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Volumn 149, Issue , 2009, Pages 131-146

Epigenetics and Ovarian Cancer

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CARBOPLATIN; VALPROIC ACID; VORINOSTAT; ZEBULARINE;

EID: 77953660916     PISSN: 09273042     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-98094-2_6     Document Type: Review
Times cited : (9)

References (115)
  • 1
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium.
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature. 2004;431:931-945.
    • (2004) Nature , vol.431 , pp. 931-945
  • 2
    • 31544478804 scopus 로고    scopus 로고
    • Momentum building for human epigenome project
    • Garber K. Momentum building for human epigenome project. J Natl Cancer Inst. 2006;98:84-86.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 84-86
    • Garber, K.1
  • 3
    • 0037068378 scopus 로고    scopus 로고
    • A. DNA methylation and cancer
    • Jones P. A. DNA methylation and cancer. Oncogene. 2002;21:5358-5360.
    • (2002) Oncogene , vol.21 , pp. 5358-5360
    • Jones, P.1
  • 5
    • 0031638515 scopus 로고    scopus 로고
    • The host defence function of genomic methylation patterns
    • discussion 195-189, 228-1132
    • Bestor TH. The host defence function of genomic methylation patterns. Novartis Found Symp. 1998;214:187-195; discussion 195-189, 228-1132
    • (1998) Novartis Found Symp , vol.214 , pp. 187-195
    • Bestor, T.H.1
  • 6
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med. 2008;358:1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 7
    • 0037115392 scopus 로고    scopus 로고
    • Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    • Fahrner JA, Eguchi S, Herman JG, Baylin SB. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res. 2002;62:7213-7218.
    • (2002) Cancer Res , vol.62 , pp. 7213-7218
    • Fahrner, J.A.1    Eguchi, S.2    Herman, J.G.3    Baylin, S.B.4
  • 8
    • 8544284078 scopus 로고    scopus 로고
    • The epigenetics of ovarian cancer drug resistance and resensitization
    • Balch C, Huang TH, Brown R, Nephew KP. The epigenetics of ovarian cancer drug resistance and resensitization. Am J Obstet Gynecol. 2004;191:1552-1572.
    • (2004) Am J Obstet Gynecol , vol.191 , pp. 1552-1572
    • Balch, C.1    Huang, T.H.2    Brown, R.3    Nephew, K.P.4
  • 10
    • 0036850325 scopus 로고    scopus 로고
    • Cellular memory and the histone code
    • Turner BM. Cellular memory and the histone code. Cell. 2002;111:285-291.
    • (2002) Cell , vol.111 , pp. 285-291
    • Turner, B.M.1
  • 11
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 2007;8:286-298.
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 12
    • 38849117845 scopus 로고    scopus 로고
    • The human trithorax protein hASH2 functions as an oncoprotein
    • Luscher-Firzlaff J, Gawlista I, Vervoorts J, et al. The human trithorax protein hASH2 functions as an oncoprotein. Cancer Res. 2008;68:749-758.
    • (2008) Cancer Res , vol.68 , pp. 749-758
    • Luscher-Firzlaff, J.1    Gawlista, I.2    Vervoorts, J.3
  • 13
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006;6:846-856.
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 14
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125:315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 15
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE, McGarvey KM, Yu X, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet. 2007;39:237-242.
    • (2007) Nat Genet , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3
  • 16
    • 34248193264 scopus 로고    scopus 로고
    • Stem cell chromatin patterns: An instructive mechanism for DNA hypermethylation?
    • Ohm JE, Baylin SB. Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle. 2007;6:1040-1043.
    • (2007) Cell Cycle , vol.6 , pp. 1040-1043
    • Ohm, J.E.1    Baylin, S.B.2
  • 17
    • 34548716445 scopus 로고    scopus 로고
    • Epigenetic ''bivalently marked'' process of cancer stem cell-driven tumorigenesis
    • Balch C, Nephew KP, Huang TH, Bapat SA. Epigenetic ''bivalently marked'' process of cancer stem cell-driven tumorigenesis. Bioessays. 2007;29:842-845.
    • (2007) Bioessays , vol.29 , pp. 842-845
    • Balch, C.1    Nephew, K.P.2    Huang, T.H.3    Bapat, S.A.4
  • 18
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet. 2006;7:21-33.
