The plant extracts of Momordica charantia and Trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus

Oxidative Medicine and Cellular Longevity

Volumn 2, Issue 5, 2009, Pages 290-296

  Tripathi, Uma Nath ^a   Chandra, Deepak ^a  

^a UNIVERSITY OF LUCKNOW   (India)

Author keywords

Alloxan; Antioxidant status; Diabetic rat; Heart; Lipid peroxidation; Momordica charantia; Trigonella foenum graecum

Indexed keywords

ALLOXAN; CATALASE; FREE RADICAL; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIPID; MOMORDICA CHARANTIA EXTRACT; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TRIGONELLA FOENUM GRAECUM EXTRACT;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HEART; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT SEED; RAT; WOOD PULP;

ANIMALS; ANTIOXIDANTS; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEART; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; MOMORDICA CHARANTIA; MYOCARDIUM; PHYTOTHERAPY; PLANT EXTRACTS; RATS; SUPEROXIDE DISMUTASE; TRIGONELLA;

ANIMALIA; MOMORDICA CHARANTIA; RATTUS; TRIGONELLA FOENUM-GRAECUM;

EID: 77953384493     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.2.5.9529     Document Type: Article

References (45)

1. Chandra D, Jackson EB, Ramana KV, Kelley R, Srivastava SK, Bhatnagar A. Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes 2002; 51:3095-101.
2. Yim S, Malhotra A, Veves A. Antioxidants and CVD in Diabetes: Where Do We Stand Now? Curr Diab Rep 2007; 7:8-13.
3. Ceriello A. Oxidative stress and glycemic regulation. Metabolism 2000; 49:27-9.
4. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes 1999; 48:1-9.
5. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40:405-12.
6. Chang KC, Chung SY, Chong WS, Suh JS, Kim SH, Noh HK, et al. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 1993; 266:992-1000.
7. Young IS, Tate S, Lightbody JH, McMaster D, Trimble ER. The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat. Free Radic Biol Med 1995; 18:833-40.
8. Chakravarthy BR, Wang J, Tremblay R, Atkinson TG, Wang F, Li H, et al. Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia. Cell Signal 1998; 10:291-5.
9. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404:787-90.
10. Creager MA, Luscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003; 108:1527-32.
11. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999; 97:889-901.
12. Bhatnagar A, Srivastava SK. Aldose reductase: congenical and injurious profiles of an enigmatic enzyme. Biochem Med Metabol Biol 1992; 48:91-121.
13. Srivastava S, Chandra A, Ansari NH, Srivastava SK, Bhatnagar A. Identification of cardiac oxidoredutase (s) involved in metabolism of lipid peroxidation derived aldehyde-4-hydroxnonenal. Biochem J 1998; 329:469-75.
14. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 2005; 4:5.
15. Maritim AC, Sanders RA, Watkins JB 3rd: Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17:24-38.
16. Stewart-Lee AL, Forster LA, Nourooz-Zadeh J, Ferns GA, Anggard EE. Vitamin E protects against impairment of endothelium mediated relaxations in cholesterol-fed rabbits. Arterioscler Thromb 1994; 14:494-9.
17. Cinar MG, Ulker S, Alper G, Evinc A. Effect of dietary vitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin- diabetic rats. Pharmacology 2001; 62:56-64.
18. Palmer AM, Thomas CR, Gopaul N, Dhir S, Anggard EE, Poston L, et al. Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat. Diabetologia 1998; 41:148-56.
19. Alper G, Olukman M, Irer S, Caglayan O, Duman E, Yilmaz C, et al. Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat. Diabetes Metab Res Rev 2006; 22:190-7.
20. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Keaney JF Jr, Creager MA. Oral antioxidant therapy improves endothelial function in type 1 but not type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 2003; 285:H2392-8.
21. Saxena AK, Srivastava P, Kale RK, Baquer NZ. Impaired antioxidant status in diabeteic rat liver: effect of vanadate. Biochem Pharmacol 1993; 45:539-42.
22. Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol 2004; 93:123-32.
23. Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol 2009; 123:464-9.
24. Batabval L, Sharma P, Mohan L, Maurya P, Srivastava CN. Relative toxicity of neem fruit, bitter guard, and castor seed extracts against the larvae of filarial vector, Culex quinquefasciatus. Parasitol Res 2009; 105:1205-10.
25. Abou El-Soud NH, Khalil MY, Hussein JS, Oraby FSH, Farrag ARH. Antidiabetic effects of fenugreek alkaloid extract in streptozotocin induced hyperglycaemic rats. J App Sci Res 2007; 3:1073-83.
26. Tripathi UN, Jamal F, Chandra D. Pharmacological potentials of Triogonella foenum-graecum (methi): A review. Nat J Life Sci 2007; 4:205-07.
27. Lenzen S. The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia 2008; 51:216-26.
28. Horie S, Ishii H, Suga T. Changes in peroxisomal fatty acid oxidation in diabetic rat liver. J Biochem 1981; 90:1691-6.
29. Xing FZ, Tan BW. Antihyperglycemic and antioxidant properties of Andrographis paniculatain normal and diabetic rats. Clin Exp Pharmacol Physiol 2000; 27:358-63.
30. Mahadevi MRV, Raghni M, Baluchnejadmojarad T. Role of Trigonella foenum graecum leaf aqueous extract has been implicated to improve vascular reactivity of the thoracic aorta from STZ diabetic rats. Ind J pharmacol 2008; 40:59-63.
31. Chandra A, Mahdi AA, Ahmad S, Singh RK. Indian herbs result in hypoglycemic responses in streptozotocin-induced diabetic rats. Nutr Res 2007; 27:161-8.
32. Nicotera P, Orrenius S. Role of thiols in protection against biological reactive intermediates. Adv Exp Med Biol 1986; 197:41-9.
33. Gregus Z, Fekete T, Halászi E, Klaassen CD. Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine. Drug Metab Dispos 1996; 24:682-8.
34. Wohaieb SA, Godin DV. Alterration of free radical tissue-defense mechanism in streptozotocin-induced diabetic rats. Effect of insulin treatment. Diabetes 1987; 36:1014-8.
35. Mc-cord JM, Keele BB, Fridovich I. An enzyme based theory of obligate anaerobiosis; the physiological functions of superoxide dismutase. Proc Natl Acad Sci USA 1976; 68:1024-7.
36. Chance B, Greenstein DS, Roughton RJW. The mechanism of catalase action steady state analysis. Arch Biochem Biophys 1952; 37:301-39.
37. Karunanayake EH, Jeevathayaparan S, Tennekoon KH. Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats. J Ethnopharmacol 1990; 30:199-204.
38. Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr 2007; 16:422-6.
39. Sochor M, Baquer NZ, McLean P. Glucose over and underutilization in diabetes: Comparative studies on the changes in activities of enzymes of glucose metabolism in rat kidney and liver. Mol Physiol 1985; 7:51-68.
40. Ohkawa H, Oshishi N, Yagi K. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-8.
41. Sinha, AK. Colorimetric assay of catalase. Anal Biochem 1972; 47:389-94.
42. Misra HP, Fridovich I. The role of superoxide anion in the auto oxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247:3170-5.
43. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249:7130-9.
44. Chandra D, Ramana KV, Wang L, Christensen BN, Bhatnagar A, Srivastava SK. Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci. 2002; 43:2285-92.
45. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265-75.