Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism

Journal of Vascular Surgery

Volumn 29, Issue 6, 1999, Pages 1097-1103

  Cipolla, M J ^a   Nicoloff, A ^a   Rebello, T ^a   Amato, A ^a   Porter, J M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; NITRIC OXIDE; PROPIONYLCARNITINE; PROSTAGLANDIN;

ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SMOOTH MUSCLE FIBER; SUBCUTANEOUS FAT; VASCULAR ENDOTHELIUM;

EID: 0033058488     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-5214(99)70251-X     Document Type: Article

References (25)

1. G Brevetti M Chiariello G Ferulano A Policicchio E Nevola A Rossini Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double-blind, cross-over study Circulation 77 1988 767 773
2. G Brevetti S Perna C Sabba VD Martone M. Condorelli Propionyl-L-carnitine in intermittent claudication: A double-blind, placebo-controlled, dose-titration, multi-center study J Am Coll Cardiol 26 1995 1411 1416
3. EP Brass AM Scarrow LJ Ruff KA Masterson E. Van Lunteren Carnitine delays rat skeletal muscle fatigue in vitro J Appl Physiol 75 1993 1595 1600
4. P Kosocharoen J Nappi P Peduzzi AL Shug AK Patel T Filipek Improved exercise tolerance of the ischemic myocardium after administration of carnitine Curr Ther Res 30 1981 753 760
5. JH Thomsen AL Shug VU Yap AK Patel TJ Karra SL. Defelice Improved pacing tolerance of the ischemic myocardium after administration of carnitine Am J Cardiol 43 1979 300 306
6. G. Zubay Biochemistry 1984 Addison-Wesley Publishing Reading (Mass) 479 482
7. G Brevetti G Angelini M Rosa R Carrozzo S Perna M Corsi Muscle carnitine deficiency in patients with severe peripheral vascular disease Circulation 84 1991 1490 1495
8. G Brevetti S Perna C Sabba A Rossini V Scotto Di Uccio E Berardi Superiority of L-propionylcarnitine vs. L-carnitine in improving walking capacity in patients with peripheral vascular disease: An acute, intravenous, double-blind, cross-over study Eur Heart J 13 1992 251 255
9. N Siliprandi F Dilisa R. Menabo Propionyl-L-carnitine: Biochemical significance and possible role in cardiac metabolism Cardiovasc Drug Ther 5 1991 11 16
10. WR Hiatt JG Regenstenier EE Wolfed L Ruff EP. Brass Carnitine and acyl-carnitine metabolism during exercise in humans J Clin Invest 84 1989 1167 1173
11. L Torielli F Conti E Cinato E Ceppi G Bianchi P. Ferrari Alterations in energy metabolism of hypertrophied rat cardiomyocytes: Influence of propionyl-L-carnitine J Cardiovasc Pharm 26 1995 372 380
12. IB Fritz E. Arrigoni-Martelli Sites of action of carnitine and its derivatives on the cardiovascular system: Interactions with membranes Trends Phamacol Sci 14 1993 355 360
13. 31P magnetic resonance spectroscopy: A phase II open study Vasc Med 1 1996 241 245
14. LMA Sassen K Bezstarosti WJ van der Giessen JMJ Lamers PD. Versouw L-propionyl carnitine increases postischemic blood flow but does not affect recovery of energy charge Am J Physiol 261 1991 H172 H180
15. A Cevese F Schema R Poltronieri G. Cerutti Short-term effects of intra-arterial PLC on isolated canine hind limbs Cardioscience 6 1995 59 64
16. WC Hulsmann ML. Dubelaar Aspects of fatty acid metabolism in vascular endothelial cells Biochimie 70 1988 681 686
17. G Osol M Cipolla S. Knutson A new method for mechanically denuding the endothelium of small (50–150 m m) arteries with a human hair Blood Vessels 26 1990 320 326
18. M Cipolla C Harker J. Porter Endothelial function and adrenergic reactivity in human type-II diabetic resistance arteries J Vasc Surg 23 1996 940 949
19. W Halpern G Osol GS. Coy Mechanical behavior of pressurized in vitro prearteriolar vessels determined with a video system Ann Biomed Eng 1984 463 479
20. CA. Wiederhielm Continuous recording of arteriolar dimensions with a television microscope J Appl Physiol 18 1963 1041 1042
21. N Inoue K Hirata H Akita M. Yokoyama Palmitoyl-L-carnitine modifies the function of vascular endothelium Cardiovasc Res 28 1994 129 134
22. DN Criddle M Rad-Niknam GH Dewar B. Woodward Vasodilator action of the isopropyl ester of palmitoyl carnitine in the rat coronary circulation and mesenteric vascular bed Eur J Pharm 255 1994 223 228
23. G Elliot AP Lauwen IL. Bonta The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187-stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages Br J Nutr 64 2 1990 497 503
24. BO Christopherson J. Norseth Arachidonic acid synthesis studied in isolated liver cells. Effect of carnitine and decanoylcarnitine FEBS Lett 133 1981 201
25. A Bertelli A Bertelli G Galmozzi L Giovannini M. Miam Thrombosis induced by endothelin (ET-1) and carrageenin in rats treated with indomethacin and propionyl carnitine Drugs Exp Clin Res 19 1993 75 78