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 21
    • 1042290351 scopus 로고    scopus 로고
    • The SWI/SNF complex - Chromatin and cancer
    • Roberts CW, Orkin SH. The SWI/SNF complex - chromatin and cancer. Nat Rev Cancer. 2004;4:133-142.
    • (2004) Nat Rev Cancer , vol.4 , pp. 133-142
    • Roberts, C.W.1    Orkin, S.H.2
  • 22
    • 33744955345 scopus 로고    scopus 로고
    • NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex
    • Srinivasan R, Mager GM, Ward RM, Mayer J, Svaren J. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2006;281:15129-15137.
    • (2006) J Biol Chem , vol.281 , pp. 15129-15137
    • Srinivasan, R.1    Mager, G.M.2    Ward, R.M.3    Mayer, J.4    Svaren, J.5
  • 23
    • 10944254152 scopus 로고    scopus 로고
    • Transcription and processing of human microRNA precursors
    • Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell. 2004;16:861-865.
    • (2004) Mol Cell , vol.16 , pp. 861-865
    • Cullen, B.R.1
  • 24
    • 41749116632 scopus 로고    scopus 로고
    • The evolution of core proteins involved in microRNA biogenesis
    • Murphy D, Dancis B, Brown JR. The evolution of core proteins involved in microRNA biogenesis. BMC Evol Biol. 2008;8:92.
    • (2008) BMC Evol Biol , vol.8 , pp. 92
    • Murphy, D.1    Dancis, B.2    Brown, J.R.3
  • 25
    • 36749037521 scopus 로고    scopus 로고
    • The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
    • Aravin AA, Hannon GJ, Brennecke J. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science. 2007;318:761-764.
    • (2007) Science , vol.318 , pp. 761-764
    • Aravin, A.A.1    Hannon, G.J.2    Brennecke, J.3
  • 26
    • 34249805994 scopus 로고    scopus 로고
    • The coming of age for Piwi proteins
    • Seto AG, Kingston RE, Lau NC. The coming of age for Piwi proteins. Mol Cell. 2007; 26:603-609.
    • (2007) Mol Cell , vol.26 , pp. 603-609
    • Seto, A.G.1    Kingston, R.E.2    Lau, N.C.3
  • 27
    • 39149139307 scopus 로고    scopus 로고
    • Small RNAs keeping stem cells in line
    • Stadler BM, Ruohola-Baker H. Small RNAs: keeping stem cells in line. Cell. 2008; 132:563-566.
    • (2008) Cell , vol.132 , pp. 563-566
    • Stadler, B.M.1    Ruohola-Baker, H.2
  • 28
    • 39749110083 scopus 로고    scopus 로고
    • Small non-coding RNAs in animal development.
    • Stefani G, Slack FJ. Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 2008;9:219-230.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 219-230
    • Stefani, G.1    Slack, F.J.2
  • 29
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 30
    • 77953669003 scopus 로고    scopus 로고
    • American Cancer Society Key Statistics About Ovarian Cancer. American Cancer Society Center 250 Williams Street, Atlanta, GA, 2006
    • American Cancer Society, Key Statistics About Ovarian Cancer. American Cancer Society Center, 250 Williams Street, Atlanta, GA, 2006.
  • 31
    • 0347625462 scopus 로고    scopus 로고
    • Status of tumor markers in ovarian cancer screening
    • Bast RC, Jr. Status of tumor markers in ovarian cancer screening. J Clin Oncol. 2003; 21:200-205.
    • (2003) J Clin Oncol , vol.21 , pp. 200-205
    • Bast Jr., R.C.1
  • 32
    • 33646560022 scopus 로고    scopus 로고
    • Systemic therapy for ovarian cancer: Current status and new treatments
    • Ozols RF. Systemic therapy for ovarian cancer: current status and new treatments. Semin Oncol. 2006;33:S3-11.
    • (2006) Semin Oncol , vol.33
    • Ozols, R.F.1
  • 33
    • 3042822370 scopus 로고    scopus 로고
    • DNA hypomethylation and ovarian cancer biology
    • Widschwendter M, Jiang G, Woods C, et al. DNA hypomethylation and ovarian cancer biology. Cancer Res. 2004;64:4472-4480.
