Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice

American Journal of Reproductive Immunology

Volumn 59, Issue 1, 2008, Pages 55-61

  Naito, Munekazu ^a   Itoh, Masahiro ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Blood testis barrier; Epididymis; Histology; Lymphocyte; Macrophage; Sperm; Testis

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANTIGEN PRESENTING CELL; BLOOD TESTIS BARRIER; EPIDIDYMIS; EPIDIDYMITIS; EXPERIMENTAL MOUSE; HISTOPATHOLOGY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; NONHUMAN; ORCHITIS; PRIORITY JOURNAL; RETE TESTIS; REVIEW; SEMINIFEROUS TUBULE; SPERMATID; T LYMPHOCYTE;

ANIMALS; AUTOIMMUNITY; BLOOD-TESTIS BARRIER; EPIDIDYMIS; LYMPHOCYTES; MALE; MICE; ORCHITIS; SPERMATIDS; TESTIS;

EID: 37349057435     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00556.x     Document Type: Review

References (37)

1. Johnson MH: An immunological barrier in the guinea-pig testis. J Pathol 1970; 101: 129-139.
2. Tung KS, Unanue ER, Dixon FJ: Pathogenesis of experimental allergic orchitis. II. The role of antibody. J Immunol 1971; 106: 1463-1472.
3. Itoh M, Ueno M, Li XQ, Satriotomo I, Takeuchi Y: Topographical uptake of blood-borne horseradish peroxidase (HRP) in the murine testis at the light microscopic level. Int J Androl 1998; 21: 74-80.
4. Taguchi O, Nishizuka Y: Experimental autoimmune orchitis after neonatal thymectomy in the mouse. Clin Exp Immunol 1981; 46: 425-434.
5. Tung KS, Smith S, Teuscher C, Cook C, Anderson RE: Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology. Am J Pathol 1987; 126: 293-302.
6. Taguchi O, Nishizuka Y: Autoimmune oophoritis in thymectomized mice: T cell requirement in adoptive cell transfer. Clin Exp Immunol 1980; 42: 324-331.
7. Taguchi O, Kojima A, Nishizuka Y: Experimental autoimmune prostatitis after neonatal thymectomy in the mouse. Clin Exp Immunol 1985; 60: 123-129.
8. Itoh M, Chen XH, Takeuchi Y, Miki T: Morphological demonstration of the immune privilege in the testis using adjuvants: Tissue responses of male reproductive organs in mice injected with Bordetella pertussigens. Arch Histol Cytol 1995; 58: 575-579.
9. Itoh M, Xie Q, Miyamoto K, Takeuchi Y: Major differences between the testis and epididymis in the induction of granulomas in response to extravasated germ cells. I. A light microscopical study in mice. Int J Androl 1999; 22: 316-323.
10. Itoh M, Miyamoto K, Ohga T, Iwahashi K, Takeuchi Y: Spontaneous accumulation of eosinophils and macrophages throughout the stroma of the epididymis and vas deferens in alymphoplasia (aly) mutant mice. I. A histological study. Am J Reprod Immunol 1999; 42: 246-253.
11. Itoh M, Miyamoto K, Ohga T, Takeuchi Y: Spontaneous occurrence of vasculitis-like lesions on male reproductive tissues in mice: A histological study. Arch Androl 1999; 42: 151-159.
12. Sato K, Hirokawa K, Hatakeyama S: Experimental allergic orchitis in mice. Histopahtological and immunological studies. Virchows Arch Pathol Anat 1981; 392: 147-158.
13. Kohno S, Munoz JA, Williams TM, Teuscher C, Bernard CC, Tung KS: Immunopathology of murine experimental allergic orchitis. J Immunol 1983; 130: 2675-2682.
14. Tung KS, Unanue ER, Dixon FJ: The immunopathology of experimental allergic orchitis. Am J Pathol 1970; 60: 313-328.
15. Hojo K, Hiramine C: Suppression of experimental allergic orchitis and cellular immune response in the guinea pig by pretreatment with testis antigen in incomplete Freund's adjuvant. Int Arch Allergy Appl Immunol 1982; 69: 40-49.
16. Wilson JT, Jones NA, Katsh S: Penetration of the testicular-tubular barrier by horseradish peroxidase induced by adjuvant. Anat Rec 1973; 176: 85-100.
17. Pelletier RM, Nemirovsky MS, Calvert R, Hugon JS: Effects of immunization with Freund's complete adjuvant and isologous spermatozoa on the seminiferous epithelium and blood-testis barrier in guinea pigs. Anat Rec 1981; 199: 197-211.
