Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine

Oxidative Medicine and Cellular Longevity

Volumn 2, Issue 2, 2009, Pages

  Adel, R A Abd Allah ^a   Helal, Gouda K ^a   Abdulaziz, A Al Yahya ^a   Aleisa, Abdulaziz M ^a   Salim, S Al Rejaie ^a   Saleh, A Al Bakheet ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Blood testes barrier; Immune regulation; L carnitine; LPS; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CARNITINE; DNA; GLUTATHIONE; INTERLEUKIN 2; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; NITRIC OXIDE; 8-HYDROXY-2'-DEOXYGUANOSINE; ANTIINFLAMMATORY AGENT; DEOXYGUANOSINE; DRUG DERIVATIVE; ISOENZYME; LACTATE DEHYDROGENASE ISOENZYME X;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS TAIL; HISTOPATHOLOGY; INFLAMMATION; MALE; NONHUMAN; OLIGOSPERMIA; OXIDATIVE STRESS; RAT; SEMINIFEROUS TUBULE; SEPSIS; SINGLE DRUG DOSE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; TISSUE HOMOGENATE; ANIMAL; BLOOD; DNA ADDUCT; DRUG EFFECT; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

ANIMALIA; BACTERIA (MICROORGANISMS); RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARNITINE; DEOXYGUANOSINE; DNA ADDUCTS; GLUTATHIONE; INTERLEUKIN-2; ISOENZYMES; L-LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDES; MALE; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; SPERM COUNT; SPERM MOTILITY; TESTIS;