    • (2004) Cancer Res , vol.64 , pp. 4472-4480
    • Widschwendter, M.1    Jiang, G.2    Woods, C.3
  • 34
    • 47649111322 scopus 로고    scopus 로고
    • LINE-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer
    • Pattamadilok J, Huapai N, Rattanatanyong P, et al. LINE-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer. Int J Gynecol Cancer. 2007;18:711-717
    • (2007) Int J Gynecol Cancer , vol.18 , pp. 711-717
    • Pattamadilok, J.1    Huapai, N.2    Rattanatanyong, P.3
  • 35
    • 0141988726 scopus 로고    scopus 로고
    • Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation
    • Leu YW, Rahmatpanah F, Shi H, et al. Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Cancer Res. 2003;63: 6110-6115.
    • (2003) Cancer Res , vol.63 , pp. 6110-6115
    • Leu, Y.W.1    Rahmatpanah, F.2    Shi, H.3
  • 36
    • 40949087119 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment
    • Barton CA, Hacker NF, Clark SJ, O'Brien PM. DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol Oncol. 2008;109:129-139.
    • (2008) Gynecol Oncol , vol.109 , pp. 129-139
    • Barton, C.A.1    Hacker, N.F.2    Clark, S.J.3    O'Brien, P.M.4
  • 37
    • 41149093072 scopus 로고    scopus 로고
    • Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation
    • Feng W, Marquez RT, Lu Z, et al. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer. 2008;112:1489-1502.
    • (2008) Cancer , vol.112 , pp. 1489-1502
    • Feng, W.1    Marquez, R.T.2    Lu, Z.3
  • 38
    • 12144288983 scopus 로고    scopus 로고
    • Epigenetic inactivation of TMS1/ASC in ovarian cancer
    • Terasawa K, Sagae S, Toyota M, et al. Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res. 2004;10:2000-2006.
    • (2004) Clin Cancer Res , vol.10 , pp. 2000-2006
    • Terasawa, K.1    Sagae, S.2    Toyota, M.3
  • 39
    • 0035798454 scopus 로고    scopus 로고
    • Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas
    • Arnold JM, Cummings M, Purdie D, Chenevix-Trench G. Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas. Br J Cancer. 2001;85: 1351-1358.
    • (2001) Br J Cancer , vol.85 , pp. 1351-1358
    • Arnold, J.M.1    Cummings, M.2    Purdie, D.3    Chenevix-Trench, G.4
  • 40
    • 0038081144 scopus 로고    scopus 로고
    • OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer
    • Sellar GC, Watt KP, Rabiasz GJ, et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet. 2003;34:337-343.
    • (2003) Nat Genet , vol.34 , pp. 337-343
    • Sellar, G.C.1    Watt, K.P.2    Rabiasz, G.J.3
  • 41
    • 33750065136 scopus 로고    scopus 로고
    • Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer
    • Yuecheng Y, Hongmei L, Xiaoyan X. Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer. Clin Exp Metastasis. 2006;23: 65-74.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 65-74
    • Yuecheng, Y.1    Hongmei, L.2    Xiaoyan, X.3
  • 42
    • 8844251504 scopus 로고    scopus 로고
    • Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest
    • Rong R, Jin W, Zhang J, Sheikh MS, Huang Y. Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest. Oncogene. 2004;23:8216-8230.
    • (2004) Oncogene , vol.23 , pp. 8216-8230
    • Rong, R.1    Jin, W.2    Zhang, J.3    Sheikh, M.S.4    Huang, Y.5
  • 43
    • 34248573044 scopus 로고    scopus 로고
    • Heparan sulphate synthetic and editing enzymes in ovarian cancer
    • Backen AC, Cole CL, Lau SC, et al. Heparan sulphate synthetic and editing enzymes in ovarian cancer. Br J Cancer. 2007;96:1544-1548.
    • (2007) Br J Cancer , vol.96 , pp. 1544-1548
    • Backen, A.C.1    Cole, C.L.2    Lau, S.C.3
  • 44
    • 34547399478 scopus 로고    scopus 로고
    • Epigenetic silencing of HSulf-1 in ovarian cancer:Implications in chemoresistance
    • Staub J, Chien J, Pan Y, et al. Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance. Oncogene. 2007;26:4969-4978.
    • (2007) Oncogene , vol.26 , pp. 4969-4978
    • Staub, J.1    Chien, J.2    Pan, Y.3
  • 45
    • 0034976644 scopus 로고    scopus 로고
    • Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
    • Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am J Pathol. 2001;158:2097-2106.
    • (2001) Am J Pathol , vol.158 , pp. 2097-2106
    • Kurose, K.1    Zhou, X.P.2    Araki, T.3    Cannistra, S.A.4    Maher, E.R.5    Eng, C.6
  • 46
    • 11144355535 scopus 로고    scopus 로고
    • Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: Its correlation with aberrant DNA methylation
    • Akahira J, Sugihashi Y, Suzuki T, et al. Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. Clin Cancer Res. 2004;10:2687-2693.
