Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3341-3343

  Tsukamoto, Sachiko ^a,b   Yamanokuchi, Rumi ^a   Yoshitomi, Makiko ^a   Sato, Kohei ^b   Ikeda, Tsuyoshi ^a   Rotinsulu, Henki ^c   Mangindaan, Remy E P ^c   de Voogd, Nicole J ^d   van Soest, Rob W M ^e   Yokosawa, Hideyoshi ^f  

^a KUMAMOTO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c SAM RATULANGI UNIVERSITY   (Indonesia)

^d NATURALIS BIODIVERSITY CENTER   (Netherlands)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Alkaloid; Chymotrypsin like activity; Proteasome; Sponge

Indexed keywords

AAPTAMINE; ALKALOID DERIVATIVE; CASPASE; CHYMOTRYPSIN; ISOAAPTAMINE; NORAAPTAMINE; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

AAPTOS SUBERITOIDES; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG INHIBITION; DRUG ISOLATION; ENZYME ACTIVITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; SPONGE (PORIFERA);

ANIMALS; HELA CELLS; HUMANS; NAPHTHYRIDINES; PORIFERA; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX;

AAPTOS SUBERITOIDES;

EID: 77953476821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.029     Document Type: Article

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