EID: 77953376585     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Naito M, Itoh M. Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice. Am J Reprod Immunol 2008 59:55-61.
2. Fijak M, Meinhardt A. The testis in immune privilege. Immunol Rev 2006; 213:66-81.
3. Itoh M, Terayama H, Naito M, Ogawa Y, Tainosho S. Tissue microcircumstances for leukocytic infiltration into the testis and epididymis in mice. J Reprod Immunol 2005; 67:57-67.
4. Pacey AA, Eley AA. Chlamydia trachomatis and male fertility. Hum Fertil 2004; 7:271-6.
5. Reddy MM, Mahipal SV, Subhashini J, Reddy MC, Roy K, RReddy GV, et al. Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats. Reprod Toxicol 2006; 22:493-500.
6. Comphaire FH, Mahmoud AM, Depuydt CE, Zalata AA, Christophe AB. Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint. Hum Reprod Update 1999; 5:393-8.
7. Witkin SS, Jeremias J, Bongiovanni AM, Munoz MG. Immune regulation in the male genital tract. Infect Dis Obstet Gynecol 1996; 4:131-5.
8. O'Bryan MK, Schlatt S, Phillips DJ, de Kretser DM, Hedger MB. Bacterial Lipopolysaccharide-Induced Inflammation Compromises Testicular Function at Multiple Levels in vivo. Endocrinol 2000; 141:238-46.
9. Wallgren M, Kindahl H, Rodriguez-Martinez H. Alterations in testicular function after endotoxin injections in the boar. Int J Androl 1993; 16:235-43.
10. Jégou B, Cudicini C, Gomez E, Stéphan JP. Interleukin-1, interleukin-6 and the germ cell-Sertoli cell cross-talk. Reprod Fertil Dev 1995; 7:723-30.
11. Gruschwitz MS, Brezinschek R, Brezinschek HP. Cytokine levels in the seminal plasma of infertile males. J Androl 1996; 17:158-63.
12. Ochsendorf RF. Infections in the male genital tract and reactive oxygen species. Hum Reprod Update 1999; 5:399-20.
13. Wang A, Fanning L, Anderson DJ, Loughlin KR. Generation of reactive oxygen species by leukocytes and sperm following exposure to urogenital tract infection. Arch Androl 1997; 39:11-7.
14. Rajasekaran M, Hellstrom WJ, Naz RK, Sikka SC. Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril 1995; 64:166-71.
15. Sanocka D, Fraczek M, Jedrzejczak P, Szumala-Kakol A, Kurpisz M. Male genital tract infection: an influence of leukocytes and bacteria on semen. J Reprod Immunol 2004; 62:111-24.
16. Fraczek M, Kurpisz M. The redox system in human semen and peroxidative damage of spermatozoa. Postepy Hig Med Dosw 2005; 59:523-34.
17. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiol-ogy of human reproduction. Fertil Steril 2003; 79:829-43.
18. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ, Agarwal A. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod 1999; 14:2801-7.
19. Kim SK, Yoon YD, Park YS, Ju Tae Seo JT, Kim JH. Involvement of the Fas-Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell-only syndrome. Fertil Steril 2007; 87:547-53.
20. Lin WW, Lamb DJ, Wheeler TM, Lipshultz LL, Kim ED. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermato-genesis. Fertil Steril 2007; 68:1065-9.
21. Takagi S, Itoh N, Kimura M, Sasao T, Tsukamoto T. Spermatogonial proliferation and apoptosis in hypospermatogenesis associated with nonobstructive azoospermia. Fertil Steril 2001; 76:901-7.
22. Bremer J. Carnitine metabolism and functions. Physiol Rev 1983; 63:142-80.
23. Famularo G, Marticardi F, Nucera E, Santini G, De Simone C. Carnitine deficiency: primary and secondary syndromes. In: De Simone C and Famularo G, Editors, Carnitine Today, Landes Bioscience and Chapman & Hall, New York 1977; 120-61.
24. Foster DW. The role of the carnitine system in human metabolism. Ann NY Acad Sci 2004; 1033:1-16.
25. Abd-Allah AR, Al-Majed AA, Al-Yahya AA, Fouda SI, Al-Shabana OA. L-Carnitine halts apoptosis and myelosuppression induced by carboplatin in rat bone marrow cell cultures (BMC). Arch Toxicol 2005; 79:406-13.
26. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of l-carnitine and acetyl-l-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann NY Acad Sci 2004; 1033:117-31.
27. Buyse J, Swennen Q, Niewold TA, Klasing KC, Janssens GPJ, Baumgartner M, et al. Dietary l-carnitine supplementation enhances the lipopolysaccharide- induced acute phase protein response in broiler chickens. Veterinary Immunol Immunopathol 2007; 118:154-9.
28. Li K, Li W, Huang YF, Shang XJ. Level of free L-carnitine in human seminal plasma and its correlation with semen quality. Zhonghua Nan Ke Xue 2007; 13:143-6.
29. De Rosa M, Boggia B, Amalfi B, Zarrilli S, Vita A, Colao A, Lombardi G. Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins. Drugs R D 2005; 6:1-9.
30. Aslesci S, De Martino MU, Kino T, Ilias I. L-Carnitine is a modulator of the glucocor-ticoid receptor alpha. Ann N Acad Sci 2004; 1024:147-52.
