Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages

Environmental Toxicology and Pharmacology

Volumn 30, Issue 1, 2010, Pages 68-75

  Himaya, S W A ^a   Ryu, BoMi ^a   Qian, Zhong Ji ^a   Kim, Se Kwon ^a  

^a Pukyong National University   (South Korea)

Author keywords

COX 2; Cytokine; Inflammation; INOS; MAPK; Sea cucumber

Indexed keywords

ACETIC ACID ETHYL ESTER; BUTANOL; CHLOROFORM; CYCLOOXYGENASE 2; CYTOKINE; HEXANE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FUNCTIONAL FOOD; GENE EXPRESSION REGULATION; IN VITRO STUDY; INHIBITION KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STICHOPUS; STICHOPUS JAPONICUS; TRANSCRIPTION REGULATION;

HOLOTHUROIDEA; MURINAE; STICHOPUS JAPONICUS;

EID: 77953362677     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.03.019     Document Type: Article

References (34)

1. Boscóa L., Zeini M., Travóes P.G., Hortelano S. Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate. Toxicology 2005, 208:249-258.
2. Cario E., Rosenberg I.M., Brandwein S.L., Beck P.L., Reinecker H.C., Podolsky D.K. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J. Immunol. 2000, 164:966-972.
3. Chen C.W., Lee S.T., Wu W.T., Fu W.M., Ho F.M., Lin W.W. Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages. Br. J. Pharmacol. 2003, 1406:1077-1087.
4. Coker R.K., Laurent G.J. Pulmonary fibrosis: cytokine in the balance. Eur. Respir. J. 1998, 11:1218-1221.
5. Crespo A., Filla M.B., Russell S.W., Murphy W.J. Indirect induction of suppressor of cytokine signaling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon α/β. Biochem. J. 2000, 349:99-104.
6. Cui F.X., Xue C.H., Li Z.J., Zhang Y.Q., Dong P., Fu X.Y., Gao X. Characterization and subunit composition of collagen from the body wall of sea cucumber Stichopus japonicus. Food Chem. 2007, 100:1120-1125.
7. Dang N.H., Thanh N.V., Kiem P.V., Huong L.M., Minh C.V., Kim Y.H. Two new triterpene glycosides from the Vietnamese sea cucumber Holothuria scabra. Arch. Pharm. Res. 2007, 30:1387-1391.
8. De Moncerrat Iiguez-Martinez A.M., Guerra-Rivas G., Rios T., Quijano L. Triterpenoid oligoglycosides from the sea cucumber Stichopus parvimensis. J. Nat. Prod. 2005, 68:1669-1673.
9. Deepa N., Kaura C., George B., Singh B., Kapoor H. Antioxidant constituents in some sweet pepper (Capsicum annuum L.) genotypes during maturity. LWT: Food Sci. Technol. 2007, 40:121-129.
10. Fredalina B.D., Ridzwan B.H., Zainal Abidin A.A., Kaswandi M.A., Zaiton H., Zali I., Kittakoop P., Mat Jais A.M. Fatty acid composition in local sea cucumber Stichopus chloronotus, for wound healing. Gen. Pharmacol. 1999, 33:337-340.
11. Fujiwara N., Kobayashi K. Macrophages in inflammation. Curr. Drug Targets - Inflamm. Allergy 2005, 4:281-286.
12. Han H., Yi Y.H., Liu B.S., Wang X.H., Pan M.X. Leucospilotaside C, a new sulfated triterpene glycoside from sea cucumber Holothuria leucospilota. Chin. Chem. Lett. 2008, 19:1462-1464.
13. Hanada T., Yoshimura A. Survey, regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev. 2002, 13:413-421.
14. Hankenson K.D., Watkins B.A., Schoenlein I.A., Allen K.G., Turek J.J. Omega-3 fatty acids enhanced ligament fibrablast collagen formation in association with changes in interleukin-6 production. Proc. Soc. Exp. Biol. Med. 2000, 223:88-95.
15. Hansen M.B., Nielson S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods. 1989, 119:203-210.
16. Jongeneel C.V. Transcriptional regulation of the tumor necrosis factor α gene. Immunobiology 1995, 193:210-216.
17. Jung H.W., Seo U.K., Kim J.H., Leem K.H., Park Y.K. Flower extract of Panax notoginseng attenuates lipopolysaccharide induced inflammatory response via blocking of NF-κB signaling pathway in murine macrophages. J. Ethnopharmacol. 2009, 122:313-319.
18. Jung H.W., Yoon C.H., Park K.M., Han H.S., Park Y.K. Hexane fraction of Zingiberis Rhizoma crudus extract inhibits the production of nitric oxide and pro-inflammatory cytokines in LPS stimulated BV2 microgilial cells via the NF-kappaB pathway. Food Chem. Toxicol. 2009, 47:1190-1197.
19. Jung W.K., Choi I., Lee D.Y., Yea S.S., Choi Y.H., Kim M.M., Park S.G., Seo S.K., Lee S.W., Lee C.M., Park Y.M., Choi I.W. Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-κB pathways. Int. J. Biochem. Cell Biol. 2008, 40:2572-2582.
20. Kaur G., Alam M.S., Jabbar Z., Javed K., Athar M. Evaluation of antioxidant activity of Cassia siamea flowers. J. Ethnopharmacol. 2006, 108:340-348.
21. Lawrence T., Willoughby D.A., Gilroy D.W. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat. Rev. Immunol. 2002, 2:787-795.
22. Mamelona J., Pelletier Eó., Girard-Lalancette K., Legault J., Karboune S., Kermasha S. Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber Cucumaria frondosa. Food Chem. 2007, 104:1040-1047.
23. Moncada S. Nitric oxide: discovery and impact on clinical medicine. J. R. Soc. Med. 1999, 92:164-169.
24. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992, 6:3051-3064.
25. Ock J., Kim S., Suk K. Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol. Res. 2009, 59:414-422.
26. Qian Z.J., Ryu B.M., Kim M.M., Kim S.K. Free radical and reactive oxygen species scavenging activities of the extracts from seahorse Hippocampus kuda Bleeler. Biotechnol Bioprocess Eng. 2008, 13:705-715.
27. Rajapakse N., Kim M.M., Mendis E., Kim S.K. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolyssacharide stimulated raw cells by carboxybutyrylated glucosamine takes place via down regulation of mitogen-activated protein kinase mediated nuclear factor-κb signaling. Immunology 2008, 123:348-357.
28. Sebban H., Courtois G. NF-κB and inflammation in genetic disease. Biochem. Pharmacol. 2006, 7:1153-1160.
29. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001, 480-481:243-268.
30. Kulinsky V.I. Biochemical aspects of inflammation. Biochemistry (Moscow) 2007, 72:595-607.
31. Whitehouse M.W., Fairlie D.P. Anti-inflammatory activity of a holothurian (sea cucumber) food supplement in rats. Inflammopharmacology 1994, 2:411-417.
32. 2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways. Int. Immunopharmacol. 2008, 8:431-441.
33. Zhang S., Yi Y., Tang H., Li L., Sun P., Wu J. Two new bioactive triterpene glycosides from the sea cucumber Pseudocolochirus violaceus. J. Asian Nat. Prod. Res. 2006, 8:1-8.
34. Zhong Y., Khan A., Shahidi F. Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa). J. Agric. Food Chem. 2007, 55:1188-1192.