Inhibitory effects of KHG26377 on glutamate dehydrogenase activity in cultured islets

BMB Reports

Volumn 43, Issue 4, 2010, Pages 245-249

  Yang, Seung Ju ^a   Hahn, Hoh Gyu ^b   Choi, Soo Young ^c   Cho, Sung Woo ^d  

^a Konyang University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Hallym University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

Glutamate dehydrogenase; Hyperinsulinism; Inhibitor; KHG26377

Indexed keywords

RATTUS;

EID: 77953509705     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.4.245     Document Type: Article

References (26)

1. Fisher, H. F. (1985) L-Glutamate dehydrogenase from bovine liver. Methods Enzymol. 113, 16-27.
2. Hudson, R. C. and Daniel, R. M. (1993) L-Glutamate dehydrogenase: distribution, properties and mechanism. Comp. Biochem. Physiol. B. 106, 767-792.
3. Nissim, I. (1999) Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes. Am. J. Physiol. 277, F493-497.
4. Bryla, J., Michalik, M., Nelson, J. and Erecinska, M. (1994) Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release. Metabolism 43, 1187-1195.
5. Yorifuji, T., Muroi, J., Uematsu, A., Hiramatsu, H. and Momoi, T. (1999) Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics. Hum. Genet. 104, 476-479.
6. Carobbio, S., Ishihara, H., Fernandez-Pascual, S., Bartley, C., Martin-Del-Rio, R. and Maechler, P. (2004) Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets. Diabetologia 47, 266-276.
7. Maechler, P. and Wollheim, C. B. (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402, 685-689.
8. Høy, M.H., Maechler, P., Efanov, A. M., Wollheim, C. B., Berggren, P. O. and Gromada, J. (2002) Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells. FEBS Lett. 531, 199-203.
9. Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M, Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Windruch, R., Alt, F. W. and Guarenta, L. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126, 941-954.
10. Ahuja, N., Schwer, B., Carobbio, S., Waltregny, D., North, B. J., Castrnovo, V., Maechler, P. and Verdin, E. (2007) Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J. Biol. Chem. 282, 33583-33592.
11. Stanley, C. A., Lieu, Y. K., Hsu, B. Y., Burlina, A. B., Greenberg, C. R., Hopwood, N. J., Perlman, K., Rich, B. H., Zammarchi, E. and Poncz, M. (1998) Hyperinsulinism and hyperammonemia in infants with regulatory muta-tions of the glutamate dehydrogenase gene. N. Engl. J. Med. 338, 1352-1357.
12. Stanley, C. A., Fang, J., Kutyna, K., Hsu, B. Y. L., Ming, J. E., Glaser, B. and Poncz, M. (2000) Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. Diabetes. 49, 667-673.
13. MacMullen, C., Fang, J., Hsu, B. Y., Kelly, A., de Lonlay Debeney, P., Saudubray, J. M., Ganguly, A., Smith, T. J. and Stanley, C. A. (2001) Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase. J. Clin. Endocrinol. Metab. 86, 1782-1787.
14. Li, C., Allen, A., Kwagh, J., Doliba, N. M., Qin, W., Najafi, H., Collins, H. W., Matschinsky, F. M., Stanley, C. A. and Smith, T. J. (2006) Green tea polyphenols modulated insulin secretion by inhibition glutamate dehydrogenase. J. Biol. Chem. 281, 10214-10221.
15. Yang, S. J., Huh, J. W., Kim, M. J., Lee, W. J., Kim, T. U., Choi, S. Y. and Cho, S.-W. (2003) Regulatory effects of 5'deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets. Biochimie. 85, 581-586.
16. Lee, K. H., Lee, W. J., Yang, S. J., Huh, J. W., Choi, J., Hong, H. N., Hwang, O. and Cho, S. W. (2004) Inhibitory effects of Cimicifuga heracleifolia extract on glutamate formation and glutamate dehydrogenase activity in cultured islets. Mol. Cells 30, 509-514.
17. Li, M., Smith C. J., Walker, M. T. and Smith, T. J. (2009) Novel inhibitors complexed with glutamate dehydrogenase. J. Biol. Chem. 284, 22988-23000.
18. Kawaguchi, A. and Bloch, K. (1976) Inhibition of glutamate dehydrogenase and malate dehydrogenases by palmitoyl coenzyme A. J. Biol. Chem. 251, 1406-1412.
19. Fumagalli, E, Funicello, M., Rauen, T., Gobbi, M. and Mennini, T. (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur. J. Pharmacol. 578, 171-176.
20. Kulkarni, S. S., Zou, M. F., Cao, J., Deschamps, J. R., Rodriguez, A. L., Conn, P. J. and Newman, A. H. (2009) Structure-activity relationships comparing N-(6-methylpy-Inhibitory effects of KHG26377 on glutamate dehydrogenase activity in cultured islets Seung-Ju Yang, et al. ridin-yl)-substituted aryl amides to 2-methyl-6-(substituted arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl) thiazoles as novel metabotropic glutamate receptor sub type 5 antagonists. J. Med. Chem. 52, 3563-3575.
21. Satoh, A., Nagatomi, Y., Hirata, Y., Ito, S., Suzuki, G., Kimura, T., Maehara, S., Hikichi, H., Satow, A., Hata, M., Ohta, H. and Kawamoto, H. (2009) Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. Bioorg. Med. Chem. Lett. 19, 5464-5468.
22. Choi, M. M., Kim, E. A., Huh, J. W., Choi, S. Y., Cho, S. W. and Yang, S. J. (2008) Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. Biotechnol. Appl. Biochem. 51, 107-110.
23. Heinrikson, R. L. and Meredith, S. C. (1984) Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothio cyanate. Anal. Biochem. 136, 65-74.
24. Herbert, V., Lou, K. S., Gottlieb, C. W. and Bleicher, S. J. (1965) Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. Metab. 25, 1375-1384.
25. Lee, E. Y., Yoon, H. Y., Ahn, J. Y., Choi, S. Y. and Cho, S.-W. (2001) Identification of GTP binding site of human glutamate dehydrogenase using cassette mutagenesis and photoaffinity labeling. J. Biol. Chem. 276, 47930-47936.
26. Yoon, H. Y., Cho, E. H., Kwon, H. Y., Choi, S. Y. and Cho, S. W. (2002) Importance of glutamate-279 for the coenzyme binding of human glutamate dehydrogenase. J. Biol. Chem. 277, 41448-41454.