    • (2004) Clin Cancer Res , vol.10 , pp. 2687-2693
    • Akahira, J.1    Sugihashi, Y.2    Suzuki, T.3
  • 47
    • 34147215968 scopus 로고    scopus 로고
    • Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression
    • Hatle KM, Neveu W, Dienz O, et al. Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol. 2007;27: 2952-2966.
    • (2007) Mol Cell Biol , vol.27 , pp. 2952-2966
    • Hatle, K.M.1    Neveu, W.2    Dienz, O.3
  • 48
    • 0035872480 scopus 로고    scopus 로고
    • Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer
    • Shridhar V, Bible KC, Staub J, et al. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. Cancer Res. 2001;61:4258-4265.
    • (2001) Cancer Res , vol.61 , pp. 4258-4265
    • Shridhar, V.1    Bible, K.C.2    Staub, J.3
  • 49
    • 0037310198 scopus 로고    scopus 로고
    • Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
    • Gupta A, Godwin AK, Vanderveer L, Lu A, Liu J. Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res. 2003;63:664-673.
    • (2003) Cancer Res , vol.63 , pp. 664-673
    • Gupta, A.1    Godwin, A.K.2    Vanderveer, L.3    Lu, A.4    Liu, J.5
  • 50
    • 34247241526 scopus 로고    scopus 로고
    • Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin
    • Litkouhi B, Kwong J, Lo CM, et al. Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia. 2007;9:304-314.
    • (2007) Neoplasia , vol.9 , pp. 304-314
    • Litkouhi, B.1    Kwong, J.2    Lo, C.M.3
  • 51
    • 33745964874 scopus 로고    scopus 로고
    • Epigenetic regulation of maspin expression in human ovarian carcinoma cells
    • Rose SL, Fitzgerald MP, White NO, et al. Epigenetic regulation of maspin expression in human ovarian carcinoma cells. Gynecol Oncol . 2006;102:319-324.
    • (2006) Gynecol Oncol , vol.102 , pp. 319-324
    • Rose, S.L.1    Fitzgerald, M.P.2    White, N.O.3
  • 52
    • 2342519358 scopus 로고    scopus 로고
    • Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors
    • Yao X, Hu JF, Li T, et al. Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors. Cancer Genet Cytogenet. 2004;151:1-13.
    • (2004) Cancer Genet Cytogenet , vol.151 , pp. 1-13
    • Yao, X.1    Hu, J.F.2    Li, T.3
  • 53
    • 27644438823 scopus 로고    scopus 로고
    • Epigenetic control of ovarian function: The emerging role of histone modifications
    • LaVoie HA. Epigenetic control of ovarian function: the emerging role of histone modifications. Mol Cell Endocrinol. 2005;243:12-18.
    • (2005) Mol Cell Endocrinol , vol.243 , pp. 12-18
    • Lavoie, H.A.1
  • 54
    • 33744954457 scopus 로고    scopus 로고
    • Differential expression of selected histone modifier genes in human solid cancers
    • Ozdag H, Teschendorff AE, Ahmed AA, et al. Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics. 2006;7:90.
    • (2006) BMC Genomics , vol.7 , pp. 90
    • Ozdag, H.1    Teschendorff, A.E.2    Ahmed, A.A.3
  • 55
    • 33748297582 scopus 로고    scopus 로고
    • Histone modifications silence the GATA transcription factor genes in ovarian cancer
    • Caslini C, Capo-chichi CD, Roland IH, Nicolas E, Yeung AT, Xu XX. Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene. 2006;25:5446-5461.
    • (2006) Oncogene , vol.25 , pp. 5446-5461
    • Caslini, C.1    Capo-Chichi, C.D.2    Roland, I.H.3    Nicolas, E.4    Yeung, A.T.5    Xu, X.X.6
  • 56
    • 0041532109 scopus 로고    scopus 로고
    • Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21 Rb and Id proteins
    • Strait KA, Dabbas B, Hammond EH, Warnick CT, Iistrup SJ, Ford CD. Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. Mol Cancer Ther. 2002;1:1181-1190.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1181-1190
    • Strait, K.A.1    Dabbas, B.2    Hammond, E.H.3    Warnick, C.T.4    Iistrup, S.J.5    Ford, C.D.6
  • 57
    • 33745228778 scopus 로고    scopus 로고
    • Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells
    • Abbosh PH, Montgomery JS, Starkey JA, et al. Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells. Cancer Res. 2006;66:5582-5591.
