Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression

Clinical and Experimental Immunology

Volumn 141, Issue 2, 2005, Pages 326-332

  Robertson, M J ^a,d   Schacterle, R S ^b   Mackin, G A ^b   Wilson, S N ^c   Bloomingdale, K L ^a   Ritz, J ^a   Komaroff, A L ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B cell; Chronic fatigue syndrome; Depression; Multiple sclerosis; NK cell; T cell

Indexed keywords

CD16 ANTIGEN; CD2 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; CD3 ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; FATIGUE; FEMALE; HUMAN; IMMUNE SYSTEM; MAJOR DEPRESSION; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; PRIORITY JOURNAL; SYMPTOMATOLOGY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; B-LYMPHOCYTE SUBSETS; DEPRESSIVE DISORDER, MAJOR; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MULTIPLE SCLEROSIS; T-LYMPHOCYTE SUBSETS;

EID: 22344443910     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02833.x     Document Type: Article

References (68)

1. Fukuda K, Straus SE, Hickie I et ai. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121:953-9.
2. Komaroff AL, Buchwald DS. Chronic fatigue syndrome: an update. Annu Rev Med 1998; 49:1-13.
3. Mawle AC, Reyes M, Schmid CS. Is chronic fatigue syndrome an infectious disease? Infect Agents Dis 1994; 2:333-41.
4. White PD, Thomas JM, Amess J et al. Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever. Br J Psychiatry 1998; 173:475-81.
5. Marmion BP, Shannon M, Maddocks I et al. Protracted debility and fatigue after acute Q fever. Lancet 1996; 347:977-8.
6. Coyle PK, Krupp L. Borrelia burgdorferi infection in the chronic fatigue syndrome. Ann Neurol 1990; 28:243-4.
7. Cunningham L, Bowles NE, Lane RJM et al. Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA. J Gen Virol 1990; 71:1399-402.
8. Yalcin S, Kuratsune H, Yamaguchi K et al. Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome. Microbiol Immunol 1994; 38:587-90.
9. Patnaik M, Komaroff AL, Conley E et al. Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome. J Infect Dis 1995; 172:1364-7.
10. Zorzenon M, Rukh G, Botta GA et al. Active HHV-6 infection in chronic fatigue syndrome patients from Italy: new data. J Chron Fatigue Syndrome 1996; 2:3-12.
11. Schwartz RB, Komaroff AL, Garada BM et al. SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression. Am J Roentgenol 1994; 162:943-51.
12. Bou-Holaigah I, Rowe PC, Kan J et al. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA 1995; 274:961-7.
13. Freeman R, Komaroff AL. Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med 1997; 102:357-62.
14. Demitrack MA, Dale JK, Straus SE et al. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 1991; 73:1224-34.
15. Dinan TG, Majeed T, Lavelle E et al. Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome. Psychoneuroendocrinology 1997; 22:261-7.
16. Scott LV, Dinan TG. Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers. J Affect Disord 1998; 47:49-54.
17. Cleare AJ, Blair D, Chambers S et al. Urinary free cortisol in chronic fatigue syndrome. Am J Psychiatry 2001; 158:641-3.
18. Tiersky LA, Johnson SK, Lange G et al. Neuropsychology of chronic fatigue syndrome: a critical review. J Clin Exp Neuropsychol 1997; 19:560-86.
19. Demitrack MA, Gold PW, Dale JK et al. Plasma and cerebrospinal fluid monamine metabolism in patients with chronic fatigue syndrome: preliminary findings. Biol Psychiatry 1992; 32:1065-77.
20. Bakheit AMO, Behan PO, Dinan TG et al. Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome. Br Med J 1992; 304:1010-2.
21. Cleare AJ, Bearn J, Allain T et al. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. J Affect Disord 1995; 35:283-9.
22. Mookens G, Berwaerts J, Wynants H et al. Characterization of pituitary function with emphasis on GH secretion in the chronic fatigue syndrome. Clin Endocrinol 2000; 53:99-106.
23. Ash-Bernal R, Wall C III, Komaroff AL et al. Vestibular function test anomalies in patients with chronic fatigue syndrome. Acta Otolaryngol 1995; 115:9-17.
24. Marcel B, Komaroff AL, Fagioli LR et al. Cognitive deficits in patients with chronic fatigue syndrome. Biol Psychiatry 1996; 40:535-41.
25. DeLuca J, Johnson SK, Ellis SP et al. Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease. J Neurol Neurosurg Psychiatry 1997; 62:151-5.
26. Michiels V, Cluydts R, Fischler B. Attention and verbal learning in patients with chronic fatigue syndrome. J Int Neuropsychol Soc 1998; 4:456-66.
27. Daly E, Komaroff AL, Bloomingdale K et al. Neuropsychological functioning in patients with chronic fatigue syndrome, multiple sclerosis and depression. App Neuropsychol 2001; 8:12-22.
28. Krupp LB, Jandorf L, Coyle PK et al. Sleep disturbance in chronic fatigue syndrome. J Psychosom Res 1993; 37:325-31.
29. Mawle AC, Nisenbaum R, Dobbins JG et al. Immune responses associated with chronic fatigue syndrome: a case-control study. J Infect Dis 1997; 175:136-41.
30. Visser J, Lentjes E, Haspels I et al. Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors. J Invest Med 2001; 49:195-204.
31. Kavelaars A, Kuis W, Knook L et al. Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome. J Clin Endocrinol Metab 2000; 85:692-6.
32. Gaab J, Huster D, Peisen R et al. Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation. Psychosom Med 2000; 64:951-62.
