Alginate-chitosan systems: In vitro controlled release of triamcinolone and in vivo gastrointestinal transit

Carbohydrate Polymers

Volumn 81, Issue 2, 2010, Pages 260-268

  Lucinda Silva, Ruth Meri ^a,b   Salgado, Hérida Regina Nunes ^b   Evangelista, Raul Cesar ^b  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Alginate; Chitosan; Colonic drug delivery; Gastrointestinal transit; Triamcinolone

Indexed keywords

COLONIC DELIVERY; COLONIC DRUG DELIVERY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; IN-VITRO; IN-VITRO ASSAYS; IN-VITRO TESTS; IN-VIVO; IN-VIVO ANALYSIS; LOW DEGREE; MORPHOLOGICAL CHARACTERISTIC; PARTICLE DIAMETERS; SWELLING DEGREE; THERAPEUTIC SYSTEMS; TRIAMCINOLONE;

ALGINATE; CHITOSAN; COAGULATION; DRUG DELIVERY; ENCAPSULATION; GELATION; SWELLING;

CHITIN;

RATTUS;

EID: 77953324222     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2010.02.016     Document Type: Article

References (29)

1. Antonin K.H., Rak R., Bieck P.R., Preiss R., Schenker U., Hastewell J., et al. The absorption of human calcitonin from the transverse colon of man. International Journal of Pharmaceutics 130 (1996) 33-39
2. Bajpai K.S., Saxena K.S., and Sharma S. Swelling behavior of barium ions crosslinked biopolymeric sodium alginate-carboxymethyl guar gum blend beads. Reactive and Functional Polymers 66 (2006) 659-666
3. Barber T.A. Particle population analysis. In: Barber T.A. (Ed). Pharmaceutical particulate matter analysis and control (1993), Interpharm Press Inc., Bufalo Grove 266-349
4. Colombo P., Bettini R., Santi P., and Peppas N.A. Swellable matrices for controlled drug delivery: Gel-layer behaviour, mechanisms and optimal performance. PSTT 3 (2000) 198-204
5. Corá L.A., Romeiro F.G., Stelzer M., Américo M.F., Oliveira R.B., Baffa O., et al. AC biosusceptometry in the study of drug delivery. Advanced Drug Delivery Reviews 57 (2005) 1223-1241
6. Costa P., and Lobo J.M.S. Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences 13 (2001) 123-133
7. Dentini M., Rinaldi G., Barbetta A., Risica D., Anselmi C., and Skjak-Braek G. Ionic gel formation of a (pseudo)alginate characterised by an alternating MG sequence produced by epimerising mannuronan with AlgE4. Carbohydrate Polymers 67 (2007) 465-473
8. Ferreiro M.G., Tillman L., Hardee G., and Bodmeier R. Characterization of alginate/poly-l-lysine particles as antisense oligonucleotide carriers. International Journal of Pharmaceutics 239 (2002) 47-59
9. Friend D.R., and Sellin J. Drug delivery in advancing the treatment of inflammatory bowel disease. Advanced Drug Delivery Reviews 57 (2005) 215-216
10. Gåserød O., Smidsrød O., and Skjåk-bræk G. Microcapsules of alginate-chitosan. I. A quantitative study of the interaction between alginate and chitosan. Biomaterials 19 (1998) 1815-1825
11. George M., and Abraham E.T. Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan-a review. Journal of Controlled Release 114 (2006) 1-14
12. Kim W.-T., Chung H., Shin I.I.-S., Yam K.L., and Chung D. Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping allyl isothiocyanate. Carbohydrate Polymers 71 (2008) 566-573
13. ® E as coating material for the pH-controlled drug release in the topical treatment of inflammatory bowel disease (IBD). Journal of Drug Targeting 6 (1998) 85-94
14. López M.E.V., Reyes L.N., Igea S.A., Espinar F.J.O., and Méndez J.B. Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting. International Journal of Pharmaceutics 179 (1999) 229-235
15. Lucinda-Silva R.M., and Evangelista R.C. Microspheres of alginate-chitosan containing isoniazid. Journal of Microencapsulation 20 (2003) 145-152
16. Lucinda-Silva R.M., and Evangelista R.C. Studies on the formation of complex coacervates between chitosan and alginate during microparticles preparation. Acta Farmaceutica Bonaerense 24 (2005) 366-370
17. Lucinda-Silva R.M., Monteiro K.C.M., Carvalho L.Q., and Evangelista R.C. Multiparticulate systems of pectin-chitosan: Study of swelling and drug release. Acta Farmaceutica Bonaerense 25 (2006) 538-543
18. Prashanth K.V.H., and Tharanathan R.N. Chitin/chitosan: Modifications and their unlimited application potential an overview. Trends in Food Science & Technology 18 (2007) 117-131
19. Rijnierse A., Nijkamp F.P., and Kraneveld A.D. Mast cells and nerves tickle in the tummy implications for inflammatory bowel disease and irritable bowel syndrome. Pharmacology & Therapeutics 116 (2007) 207-235
20. Sinha V.R., and Kumria R. Polysaccharides in colon-specific drug delivery. International Journal of Pharmaceutics 224 (2001) 19-38
21. Sinha V.R., Mittal B.R., Bhutani K.K., and Kumria R. Colonic drug delivery of 5-fluorouracil: An in vitro evaluation. International Journal of Pharmaceutics 269 (2004) 101-108
22. Sriamornsak P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. European Journal of Pharmaceutical Sciences 8 (1999) 221-227
23. Vandamme Th.F., Lenourry A., Charrueau C., and Chaumeil J.-C. The use of polysaccharides to target drugs to the colon. Carbohydrate Polymers 48 (2002) 219-231
24. Wakerly Z., Fell J.T., Attwood D., and Parkins D. Studies on amidated pectins as potential carriers in colonic drug delivery. Journal of Pharmacy and Pharmacology 49 (1997) 622-625
25. Wittaya-Areekul S., Kruenate J., and Prahsarn C. Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. International Journal of Pharmaceutics 312 (2006) 113-118
26. Yamamoto A., Tozaki H., Okada N., and Fujita T. Colon-specific delivery of peptide drugs and anti-inflammatory drugs using chitosan capsules. S.T.P. Pharmaceutical Sciences 10 (2000) 23-34
27. Yang L. Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora. Journal of Controlled Release 125 (2008) 77-86
28. Zhang H., Alsarra A.I., and Neau H.S. An in vitro evaluation of a chitosan containing multiparticulate system for macromolecule delivery to the colon. International Journal of Pharmaceutics 239 (2002) 197-205
29. Zheng Y., Qiu Y., Fu Lu M.-Y., Hoffman D., and Reiland T.L. Permeability and absorption of leuprolide from various intestinal regions in rabbits and rats. International Journal of Pharmaceutics 185 (1999) 83-92