Oxidative Stress in COPD and its measurement through exhaled breath condensate

Clinical and Translational Science

Volumn 2, Issue 2, 2009, Pages 150-155

  Lee, Wei ^a,b   Thomas, Paul S ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Antioxidant capacity; Chronic obstructive pulmonary disease; Exhaled breath condensate; Inflammation; Oxidative stress

Indexed keywords

BIOLOGICAL MARKER; CATALASE; GLUTATHIONE; SUPEROXIDE DISMUTASE; ANTIOXIDANT;

AIRWAY CONSTRICTION; AIRWAY OBSTRUCTION; APOPTOSIS; BREATH ANALYSIS; CARBOXYLATION; CELL DAMAGE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL EFFECTIVENESS; DISEASE MARKER; EPITHELIUM CELL; HUMAN; NITRATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; REVIEW; EXHALATION; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ANTIOXIDANTS; BREATH TESTS; EXHALATION; HUMANS; LUNG; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 77953399180     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/j.1752-8062.2009.00093.x     Document Type: Review

References (87)

1. National Heart Lung and Blood Institute. Morbidity & Mortality. 2007 Chart Book on Cardiovascular, Lung, and Blood Diseases. Bethesda, Maryland: US Department of Health and Human Services, Public Health Service, National Institutes of Health; 2007
2. Pauwels RA, Burst AS, Calverley PMA, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001; 163: 1256-1276.
3. Joppa P, Petrasova D, Stancak B, Dorkova Z, Tkacova R. Oxidative stress in patients with COPD and pulmonary hypertension. Wien Klin Wochenschr. 2007; 119: 428-434.
4. Daga MK, Chhabra R, Sharma B, Mishra TK. Effects of exogenous vitamin E supplementation on the levels of oxidants and antioxidants in chronic obstructive pulmonary disease. J Biosci 2003; 28: 7-11.
5. Kluchova Z, Petrasova D, Joppa P, Dorkova Z, Tkacova R. The association between oxidative stress and obstructive lung impairment in patients with COPD. Physiol Res. 2007; 56: 51-56
6. Santus P, Sola A, Carlucci P, Fumagalli F, Di Gennaro A, Mondoni M, Carnini C, Centanni S, Sala A. Lipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005; 171: 838-843.
7. Caramon G, Papi A. Oxidants and asthma. Thorax. 2004; 59: 170-173
8. Fireman E, Shtark M, Priel IE, Shiner R, Mor R, Kivity S, Fireman Z. Hydrogen peroxide in exhaled breath condensate (EBC) versus eosinophil count in induced sputum (IS) in parenchymal versus airways lung diseases. Inflammation. 2007; 30: 44-51
9. Kostikas K, Papatheodorou G, Ganas K, Psathakis K, Panagou P, Loukides S. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 2002; 165: 1364-1370.
10. Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res. 1997; 8: 1-7
11. Rahman I, Gilmour PS, Jimenez LA, MacNee W. Oxidative stress and TNF-alpha induce histone acetylation and NF-kB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem. 2002; 234: 239-248
12. Sadeghi-Hashjin G, Folkerts G, Henricks PA, Verheyen AK, Van Der Linde HJ, van Ark I, Coene A, Nijkamp FP. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med. 1996; 153: 1697-1701.
13. Krishna MT, Madden J, Teran LM, Biscione GL, Lau LCK, Withers NJ, Sandstrom T, Mudway I, Kelly FJ, Walls A, Frew AJ, Holgate ST. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. Eur Respir J. 1998; 11: 1294-1300.
14. Rahman I, Morrison D, Donaldson K, MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med. 1996; 154: 1055-1060
15. Noguera A, Batle S, Miralles C, Iglesias J, Busquets X, MacNee W, Agusti AGN. Enhanced neutrophil response in chronic obstructive pulmonary disease. Thorax. 2001; 56: 432-437
16. Ricciardolo F, Caramori G, Ito K, Capelli A, Brun P, Abatangelo G, Papi A, Chung K, Adcock I, Barnes P, Donner C, Rossi A, Di Stefano A. Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2005; 116: 1028-1035
17. Lehr HA, Kress E, Menger MD, Friedl HP, Hubner C, Arfors KE, Messer K. Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: inhibition by CuZnSOD. Tree Radio Biol Med. 1993; 14: 573-581.