33. Patarca-Montero R, Mark T, Fletcher MA et al. Immunology of chronic fatigue syndrome. In: DeMeirleir K, Patarca-Montero R, eds. Chronic fatigue syndrome: critical reviews and clinical advances. New York: Haworth Medical Press, 2000:69-107.
34. Holmes GP, Kaplan JE, Gantz NM et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988; 108:387-9.
35. Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13:227-31.
36. Motulsky HJ. Intuitive biostatistics. New York: Oxford University Press, 1995.
37. Fukuda H, Ohashi Y. A guideline for reporting results of statistical analysis. Jap J Clin Oncol 1997; 27:121-7.
38. Klimas NG, Salvato FR, Morgan R et al. Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 1990; 28:1403-10.
39. Landay AL, Jessop C, Lennette ET et al. Chronic fatigue syndrome: clinical condition associated with immune activation. Lancet 1991; 338:707-12.
40. Hassan IS, Bannister BA, Akbar A et al. A study of the immunology of the chronic fatigue syndrome: correlation of immunologic parameters to health dysfunction. Clin Immunol Immunopathol 1998; 87:60-7.
41. Peakman M, Deale A, Field R et al. Clinical improvement in chronic fatigue syndrome is not associated with lymphocyte subsets of function or activation. Clin Immunol Immunopathol 1997; 82:83-91.
42. Straus SE, Fritz S, Dale JK et al. Lymphocyte phenotype and function in the chronic fatigue syndrome. J Clin Immunol 1993; 13:30-40.
43. Natelson BH, LaManca JJ, Denny TN et al. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis. Am J Med 1998; 105:S43-9.
44. Swanink CMA, Vercoulen JHMM, Galama JMD et al. Lymphocyte subsets, apoptosis, and cytokines in patients with chronic fatigue syndrome. J Infect Dis 1996; 173:460-3.
45. Caligiuri MA, Murray C, Buchwald D et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol 1987; 139:3306-13.
46. Levine PH, Whiteside TL, Friberg D et al. Dysfunction of natural killer activity in a family with chronic fatigue syndrome. Clin Immunol Immunopathol 1998; 88:96-104.
47. Gupta S, Vayuvegula B. A comprehensive immunological analysis in chronic fatigue syndrome. Scand J Immunol 1991; 33:319-27.
48. Tirelli U, Marotta G, Improta S et al. Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol 1994; 40:601-8.
49. Masuda A, Nozoe S-I, Matsuyama T et al. Psycobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome. Psychosom Med 1994; 56:512-8.
50. Morrison LJA, Behan WHM, Behan PO. Changes in natural killer cell phenotype in patients with post-viral chronic fatigue syndrome. Clin Exp Immunol 1991; 83:441-6.
51. Nagler A, Lanier LL, Cwirla S et al. Comparative studies of human FcR III-positive and negative natural killer cells. J Immunol 1989; 143:3183-91.
52. bright+ natural killer cell subpopulations. Int Arch Allergy Immunol 1996; 110:308-13.
53. Van de Griend RJ, van Krimpen BA, Ronteltap CPM et al. Rapidly expanded activated human killer cell clones have strong antitumor cell activity and have the surface phenotype of either Tγ, T-non-γ, or null cells. J Immunol 1984; 132:3185-91.
54. Robertson MJ, Cochran KJ, Ritz J. Characterization of surface antigens expressed by normal and neoplastic human natural killer cells. In: Schlossman SF, Boumsell L, Gilks W et al., eds. Leucocyte typing V. White cell differentiation antigens. Oxford: Oxford University Press, 1995:1374-7.
55. + B) cells. Int Immunol 1992; 4:243-52.
56. Kipps TJ. The CD5 B cell. Adv Immunol 1989; 47:117-85.
57. Maes M, Stevens WJ, DeClerck LS et al. A significantly increased number and percentage of B cells in depressed subjects: results of flow cytometric measurements. J Affect Disord 1992; 24:127-34.
58. Maes M, Lambrechts J, Bosmans E et al. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med 1992; 22:45-53.
59. Darko DF, Lucas AH, Gillin JC et al. Cellular immunity and the hypothalamic-pituitary axis in major affective disorder: a preliminary study. Psych Res 1988; 25:1-9.
60. Ravindran AV, Griffiths J, Merali Z et al. Lymphocyte subsets associated with major depression and dysthymia: modification by antidepressant treatment. Psychosom Med 1995; 57:555-63.
61. Ravindran AV, Griffiths J, Merali Z et al. Circulating lymphocyte subsets in major depression and dysthymia with typical or atypical features. Psychosom Med 1998; 60:283-9.
62. Schliefer SJ, Keller SE, Bond RN et al. Major depressive disorder and immunity: role of age, sex, severity, and hospitalization. Arch Gen Psychiatry 1989; 46:81-7.
63. Natelson BH, Denny T, Zhou X-D et al. Is depression associated with immune activation? J Affect Dis 1999; 53:179-84.
64. Maes M, Bosmans E, Suy E et al. Immune disturbances during major depression: upregulated expression of interleukin-2 receptors. Neuropsychobiology 1990; 24:115-20.
65. Maes M, Scharpe S, Meltzer HY et al. Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depression. Biol Psychiatry 1993; 34:690-701.
66. Vrethem M, Dahle C, Ekerfelt C et al. CD4 and CD8 lymphocyte subsets in cerebrospinal fluid and peripheral blood from patients with multiple sclerosis, meningitis and normal controls. Acta Neurol Scand 1998; 97:215-20.
67. Calopa M, Bas J, Mestre M et al. T cell subsets in multiple sclerosis: a serial study. Acta Neurol Scand 1995; 92:361-8.
68. Oreja-Guevara C, Sindern E, Raulf-Heimsoth M et al. Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in patients with multiple sclerosis and inflammatory diseases of the nervous system. Acta Neurol Scand 1998; 98:310-3.