-
1
-
-
38349190476
-
Idiopathic thrombocytopenic purpura: Current concepts in pathophysiology and management
-
Stasi R, Evangelista ML, Stipa E, Buccisano F, Venditti A, Amadori S. Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost. 2008;99:4-13.
-
(2008)
Thromb Haemost.
, vol.99
, pp. 4-13
-
-
Stasi, R.1
Evangelista, M.L.2
Stipa, E.3
Buccisano, F.4
Venditti, A.5
Amadori, S.6
-
2
-
-
0141651537
-
High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura
-
Ogawara H, Handa H, Morita K, Hayakawa M, Kojima J, Amagai H, et al. High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;71:283-288
-
(2003)
Eur J Haematol.
, vol.71
, pp. 283-288
-
-
Ogawara, H.1
Handa, H.2
Morita, K.3
Hayakawa, M.4
Kojima, J.5
Amagai, H.6
-
3
-
-
1642320808
-
Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response
-
Panitsas FP, Theodoropoulou M, Kouraklis A, Karakantza M, Theodorou GL, Zoumbos NC, et al. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood. 2004;103:2645-2647
-
(2004)
Blood.
, vol.103
, pp. 2645-2647
-
-
Panitsas, F.P.1
Theodoropoulou, M.2
Kouraklis, A.3
Karakantza, M.4
Theodorou, G.L.5
Zoumbos, N.C.6
-
4
-
-
33846059033
-
Abnormality of CD4(+)CD25(+) regulatory T cell in idiopathic thrombocytopenic purpura
-
Liu B, Zhao H, Poon MC, Han Z, Gu D, Xu M, et al. Abnormality of CD4(+)CD25(+) regulatory T cell in idiopathic thrombocytopenic purpura. Eur J Haematol. 2007;78:139-143
-
(2007)
Eur J Haematol.
, vol.78
, pp. 139-143
-
-
Liu, B.1
Zhao, H.2
Poon, M.C.3
Han, Z.4
Gu, D.5
Xu, M.6
-
5
-
-
51649127854
-
Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
-
Yu J, Heck S, Patel V, Levan J, Yu Y, Bussel JB, et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood. 2008;112:1325-1328
-
(2008)
Blood.
, vol.112
, pp. 1325-1328
-
-
Yu, J.1
Heck, S.2
Patel, V.3
Levan, J.4
Yu, Y.5
Bussel, J.B.6
-
6
-
-
0141684568
-
T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
-
Olsson B, Andersson PO, Jernås M, Jacobsson S, Carlsson B, Carlsson LM, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9:1123-1124
-
(2003)
Nat Med.
, vol.9
, pp. 1123-1124
-
-
Olsson, B.1
Andersson, P.O.2
Jernås, M.3
Jacobsson, S.4
Carlsson, B.5
Carlsson, L.M.6
-
7
-
-
50849101392
-
Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies
-
Zhao C, Li X, Zhang F, Wang L, Peng J, Hou M. Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies. Haematologica. 2008;93:1428-1430
-
(2008)
Haematologica.
, vol.93
, pp. 1428-1430
-
-
Zhao, C.1
Li, X.2
Zhang, F.3
Wang, L.4
Peng, J.5
Hou, M.6
-
8
-
-
42649134105
-
Interleukin-21: Basic biology and implications for cancer and autoimmunity
-
Spolski R, Leonard WL. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 2007;26:57-79.
-
(2007)
Annu Rev Immunol.
, vol.26
, pp. 57-79
-
-
Spolski, R.1
Leonard, W.L.2
-
9
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408:57-63.
-
(2000)
Nature.
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
Dillon, S.R.2
Nelson, A.3
Hammond, A.4
Sprecher, C.5
Gross, J.A.6
-
10
-
-
37249029836
-
Interleukin-21 signaling: Functions in cancer and autoimmunity
-
Davis ID, Skak K, Smyth MJ, Kristjansen PE, Miller DM, Sivakumar PV. Interleukin-21 signaling: functions in cancer and autoimmunity. Clin Cancer Res. 2007;13:6926-6932
-
(2007)
Clin Cancer Res.
, vol.13
, pp. 6926-6932
-
-
Davis, I.D.1
Skak, K.2
Smyth, M.J.3
Kristjansen, P.E.4
Miller, D.M.5
Sivakumar, P.V.6
-
11
-
-
34247257447
-
Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
-
Young DA, Hegen M, Ma HL, Whitters MJ, Albert LM, Lowe L, et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 2007;56:1152-1163
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 1152-1163
-
-
Young, D.A.1
Hegen, M.2
Ma, H.L.3
Whitters, M.J.4
Albert, L.M.5
Lowe, L.6
-
12
-
-
33947215987
-
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R:Fc reduces disease progression
-
Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R:Fc reduces disease progression. J Immunol. 2007;178:3822-3830
-
(2007)
J Immunol.
, vol.178
, pp. 3822-3830
-
-
Herber, D.1
Brown, T.P.2
Liang, S.3
Young, D.A.4
Collins, M.5
Dunussi-Joannopoulos, K.6
-
13
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology. 2008;134:1038-1048
-
(2008)
Gastroenterology.
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
Rizzo, A.4
Caruso, R.5
Caprioli, F.6
-
14
-
-
33644690387
-
Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus
-
Mitoma H, Horiuchi T, Kimoto Y, Tsukamoto H, Uchino A, Tamimoto Y, et al. Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Int J Mol Med. 2005;16:609-615
-
(2005)
Int J Mol Med.
