Alteration of bone cell function by RANKL and OPG in different in vitro models

European Journal of Clinical Investigation

Volumn 37, Issue 5, 2007, Pages 407-415

  Lin, J M ^a   Callon, K E ^a   Lin, C Q ^a   Bava, U ^a   Zheng, M H ^b   Reid, I R ^a   Cornish, J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Calvariae; OPG; Osteoblasts; Osteoclasts; RANKL

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE CELL; BONE MARROW CULTURE; CALCIUM TRANSPORT; CALVARIA; CELL ACTIVITY; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; IN VITRO STUDY; MOUSE; NONHUMAN; ORGAN CULTURE; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

ANIMALS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELLS, CULTURED; MICE; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; OSTEOCLASTS; OSTEOPROTEGERIN; RANK LIGAND; RATS;

EID: 34247537979     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01800.x     Document Type: Article

References (51)

1. Suda T, Udagawa N, Takahashi N. Cells of bone:osteoclast generation. In : Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. San Diego, CA : Academic Press 1996 87 102.
2. Aubin JE, Liu F. The osteoblast lineage. In : Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of Bone Biology. San Diego, CA : Academic Press 1996 51 67.
3. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R et al. Osteoprotegerin - a novel secreted protein involved in the regulation of bone density. Cell 1997 89 : 309 19.
4. Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T et al. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997 234 : 137 42.
5. Kwon BS, Wang SA, Udagawa N, Haridas V, Lee ZH, Kim KK et al. Tr1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J 1998 12 : 845 54.
6. Wong BR, Rho JR, Arron J, Robinson E, Orlinick J, Chao M et al. Trance is a novel ligand of the tumor necrosis factor receptor family that activates c-jun n-terminal kinase in t cells. J Biol Chem 1997 272 : 25190 4.
7. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER et al. A homologue of the tnf receptor and its ligand enhance t-cell growth and dendritic-cell function. Nature 1997 390 : 175 9.
8. Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun 1998 253 : 395 400.
9. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Goto M et al. A novel molecular mechanism modulating osteoclast differentiation and function. Bone 1999 25 : 109 13.
10. Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor osteoprotegerin. Biochem Biophys Res Commun 1998 247 : 610 5.
11. Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N et al. Identity of osteoclastogenesis inhibitory factor (ocif) and osteoprotegerin (opg) - a mechanism by which opg/ocif inhibits osteoclastogenesis in vitro. Endocrinology 1998 139 : 1329 37.
12. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999 397 : 315 23.
13. Cundy T, Hegde M, Naot D, Chong B, King A, Wallace R et al. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum Mol Genet 2002 11 : 2119 27.
14. Middleton-Hardie C, Zhu Q, Cundy H, Lin JM, Callon K, Tong PC et al. Deletion of aspartate 182 in OPG causes juvenile Paget's disease by impairing both protein secretion and binding to RANKL. J Bone Miner Res 2006 21 : 438 45.
15. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998 93 : 165 76.
16. Quinn JM, Itoh K, Udagawa N, Hausler K, Yasuda H, Shima N et al. Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions. J Bone Miner Res 2001 16 : 1787 94.
17. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S et al. Osteoclast differentiation factor is a ligand for osteoprotegerin osteoclastogenesis-inhibitory factor and is identical to trance/rankl. Proc Natl Acad Sci USA 1998 95 : 3597 602.
18. Shalhoub V, Faust J, Boyle WJ, Dunstan CR, Kelley M, Kaufman S et al. Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. J Cell Biochem 1999 72 : 251 61.
19. Quinn JMW, Elliott J, Gillespie MT, Martin TJ. A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 1998 139 : 4424 7.
20. Xu JK, Tan JW, Huang L, Gao XH, Laird R, Liu D et al. Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappa B ligand. J Bone Miner Res 2000 15 : 2178 86.
21. Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nature Rev Genet 2003 4 : 638 49.
22. Reid IR, Lowe C, Cornish J, Skinner SJ, Hilton DJ, Willson TA et al. Leukemia inhibitory factor: a novel bone-active cytokine. Endocrinology 1990 126 : 1416 20.
