Effect of repeated sputum induction on cell counts in normal volunteers

Thorax

Volumn 53, Issue 2, 1998, Pages 87-90

  Nightingale, Julia A ^a   Rogers, Duncan F ^a   Barnes, Peter J ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Hypertonic saline; Neutrophils; Sputum induction

Indexed keywords

SODIUM CHLORIDE;

ADULT; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EOSINOPHIL; FEMALE; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE DIFFERENTIAL COUNT; MACROPHAGE; MALE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SPUTUM ANALYSIS;

EID: 0031923960     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.53.2.87     Document Type: Article

References (17)

1. Pin I, Gibson PG, Kolendowicx R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47:25-9.
2. Gibson PG, Girgis-Gabardo A, Morris MM, Mattoli S, Kay JM, Dolovich J. Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax 1989; 44:693-9.
3. Pizzichini H, Pizzichini MM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996;154:308-17.
4. Fahy JV, Liu J, Wong H, Boushey HA. Analysis of cellular and biochemical constituents in induced sputum after allergen challenge: a method for studying allergic airway inflammation. J Allergy Clin Immunol 1994;93:1031-9.
5. Claman DM, Boushey HA, Liu J, Wong H, Fahy JV. Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994;94:861-9.
6. Holz O, Richter K, Jörres RA, Speckin P, Mücke M, Magnussen H. Changes in sputum composition between two inductions performed on consecutive days. Thorax 1998; 53:83-6.
7. In't Veen JC, de Gouw HW, Smits HH, et al. Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. Eur Respir J 1996;9: 2441-7.
8. Pizzichini E, Pizzichini MM, Efthimiadis A, Hargreave FE, Dolovich J. Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination. Eur Respir J 1996;9:1174-80.
9. Gravelyn TR, Pan PM, Eschenbacher WL. Mediator release in an isolated airway segment in subjects with asthma. Am Rev Respir Dis 1988;137:641-6.
10. Maxwell DL, Hawksworth RJ, Lee TH. Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. Eur Respir J 1993;6:1145-50.
11. Silber G, Proud D, Warner J. In vivo release of inflammatory mediators by hyperosmolar solutions. Am Rev Respir Dis 1988;137:606-12.
12. Boulet LP, Turcotte H, Tennina S. Comparative efficacy of salbutamol, ipratropium and cromoglycate in the prevention of bronchospasm induced by exercise and hyperosmolar challenges. J Allergy Clin Immunol 1989;83:882-7.
13. Finnerty JP, Wilmont C, Holgate ST. Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen: evidence for the predominant role of histamine. Am Rev Respir Dis 1989;140:593-7.
14. Spanevello A, Migliori GB, Satta A, Neri M, Ind PW. Sputum induction: a method to assess airway inflammation in asthma. Monaldi Arch Chest Dis 1995;50: 208-10.
15. Keatings VM, Evans DJ, O'Connor BJ, Barnes PJ. Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. Thorax 1997;52:372-4.
16. Pizzichini MM, Popov TA, Efthimiadis A, et al. Spontaneous and induced sputum to measure indices of airway inflammation in asthma. Am J Respir Crit Care Med 1996; 154:866-9.
17. Bacci H, Cianchetti S, Paggiaro PL, et al. Comparison between hypertonic and isotonic saline-induced sputum in the evaluation of airway inflammation in subjects with moderate asthma. Clin Exp Allergy 1996;26:1395-400.