.M., Flintoff W.F. Complementation of a methotrexate uptake defect in Chinese hamster ovary cells by DNA-mediated gene transfer. Mol. Cell Biol. 1989, 9:1754-1758.
    • (1989) Mol. Cell Biol. , vol.9 , pp. 1754-1758
    • Underhill, T.M.1    Flintoff, W.F.2
  • 42
    • 45949118213 scopus 로고
    • Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity
    • Galloway S.M., Deasy D.A., Bean C.L., Kraynak A.R., Armstrong M.J., Bradley M.O. Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity. Mutat. Res. 1987, 189:15-25.
    • (1987) Mutat. Res. , vol.189 , pp. 15-25
    • Galloway, S.M.1    Deasy, D.A.2    Bean, C.L.3    Kraynak, A.R.4    Armstrong, M.J.5    Bradley, M.O.6
  • 45
    • 0029590246 scopus 로고
    • Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes
    • Elhajouji A., Van Hummelen P., Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 1995, 26:292-304.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 292-304
    • Elhajouji, A.1    Van Hummelen, P.2    Kirsch-Volders, M.3
  • 46
    • 0036304758 scopus 로고    scopus 로고
    • Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187
    • Wang L., Eastmond D.A. Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187. Environ. Mol. Mutagen. 2002, 39:348-356.
    • (2002) Environ. Mol. Mutagen. , vol.39 , pp. 348-356
    • Wang, L.1    Eastmond, D.A.2
  • 47
    • 33747889217 scopus 로고    scopus 로고
    • Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
    • Sonoda E., Hochegger H., Saberi A., Taniguchi Y., Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair 2006, 5:1021-1029.
    • (2006) DNA Repair , vol.5 , pp. 1021-1029
    • Sonoda, E.1    Hochegger, H.2    Saberi, A.3    Taniguchi, Y.4    Takeda, S.5


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