Binding of the prototypical adenosine A 2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A 1 and A 2A receptor knockout mice

British Journal of Pharmacology

Volumn 141, Issue 6, 2004, Pages 1006-1014

  Lopes, Luísa V ^a   Halldner, Linda ^b   Rebola, Nelson ^c   Johansson, Björn ^b   Ledent, Catherine ^d   Chen, Jian Fan ^e   Fredholm, Bertil B ^b   Cunha, Rodrigo A ^c  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A 1 receptors; A 2A receptors; Adenosine; CGS 21680; Cortex; SCH 58261; Striatum

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BRAIN CELL; BRAIN CORTEX; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; KNOCKOUT MOUSE; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; STRIATE CORTEX; WESTERN BLOTTING; WILD TYPE;

ADENOSINE; ANIMALS; AUTORADIOGRAPHY; BASAL GANGLIA; BINDING, COMPETITIVE; BLOTTING, WESTERN; CEREBRAL CORTEX; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; PHENETHYLAMINES; PYRIMIDINES; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; TRIAZOLES; TRITIUM; XANTHINES;

EID: 1942472484     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705692     Document Type: Article

References (51)

1. 2A knockout mice. Stroke, 34, 739-744.
2. 2A receptors in PC12 cells and increases receptor-mediated formation of cAMP. Naunyn-Schmiedeberg's Arch. Pharmacol., 365, 150-157.
3. 2A receptor antagonists. Br. J. Pharmacol., 135, 1435-1442.
4. 3H]NECA in rat striatal membranes. Mol. Pharmacol., 29, 331-346.
5. 2A adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J. Neurosci., 19, 9192-9200.
6. 1 adenosine receptors in brain cortex. J. Neurosci. Res., 42, 818-828.
7. CUNHA, R.A. (2001). Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem. Int., 38, 107-125.
8. 2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Br. J. Pharmacol., 122, 1279-1284.
9. 2A receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 359, 295-302.
10. 2A receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 261-271.
11. 2a receptors in the rat hippocampus. Brain Res., 649, 208-216.
12. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1992). Ecto-5′-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat. J. Neurochem., 59, 657-666.
13. DIXON, A.K., GUBITZ, A.K., SIRINATHSINGHJI, D.J.S., RICHARDSON, P.J. & FREEMAN, T.C. (1996). Tissue distribution of adenosine receptor mRNA in the rat. Br. J. Pharmacol., 118, 1461-1468.
14. DUNWIDDIE, T.V. & MASINO, S.A. (2001). The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci., 24, 31-55.
15. 2A receptor. Eur. J. Pharmacol., 401, 63-77.
16. 3H]SCH 58261. Eur. J. Neurosci., 14, 1567-1570.
17. 1 receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neuroscience, 22, 813-826.
18. 2B receptors in angiogenic factor regulation. Circ. Res., 90, 531-538.
19. 2A receptors and therapeutic applications. Curr. Top. Med. Chem., 3, 413-426.
20. FREDHOLM, B.B., IJZERMAN, A.P., JACOBSON, K.A., KLOTZ, K.N. & LINDEN, J. (2001). International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev., 53, 527-552.
21. 2A receptor anta-gonist, is a useful ligand in autoradiographic studies. J. Neurochem., 70, 1210-1216.
22. 2 receptor antagonist, reduces cerebral ischemic injury in the mongolian gerbil. Life Sci., 55, 61-65.
23. 2A receptor antagonist. Eur. J. Pharmacol., 406, 345-354.
24. JAMES, S., XUEREB, J.H., ASKALAN, R. & RICHARDSON, P.J. (1992). Adenosine receptors in post-mortem human brain. Br. J. Pharmacol., 105, 238-244.
25. 2 receptors in rat brain. J. Pharmacol. Exp. Ther., 251, 888-893.
26. 3H]CGS 21680. Eur. J. Pharmacol, 168, 243-246.
27. 3H]CGS 21680 to rat brain using autoradiography. Neuropharmacology, 34, 393-403.
28. 3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur. J. Pharmacol., 247, 103-110.
29. 1 receptor. Proc. Natl. Acad. Sci. USA, 98, 9407-9412.
30. 2A receptor antagonist. Brain Res., 800, 328-335.
31. 3H]-CGS 21680 binding sites in the rat striatum and cortex. Br. J. Pharmacol., 114, 537-543.
32. KLOTZ, K.N. (2000). Adenosine receptors and their ligands. Naunyn-Schmiedeberg's Arch. Pharmacol., 362, 382-391.
33. 2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices. Br. J. Pharmacol., 128, 1035-1044.
34. 2a receptor. Nature, 388, 674-678.
35. 2a adenosine receptors. Life Sci., 68, 1343-1350.
36. 3H]-CGS 21680 in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 539-541.
37. 1 receptor inhibition. Neuroscience, 112, 319-329.
38. 2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes. Br. J. Pharmacol., 136, 434-440.
39. 2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. NeuroReport, 9, 3955-3959.
40. 1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol. Pharmacol., 48, 806-817.
41. 2a adenosine receptors. Glia. 39, 133-147.
42. O'REAGAN, M.H., SIMPSON, R.E., PERKINS, L.M. & PHILLIS, J.W. (1992). Adenosine receptor agonists inhibit the release of γ-aminobutyric acid (GABA) from the ischemic rat cerebral cortex. Brain Res., 582, 22-26.
43. 3H]-CGS 21680 as a ligand. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 85-91.
44. 2a adenosine receptor gene. J. Neurochem., 66, 362-368.
45. 2A adenosine receptor leads to c-fos inhibition in a rat model of brain ischemia. Pharmacol. Res., 45, 125-128.
46. 2A receptors to facilitate acetylcholine release in the rat hippocampus. Eur. J. Pharmacol., 454, 31-38.
47. 2A receptors. Prog. Neurobiol., 59, 355-396.
48. TEBANO, M.T., DOMENICI, M.R. & POPOLI, P. (2002). SCH 58261 differentially influences quinolinic acid-induced effects in striatal and in hippocampal slices. Eur. J. Pharmacol., 450, 253-257.
49. 3H]CGS 21680 to human and rat brain: evidence of multiple affinity sites. J. Neurochem., 55, 1763-1771.
50. YOSHIOKA, K., SAITOH, O. & NAKATA, H. (2001). Heteromeric association creates a P2Y-like adenosine receptor. Proc. Natl. Acad. Sci. USA, 98, 7617-7622.
51. 2A adenosine receptor antagonist, to rat striatal membranes. Br. J. Pharmacol., 117, 1381-1386.