Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Krech, Till ^a,b   Thiede, Margarethe ^a   Hilgenberg, Ellen ^a   Schäfer, Reinhold ^a   Jürchott, Karsten ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE C; SH 5; SH 6; UNCLASSIFIED DRUG; 1 ((1 O OCTADECYL 2 O METHYLGLYCERO)PHOSPHO) 3 DEOXY MYO INOSITOL; 1-((1-O-OCTADECYL-2-O-METHYLGLYCERO)PHOSPHO)-3-DEOXY-MYO-INOSITOL; ANTINEOPLASTIC AGENT; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL; PROTEIN KINASE INHIBITOR; SH 6 COMPOUND; SH-6 COMPOUND;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CELL CYCLE; CELL SHAPE; CELL STRUCTURE; CELL VACUOLE; CELL VIABILITY; COLORECTAL CANCER; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOKINESIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MITOSIS; MITOSIS SPINDLE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BIOLOGY; CELL SEPARATION; CELL STRAIN HCT116; CELL STRAIN HT29; CELL SURVIVAL; COLORECTAL TUMOR; CONFOCAL MICROSCOPY; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MICROSCOPY; PATHOLOGY; PHOSPHORYLATION; TIME;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL SEPARATION; CELL SHAPE; CELL SURVIVAL; COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; CYTOKINESIS; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; INOSITOL PHOSPHATES; MICROSCOPY, CONFOCAL; MICROSCOPY, VIDEO; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 77953345321     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-287     Document Type: Article

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