31. Manoli L, De Martino MU, Kino T, Alesci S. Modulatory effects of L-carnitine on glucocorticoid receptor activity. Ann NY Acad Sci 2004; 1033:147-57.
32. Schulz M, Eggert M. Novel ligands: fine tuning the transcriptional activity of the gluco-corticoid receptor. Curr Pharm Des 2004; 10:2817-26.
33. Tulassay Z, Viczián M, Böjthe L, Czeizel A. Quantitative histological studies on the injury of spermatogenesis induced by endotoxin in rats. J Reprod Fertil 1970; 22:161-4.
34. Okuda Y, Bardin CW, Hodgskin LR, Morris PL. Interleukins-1 and -1β regulate interleu-kin-6 expression in Leydig and Sertoli cells. Recent Prog Horm Res 1995; 50:367-72.
35. Feldmann M, Saklatvala J. Proinflammatory cytokines. In: Oppenheim JJ & Feldman M, eds. Cytokine Reference. New York: Academic Press 2001; 291-305.
36. Keck C, Gerber-Schafer C, Clad A, Wilhelm C, Breckwoldt M. Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 1998; 4:891-903.
37. Potts JM, Sharma R, Pasqualotto F, Nelson D, Hall G, Agarwal A. Association of ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol 2000; 163:1775-8.
38. Leclerc E, de Lamirande E, Gagnon C. Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives. Free Radic Biol Med 1997; 22:643-56.
39. Aitken RJ. The Amoroso Lecture. The human spermatozoon-a cell in crisis? J Reprod Fertil 1999; 115:1-7.
40. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12.
41. Shimoya K, Matsuzaki N, Tsutsui T, Taniguchi T, Saji F, Tanizawa O. Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia. Fertil Steril 1993; 59:885-8.
42. Buch JP, Kolon TF, Maulik N, Kreutzer DL, Das DK. Cytokines stimulate lipid mem-brane peroxidation of human sperm. Fertil Steril 1994; 62:186-8.
43. Fraczek M, Kurpisz M. Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl 2007; 28:325-33.
44. Mahfouz RZ, du Plessis SS, Aziz N, Sharma R, Sabanegh E, Agarwal A. Sperm viability, apoptosis and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress. Fertil Steril 2008; PMID:19100530.
45. Fatma BA, Nozha CF, Ines D, Hamadi A, Basma H, Leila AK. Sperm quality improve-ment after date seed oil in vitro supplementation in spontaneous and induced oxidative stress. Asian J Androl 2009; PMID:19151733.
46. Tremellen K. Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update 2008; 14:243-58.
47. Gu Y, Davis DR, Lin YC. Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats. Arch Androl 1989; 22:131-6.
48. Verma PK, Singh JN, Quadros M. LDH-X in azospermia: a new diagnostic alternative to vasography and testicular biopsy. Indian J Med 1993; 97:204-7.
49. Kumar R, Gautam G, Gupta NP. Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol 2006; 176:1307-12.
50. Famularo G, De Simone C, Trinchieri V, Mosca L. Carnitine and its congeners. A meta-bolic pathway to the regulation of immune response and inflammation. Ann NY Acad Sci 2004; 1033:1-7.
51. Simone C, Tsantzoglou S, Famularo G, Moretti S, Paoletti F, Vullo V, Delia S. High dose l-carnitine improves immunologic and metabolic parameters in AIDS patients. Immunopharmacol Immunotoxicol 1993; 15:1-12.
52. Cavallini G, Modenini F, Vitali G, Koverech A. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. Urology 2005; 66:1080-5.
53. Mast J, Buyse J, Goddeeris BM. Dietary l-carnitine supplementation increases antigen-specific immunoglobulin G production in broiler chickens. Br J Nutr 2000; 83:161-6.
54. Janssens GPJ, Mast J, Goddeeris BM, Cox E, Hesta M, De Wilde ROM. Enhanced specific antibody response to bovine serum albumin in pigeons due to l-carnitine supple-mentation. Br Poult Sci 2000; 41:448-53.
55. Deng K, Wong CW, Nolan JV. Long-term effects of early-life dietary l-carnitine on lymphoid organs and immune responses in Leghorn-type chickens. J Anim Physiol Anim Nutr 2006; 90:81-6.
56. Athanassakis I, Mouratidou M, Sakka P, Evangeliou A, Spilioti M, Vassiliadis S. L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment. Int Immunopharmacol 2001; 1:1813-22.
57. Vicari E. Effectiveness and limits of antimicrobial treatment on seminal leukocyte con-centration and related reactive oxygen species production in patients with male accessory gland infection. Hum Reprod 2000; 15:2536-44.
58. Abd-Allah AR. L-carnitine ameliorates immunological-induced hepatitis in rats. Saudi Pharmaceutical Journal 2006; 14:59-68.
59. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82:70-7.
60. Uchiyama M, Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86:271-8.
61. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001; 5:62-7.
62. Racevskis J. Molecular diagnosis of cancer: Methods and Protocols; second edition. Med Oncol 2005; 22:325-6.