Glutamate differently modulates excitatory and inhibitory adenosine receptors in neuronal and glial cells

Neurochemistry International

Volumn 57, Issue 1, 2010, Pages 33-42

  Castillo, Carlos Alberto ^a   León, David Agustín ^a   Ballesteros Yáñez, Inmaculada ^a   Albasanz, José Luis ^a   Martín, Mairena ^a  

^a University of Castilla La Mancha   (Spain)

Author keywords

Adenosine receptors; Cross talk; Excitotoxicity; Neuroprotection; Rat

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENYLATE CYCLASE; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EXCITOTOXICITY; GLIA CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; CELL LINE, TUMOR; CELLS, CULTURED; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; INHIBITORY POSTSYNAPTIC POTENTIALS; NEURAL INHIBITION; NEUROGLIA; NEURONS; RATS; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A;

RATTUS;

EID: 77953535083     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.04.008     Document Type: Article

References (70)

1. Albasanz J.L., Perez S., Barrachina M., Ferrer I., Martín M. Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. Brain Pathol. 2008, 18:211-219.
2. Albasanz J.L., Rodríguez A., Ferrer I., Martín M. Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex. Brain Pathol. 2006, 16:249-255.
3. Angulo E., Casadó V., Mallol J., Canela E.I., Viñals F., Ferrer I., Lluis C., Franco R. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain Pathol. 2003, 13:440-451.
4. Biber K., Pinto-Duarte A., Wittendorp M.C., Dolga A.M., Fernandes C.C., Von Frijtag Drabbe Kunzel J., Keijser J.N., de Vries R., Ijzerman A.P., Ribeiro J.A., Eisel U., Sebastião A.M., Boddeke H.W. Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection. Neuropsychopharmacology 2008, 33:2237-2250.
5. Blum D., Gall D., Galas M.C., d'Alcantara P., Bantubungi K., Schiffmann S.N. The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. J. Neurosci. 2002, 22:9122-9133.
6. Calon F., Dridi M., Hornykiewicz O., Bedard P.J., Rajput A.H., Di Paolo T. Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias. Brain 2004, 127:1075-1084.
7. Canas P.M., Porciuncula L.O., Cunha G.M., Silva C.G., Machado N.J., Oliveira J.M., Oliveira C.R., Cunha R.A. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J. Neurosci. 2009, 29:14741-14751.
8. Castillo C.A., Albasanz J.L., Fernández M., Martín M. Endogenous expression of adenosine A(1), A(2) and A(3) receptors in rat C6 glioma cells. Neurochem. Res. 2007, 32:1056-1070.
9. Castillo C.A., León D., Ruiz M.A., Albasanz J.L., Martín M. Modulation of adenosine A(1) and A(2A) receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine. J. Neurochem. 2008, 105:2315-2329.
10. Ceccarelli I., Rossi A., Maddalena M., et al. Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. J. Cell Physiol. 2009, 221:1-4.
11. Chen J.F., Huang Z., Ma J., Zhu J., Moratalla R., Standaert D., Moskowitz M.A., Fink J.S., Schwarzschild M.A. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J. Neurosci. 1999, 19:9192-9200.
12. Conn P.J., Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 1997, 37:205-237.
13. Corona J.C., Tovar-y-Romo L.B., Tapia R. Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis. Expert. Opin. Ther. Targets 2007, 11:1415-1428.
14. Cunha G.M., Canas P.M., Oliveira C.R., Cunha R.A. Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience 2006, 141:1775-1781.
15. Cunha R.A. Neuroprotection by adenosine in the brain: From A(1) receptor activation to A(2A) receptor blockade. Purinergic Signal. 2005, 1:111-134.
16. Dall'Igna O.P., Porciúncula L.O., Souza D.O., Cunha R.A., Lara D.R. Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity. Br. J. Pharmacol. 2003, 138:1207-1209.
17. de Mendonça A., Sebastião A.M., Ribeiro J.A. Adenosine: does it have a neuroprotective role after all?. Brain Res. Brain Res. Rev. 2000, 33:258-274.
18. Dong X.X., Wang Y., Qin Z.H. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol. Sin. 2009, 30:379-387.