18. Shoji S, Ertl RF, Koyama S, Robbins R, Leikauf G, Von Essen S, Rennard SI. Cigarette smoke stimulates release of neutrophil chemotactic activity from cultured bovine bronchial epithelia cells. Clin Sci. 1995; 88: 337-344.
19. Liu J, Thomas PS. Cigarette smoking increases nitrite/nitrate in exhaled breath condensate. Respirology. 2004; 9: A40.
20. Masubuchi T, Koyama S, Sato E, Takamizawa A, Kubo K, Sekiguchi M, Nagai S, Izumi T. Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity Am J Pathol. 1998; 153: 1903-1912.
21. MacNee W, Wrggs B, Belzberg AS, Hogg JC. The effect of cigarette smoking on neutrophil kinetics in human lungs. N Engl J Med. 1989; 321: 924-928.
22. Churg A, Dai J, Tai H, Xre C, Wright JL. Tumor necrosis factor-(alpha) is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 2002; 166: 849-854.
23. Hersey P, Prendergast D, Edwards A. Effects of cigarette smoking on the immune system Follow-up studies in normal subjects after cessation of smoking. MedJAust. 1983; 2: 425-429
24. Kanazawa H, Shiraishi S, Hirata K, Yoshikawa J. Imbalance between levels of nitrogen oxides and peroxynitrite inhibitory activity in chronic obstructive pulmonary disease. Thorax. 2003; 58: 106-109
25. Torok SS, Leuppi JD. Bronchial hyperresponsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease. Swiss Med Wkly. 2007; 137: 385-391
26. Yeadon M, Wilkinson D, Payne AN. Ozone induces bronchial hyperreactivity to inhaled substance P by functional inhibition of enkephalinase. Br J Pharmacol. 1990; 99: 191P
27. Yan K, Salome CM, Woolcock AJ. Prevalence and nature of bronchial hyperresponsiveness in subjects with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1985; 132: 25-29
28. Bar TR, Zhou D, Weir T, Walker B, Hegele R, Hayashi S, McKay K, Bondy GP, Fong T. Substance P (NK1)-and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases. Am J Physiol Lung Cell Mol Physiol. 1995; 269: L309-L317
29. 2alpha. J Pharmacol Exp Ther. 1997; 281: 957-964.
30. Henricks PAJ, Nijkamp FP. Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther. 2001; 14: 409-421.
31. Parola M, Bellomo G, Robino G, Barrera G, Dianzani MU. 4-hydroxynonenal as a biological signal: Molecular basis and pathophysiological implications. Antioxid Redox Signal. 1999; 1: 255-284.
32. Ji C, Amarnath V, Pietenpol JA, Marnett U. 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome C release. Chem Res Toxicol. 2001; 14: 1090-1096.
33. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, Miao QX, Kane LS, Gow AJ, Stamler JS. Fas-induced caspase denitrosylation. Science. 1999; 284: 651-654.
34. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NFkB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell MolPhysiol. 2007; 292: L567-L576.
35. Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, Mac-Nee W, Rahman I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir CellMol Bid. 2004; 31: 633-642.
36. Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEBJ. 2001; 15: 1110-1112.
37. Lander HM, Sehajpal P, Levine DM, Novogrodsky A. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J Immunol. 1993; 150: 1509-1516.
38. Lawler JM, Song W. Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors. Biochem Biophys Res Commun. 2002; 294: 1093-1100.
39. Moreno JJ, Pryor WA. Inactivation of alpha 1-proteinase inhibitor by peroxynitrite. Chem Res Toxicol. 1992; 5: 425-431.
40. Maier KL, Matejkova E, Hinze H, Leuschel L, Weber H, Beck-Speier I. Different selectivities of oxidants during oxidation of methionine residues in the alpha-1-proteinase inhibitor. FEBS Lett. 1989; 250: 221-226.
41. Alvarez B, Ferrer-Sueta G, Freeman BA, Radi R. Kinetics of peroxynitrite reaction with amino acids and human serum albumin. J BioiChem. 1999; 274: 842-848.
42. Grzelak A, Soszynski M, Bartosz G. Inactivation of antioxidant enzymes by peroxynitrite. Scond J Clin Lab Invest. 2000; 60: 253-258.