    • (2006) Cancer Res , vol.66 , pp. 5582-5591
    • Abbosh, P.H.1    Montgomery, J.S.2    Starkey, J.A.3
  • 58
    • 50249175130 scopus 로고    scopus 로고
    • Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
    • Wei Y, Xia W, Zhang Z, et al. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 2008;47:701-706
    • (2008) Mol Carcinog , vol.47 , pp. 701-706
    • Wei, Y.1    Xia, W.2    Zhang, Z.3
  • 59
    • 25444516265 scopus 로고    scopus 로고
    • Amplification of a chromatin remodeling gene, Rsf- 1/HBXAP, in ovarian carcinoma
    • Shih Ie M, Sheu JJ, Santillan A, et al. Amplification of a chromatin remodeling gene, Rsf- 1/HBXAP, in ovarian carcinoma. Proc Natl Acad Sci USA. 2005;102:14004-14009.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14004-14009
    • Shih Ie, M.1    Sheu, J.J.2    Santillan, A.3
  • 60
    • 33751432609 scopus 로고    scopus 로고
    • Expression of the chromatin remodeling factor Rsf-1 is upregulated in ovarian carcinoma effusions and predicts poor survival
    • Davidson B, Trope CG, Wang TL, Shih Ie M. Expression of the chromatin remodeling factor Rsf-1 is upregulated in ovarian carcinoma effusions and predicts poor survival. Gynecol Oncol. 2006;103:814-819.
    • (2006) Gynecol Oncol , vol.103 , pp. 814-819
    • Davidson, B.1    Trope, C.G.2    Wang, T.L.3    Shih Ie, M.4
  • 61
    • 0037221370 scopus 로고    scopus 로고
    • Tumor metastasis- associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulation
    • Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K, Moustafa A. Tumor metastasis- associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis. 2003;20:19-24.
    • (2003) Clin Exp Mtastasis , vol.20 , pp. 19-24
    • Nicolson, G.L.1    Nawa, A.2    Toh, Y.3    Taniguchi, S.4    Nishimori, K.5    Moustafa, A.6
  • 62
    • 0033795072 scopus 로고    scopus 로고
    • Tumor metastasis-associated human MTA1 gene: Its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides
    • Nawa A, Nishimori K, Lin P, et al. Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J Cell Biochem. 2000;79:202-212.
    • (2000) J Cell Biochem , vol.79 , pp. 202-212
    • Nawa, A.1    Nishimori, K.2    Lin, P.3
  • 63
    • 0034697973 scopus 로고    scopus 로고
    • BRCA1 is associated with a human SWI/SNFrelated complex: Linking chromatin remodeling to breast cancer
    • Bochar DA, Wang L, Beniya H, et al. BRCA1 is associated with a human SWI/SNFrelated complex: linking chromatin remodeling to breast cancer. Cell. 2000;102:257-265.
    • (2000) Cell , vol.102 , pp. 257-265
    • Bochar, D.A.1    Wang, L.2    Beniya, H.3
  • 65
    • 34548746977 scopus 로고    scopus 로고
    • MicroRNA signatures in human ovarian cancer
    • Iorio MV, Visone R, Di Leva G, et al. MicroRNA signatures in human ovarian cancer. Cancer Res. 2007;67:8699-8707.
    • (2007) Cancer Res , vol.67 , pp. 8699-8707
    • Iorio, M.V.1    Visone, R.2    Di Leva, G.3
  • 66
    • 39049086391 scopus 로고    scopus 로고
    • MicroRNA expression profiling in human ovarian cancer: MiR-214 induces cell survival and cisplatin resistance by targeting PTEN
    • Yang H, Kong W, He L, et al. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008;68:425-433.
    • (2008) Cancer Res , vol.68 , pp. 425-433
    • Yang, H.1    Kong, W.2    He, L.3
  • 67
    • 44349124725 scopus 로고    scopus 로고
    • Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
    • Zhang L, Volinia S, Bonome T, et al. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci USA. 2008;105:7004-7009.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7004-7009
    • Zhang, L.1    Volinia, S.2    Bonome, T.3
  • 68
    • 33646725688 scopus 로고    scopus 로고
    • Prognostic DNA methylation biomarkers in ovarian cancer
    • Wei SH, Balch C, Paik HH, et al. Prognostic DNA methylation biomarkers in ovarian cancer. Clin Cancer Res. 2006;12:2788-2794.