23. Cornish J, Callon KE, Bava U, Kamona SA, Cooper GJ, Reid IR. Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. Bone 2001 29 : 162 8.
24. Cornish J, Callon KE, Lin CQ, Xiao CL, Mulvey TB, Coy DH et al. Dissociation of the effects of amylin on osteoblast proliferation and bone resorption. Am J Physiol 1998 274 : E827 33.
25. Burgess TL, Qian YX, Kaufman S, Ring BD, Van G, Capparelli C et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol 1999 145 : 527 38.
26. Cornish J, Callon KE, Edgar SG, Reid IR. Leukemia inhibitory factor is mitogenic to osteoblasts. Bone 1997 21 : 243 7.
27. Ibbotson KJ, Roodman GD, McManus LM, Mundy GR. Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells. J Cell Biol 1984 99 : 471 80.
28. Kurihara N, Suda T, Miura Y, Nakauchi H, Kodama H, Hiura K et al. Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 1989 74 : 1295 302.
29. Pfeilschifter J, Seyedin SM, Mundy GR. Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures. J Clin Invest 1988 82 : 680 5.
30. Jimi E, Akiyama S, Tsurukai T, Okahashi N, Kobayashi K, Udagawa N et al. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol 1999 163 : 434 42.
31. Lacey DL, Tan HL, Lu J, Kaufman S, Van G, Qiu WR et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 2000 157 : 435 48.
32. Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K et al. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor. Bone 1999 25 : 517 23.
33. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000 15 : 2 12.
34. Wu X, Pan G, McKenna MA, Zayzafoon M, Xiong WC, McDonald JM. RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts. J Bone Miner Res 2005 20 : 107 16.
35. Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K et al. Transforming growth factor-beta 1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun 1998 252 : 747 52.
36. Hoebertz A, Arnett TR. Isolated osteoclast cultures. In : Helfrich MH, Ralston SH, editors. Bone Research Protocols. Totowa, NJ : Humana Press 2003 53 64.
37. Howard GA, Bottemiller BL, Turner RT, Rader JI, Baylink DJ. Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism. Proc Natl Acad Sci USA 1981 78 : 3204 8.
38. Oreffo RO, Mundy GR, Seyedin SM, Bonewald LF. Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. Biochem Biophys Res Commun 1989 158 : 817 23.
39. Linkhart TA, Mohan S. Parathyroid hormone stimulates release of insulin-like growth factor-I (IGF-I) and IGF-II from neonatal mouse calvaria in organ culture. Endocrinology 1989 125 : 1484 91.
40. Linkhart TA, Keffer MJ. Differential regulation of insulin-like growth factor-I (IGF-I) and IGF-II release from cultured neonatal mouse calvaria by parathyroid hormone, transforming growth factor-beta, and 1,25-dihydroxyvitamin D3. Endocrinology 1991 128 : 1511 8.
41. Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 2005 11 : 76 81.
42. Nakamura M, Udagawa N, Matsuura S, Mogi M, Nakamura H, Horiuchi H et al. Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology 2003 144 : 5441 9.
43. Kubota K, Sakikawa C, Katsumata M, Nakamura T, Wakabayashi K. Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factor. J Bone Miner Res 2002 17 : 257 65.
44. Phan T, Han R, Smuts V, Zheng MH, Xu J. Identification and functional characterization of an osteoclast-derived osteoblastic factor (ODOF): novel growth factor in bone. In: ANZBMS Annual Scientific Meeting; 2004 18-20 August; Hunter Valley, NSW, Australia: ANZBMS 2004 41.
45. Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metabolism 2006 4 : 111 21.
46. Boyce BF, Xing L. Osteoclasts, no longer osteoblast slaves. Nat Med 2006 12 : 1356 8.
47. Mundy GR, Elefteriou F. Boning up on ephrin signaling.[comment]. Cell 2006 126 : 441 3.
48. Hakeda Y, Kobayashi Y, Yamaguchi K, Yasuda H, Tsuda E, Higashio K et al. Osteoclastogenesis inhibitory factor (ocif) directly inhibits bone-resorbing activity of isolated mature osteoclasts. Biochem Biophys Res Commun 1998 251 : 796 801.
49. Kartsogiannis V, Zhou H, Horwood NJ, Thomas RJ, Hards DK, Quinn JMW et al. Localization of RANKL (Receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone 1999 25 : 525 34.
50. Myers DE, Collier FM, Minkin C, Wang H, Holloway WR, Malakellis M et al. Expression of functional RANK on mature rat and human osteoclasts. FEBS Lett 1999 463 : 295 300.
51. Bekker PJ, Holloway DL, Rasmussen AS, Murphy R, Martin SW, Leese PT et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004 19 : 1059 66.