The promise of canonical Wnt signaling modulators in enhancing bone repair

Drug News and Perspectives

Volumn 19, Issue 8, 2006, Pages 445-452

  Gregory, Carl A ^a   Green, Angela ^a   Lee, Narae ^a   Rao, Ashwin ^a   Gunn, William ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN; WNT PROTEIN INHIBITOR;

BONE DEVELOPMENT; BONE REMODELING; CELL DIFFERENTIATION; HUMAN; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSTEOBLAST; OSTEOGENESIS IMPERFECTA; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANTIBODIES; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; BONE DISEASES; BONE REGENERATION; CELL DIFFERENTIATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS; PPAR GAMMA; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 33845992865     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2006.19.8.1043960     Document Type: Review

References (68)

1. Gronthos, S., Graves, S.E., Ohta, S. and Simmons, P.J. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood 1994, 84: 4164-73.
2. Pereira, R.F., Halford, K.W., O'Hara, MD. et al. Cultures of adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage and lung in irradiated mice. Proc Natl Acad Sci U S A 1995, 92: 4857-61.
3. Pereira, R.F., O'Hara, M.D., Laptev, A.V. et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A 1998, 95: 1142-7.
4. Pittenger, M.F., Mackay, A.M., Beck, S.C et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284: 143-7.
5. Horwitz, E.M., Prockop, D.J., Fitzpatrick, W.W. et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999, 5: 309-13.
6. Colter, D.C., Class, R., DiGirolamo, C.M. and Prockop, D.J. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A, 2000 96: 7294-9.
7. Sekiya, I., Larson, B.L., Smith, J.R., Pochampally, R., Cui, J.G. and Prockop, D.J. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells, 20: 530-41.
8. Gregory, C.A., Prockop, D.J. and Spees, J.L. Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation. Exp Cell Res 2005, 306: 330-5.
9. Sotiropoulou, P.A., Perez, S.A., Salagianni, M., Baxevanis, C.N. and Papamichail, M. Cell culture medium composition and translational adult bone marrow-derived stem cell research. Stem Cells 2006, 24: 1409-10.
10. Gregory, C.A., Gunn, W.G., Piester, A. and Prockop, D.J. An Alizarin red based method for the assay of mineralization by adherent cells in culture. Comparison with cetylpyridinium chloride extraction. Anal Biochem 2004, 329: 77-84.
11. Bain, G., Muller, T., Wang, X., Papkoff, J. Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun 2003, 301: 84-91.
12. Rawadi, G., Vayssiere, B., Dunn, F., Baron, R. and Roman-Roman, S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003, 18: 1842-53.
13. Gregory, C.A., Gunn, W.G., Reyes, E. et al. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Ann N Y Acad Sci 2005, 1049: 97-107.
14. Hartmann, C. A Wnt canon orchestrating osteoblastogenesis. Trends Cell Biol 2006, 16: 151-8.
15. Krishnan, V., Bryant, H.U. and Macdougald, O.A. Regulation of bone mass by Wnt signaling. J Clin Invest 2006, 116: 1202-9.
16. Cadigan, K.M. and Nusse, R. Wnt signaling: A common theme in animal development. Genes Dev 1997, 11: 3286-305.
17. Pandur, P., Maurus, D. and Kuhl, M. Increasingly complex: New players enter the Wnt signaling network. Bioessays 2002, 24: 881-4.
18. Huelsken, J. and Birchmeier, W. New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 2001, 11: 547-53.
19. Kikuchi, A. Regulation of beta-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 2000, 268: 243-8.
20. Willert, K., Brown, J.D., Danenberg, E. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423: 448-52.
21. Logan, C.Y. and Nusse, R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20: 781-810.
22. Burrus, L.W. Wnt-1 as a short-range signaling molecule. Bioessays 1994, 16: 155-7.
23. Christian, J.L. BMP, Wnt and Hedgehog signals: how far can they go? Curr Opin Cell Biol 2004, 12: 244-9.
24. Kawano, Y. and Kypta, R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003, 116: 2627-34.
25. Nusse, R. Making head or tail of Dickkopf. Nature 2001, 411: 255-6.
26. Glinka, A., Wu, W., Delius, H., Monaghan, A.P., Blumenstock, C. and Niehrs, C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998, 391: 357-62.
27. Mao, B., Wu, W., Davidson, G. et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002, 417: 664-7.
28. Krupnik, V.E., Sharp, J.D., Jiang, C. et al. Functional and structural diversity of the human Dickkopf gene family. Gene 1999, 238: 301-13.
29. Brott, B.K., Sokol, S.Y. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol 2002, 22: 6100-10.
30. Uren, A., Reichsman, F., Anest, V. et al. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem 2000, 275: 4374-82.
31. Hsieh, J.C., Kodjabachian, L., Rebbert, M.L. et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 1999, 398: 431-6.