    • (2006) Clin Cancer Res , vol.12 , pp. 2788-2794
    • Wei, S.H.1    Balch, C.2    Paik, H.H.3
  • 69
    • 7044220689 scopus 로고    scopus 로고
    • Analysis of methylated genes in peritoneal fluids of ovarian cancer patients: A new prognostic tool
    • Muller HM, Millinger S, Fiegl H, et al. Analysis of methylated genes in peritoneal fluids of ovarian cancer patients: a new prognostic tool. Clin Chem. 2004;50:2171-2173.
    • (2004) Clin Chem , vol.50 , pp. 2171-2173
    • Muller, H.M.1    Millinger, S.2    Fiegl, H.3
  • 70
    • 27144499187 scopus 로고    scopus 로고
    • Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer
    • Chan MW, Wei SH, Wen P, et al. Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer. Clin Cancer Res. 2005;11:7376-7383.
    • (2005) Clin Cancer Res , vol.11 , pp. 7376-7383
    • Chan, M.W.1    Wei, S.H.2    Wen, P.3
  • 71
    • 25444485414 scopus 로고    scopus 로고
    • CpG island methylation of DNA damage response genes in advanced ovarian cancer
    • Teodoridis JM, Hall J, Marsh S, et al. CpG island methylation of DNA damage response genes in advanced ovarian cancer. Cancer Res. 2005;65:8961-8967.
    • (2005) Cancer Res , vol.65 , pp. 8961-8967
    • Teodoridis, J.M.1    Hall, J.2    Marsh, S.3
  • 72
    • 23044466227 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of ovarian epithelial neoplasms
    • Makarla PB, Saboorian MH, Ashfaq R, et al. Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res. 2005;11:5365-5369.
    • (2005) Clin Cancer Res , vol.11 , pp. 5365-5369
    • Makarla, P.B.1    Saboorian, M.H.2    Ashfaq, R.3
  • 73
    • 33747514481 scopus 로고    scopus 로고
    • Silencing of the UCHL1 gene in human colorectal and ovarian cancers
    • Okochi-Takada E, Nakazawa K, Wakabayashi M, et al. Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer. 2006;119:1338-1344.
    • (2006) Int J Cancer , vol.119 , pp. 1338-1344
    • Okochi-Takada, E.1    Nakazawa, K.2    Wakabayashi, M.3
  • 74
    • 46049092192 scopus 로고    scopus 로고
    • HOXA11 DNA methylation-A novel prognostic biomarker in ovarian cancer
    • Fiegl H, Windbichler G, Mueller-Holzner E, et al. HOXA11 DNA methylation-A novel prognostic biomarker in ovarian cancer. Int J Cancer. 2008;123:729-739
    • (2008) Int J Cancer , vol.123 , pp. 729-739
    • Fiegl, H.1    Windbichler, G.2    Mueller-Holzner, E.3
  • 75
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • Gifford G, Paul J, Vasey PA, Kaye SB, Brown R. The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res. 2004;10:4420-4426.
    • (2004) Clin Cancer Res , vol.10 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 76
    • 4644271551 scopus 로고    scopus 로고
    • Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients
    • Ibanez de Caceres I, Battagli C, Esteller M, et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res. 2004;64:6476-6481.
    • (2004) Cancer Res , vol.64 , pp. 6476-6481
    • Ibanez De Caceres, I.1    Battagli, C.2    Esteller, M.3
  • 77
    • 13844322072 scopus 로고    scopus 로고
    • Lessons from controversy: Ovarian cancer screening and serum proteomics
    • Ransohoff DF. Lessons from controversy: ovarian cancer screening and serum proteomics. J Natl Cancer Inst. 2005;97:315-319.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 315-319
    • Ransohoff, D.F.1
  • 79
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med. 2001;134:573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 80
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors-state of the art
    • Goffin J, Eisenhauer E. DNA methyltransferase inhibitors-state of the art. Ann Oncol. 2002;13:1699-1716.
    • (2002) Ann Oncol , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 81
    • 21044439177 scopus 로고    scopus 로고
    • Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
    • Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res. 2005;11:3604-3608.