18. Tung PS, Fritz IR: Histopathological changes in testes of adult inbred rats immunized against pachytene spermatocytes or Sertoli cells. Int J Androl 1987; 2: 459-481.
19. Lustig L, Satz ML, Stzein MB: Antigens of the basement membrane of the seminiferous tubules induce autoimmunity in Wister rats. J Reprod Immunol 1982; 4: 79-90.
20. Ichisohasama R, Hirokawa K, Hatakeyama S: Spermatogenic disturbance induced in mice by combined local injection of monoclonal antibodies to Sertoli cell and to basal lamina of seminiferous tubule. Am J Reprod Immunol 1986; 10: 158-165.
21. Yule TD, Montoya GD, Russell LD, Williams TM, Tung KS: Autoantigenic germ cells exist outside the blood-testis barrier. J Immunol 1988; 141: 1161-1167.
22. Itoh M, Hiramine C, Hojo K: A new murine model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone. I. Immunological and histological studies. Clin Exp Immunol 1991; 83: 137-142.
23. Tokunaga Y, Terayama H, Naito M, Qu N, Hirai S, Ogawa Y, Yi SQ, Itoh M: Splenic cytokines in mice immunized with testicular germ cells. Int J Androl 2007. [Epub ahead of print].
24. Itoh M, Hiramine C, Tokunaga Y, Mukasa A, Hojo K: A new murine model of autoimmune orchitis induced by immunizaiton with viable syngeneic testicular germ cells alone. II. Immunohistological findings of fully-developed lesion. Autoimmunity 1991; 10: 89-97.
25. Itoh M, Miyake M, Miki T, Takeuchi Y, De-Rooij DG: Immunohistological localization of autoantigens detected by serum autoantibodies from mice with experimental autoimmune orchitis without using adjuvants. Arch Androl 1994; 32: 45-52.
26. Tung KS, Yule TD, Mahi-Brown CA, Listrom MB: Distribution of histopathology and Ia positive cells in actively induced and passively transferred experimental autoimmune orchitis. J Immunol 1987; 138: 752-759.
27. Itoh M, De-Rooij DG, Takeuchi Y: Mode of inflammatory cell infiltration in testes of mice injected with syngeneic testicular germ cells without adjuvant. J Anat 1995; 187: 671-679.
28. Itoh M, Moriyama H, Yano A, Li XQ, Takeuchi Y: Mode of migration of normal lymphocytes inside murine testis. Anat Rec 1998; 251: 152-160.
29. Takahashi K, Naito M, Terayama H, Qu N, Cheng L, Tainosho S, Itoh M: Immunomorphological aspects of the tubuli recti and the surrounding interstitium in normal mice. Int J Androl 2007; 30: 21-27.
30. Mahi-Brown CA, Yule TD, Tung KS: Adoptive transfer of murine autoimmune orchitis to naive recipients with immune lymphocytes. Cell Immunol 1987; 106: 408-419.
31. Itoh M, Mukasa A, Tokunaga Y, Hiramine C, Hojo K: New experimental model for adoptive transfer of murine autoimmune orchitis. Andrologia 1991; 23: 415-420.
32. Itoh M, Hiramine C, Mukasa A, Tokunaga Y, Fukui Y, Takeuchi Y, Hojo K: Establishment of an experimental model of autoimmune epididymo-orchitis mediated by T cell line in mice. Int J Androl 1992; 15: 170-181.
33. Hiramine C, Hojo K: Requirement of B lymphocytes in local adoptive transfer of experimental allergic orchitis (EAO) by lymph node cells. Am J Reprod Immunol 1984; 6: 85-91.
34. Itoh M, Xie Q, Miyamoto K, Takeuchi Y: F4/80-positive cells rapidly accumulate around tubuli recti and rete testis between 3 and 4 weeks of age in the mouse. An immunohistochemical study. Am J Reprod Immunol 1999; 42: 321-326.
35. Soramoto S, Hiramine C, Takenaka I, Hojo K: Murine experimental autoimmune orchitis (EAO) induced by syngeneic testicular germ cells (TC) alone: Orchitogenic and lymphostimulatory activities of TC from mice at various ages. Clin Immunol Immunopathol 1993; 69: 292-299.
36. Tokuda N, Kasahara M, Levy RB: Differential regulation and expression of major histocompatibility complex (MHC) and Ly-6 gene products on mouse testicular Leydig and Sertoli cell lines. J Autoimmun 1990; 3: 457-471.
37. Housseau F, Rouas-Freiss N, Roy M, Bidart JM, Guillet JG, Bellet D: Antigen-presenting function of murine gonadal epithelial cell lines. Cell Immunol 1997; 177: 93-101.