19. Duarte J.M., Carvalho R.A., Cunha R.A., Gruetter R. Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. J. Neurochem. 2009, 111:368-379.
20. Dugan L.L., Kim J.S., Zhang Y., et al. Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J. Biol. Chem. 1999, 274:25842-25848.
21. Dunwiddie T.V., Masino S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 2001, 24:31-55.
22. El Yacoubi M., Ledent C., Parmentier M., Costentin J., Vaugeois J.M. Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. Neuropharmacology 2008, 55:35-40.
23. El Yacoubi M., Ledent C., Parmentier M., Costentin J., Vaugeois J.M. Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 380:223-232.
24. Farooqui A.A., Ong W., Horrocks L. Glutamate receptors and neurological disorders. Neurochemical Aspects of Excitotoxicity 2008, Springer, New York, pp. 161-204.
25. Fatokun A.A., Stone T.W., Smith R.A. Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands. Brain Res. 2007, 1132:193-202.
26. Fredholm B.B. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007, 14:1315-1323.
27. Fredholm B.B., Chen J.F., Cunha R.A., Svenningsson P., Vaugeois J.M. Adenosine and brain function. Int. Rev. Neurobiol. 2005, 63:191-270.
28. Gatti R., Belletti S., Orlandini G., Bussolati O., Dall'Asta V., Gazzola G.C. Comparison of annexin V and calcein-AM as early vital markers of apoptosis in adherent cells by confocal laser microscopy. J. Histochem. Cytochem. 1998, 46:895-900.
29. Hazell A.S. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem. Int. 2007, 50:941-953.
30. Higuchi R., Fockler C., Dollinger G., Watson R. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N.Y.) 1993, 11:1026-1030.
31. Iglesias I., León D., Ruiz M.A., Albasanz J.L., Martín M. Chronic intake of caffeine during gestation down regulates metabotropic glutamate receptors in maternal and fetal rat heart. Amino Acids 2006, 30:257-266.
32. Janssens N., Lesage A.S. Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. J. Neurochem. 2001, 77:1457-1474.
33. Koller W.C., Cersosimo M.G. Neuroprotection in Parkinson's disease: an elusive goal. Curr. Neurol. Neurosci. Rep. 2004, 4:277-283.
34. Lee H.K., Choi S.S., Han K.J., Han E.J., Suh H.W. Roles of adenosine receptors in the regulation of kainic acid-induced neurotoxic responses in mice. Brain Res. Mol. Brain Res. 2004, 125:76-85.
35. León D., Albasanz J.L., Castillo C.A., Martín M. Effect of glutamate intake during gestation on adenosine A(1) receptor/adenylyl cyclase pathway in both maternal and fetal rat brain. J. Neurochem. 2008, 104:435-445.
36. León D., Albasanz J.L., Ruíz M.A., Iglesias I., Martín M. Effect of chronic gestational treatment with caffeine or theophylline on Group I metabotropic glutamate receptors in maternal and fetal brain. J. Neurochem. 2005, 94:440-451.
37. León D.A., Albasanz J.L., Castillo C.A., Iglesias I., Martín M. Effect of chronic gestational treatment with the adenosine A1 receptor agonist R-phenylisopropyladenosine on metabotropic glutamate receptors/phospholipase C pathway in maternal and fetal brain. J. Neurosci. Res. 2008, 86:3295-3305.
38. Li W., Dai S., An J., Xiong R., Li P., Chen X., Zhao Y., Liu P., Wang H., Zhu P., Chen J., Zhou Y. Genetic inactivation of adenosine A2A receptors attenuates acute traumatic brain injury in the mouse cortical impact model. Exp. Neurol. 2009, 215:69-76.
39. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 1994, 330:613-622.
40. Lo Vasco V.R., Fabrizi C., Fumagalli L., Cocco L. Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes activated after stimulation with lipopolysaccharide. J. Cell Biochem. 2010, 109:1006-1012.
41. Lopes L.V., Cunha R.A., Ribeiro J.A. Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. J. Neurochem. 1999, 73:1733-1738.
42. Lopes L.V., Halldner L., Rebola N., Johansson B., Ledent C., Chen J.F., Fredholm B.B., Cunha R.A. Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice. Br. J. Pharmacol. 2004, 141:1006-1014.
43. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
