The Amoroso Lecture: The human spermatozoon - A cell in crisis?

Journal of Reproduction and Fertility

Volumn 115, Issue 1, 1999, Pages 1-7

  Aitken, R John ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; FREE RADICAL; REACTIVE OXYGEN METABOLITE;

CHILDHOOD CANCER; DNA DAMAGE; GENE MUTATION; GERM CELL; GERM LINE; HUMAN; LEUKOCYTE; MALE; MALE GENITAL SYSTEM; MALE INFERTILITY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; REVIEW; SPERM; SPERMATOZOON; SPERMATOZOON CAPACITATION; TESTIS CANCER;

EID: 0033046440     PISSN: 00224251     EISSN: None     Source Type: Journal    
DOI: 10.1530/jrf.0.1150001     Document Type: Review

References (49)

1. Adami HO, Bergstrom R, Mohner M et al. (1994) Testicular cancer in nine Northern European countries International Journal of Cancer 59 33-38
2. Agulnik AI, Bishop CE, Lemer JL, Agulnik SI and Solovyev VV (1997) Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven Mammalian Genome 8 134-138
3. Aitken RJ (1997) Leukocytospermia, oxidative stress and sperm function. In Male Infertility and Dysfunction pp 100-109 Ed. WJG Hellstrom. Springer-Verlag, New York
4. Aitken RJ and Fisher H (1994) Reactive oxygen species generation and human spermatozoa: the balance of benefit and risk Bioessays 16 259-267
5. Aitken RJ and Clarkson JS (1987) Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa Journal of Reproduction and Fertility 81 459-469
6. Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS and Wu FCW (1989) Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia Journal of Andrology 10 214-220
7. Aitken RJ, Buckingham D, West K, Wu FC, Zikopoulos K and Richardson DW (1992) Differential contribution of leucocytes and spermatozoa to the high levels of reactive oxygen species recorded in the ejaculates of oligozoospermic patients Journal of Reproduction and Fertility 94 451-462
8. Aitken RJ, West K and Buckingham D (1994) Leukocyte infiltration into the human ejaculate and its association with semen quality, oxidative stress and sperm function Journal of Andrology 15 343-352
9. Aitken RJ, Buckingham D, Brindle J, Gomez E, Baker G and Irvine S (1995a) Analysis of sperm movement in relation to the oxidative stress created by leucocytes in washed sperm preparations and seminal plasma Human Reproduction 10 2061-2071
10. Aitken RJ, Paterson M, Fisher H, Buckingham DW and van Duin M (1995b) Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function Journal of Cell Science 108 2017-2025
11. Aitken RJ, Buckingham W, West K and Brindle J (1996) On the use of paramagnetic beads and ferrofluids to assess and eliminate the leukocytic contribution to oxygen radical generation by human sperm suspensions American Journal of Reproductive Immunology 35 541-551
12. Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B and Irvine DS (1997) Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine Molecular Reproduction and Development 47 468-482
13. Aitken RJ, Harkiss D, Knox W, Paterson M and Irvine DS (1998a) A novel signal transduction cascade in capacitating human spermatozoa characterized by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation Journal of Cell Science 111 645-656
14. Aitken RJ, Gordon E, Harkiss D, Twigg JP, Milne P, Jennings Z and Irvine DS (1998b) On the relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa Biology of Reproduction 59 1037-1046
15. Auger J, Kunstmann JM, Czyglik F and Jouannet P (1995) Decline in semen quality among fertile men in Paris during the past 20 years New England Journal of Medicine 281-285
16. Baker HWG, Brindle J, Irvine DS and Aitken RJ (1996) Protective effect of antioxidants on the impairment of sperm motility by activated polymorphonuclear leukocytes Fertility and Sterility 65 411-419
17. Bize I, Santander G, Cabello P, Driscoll D and Sharpe C (1991) Hydrogen peroxide is involved in hamster sperm capacitation in vitro. Biology of Reproduction 44 389-403
18. Carlsen E, Giwereman A, Keiding N and Skakkebaek NE (1992) Evidence for decreasing quality of semen during the past 50 years British Medical Journal 305 609-613
19. Fisher HM and Aitken RJ (1997) Comparative analysis of the ability of precursor germ cells and epididymal spermatozoa to generate reactive oxygen metabolites Journal of Experimental Zoology 277 390-400
20. Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM and Ames BN (1996) Smoking and low antioxidant levels increase oxidative damage to sperm DNA Mutation Research 351 199-203
21. Godeas C, Tramer F, Micali F, Soranzo M, Sandri G and Panfili E (1997) Distribution and possible novel role of phospholipid hydroperoxide glutathione peroxidase in rat epididymal spermatozoa Biology of Reproduction 57 1502-1508
22. Gomez E and Aitken RJ (1996) Impact of IVF-ET culture media on peroxidative damage to human spermatozoa Fertility and Sterility 65 880-882
