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Volumn 184, Issue , 2010, Pages 235-238

GDC-0449 - Targeting the hedgehog signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; GDC 0449; LIGAND; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 77953679047     PISSN: 00800015     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-01222-8_17     Document Type: Review
Times cited : (20)

References (19)
  • 1
    • 0032694528 scopus 로고    scopus 로고
    • Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    • Aszterbaum M, Epstein J, Oro A et al (1999) Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 5(11): 1285-1291
    • (1999) Nat Med , vol.5 , Issue.11 , pp. 1285-1291
    • Aszterbaum, M.1    Epstein, J.2    Oro, A.3
  • 2
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A et al (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425(6960):846-851
    • (2003) Nature , vol.425 , Issue.6960 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 3
    • 34547683699 scopus 로고    scopus 로고
    • Essential role of stromally induced hedgehog signaling in B-cell malignancies
    • Dierks C, Grbic J, Zirlik K et al (2007) Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 13(8):944-951
    • (2007) Nat Med , vol.13 , Issue.8 , pp. 944-951
    • Dierks, C.1    Grbic, J.2    Zirlik, K.3
  • 4
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C, Beigi R, Guo GR et al (2008) Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 14(3):238-249
    • (2008) Cancer Cell , vol.14 , Issue.3 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3
  • 5
    • 0037118056 scopus 로고    scopus 로고
    • Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin e
    • Duman-Scheel M, Weng L, Xin S et al (2002) Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417(6886):299-304
    • (2002) Nature , vol.417 , Issue.6886 , pp. 299-304
    • Duman-Scheel, M.1    Weng, L.2    Xin, S.3
  • 6
    • 16044363842 scopus 로고    scopus 로고
    • The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
    • Gailani MR, Stahle-Backdahl M, Leffell DJ et al (1996) The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet 14(1):78-81
    • (1996) Nat Genet , vol.14 , Issue.1 , pp. 78-81
    • Gailani, M.R.1    Stahle-Backdahl, M.2    Leffell, D.J.3
  • 7
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM et al (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277(5329):1109-1113
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3
  • 8
    • 0032409157 scopus 로고    scopus 로고
    • Hedgehog and patched in neural development and disease
    • Goodrich LV, Scott MP (1998) Hedgehog and patched in neural development and disease. Neuron 21(6):1243-1257
    • (1998) Neuron , vol.21 , Issue.6 , pp. 1243-1257
    • Goodrich, L.V.1    Scott, M.P.2
  • 9
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG et al (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85(6):841-851
    • (1996) Cell , vol.85 , Issue.6 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3
  • 10
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H, Wojnowski L, Miller G et al (1998) Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 4(5):619-622
    • (1998) Nat Med , vol.4 , Issue.5 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Miller, G.3
  • 11
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272(5268): 1668-16671
    • (1996) Science , vol.272 , Issue.5268 , pp. 1668-16671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3
  • 13
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar SS, Bova GS, Abdallah N et al (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431(7009): 707-712
    • (2004) Nature , vol.431 , Issue.7009 , pp. 707-712
    • Karhadkar, S.S.1    Bova, G.S.2    Abdallah, N.3
  • 14
    • 0029843937 scopus 로고    scopus 로고
    • Regulation of patched by sonic hedgehog in the developing neural tube
    • Marigo V, Tabin CJ (1996) Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci U S A 93(18): 9346-9351
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.18 , pp. 9346-9351
    • Marigo, V.1    Tabin, C.J.2
  • 15
    • 0031036694 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain PTCH mutations
    • Raffel C, Jenkins RB, Frederick L et al (1997) Sporadic medulloblastomas contain PTCH mutations. Cancer Res 57(5):842-845
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 842-845
    • Raffel, C.1    Jenkins, R.B.2    Frederick, L.3
  • 16
    • 7444247429 scopus 로고    scopus 로고
    • Activation of the BCL2 promoter in response to Hedgehog/ GLI signal transduction is predominantly mediated by GLI2
    • Regl G, Kasper M, Schnidar H et al (2004) Activation of the BCL2 promoter in response to Hedgehog/ GLI signal transduction is predominantly mediated by GLI2. Cancer Res 64(21): 7724-7731
    • (2004) Cancer Res , vol.64 , Issue.21 , pp. 7724-7731
    • Regl, G.1    Kasper, M.2    Schnidar, H.3
  • 17
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, Di Magliano MP, Heiser PW et al (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425 (6960):851-856
    • (2003) Nature , vol.425 , Issue.6960 , pp. 851-856
    • Thayer, S.P.1    Di Magliano, M.P.2    Heiser, P.W.3
  • 18
    • 29744463531 scopus 로고    scopus 로고
    • Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
    • Tostar U, Malm CJ, Meis-Kindblom JM et al (2006) Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 208(1): 17-25
    • (2006) J Pathol , vol.208 , Issue.1 , pp. 17-25
    • Tostar, U.1    Malm, C.J.2    Meis-Kindblom, J.M.3
  • 19
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Burkholder SG et al (2003) Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422(6929):313-317
    • (2003) Nature , vol.422 , Issue.6929 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.