Transcription factor E2F1 suppresses dendritic cell maturation

Journal of Immunology

Volumn 184, Issue 11, 2010, Pages 6084-6091

  Fang, Fang ^a   Wang, Yan ^a   Li, Rui ^a   Zhao, Ying ^a   Guo, Yang ^a   Jiang, Ming ^a   Sun, Jie ^a   Ma, Yang ^a   Ren, Zijia ^a   Tian, Zhigang ^a   Wei, Feng ^b   Yang, De ^b,c   Xiao, Weihua ^a,d  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 13; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL MATURATION; DENDRITIC CELL; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHASE TRANSITION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CELL SEPARATION; CYTOLOGY; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL SEPARATION; DENDRITIC CELLS; E2F1 TRANSCRIPTION FACTOR; FLOW CYTOMETRY; HUMANS; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 77953408779     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902561     Document Type: Article

References (40)

1. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
2. Mellman, I. 2005. Antigen processing and presentation by dendritic cells: cell biological mechanisms. Adv. Exp. Med. Biol. 560: 63-67.
3. Randolph, G. J., V. Angeli, and M. A. Swartz. 2005. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 5: 617-628.
4. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
5. Oppenheim, J. J., and D. Yang. 2005. Alarmins: chemotactic activators of immune responses. Curr. Opin. Immunol. 17: 359-365.
6. Yang, D., Q. Chen, S. B. Su, P. Zhang, K. Kurosaka, R. R. Caspi, S. M. Michalek, H. F. Rosenberg, N. Zhang, and J. J. Oppenheim. 2008. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J. Exp. Med. 205: 79-90.
7. + monocytes through distinct pathways that activate NK-κB. J. Immunol. 165: 3647-3655.
8. Arrighi, J. F., M. Rebsamen, F. Rousset, V. Kindler, and C. Hauser. 2001. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers. J. Immunol. 166: 3837-3845.
9. + T cell memory responses. J. Immunol. 172: 6047-6056.
10. Mann, J., F. Oakley, P. W. Johnson, and D. A. Mann. 2002. CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-κB, and CBF1. J. Biol. Chem. 277: 17125-17138.
11. Ardeshna, K. M., A. R. Pizzey, S. Devereux, and A. Khwaja. 2000. The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocytederived dendritic cells. Blood 96: 1039-1046.
12. Rescigno, M., M. Martino, C. L. Sutherland, M. R. Gold, and P. Ricciardi-Castagnoli. 1998. Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med. 188: 2175-2180.
13. Li, M., X. Zhang, X. Zheng, D. Lian, Z. X. Zhang, W. Ge, J. Yang, C. Vladau, M. Suzuki, D. Chen, et al. 2007. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J. Immunol. 178: 5480-5487.
14. Shinkura, R., K. Kitada, F. Matsuda, K. Tashiro, K. Ikuta, M. Suzuki, K. Kogishi, T. Serikawa, and T. Honjo. 1999. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase. Nat. Genet. 22: 74-77.
15. Lind, E. F., C. L. Ahonen, A. Wasiuk, Y. Kosaka, B. Becher, K. A. Bennett, and R. J. Noelle. 2008. Dendritic cells require the NF-κB2 pathway for cross-presentation of soluble antigens. J. Immunol. 181: 354-363.
16. DeGregori, J., and D. G. Johnson. 2006. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr. Mol. Med. 6: 739-748.
17. Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352.
18. Wu, L., C. Timmers, B. Maiti, H. I. Saavedra, L. Sang, G. T. Chong, F. Nuckolls, P. Giangrande, F. A. Wright, S. J. Field, et al. 2001. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414: 457-462.
19. Wu, X., and A. J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91: 3602-3606.
20. Nahle, Z., J. Polakoff, R. V. Davuluri, M. E. McCurrach, M. D. Jacobson, M. Narita, M. Q. Zhang, Y. Lazebnik, D. Bar-Sagi, and S. W. Lowe. 2002. Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell Biol. 4: 859-864.
21. Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and N. J. Dyson. 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537-548.
22. Field, S. J., F. Y. Tsai, F. Kuo, A. M. Zubiaga, W. G. Kaelin, Jr., D. M. Livingston, S. H. Orkin, and M. E. Greenberg. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85: 549-561.
23. Zhu, J. W., S. J. Field, L. Gore, M. Thompson, H. Yang, Y. Fujiwara, R. D. Cardiff, M. Greenberg, S. H. Orkin, and J. DeGregori. 2001. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol. Cell. Biol. 21: 8547-8564.
24. Lim, C. A., F. Yao, J. J. Wong, J. George, H. Xu, K. P. Chiu, W. K. Sung, L. Lipovich, V. B. Vega, J. Chen, et al. 2007. Genome-wide mapping of RELA (p65) binding identifies E2F1 as a transcriptional activator recruited by NF-κB upon TLR4 activation. Mol. Cell 27: 622-635.
25. Kishore, R., C. Luedemann, E. Bord, D. Goukassian, and D. W. Losordo. 2003. Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways. Circ. Res. 93: 932-940.
26. Chaussepied, M., and D. Ginsberg. 2004. Transcriptional regulation of AKT activation by E2F. Mol. Cell 16: 831-837.
27. Hershko, T., K. Korotayev, S. Polager, and D. Ginsberg. 2006. E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1. J. Biol. Chem. 281: 31309-31316.
28. Yang, D., Q. Chen, A. P. Schmidt, G. M. Anderson, J. M. Wang, J. Wooters, J. J. Oppenheim, and O. Chertov. 2000. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192: 1069-1074.
29. Yang, D., H. F. Rosenberg, Q. Chen, K. D. Dyer, K. Kurosaka, and J. J. Oppenheim. 2003. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. Blood 102: 3396-3403.
30. Shen, Z., G. Reznikoff, G. Dranoff, and K. L. Rock. 1997. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J. Immunol. 158: 2723-2730.
31. Zheng, C., Z. Ren, H. Wang, W. Zhang, D. V. Kalvakolanu, Z. Tian, and W. Xiao. 2009. E2F1 Induces tumor cell survival via nuclear factor-κB- dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 69: 2324-2331.
32. Xie, W., P. Jiang, L. Miao, Y. Zhao, Z. Zhimin, L. Qing, W. G. Zhu, and M. Wu. 2006. Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1. Nucleic Acids Res. 34: 2046-2055.
33. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161: 526-546.
34. Müller, H., A. P. Bracken, R. Vernell, M. C. Moroni, F. Christians, E. Grassilli, E. Prosperini, E. Vigo, J. D. Oliner, and K. Helin. 2001. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15: 267-285.
35. Stanelle, J., T. Stiewe, C. C. Theseling, M. Peter, and B. M. Pützer. 2002. Gene expression changes in response to E2F1 activation. Nucleic Acids Res. 30: 1859-1867.
36. Jamshidi-Parsian, A., Y. Dong, X. Zheng, H. S. Zhou, W. Zacharias, and K. M. McMasters. 2005. Gene expression profiling of E2F-1-induced apoptosis. Gene 344: 67-77.
37. Mookherjee, N., P. Hamill, J. Gardy, D. Blimkie, R. Falsafi, A. Chikatamarla, D. J. Arenillas, S. Doria, T. R. Kollmann, and R. E. Hancock. 2009. Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells. Mol. Biosyst. 5: 483-496.
38. Chen, M., C. Capps, J. T. Willerson, and P. Zoldhelyi. 2002. E2F-1 regulates nuclear factor-κB activity and cell adhesion: potential antiinflammatory activity of the transcription factor E2F-1. Circulation 106: 2707-2713.
39. Salam, M. A., K. Matin, N. Matsumoto, Y. Tsuha, N. Hanada, and H. Senpuku. 2004. E2f1 mutation induces early onset of diabetes and Sjögren's syndrome in nonobese diabetic mice. J. Immunol. 173: 4908-4918.
40. -/- C57BL/6 mice overexpressing a human Bcl-2 transgene in B cells develop a mild autoimmune syndrome. Ann. N. Y. Acad. Sci. 1051: 156-165.