23. Gomez E, Buckingham DW, Brindle J, Lanzafame F, Irvine DS and Aitken RJ (1996) Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: correlation with biochemical markers of the cytoplasmic space, oxidative stress and sperm function Journal of Andrology 17 276-287
24. Gomez E, Irvine DS and Aitken RJ (1998) Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function International Journal of Andrology 21 81-94
25. Hull MGR, Glazener CMA, Kelly NJ et al. (1985) Population study of causes, treatment and outcome of infertility British Medical Journal 291 1693-1697
26. Huszar G, Sbracia M, Vigue L, Miller DJ and Shur BD (1997) Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane beta 1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios Biology of Reproduction 56 1020-1024
27. Irvine DS, Cawood E, Richardson D, MacDonald E and Aitken RJ (1996) Evidence of deteriorating semen quality in the United Kingdom: birth cohort study of 577 men in Scotland over 11 years British Medical Journal 312 467-471
28. Irvine DS, Twigg J, Gordon E, Fulton N, Milne P and Aitken RJ DNA integrity in human spermatozoa: relationship with semen quality Journal of Andrology (in press)
29. Ji BT, Shu XO, Linet MS, Zheng W, Wacholder S, Gao YT, Ying DM and Jin F (1997) Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers Journal of the National Cancer Institute 89 238-244
30. Jones R, Mann T and Sherins RJ (1979) Peroxidative breakdown of phospholipids in human spermatozoa: spermicidal effects of fatty acid peroxides and protective action of seminal plasma Fertility and Sterility 31 531-537
31. Kodoma H, Yamaguchi R, Fukuda J, Kasai H and Tanaka T (1997) Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients Fertility and Sterility 68 519-524
32. Krausz C, Mills C, Rogers S, Tan SL and Aitken RJ (1994) Stimulation of oxidant generation by human sperm suspensions using phorbol esters and formyl peptides: relationship with motility and fertilization in vitro. Fertility and Sterility 62 599-605
33. Liang F, Han M, Romanienko PJ and Jasin M (1998) Homology-directed repair is a major double strand break repair pathway in mammalian cells Proceedings National Academy of Science USA 95 5172-5177
34. Multigner L and Spira A (1997) The epidemiology of male reproduction. In Genetics of Human Male Fertility pp 43-65 Eds C Barratt, C de Jong, D Mortimer and J Parinaud. EDK Press, Paris
35. Ni Z-Y, Liu Y-Q, Shen H-M, Chia SE and Ong CN (1997) Does the increase of 8-hydroxyguanosine lead to poor sperm quality? Mutation Research 381 77-82
36. Pajarinen J, Laippala P, Pentilla A and Kahrunen P (1997) Incidence of disorders of spermatogenesis in middle aged Finnish men, 1981-91: two necropsy series British Medical Journal 314 13-18
37. Richer S, Whittington K and Ford WCL (1998) Confirmation of NADPH oxidase activity in human sperm Journal of Reproduction and Fertility Abstract Series 21 Abstract 118
38. Roberts KP (1998) Y chromosome deletions and male infertility: state of the art and clinical implications Journal of Andrology 19 255-259
39. Sharma RK and Agarwal A (1996) Role of reactive oxygen species in male infertility Urology 48 835-850
40. Sorahan T, Lancashire RJ, Hulten MA, Peck I and Stewart AM (1997) Childhood cancer and parental use of tobacco: deaths from 1953 to 1955 British Journal of Cancer 75 134-138
41. Sukcharoen N, Keith J, Irvine DS and Aitken RJ (1995) Predicting the fertilizing potential of human sperm suspensions in vitro: importance of sperm morphology and leukocyte contamination Fertility and Sterility 63 1293-1300
42. Sun JG, Jurisicova A and Casper RF (1997) Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biology of Reproduction 56 602-607
43. Swan SH, Elkin EP and Fenster L (1997) Have sperm densities declined? A reanalysis of global trend data Environmental Health Perspectives 105 1228-1232
44. Tomlinson MJ, Barratt CLR and Cooke ID (1993) Prospective study of leukocytes and leukocyte subpopulations in semen suggests that they are not a cause of male infertility Fertility and Sterility 60 1069-1075
45. Twigg JP, Irvine DS and Aitken RJ (1998) Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at ICSI Human Reproduction 13 1864-1871
46. Yogt PH, Edelmann A, Kirsch S et al. (1996) Human Y chromosome azoospermia factors (AZF) mapped to different subregions of Yq11 Human Molecular Genetics 5 933-943
47. Zhang H and Zheng R-L (1996) Promotion of human sperm capacitation by superoxide anion Free Radical Research 24 261-268
48. Zhu X, Dunn JM, Goddarde AD, Squire JA, Becker A, Phillips RA and Gallie BL (1992) Mechanisms of loss of heterozygosity in retinoblastoma Cytogenetics and Cell Genetics 59 248-252
49. Zini A, de Lamirande E and Gagnon C (1993) Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa International Journal of Andrology 16 183-188