, vol.16
, pp. 609-615
-
-
Mitoma, H.1
Horiuchi, T.2
Kimoto, Y.3
Tsukamoto, H.4
Uchino, A.5
Tamimoto, Y.6
-
15
-
-
44849114296
-
Neutralizing I.L.-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis
-
Andersson AK, Feldmann M, Brennan FM. Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis. Scand Immunol. 2008;68:103-111
-
(2008)
Scand Immunol.
, vol.68
, pp. 103-111
-
-
Andersson, A.K.1
Feldmann, M.2
Brennan, F.M.3
-
16
-
-
20144362420
-
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis
-
Distler JH, Jüngel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, et al. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum. 2005;52:856-864
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 856-864
-
-
Distler, J.H.1
Jüngel, A.2
Kowal-Bielecka, O.3
Michel, B.A.4
Gay, R.E.5
Sprott, H.6
-
17
-
-
64049085194
-
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: Report from an international working group
-
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113:2386-2393
-
(2009)
Blood.
, vol.113
, pp. 2386-2393
-
-
Rodeghiero, F.1
Stasi, R.2
Gernsheimer, T.3
Michel, M.4
Provan, D.5
Arnold, D.M.6
-
18
-
-
0038810290
-
Mycophenolate mofetil (MMF) for the treatment of steroidresistant idiopathic thrombocytopenic purpura
-
Hou M, Peng J, Shi Y, Zhang C, Qin P, Zhao C, et al. Mycophenolate mofetil (MMF) for the treatment of steroidresistant idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;70:353-357
-
(2003)
Eur J Haematol.
, vol.70
, pp. 353-357
-
-
Hou, M.1
Peng, J.2
Shi, Y.3
Zhang, C.4
Qin, P.5
Zhao, C.6
-
19
-
-
45449104408
-
The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
-
Spolski R, Leonard WJ. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol. 2008;20:295-301.
-
(2008)
Curr Opin Immunol.
, vol.20
, pp. 295-301
-
-
Spolski, R.1
Leonard, W.J.2
-
20
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448:480-483
-
(2007)
Nature.
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
-
21
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007;448:484-487
-
(2007)
Nature.
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jäger, A.5
Strom, T.B.6
-
22
-
-
33947663871
-
Role of interleukin-21 in inflammation and allergy
-
Fina D. Role of interleukin-21 in inflammation and allergy. Inflamm Allergy Drug Targets. 2007;6:63-68
-
(2007)
Inflamm Allergy Drug Targets.
, vol.6
, pp. 63-68
-
-
Fina, D.1
-
23
-
-
0036784616
-
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 responses
-
Strengel M, Sareneva T, Foste D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 responses. J Immunol. 2002;169:3600-3605
-
(2002)
J Immunol.
, vol.169
, pp. 3600-3605
-
-
Strengel, M.1
Sareneva, T.2
Foste, D.3
Julkunen, I.4
Matikainen, S.5
-
24
-
-
15744390341
-
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
-
Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology. 2005;128:687-694
-
(2005)
Gastroenterology.
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
Monteleone, I.2
Fina, D.3
Vavassori, P.4
Del Vecchio Blanco, G.5
Caruso, R.6
-
25
-
-
46349089381
-
Interleukin-21 contributes to the mucosal T helper Cell type 1 response in celiac disease
-
Fina D, Sarra M, Caruso R, Del Vecchio Blanco G, Pallone F, MacDonald T, et al. Interleukin-21 contributes to the mucosal T helper Cell type 1 response in celiac disease. Gut. 2008;57:887-892
-
(2008)
Gut.
, vol.57
, pp. 887-892
-
-
Fina, D.1
Sarra, M.2
Caruso, R.3
Del Vecchio Blanco, G.4
Pallone, F.5
MacDonald, T.6
-
26
-
-
0037037544
-
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon g-producing Th1 cells
-
Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon g-producing Th1 cells. J Exp Med. 2002;196:969-977
-
(2002)
J Exp Med.
, vol.196
, pp. 969-977
-
-
Wurster, A.L.1
Rodgers, V.L.2
Satoskar, A.R.3
Whitters, M.J.4
Young, D.A.5
Collins, M.6
-
27
-
-
33847412873
-
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
-
Fröhlich A, Marsland BJ, Sonderegger I, Kurrer M, Hodge MR, Harris NL. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood. 2007;109:2023-2031
-
(2007)
Blood.
, vol.109
, pp. 2023-2031
-
-
Fröhlich, A.1
Marsland, B.J.2
Sonderegger, I.3
Kurrer, M.4
Hodge, M.R.5
Harris, N.L.6
-
28
-
-
34547188748
-
IL- 6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T. IL- 6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8:967-974
-
(2007)
Nat Immunol.
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
-
29
-
-
46749133961
-
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
-
Sonderegger I, Kisielow J, Meier R, King C, Kopf M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur J Immunol. 2008;38:1833-1838
-
(2008)
Eur J Immunol.
, vol.38
, pp. 1833-1838
-
-
Sonderegger, I.1
Kisielow, J.2
Meier, R.3
King, C.4
Kopf, M.5
-
30
-
-
46749156754
-
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
-
Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol. 2008;180:7097-7101
-
(2008)
J Immunol.
, vol.180
, pp. 7097-7101
-
-
Coquet, J.M.1
Chakravarti, S.2
Smyth, M.J.3
Godfrey, D.I.4
|