43. Kanazawa H, Shiraishi S, Hirata K, Yoshikawa J. Decreased peroxynitrite inhibitory activity in induced sputum in patients with bronchial asthma. Thorax. 2002; 57: 509-513.
44. Takeyama K, Agusti C, Ueki I, Lausier J, Cardell LO, Nadel JA. Neutrophil-dependent goblet cell degranulation: Role of membrane-bound elastase and adhesion molecules. Am J Physiol Lung Cell Mol Physiol. 1998; 275: 294-302.
45. Haddad IY, Ischiropoulos H, Holm BA, Beckman JS, Baker JR, Matalon S. Mechanisms of peroxynitrite-induced injury to pulmonary surfactants. Am J Physiol Lung Cell Mol Physiol. 1993; 265: L555-L564.
46. Takabatake N, Nakamura H, Abe S, Inoue S, Hino T, Saito H, Yuki H, Kato S, Tomoike H. The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000; 161: 1179-1184.
47. Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med. 2000; 162: 701-706.
48. 2alpha-III, an index of oxidant stress. Am J Respir Crit Care Med. 1998; 158: 1709-1714.
49. Godoy ID, Donahoe M, Calhoun WJ, Mancino J, Rogers RM. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med. 1996; 153: 633-637.
50. Huiart L, Ernst P, Suissa S. Cardiovascular morbidity and mortality in COPD. Chest. 2005; 128: 2640-2646.
51. Smith LJ, Houston M, Anderson J. Increased levels of glutathione in bronchoalveolar lavage fluid from patients with asthma. Am Rev Respir Dis. 1993; 147: 1461-1464.
52. Duperat VG, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N. Characterization of the human mucin gene MUC5AC: A consensus cysteine-rich domain for 1 lpl5 mucin genes? Biochem J. 1995; 305: 211-219.
53. Koren HS, Hatch GE, Graham DE Nasal lavage as a tool in assessing acute inflammation in response to inhaled pollutants. Toxicology. 1990; 60: 15-25.
54. van derVliet A, O'Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S. Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol Lung Cell Mol Physiol. 1999; 276: 289-296.
55. Kelly FJ, Cotgrove M, Mudway IS. Respiratory tract lining fluid antioxidants: The first line of defence against gaseous pollutants. Cent EurJ Public Health. 1996; 4: 11-14.
56. Rustow B, Haupt R, Stevens PA, Kunze D. Type II pneumocytes secrete vitamin E together with surfactant lipids. Am J Physiol Lung Cell Mol Physiol. 1993; 265: 133-139.
57. Sevanian A, Elsayed N, Hacker AD. Effects of vitamin E deficiency and nitrogen dioxide exposure on lung lipid peroxidation: Use of lipid epoxides and malonaldehyde as measures of peroxidation. J Toxicol Environ Health. 1982; 10: 743-756.
58. Nyyssonen K, Porkkala-Sarataho E, Kaikkonen J, Salonen JT. Ascorbate and urate are the strongest determinants of plasma antioxidative capacity and serum lipid resistance to oxidation in Finnish men. Atherosclerosis. 1997; 130: 223-233.
59. Ghio AJ, Carter JD, Samet JM, Reed W, Quay J, Dailey LA, Richards JH, Devlin RB. Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells. Am J Physiol Lung Cell Mol Physiol. 1998; 274: 728-736.
60. Cantin AM, Fells GA, Hubbard RC, Crystal RG. Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract. J Clin Invest. 1990; 86: 962-971.
61. Lakari E, Paakko P, Kinnula VL. Manganese superoxide dismutase, but not CuZn superoxide dismutase, is highly expressed in the granulomas of pulmonary sarcoidosis and extrinsic allergic alveolitis. Am J Respir Crit Care Med. 1998; 158: 589-596.
62. Oury TD, Chang LY, Marklund SL, Day BJ, Crapo JD. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest. 1994; 70: 889-898.
63. Rahman I, van Schadewijk AA, Hiemstra PS, Stolk J, van Krieken JH, MacNee W, de Boer Wl. Localization of gamma-glutamylcysteine synthetase messenger RNA expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Free Radic BiolMed. 2000; 28: 920-925.
64. Pietarinen-Runtti P, Raivio KO, Saksela M, Asikainen TM, Kinnula VL. Antioxidant enzyme regulation and resistance to oxidants of human bronchial epithelial cells cultured under hyperoxic conditions. Am J Respir Cell Mol Biol. 1998; 19: 286-292.