    • (2005) Clin Cancer Res , vol.11 , pp. 3604-3608
    • Kaminskas, E.1    Farrell, A.2    Abraham, S.3
  • 83
    • 0037613315 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers
    • Sasaki M, Kaneuchi M, Fujimoto S, Tanaka Y, Dahiya R. Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers. Mol Cell Endocrinol. 2003;202:201-207.
    • (2003) Mol Cell Endocrinol , vol.202 , pp. 201-207
    • Sasaki, M.1    Kaneuchi, M.2    Fujimoto, S.3    Tanaka, Y.4    Dahiya, R.5
  • 84
    • 0037112369 scopus 로고    scopus 로고
    • Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza- 2'-deoxycytidine
    • Nguyen CT, Weisenberger DJ, Velicescu M, et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza- 2'-deoxycytidine. Cancer Res. 2002;62:6456-6461.
    • (2002) Cancer Res , vol.62 , pp. 6456-6461
    • Nguyen, C.T.1    Weisenberger, D.J.2    Velicescu, M.3
  • 85
    • 27644582534 scopus 로고    scopus 로고
    • Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
    • Balch C, Yan P, Craft T, et al. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Mol Cancer Ther. 2005;4:1505-1514.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1505-1514
    • Balch, C.1    Yan, P.2    Craft, T.3
  • 86
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides
    • Yoo CB, Jeong S, Egger G, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007;67:6400-6408.
    • (2007) Cancer Res , vol.67 , pp. 6400-6408
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3
  • 87
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • Lee WJ, Shim JY, Zhu BT. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol. 2005;68:1018-1030.
    • (2005) Mol Pharmacol , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.Y.2    Zhu, B.T.3
  • 88
    • 10744225448 scopus 로고    scopus 로고
    • Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy
    • Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, et al. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy. Clin Cancer Res. 2003;9:1596-1603.
    • (2003) Clin Cancer Res , vol.9 , pp. 1596-1603
    • Segura-Pacheco, B.1    Trejo-Becerril, C.2    Perez-Cardenas, E.3
  • 89
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea A, Fraga MF, Espada J, Esteller M. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res. 2003;63: 4984-4989.
    • (2003) Cancer Res , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 91
    • 0042090316 scopus 로고    scopus 로고
    • The role of p53 deacetylation in p21Waf1 regulation by laminar flow
    • Zeng L, Zhang Y, Chien S, Liu X, Shyy JY. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem. 2003;278:24594-24599.
    • (2003) J Biol Chem , vol.278 , pp. 24594-24599
    • Zeng, L.1    Zhang, Y.2    Chien, S.3    Liu, X.4    Shyy, J.Y.5
  • 92
    • 0036731055 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity
    • Blagosklonny MV, Robey R, Sackett DL, et al. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. Mol Cancer Ther. 2002;1:937-941.
    • (2002) Mol Cancer Ther , vol.1 , pp. 937-941
    • Blagosklonny, M.V.1    Robey, R.2    Sackett, D.L.3
  • 93
    • 10044225745 scopus 로고    scopus 로고
    • Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis
    • Takai N, Kawamata N, Gui D, Said JW, Miyakawa I, Koeffler HP. Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis. Cancer. 2004;101:2760-2770.
    • (2004) Cancer , vol.101 , pp. 2760-2770
    • Takai, N.1    Kawamata, N.2    Gui, D.3    Said, J.W.4    Miyakawa, I.5    Koeffler, H.P.6
  • 94
    • 43049091153 scopus 로고    scopus 로고
    • A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
    • Modesitt SC, Sill M, Hoffman JS, Bender DP. A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2008;109:182-186.
    • (2008) Gynecol Oncol , vol.109 , pp. 182-186
    • Modesitt, S.C.1    Sill, M.2    Hoffman, J.S.3    Bender, D.P.4
  • 95
    • 1642453460 scopus 로고    scopus 로고
    • Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
    • Plumb JA, Finn PW, Williams RJ, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther. 2003;2:721-728.
    • (2003) Mol Cancer Ther , vol.2 , pp. 721-728
    • Plumb, J.A.1    Finn, P.W.2    Williams, R.J.3
  • 96
    • 33644863529 scopus 로고    scopus 로고
    • A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells
    • Takai N, Ueda T, Nishida M, Nasu K, Narahara H. A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells. Int J Mol Med. 2006;17:323-329.
