Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo

Neuroendocrinology Letters

Volumn 30, Issue 5, 2009, Pages 592-598

  Pav, Marek ^a   Kovaru, Hana ^a   Kovaru, Frantisek ^b,c   Lisa, Vera ^d   Ondrackova Zelnickova, Petra ^b   Fiserova, Anna ^e  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^c INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

^d INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^e INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

Antidepressant; C6 astrocytoma cell line; C6 glioma cells; cAMP; Depressive disorder; G protein; Glia; IP3; Trimeric GTP binding protein

Indexed keywords

CITALOPRAM; DESIPRAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MOCLOBEMIDE; SERTRALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLIOMA CELL; MALE; NONHUMAN; RAT;

EID: 77649253490     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Avissar S, Nechamkin Y, Roitman G, Schreiber G (1998). Dynamics of ECT normalization of low G protein function and immunoreactivity in mononuclear leukocytes of patients with major depression. Am J Psychiatry. 155: 666-671.
2. Avissar S, Schreiber G (2006). The involvement of G proteins and regulators of receptor-G protein coupling in the pathophysiology, diagnosis and treatment of mood disorders. Clin Chim Acta. 366: 37-47.
3. Chen J, Rasenick MM (1995). Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between G protein (Gs) and adenylyl cyclase. J Neurochem. 64: 724-732.
4. Donati JR, Rasenick MM (2003). G protein signalling and the molecular basis of antidepressant action. Life Sci. 73: 1-17.
5. Donati RJ, Rasenick MM (2005). Chronic antidepressant treatment prevents accumulation of Gs alpha in cholesterol-rich, cytoskeletal-associated, plasma membrane domains (lipid rafts). Neuropsychopharmacology. 30: 1238-1245.
6. Donati RJ, Dwivedi Y, Roberts RC, Conley RR, Pandey GN, Rasenick MM (2008). Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylate cyclase. J Neurosci. 28: 3042-3050.
7. Duman R (2004). Role of neurotrophic factors in the aetiology and treatment of mood disorders. Neuromolecular Med. 5: 11-25.
8. Emamghoreishi M, Warsh JJ, Sibony D, Li PP (1996). Lack of effect of chronic antidepressant treatment on Gs and Gi alpha-subunit protein and mRNA levels in the rat cerebral cortex. Neuropsychopharmacology. 15: 281-287.
9. Fišerová A, Kovářů H, Hajduová Z, Mareš V, Starec M, Křen V, Flieger M, Pospíšil M (1997). Neuroimmunomodulation of natural killer (NK) cells by ergot alkaloid derivates. Physiol Res. 46: 119-125.
10. Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ (1995). Distinct pathways of G(i)- and G(q)-mediated mitogen-activated protein kinase activation. J Biol Chem. 270: 17148-17153.
11. Hisaoka K, Nishida A, Koda T, Miyata M, Zensho H, Morinobu S, Ohta M, Yamawaki S (2001). Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells. J Neurochem. 79: 25-34.
12. Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M (2008). Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production. Brain Res. 1196: 53-58.
13. Hubbard KB, Hepler JR (2006). Cell signalling diversity of the Gq alpha family of heterotrimeric G proteins. Cell Signal. 18: 135-150.
14. Jenab S, Quinone-Jenab V (2002). The effects of interleukin-6, leukaemia inhibitory factor and interfero-gamma on STAT DNA binding and c-fos mRNA in cortical astrocytes and C6 glioma cells. Neuroendocrinol Lett. 23: 325-328.
15. Kitzlerová E, Anders M (2007). The role of some new factors in the pathophysiology of depression and cardiovascular disease: Overview of recent research. Neuro endocrinol Lett. 28(6): 832-840.
16. Klimek V, Zak-Knapik J, Maj J (1991). Antidepressants given repeatedly increase the α1-adrenoceptor agonist affinity in the rat brain. Pol J Pharmacol Pharm. 43: 347-352.
17. Koe BK, Lebel LA (1995). Effects of serotoninergic agents on down regulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline. Arch Int Pharmacodyn Ther. 329: 231-244.
18. Kovářů H, Fišerová A, Španová A, Lisá V, Fišar Z, Velek J. (1998a): Antidepressants as neuroimmunomodulators at postreceptor level. J Neuroimmunology. 90: 41-42.
19. Kovářů H, Kovářů F, Žižkovský V, Velek J. (1998b): Developmental changes of trimeric GTP-binding proteins in porcine brain and immune system. Acta Vet, Brno, 67: 15-20.
20. Kovářů H, Fišerová A, Kovářů F, Paclt I, Lisá V (2000). Antidepressant or immunomodulator induced regulation of cell signalling in brain and immune system. Eur Neuropsychopharmacol. Suppl. 3, 269-270.
21. Kovářú H, Fišerová A, Kovářů F, Pospíšil M, Lisá V (2001). Modulation of heterotrimeric GTP-binding proteins in immune system and brain. Czech J Anim Sci. 46: 62-67.
22. Kovářů H, Kovářů F (2005). Basis of neuroimmunomodulation. In: Základy neuroimmunomodulace. Galén, Praha, pp. 203-208.
23. Lee Y, Gaskins D, Anand A, Shekkar A (2007). Glia mechanisms in mood regulation: a novel model of mood disorders. Psychopharmacology (Berl). 19: 55-65.
