Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 Cells

European Journal of Pharmacology

Volumn 638, Issue 1-3, 2010, Pages 21-28

  Yang, Su Jung ^a   Chang, Shi Chuan ^a   Wen, Hui Chin ^b   Chen, Ching Yu ^b   Liao, Jyh Fei ^a   Chang, Chung Ho ^b,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; Extracellular signal regulated kinase (ERK1 2); NADPH oxidase; Plumbagin; Src tyrosine kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PLUMBAGIN; PROTEIN KINASE B; PROTEIN KINASE P60; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; AMIDE; ANTINEOPLASTIC AGENT; CHROMONE DERIVATIVE; FLAVONOID; MANUMYCIN; MORPHOLINE DERIVATIVE; NAPHTHOQUINONE; POLYENE; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; SCAVENGER; SUPEROXIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG INTERACTION; METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMONES; DRUG INTERACTIONS; ENZYME ACTIVATION; FLAVONOIDS; FREE RADICAL SCAVENGERS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MORPHOLINES; NAPHTHOQUINONES; POLYENES; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; SRC-FAMILY KINASES; SUPEROXIDES; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 77953542947     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.016     Document Type: Article

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