65. Sahin U, Unlu M, Ozguner F, Sutcu R, Akkaya A, Delibas N. Lipid peroxidation and glutathione peroxidase activity in chronic obstructive pulmonary disease exacerbation: Prognostic value of malondialdehyde. J Basic Clin Physiol Pharmacol. 2001; 12: 59-68.
66. Hanta I, Kocabas A, Canacankatan N, Kulec S, Seydaoglu G. Oxidant-antioxidant balance in patients with COPD. Lung. 2006; 184: 51-55.
67. Beeh KM, Beier J, Koppenhoefer N, Buhl R. Increased glutathione disulfide and nitrosothiols in sputum supernatant of patients with stable COPD. Chest. 2004; 126: 1116-1122.
68. Calikoglu M, Unlu A, Tamer L, Ercan B, Bugdayci R, Atik U. The levels of serum vitamin Q malonyldialdehyde and erythrocyte reduced glutathione in chronic obstructive pulmonary disease and in healthy smokers. Clin Chem Lab Med. 2002; 40: 1028-1031.
69. Tug T, Karatas F, Terzi SM. Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease. Clin Invest Med. 2004; 27: 123-128.
70. Vernooy JH, Kucukaycan M, Jacobs JA, Chavannes NH, Buurman WA, Dentener MA, Wouters EF. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: Soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med. 2002; 166: 1218-1224.
71. Drost EM, Skwarski KM, Sauleda J, Soler N, Roca J, Agusti A, MacNee W. Oxidative stress and airway inflammation in severe exacerbations of COPD. Thorax. 2005; 60: 293.
72. Morrison D, Rahman I, Lannan S, MacNee W. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med. 1999; 159: 473-479.
73. Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEBJ. 2001; 15: 70-78.
74. Gilks CB, Price K, Wright JL, Churg A. Antioxidant gene expression in rat lung after exposure to cigarette smoke. Am J Pathol. 1998; 152: 269-278.
75. Rahman I, Smith CA, Lawson MF, Harrison DJ, MacNee W. Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett, 1996; 396: 21-25.
76. Brutsche MH, Downs SH, Schindler C, Gerbase MW, Schwartz J, Frey M, Russi EW, Ackermann-Liebrich U, Leuenberger P. Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study. Thorax. 2006; 61: 671-677
77. Parameswaran K, Pizzichini E, Pizzichini MM, Hussack P, Efthimiadis A, Hargreave FE. Clinical judgement of airway inflammation versus sputum cell counts in patients with asthma. Eur Respir J. 2000; 15: 486-490.
78. Nightingale JA, Rogers DF, Barnes PJ. Effect of repeated sputum induction on cell counts in normal volunteers. Thorax. 1998; 53: 87-90.
79. Liu J, Sandrini A, Thurston MC, Yates DH, Thomas PS. Nitric oxide and exhaled breath nitrite/nitrates in chronic obstructive pulmonary disease patients. Respiration. 2007; 74: 617-623.
80. Clini E, Bianchi L, Pagani M, Ambrosino N. Endogenous nitric oxide in patients with stable COPD: Correlates with severity of disease. Thorax. 1998; 53: 881-883.
81. Robbins RA, Millatmal T, Lassi K, Rennard S, Daughton D. Smoking cessation is associated with an increase in exhaled nitric oxide. Chest. 1997; 112: 313-318.
82. Nowak D, Kasielski M, Antczak A, Pietras T, Bialasiewicz P. Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: No significant effect of cigarette smoking. Respir Med. 1999; 93: 389-396.
83. Corradi M, Montuschi P, Donnelly LE, Pesci A, Kharitonov SA, Barnes PJ. Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med. 2001; 163: 854-858.
84. Montuschi P, Collins JV, Ciabattoni G, Lazzeri N, Corradi M, Kharitonov SA, Barnes PJ. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med. 2000; 162: 1175-1177
85. Liu J, Chow S, Yates DH, Thomas PS. Exhaled breath condensate antioxidant capacity in asthma and COPD. Respirology. 2007; 12: A31.
86. Kelly FJ, Mudway I, Blomberg A, Frew A, Sandstrom T. Altered lung antioxidant status in patients with mild asthma. Lancet. 1999; 354: 482-483.
87. Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: A new marker of oxidative stress. Thorax. 1998; 53: 668-672.