24. Lesch, KP, Manji HK (1992a). Signal transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain. Biol Psychiat. 32: 549-579.
25. Lesch KP, Hough CJ, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL Akioyoshi J, Chuang DM, Murphy DL (1992b). Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain.Eur J Pharmacol. 277: 233-237.
26. Luttrell LM (2006). Transmembrane signalling by G protein-coupled receptors. Methods Mol Biol. 332: 3-49.
27. Maes M (2001). The immunoregulatory effect of antidepressants. Hum Psychopharmacol. 16: 95-103.
28. Maes M (2008). The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuroendocrinol. Lett. 29: 287-291.
29. Manev H, Uz T, Manev R (2003). Glia as a putative target for antidepressant treatments.J Affect Disord. 75: 59-64.
30. Manji HK, Chen G, Shimon H, Hsiao JK, Potter WZ, Belmaker RH (1995). Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. Arch Gen Psychiatry. 52: 35-44.
31. Mareš V., Giordano P.A., Pellicciari C., Scherini E., Lisá V., Bottone M.G., Bottiroli G.(1991): Changes in cell cycle and chromatin distribution in C6 glioma cells treated by dibutyryl cyclic AMP. Cell Proliferation, 24: 569-577.
32. Menkes DB, Rasenick MM, Wheeler MA, Bitensky MW (1983). Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment. Science 219: 65-67.
33. Miklič Š, Jurič DM,Čarman-Kržan M (2004). Differences in the regulation of BDNF and NGF synthesis in cultured neonatal rat astrocytes. Int. J. Dev. Neurosci. 22: 119-130.
34. Milligan G (1988). Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins. Biochem J. 255: 1-13.
35. Mori S, Zanardi R, Popoli M, Garbini S, Brunello N, Smeraldi E, Racagni G, Perez J (1998). cAMP-dependent phosphorylation system after short- and long-term administration of moclobemide. J Psychiatr Res. 32: 111-115.
36. Nair A, Vaidya VA (2006). Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? J Biosci. 31: 423-434.
37. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002). Neurobiology of depression. Neuron. 34: 13-25.
38. Páv M, Kovářů H, Fišerová A, Havrdová E, Lisá V (2008). Neurobiological aspects of depressive disorder and antidepressant treatment: role of glia. Physiol Res. 57: 151-64.
39. Pacheco MA, Stockmeier C, Meltzer HY, Overholser JC, Dille GE, Jope RS (1996). Alterations in phosphoinositide signalling and G-protein levels in depressed suicide brain. Brain Res. 723: 37-45.
40. Peavy RD, Chang MS, Sanders-Bus E, Conn PJ (2001). Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. J Neurosci. 21 (24): 9619-9628.
41. Perea G, Araque A (2005). Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes. J Neurosci. 25: 2192-2203.
42. Rajkowska G, Miguel-Hidalgo JJ (2007). Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets. 6(3): 219-233.
43. Ransnas LA, Insel PA (1989).Quantification of a guanine nucleotide binding regulatory protein by an enzyme-linked immunosorbent competition assay. Anal Biochem. 176: 185-190.
44. Španová A., Kovářů H, Lisá V, Lukášová E, Rittich B (1997). Estimation of apoptosis in C6 glioma cells treated with antidepressants. Physiol Res. 46: 161-164.
45. Spiegel AM (1996). Defects in G protein-coupled signal transduction in human disease. Ann Rev Physiol., 58: 143-170.
46. Sun K, Alkon L (2005). Dual effects of bryostatin-1 on spatial memory and depression. Eur J Pharmacol. 512: 43-51.
47. Tadokoro C, Kiuchi Y, Yamazaki Y, Nara K, Oguchi K, Kamijima K (1997). Behavioural stimulation without alteration of beta- and 5-HT receptors and adenylate cyclase activity in rat brain after sertraline administration. Psychopharmacology (Berl). 130: 124-130.
48. Tadokoro C, Kiuchi Y, Yamazaki Y, Oguchi K, Kamijima K (1998). Effect of Imipramine and sertraline on protein kinase activity in rat frontal cortex. Eur J Pharmacol. 342: 51-54.
49. Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G, Popoli M (2006). Signalling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev. 58: 115-134.
50. Tijjsen P (1993): Practice and theory of enzyme immunoassays, Elsevier, Amsterdam, London, N,York,Tokyo: 329-447.
51. Tiraboshi E, Tardito D, Kasahara J, Morash S, Pruneri P, Gennarelli M, Racagni G, Popoli M (2004). Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Neuropsychopharmacology. 29: 1831-1840.
52. Tyeryar KR, Undie AS (2007). Tandem regulation of phosphoinositide signalling and acute behavioural effects induced by antidepressant agents in rats. Psychopharmacology (Berl). 193: 271-282.
53. Wettschureck N, Offermanns S (2005). Mammalian G proteins and their cell type specific functions. Physiol Rev. 85: 1159-1204.
54. Young LT, Li PP, Kish SJ, Siu KP, Kamble A, Hornykiewicz O, Warsh JJ (1993). Cerebral cortex Gs alpha protein levels and forskolin stimulated cyclic AMP formation are increased in bipolar affective disorder. J Neurochem. 61: 890-898.