    • (2006) Int J Mol Med , vol.17 , pp. 323-329
    • Takai, N.1    Ueda, T.2    Nishida, M.3    Nasu, K.4    Narahara, H.5
  • 97
    • 36148966966 scopus 로고    scopus 로고
    • R306465 is a novel potent inhibitor of class i histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies
    • Arts J, Angibaud P, Marien A, et al. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. Br J Cancer. 2007;97:1344-1353.
    • (2007) Br J Cancer , vol.97 , pp. 1344-1353
    • Arts, J.1    Angibaud, P.2    Marien, A.3
  • 98
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 99
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA, Plath K, Zeitlinger J, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 2006;441:349-353.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3
  • 100
    • 33748274499 scopus 로고    scopus 로고
    • Human embryonic stem cells have a unique epigenetic signature
    • Bibikova M, Chudin E, Wu B, et al. Human embryonic stem cells have a unique epigenetic signature. Genome Res. 2006;16:1075-1083.
    • (2006) Genome Res , vol.16 , pp. 1075-1083
    • Bibikova, M.1    Chudin, E.2    Wu, B.3
  • 101
    • 33846929668 scopus 로고    scopus 로고
    • In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer
    • Cooper AL, Greenberg VL, Lancaster PS, van Nagell JR Jr, Zimmer SG, Modesitt SC. In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer. Gynecol Oncol. 2007;104:596-601.
    • (2007) Gynecol Oncol , vol.104 , pp. 596-601
    • Cooper, A.L.1    Greenberg, V.L.2    Lancaster, P.S.3    Van Nagell Jr, J.R.4    Zimmer, S.G.5    Modesitt, S.C.6
  • 102
    • 33847130464 scopus 로고    scopus 로고
    • Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients
    • Sonnemann J, Gange J, Pilz S, Stotzer C, Ohlinger R, Belau A, Lorenz G, Beck JF. Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients. BMC Cancer. 2006;6:183.
    • (2006) BMC Cancer , vol.6 , pp. 183
    • Sonnemann, J.1    Gange, J.2    Pilz, S.3    Stotzer, C.4    Ohlinger, R.5    Belau, A.6    Lorenz, G.7    Beck, J.F.8
  • 103
    • 33748353002 scopus 로고    scopus 로고
    • Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
    • Qian X, LaRochelle WJ, Ara G, et al. Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther . 2006;5:2086-2095.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2086-2095
    • Qian, X.1    Larochelle, W.J.2    Ara, G.3
  • 104
    • 43549123821 scopus 로고    scopus 로고
    • Valproic acid resensitizes cisplatin-resistant ovarian cancer cells
    • Lin CT, Lai HC, Lee HY, et al. Valproic acid resensitizes cisplatin-resistant ovarian cancer cells. Cancer Sci. 2008;99:1218-1226.
    • (2008) Cancer Sci , vol.99 , pp. 1218-1226
    • Lin, C.T.1    Lai, H.C.2    Lee, H.Y.3
  • 105
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res. 2000;60:6039-6044.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 106
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee G, MacKean MJ, Illand M, Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene. 1999;18:2335-2341.
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 107
    • 34548395116 scopus 로고    scopus 로고
    • A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
    • Candelaria M, Gallardo-Rincon D, Arce C, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann Oncol. 2007;18:1529-1538.
    • (2007) Ann Oncol , vol.18 , pp. 1529-1538
    • Candelaria, M.1    Gallardo-Rincon, D.2    Arce, C.3
  • 108
    • 0033714888 scopus 로고    scopus 로고
    • HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
    • Lau OD, Kundu TK, Soccio RE, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 2000;5:589-595.
    • (2000) Mol Cell , vol.5 , pp. 589-595
    • Lau, O.D.1    Kundu, T.K.2    Soccio, R.E.3
  • 109
    • 34247860920 scopus 로고    scopus 로고
    • Mechanisms of disease: Methyl-binding domain proteins as potential therapeutic targets in cancer
    • Sansom OJ, Maddison K, Clarke AR. Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nat Clin Pract Oncol. 2007;4:305-315.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 305-315
    • Sansom, O.J.1    Maddison, K.2    Clarke, A.R.3
  • 110
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006; 20:1123-1136.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 112
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007;21:1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 113
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S, Balch C, Chan MW, et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res , 2008;68:4311-4320
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3
  • 114
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells - Perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006;66: 9339-9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 115
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • DOI 10.1146/annurev.med.58.062105.204854
    • Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med. 2007;58:267-284. (Pubitemid 46706514)
    • (2007) Annual Review of Medicine , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3


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