Eudragit® E as coating material for the pH-controlled drug release in the topical treatment of inflammatory bowel disease (IBD)

Journal of Drug Targeting

Volumn 6, Issue 2, 1998, Pages 85-94

  Leopold, Claudia S ^a   Eikeler, Dorothee ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Colon specific drug delivery; Inflammatory bowel disease; Lag time; pH controlled drug release

Indexed keywords

CARBOMER; DEXAMETHASONE; EUDRAGIT; POLYMER;

ARTICLE; COLON; DISSOLUTION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENTERIC COATED TABLET; ENTERITIS; PH; PRIORITY JOURNAL; THICKNESS; TOPICAL DRUG ADMINISTRATION; ULCERATIVE COLITIS; CHEMISTRY; DELAYED RELEASE FORMULATION; HUMAN; METHODOLOGY; SOLUBILITY;

ADMINISTRATION, TOPICAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATORY BOWEL DISEASES; POLYMERS; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 0032217166     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808997884     Document Type: Article

References (13)

1. Ashford, M., Fell, J.T., Attwood, D. and Woodhead, P.J. (1992) Colonic drug delivery via the use of pH-dependent polymers, an in vitro investigation. 6th Congr. Int. Technol. Pharm., Vol. 2, pp. 59-65.
2. Ashford, M., Fell, J.T., Attwood, D., Sharma, H. and Woodhead, P.J. (1993a) An in vivo investigation into the suitability of pH-dependent polymers for colonic targeting. Int. J. Pharm., 95, 193-199.
3. Ashford, M., Fell, J.T., Attwood, D. and Woodhead, P.J. (1993b) An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting. Int. J. Pharm., 91, 241-145.
4. Evans, D.F., Pye, G., Bramley, R., Clark, A.G., Dyson, T.J. and Hardcastle, J.D. (1988) Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut, 29, 1035-1041.
5. Fallingborg, J., Christensen, L.A., Jacobsen, B.A. and Rasmussen, S.N. (1993) Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig. Dis. Sci., 38, 1989-1993.
6. Hutton, D.A., Pearson, J.P., Allen, A. and Foster, S.N.E. (1990) Mucolysis of the colonic mucus barrier by faecal proteinases: Inhibition by interacting polyacrylate. Clin. Sci., 78, 265-271.
7. Ishibashi, T., Hatano, H., Matukawa, Y., Mizobe, M., Kobayashi, M. and Yoshino, H. (1996) Design and evaluation of a new capsule-type dosage form for colon-targeted delivery of drugs. Proc. Int. Symp. Controlled Release Bioact. Mater., 23, 549-550.
8. Raimundo, A.H., Evans, D.F., Rogers, J., Jameson, J. and Silk, D.B.A. (1992) Intestinal pH in ulcerative colitis: Acute (untreated) and in remission on 5 amino salicylic acid (5-ASA) therapy. Gut, 33, S63-S63.
9. Rankin, B.J., Srivastava, E.D., Record, C.O., Pearson, J.P. and Allen, A. (1995) Patients with ulcerative colitis have reduced mucin polymer content in the adherent colonic mucus gel. Biochem. Soc. Trans., 23, S104-S104.
10. Roediger, W., Lawson, M.J., Kwok, V., Grant, A.K. and Pannall, P.R. (1984) Colonic bicarbonate output as a test of disease activity in ulcerative colitis. J. Clin. Pathol., 37, 704-707.
11. Rubinstein, A. and Tirosh, B. (1994) Mucus gel thickness and turnover in the gastrointestinal tract of the rat: Response to cholinergic stimulus and implication for mucoadhesion. Pharm. Res., 11, 794-799.
12. Ueda, S., Hata, T., Asakura, S., Yamaguchi, H., Kotani, M. and Ueda, Y. (1994) Development of a novel drug release system, Time-controlled Explosion System (TES). I. Concept and design. J. Drug Targeting, 2, 35-44.
13. Watanabe, S., Kawai, H., Katsuma, M. and Fukui, M. (1995) Colon-specific drug release system. International Patent, WO 95/28963.