32. Li, X., Zhang, Y., Kang, H. et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 2005, 280: 19883-7.
33. Semenov, M., Tamai, K. and He, X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 2005, 280: 26770-5.
34. van Bezooijen, R.L., ten Dijke, P., Papapoulos, S.E., Lowik, C.W. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev 2005, 16: 319-27.
35. Ott, S.M. Editorial: Sclerostin and Wnt signaling-the pathway to bone strength. J Clin End Met 2006, 90: 6741-3.
36. Gong, Y., Slee, R.B., Fukai, N. et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107: 513-23.
37. Boyden, L.M., Mao, J., Belsky, J. et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002, 346: 1513-21.
38. Babij, P., Zhao, W. and Small, C. High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res 2003, 18: 960-74.
39. Little, R.D., Carulli, J.P., Del Mastro, R.G. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 2000, 70: 11-9.
40. Ferrari, S.L., Deutsch, S., Choudhury, U. et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet 2004, 74: 866-75.
41. Koay, M.A., Woon, P.Y., Zhang, Y. et al. Influence of LRP5 polymorphisms on normal variation in BMD. J Bone Miner Res 2004, 19: 1619-27.
42. Ferrari, S.L., Deutsch, S. and Antonarakis, S.E. Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Curr Opin Lipidol 2005, 16: 207-14.
43. Bennett, C.N., Longo, K.A., Wright, W.S. et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 2005, 102: 3324-29.
44. Holmen, S.L., Zylstra, C.R., Mukherjee, A. et al. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 2005, 280: 21162-8.
45. Bodine, P.V.N., Weiguang, Z., Kharode, Y.P. et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 2004, 18: 1222-37.
46. Morvan, F., Boulukos, K., Clement-Lacroix, P. et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 2006, 21: 934-45.
47. Li, J., Sarosi, I., Cattley, R.C. et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006, 39: 754-66.
48. Huston, A., Roodman, G.D. Role of the microenvironment in multiple myeloma bone disease. Future Oncol 2006, 2: 371-8.
49. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B. and Shaughnessy, J.D. Jr. The role of Wnt signaling antagonist Dkk-1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003, 349: 2483-94.
50. Gunn, W.G., Conley, A., Deininger, L., Olson, S.D., Prockop, D.J. and Gregory, C.A. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and IL-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells 2005, 24: 986-91.
51. Gregory, C.A., Gunn, W.G., Reyes, E. et al. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Ann N Y Acad Sci 2005, 1049: 97-106.
52. Gregory C.A., Singh, H., Perry, A.S., and Prockop D.J. Wnt signaling inhibitor Dkk-1 is required for re-entry into the cell cycle of human adult stem cells from bone marrow stroma (hMSCs). J Biol Chem 2003, 278: 28067-78.
53. Frisch, B. and Bartl, R. Biopsy interpretation of bone and bone marrow. 2nd Edition. Arnold Publishers, London 1999.
54. Manelli, F. and Giustina, A. Glucocorticoid-induced osteoporosis. Trends Endocrinol Metab 2000, 11: 79-85.
55. Weinstein, R.S., Jilka, R.L., Parfitt, A.M and Manolagas, S.C. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 1998, 102: 274-82.
56. Ohnaka, K., Taniguchi, H., Kawate, H., Nawata, H. and Takayanagia, R. Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: Novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Commun 2004, 318: 259-64.
57. Jope, R.S. Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 2003, 9: 441-3.
58. de Boer, J., Siddappa, R., Gaspar, C., van Apeldoorn, A., Fodde, R. and van Blitterswijk, C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 2004, 34: 818-26.
59. Gregory, C.A., Perry A.S., Reyes, E., Conley, A., Gunn, W.G. and Prockop, D.J. Dkk-1 derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. J Biol Chem 2005, 280: 2309-23.
60. Clement-Lacroix, P., Ai, M., Morvan, F. et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A 2005, 102: 17406-11.
61. Kulkarni, N.H., Onyia, J.E., Zeng, Q. et al. Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res 2006, 21: 910-20.
62. Farmer, S.R. Regulation of PPARgamma activity during adipogenesis. Int J Obes (Lond) 2005, 29(Suppl. 1): S13-16.
63. Khan, E. and Abu-Amer, Y. Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. J Lab Clin Med 2003, 142: 29-34.
64. Liu, J. and Farmer, S.R. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem 2004, 279: 45020-7.
65. Christodoulides, C., Laudes, M., Cawthorn, W.P. et al. The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. J Cell Sci 2006, 119: 2613-20.
66. Akune, T., Ohba, S., Kamekura, S. et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004, 113: 846-55.
67. Vestergaard, P., Rejnmark, L. and Mosekilde, L. Reduced relative risk of fractures among users of lithium. Calcif Tissue Int 2005, 77: 1-8.
68. Reya, T. and Clevers, H. Wnt signalling in stem cells and cancer. Nature 2005, 434: 843-50.