L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: Role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation

Journal of Nutritional Biochemistry

Volumn 21, Issue 7, 2010, Pages 580-588

  Chao, Hung Hsin ^a   Chen, Cheng Hsien ^b   Liu, Ju Chi ^b   Lin, Jia Wei ^b   Wong, Kar Lok ^c   Cheng, Tzu Hurng ^d  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Angiotensin II; Cardiac fibroblasts; L carnitine; NADPH oxidase; Prostacyclin; Sphingosine 1 phosphate

Indexed keywords

ANGIOTENSIN II; CARNITINE; ENDOTHELIN 1; OXIDOREDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROSTACYCLIN SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; TRANSCRIPTION FACTOR AP 1; CARDIOTONIC AGENT; LYSOPHOSPHOLIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; HEART; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING; NONHUMAN; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; METABOLISM; NEWBORN; OSMOLARITY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANGIOTENSIN II; ANIMALS; ANIMALS, NEWBORN; CARDIOTONIC AGENTS; CARNITINE; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE EXPRESSION REGULATION; HEART; LYSOPHOSPHOLIPIDS; MYOCARDIUM; NADPH OXIDASE; OSMOLAR CONCENTRATION; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSCRIPTION FACTOR AP-1;

RATTUS;

EID: 77953812861     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.03.003     Document Type: Article

References (37)

1. Rebouche C.J. Kinetics, pharmacokinetics, and regulation of l-carnitine and acetyl-l-carnitine metabolism. Ann N Y Acad Sci 2004, 1033:30-41.
2. Alvarez M., Malecot C.O., Gannier F., Lignon J.M. Antimony-induced cardiomyopathy in guinea-pig and protection by l-carnitine. Br J Pharmacol 2005, 144:17-27.
3. Vanella A., Russo A., Acquaviva R., Campisi A., Di Giacomo C., Sorrenti V., et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol 2000, 16:99-104.
4. Iliceto S., Scrutinio D., Bruzzi P., D'Ambrosio G., Boni L., Di Biase M., et al. Effects of l-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the l-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. J Am Coll Cardiol 1995, 26:380-387.
5. Schnee J.M., Hsueh W.A. Angiotensin II, adhesion, and cardiac fibrosis. Cardiovasc Res 2000, 46:264-268.
6. Zafari A.M., Ushio-Fukai M., Akers M., Yin Q., Shah A., Harrison D.G., et al. Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension 1998, 32:488-495.
7. Cheng T.H., Cheng P.Y., Shih N.L., Chen I.B., Wang D.L., Chen J.J. Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts. J Am Coll Cardiol 2003, 42:1845-1854.
8. Pyne S., Pyne N.J. Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 2000, 349:385-402.
9. Saba J.D., Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res 2004, 94:724-734.
10. Sivarajah A., Chatterjee P.K., Patel N.S., Todorovic Z., Hattori Y., Brown P.A., et al. Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am J Nephrol 2003, 23:267-276.
11. Zhang A.Y., Yi F., Jin S., Xia M., Chen Q.Z., Gulbins E., et al. Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxid Redox Signal 2007, 9:817-828.
12. Mulders A.C., Hendriks-Balk M.C., Mathy M.J., Michel M.C., Alewijnse A.E., Peters S.L. Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin II. Arterioscler Thromb Vasc Biol 2006, 26:2043-2048.
13. Cowart L.A., Wei S., Hsu M.H., Johnson E.F., Krishna M.U., Falck J.R., et al. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J Biol Chem 2002, 277:35105-35112.
14. Smith R.S., Agata J., Xia C.F., Chao L., Chao J. Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Life Sci 2005, 76:2457-2471.
15. Steen H., Kolmakova A., Stuber M., Rodriguez E.R., Gao F., Chatterjee S., et al. MRI visualized neo-intimal dissection and co-localization of novel apoptotic markers apolipoprotein C-1, ceramide and caspase-3 in a Watanabe hyperlipidemic rabbit model. Atherosclerosis 2007, 191:82-89.
16. Garrelds I.M., Elliott G.R., Zijlstra F.J., Bonta I.L. Effects of short- and long-term feeding of l-carnitine and congeners on the production of eicosanoids from rat peritoneal leucocytes. Br J Nutr 1994, 72:785-793.
17. Bueno R., Alvarez de Sotomayor M., Perez-Guerrero C., Gomez-Amores L., Vazquez C.M., Herrera M.D. l-carnitine and propionyl-l-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci 2005, 77:2082-2097.
18. Cipolla M.J., Nicoloff A., Rebello T., Amato A., Porter J.M. Propionyl-l-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism. J Vasc Surg 1999, 29:1097-1103.
19. Virag L., Kerekgyarto C., Fachet J. A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity. J Immunol Methods 1995, 185:199-208.
20. Cheng T.H., Shih N.L., Chen S.Y., Loh S.H., Cheng P.Y., Tsai C.S., et al. Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J Mol Cell Cardiol 2001, 33:1805-1814.
21. Cheng T.H., Shih N.L., Chen S.Y., Wang D.L., Chen J.J. Reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes. Cardiovasc Res 1999, 41:654-662.
22. Gyllenhammar H. Lucigenin chemiluminescence in the assessment of neutrophil superoxide production. J Immunol Methods 1987, 97:209-213.
23. Griendling K.K., Minieri C.A., Ollerenshaw J.D., Alexander R.W. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994, 74:1141-1148.
24. Bass D.A., Parce J.W., Dechatelet L.R., Szejda P., Seeds M.C., Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 1983, 130:1910-1917.
25. Edsall L., Vann L., Milstien S., Spiegel S. Enzymatic method for measurement of sphingosine 1-phosphate. Methods Enzymol 2000, 312:9-16.
26. Minter A.J., Keoshkerian E., Chesterman C.N., Dawes J. Fibroblast growth factor and heparin protect endothelial cells from the effects of interleukin 1. J Cell Physiol 1996, 167:229-237.
27. Matsusaka T., Katori H., Homma T., Ichikawa I. Mechanism of cardiac fibrosis by angiotensin. New insight revealed by genetic engineering. Trends Cardiovasc Med 1999, 9:180-184.
28. Rosenkranz S. TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res 2004, 63:423-432.
29. Das D.K., Maulik N., Engelman R.M. Redox regulation of angiotensin II signaling in the heart. J Cell Mol Med 2004, 8:144-152.
30. Merrill A.H., Schmelz E.M., Dillehay D.L., Spiegel S., Shayman J.A., Schroeder J.J., et al. Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol 1997, 142:208-225.
31. Andrieu-Abadie N., Jaffrezou J.P., Hatem S., Laurent G., Levade T., Mercadier J.J. l-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation. FASEB J 1999, 13:1501-1510.
32. Kitatani K., Idkowiak-Baldys J., Hannun Y.A. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 2008, 20:1010-1018.
33. Cheng C.P., Ukai T., Onishi K., Ohte N., Suzuki M., Zhang Z.S., et al. The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure. Am J Physiol Heart Circ Physiol 2001, 280:H1853-H1860.
34. Brown J.D., Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 2007, 115:518-533.
35. Diep Q.N., Amiri F., Touyz R.M., Cohn J.S., Endemann D., Neves M.F., et al. PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension 2002, 40:866-871.
36. Girnun G.D., Domann F.E., Moore S.A., Robbins M.E. Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol Endocrinol 2002, 16:2793-2801.
37. Baranowski M., Blachnio A., Zabielski P., Gorski J. PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. J Physiol Pharmacol 2007, 58:57-72.