44. Luján R., Shigemoto R., López-Bendito G. Glutamate and GABA receptor signalling in the developing brain. Neuroscience 2005, 130:567-580.
45. MacGregor D.G., Graham D.I., Stone T.W. The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists. Exp. Neurol. 1997, 148:110-123.
46. MacGregor D.G., Miller W.J., Stone T.W. Mediation of the neuroprotective action of R-phenylisopropyl-adenosine through a centrally located adenosine A1 receptor. Br. J. Pharmacol. 1993, 110:470-476.
47. Mamelak M. Alzheimer's disease, oxidative stress and gammahydroxybutyrate. Neurobiol. Aging 2007, 28:1340-1360.
48. Meldrum B.S. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J. Nutr. 2000, 130:1007S-1015S.
49. Monopoli A., Lozza G., Forlani A., Mattavelli A., Ongini E. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport 1998, 9:3955-3959.
50. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
51. Murphy M.G., Moak C.M., Byczko Z., MacDonald W.F. Adenosine-dependent regulation of cyclic AMP accumulation in primary cultures of rat astrocytes and neurons. J. Neurosci. Res. 1991, 30:631-640.
52. Nedergaard M., Takano T., Hansen A.J. Beyond the role of glutamate as a neurotransmitter. Nat. Rev. Neurosci. 2002, 3:748-755.
53. Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969, 164:719-721.
54. Pav M., Kovaru H., Kovaru F., et al. Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo. Neuro Endocrinol. Lett. 2009, 30:592-598.
55. Perez-Buira S., Barrachina M., Rodríguez A., Albasanz J.L., Martín M., Ferrer I. Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease. Neurosci. Lett. 2007, 423:194-199.
56. Pinna A., Corsi C., Carta A.R., Valentini V., Pedata F., Morelli M. Modification of adenosine extracellular levels and adenosine A(2A) receptor mRNA by dopamine denervation. Eur. J. Pharmacol. 2002, 446:75-82.
57. Popoli P., Pintor A., Domenici M.R., Frank C., Tebano M.T., Pèzzola A., Scarchilli L., Quarta D., Reggio R., Malchiodi-Albedi F., Falchi M., Massotti M. Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J. Neurosci. 2002, 22:1967-1975.
58. Rebola N., Porciuncula L.O., Lopes L.V., Oliveira C.R., Soares-da-Silva P., Cunha R.A. Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia 2005, 46(Suppl. 5):159-165.
59. Rego A.C., de Almeida L.P. Molecular targets and therapeutic strategies in Huntington's disease. Curr. Drug Targets CNS Neurol. Disord. 2005, 4:361-381.
60. Riedel G., Platt B., Micheau J. Glutamate receptor function in learning and memory. Behav. Brain Res. 2003, 140:1-47.
61. Rodrigues R.J., Alfaro T.M., Rebola N., Oliveira C.R., Cunha R.A. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J. Neurochem. 2005, 92:433-441.
62. Sheldon A.L., Robinson M.B. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem. Int. 2007, 51:333-355.
63. Sikka P., Walker R., Cockayne R., et al. d-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not d-amino acid oxidase (DAO). J. Neurosci. Res. 2010.
64. Sribnick E.A., Ray S.K., Banik N.L. Estrogen prevents glutamate-induced apoptosis in C6 glioma cells by a receptor-mediated mechanism. Neuroscience 2006, 137:197-209.
65. Svenningsson P., Fredholm B.B. Glucocorticoids regulate the expression of adenosine A1 but not A(2A) receptors in rat brain. J. Pharmacol. Exp. Ther. 1997, 280:1094-1101.
66. Tebano M.T., Martire A., Rebola N., Pepponi R., Domenici M.R., Grò M.C., Schwarzschild M.A., Chen J.F., Cunha R.A., Popoli P. Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-d-aspartate effects. J. Neurochem. 2005, 95:1188-1200.
67. i synergy with adenosine A1 receptors. Neuropharmacology 1999, 38:1511-1517.
68. Tsutsui S., Schnermann J., Noorbakhsh F., Henry S., Yong V.W., Winston B.W., Warren K., Power C. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. J. Neurosci. 2004, 24:1521-1529.
69. Uustare A., Vonk A., Terasmaa A., Fuxe K., Rinken A. Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors. Life Sci. 2005, 76:1513-1526.
70. Yi J.H., Hazell A.S. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem. Int. 2006, 48:394-403.