Colonic drug delivery of 5-fluorouracil: An in vitro evaluation

International Journal of Pharmaceutics

Volumn 269, Issue 1, 2004, Pages 101-108

  Sinha, V R ^a   Mittal, B R ^b   Bhutani, K K ^c   Kumria, Rachna ^a  

^a PANJAB UNIVERSITY   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

5 Fluorouracil; Colon specific drug delivery; Colorectal cancer; Guar gum; Xanthan gum

Indexed keywords

FLUOROURACIL; GUAR GUM; XANTHAN;

ARTICLE; CANCER CHEMOTHERAPY; COLORECTAL CARCINOMA; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG GRANULATION; DRUG SCREENING; IN VITRO STUDY; PRIORITY JOURNAL; SIMULATION; TABLET; TIME; UPPER GASTROINTESTINAL TRACT;

EID: 0346787822     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.036     Document Type: Article

References (14)

1. Calabresi, P., Chabner, B.A., 1992. Chemotherapy of neoplastic diseases. In: Hardman, J.G., Limbird, L.E., Perry, B.M., Raymond, W.R. (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, pp. 1225-1232.
2. Colombo P., Bettini R., Santi P., Peppas N.A. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanism and optimal performance. Pharm. Sci. Tech. Today. 3:2000;198-204.
3. Hahn R.G., Moertel C.G., Schutt A.T. A double-blind comparison of intensive course 5-fluorouracil by oral versus intravenous route in the treatment of colorectal carcinoma. Cancer. 35:1975;1031-1035.
4. Kinget R., Kalala W., Vervoort L., Mooter G.V. Colonic drug targeting. J. Drug Target. 6:1998;129-149.
5. Krishnaiah Y.S.R., Satyanaryana S., Rama Prasad Y.R. Studies of guar gum compression-coated 5-aminosalicylic acid tablets for colon-specific drug delivery. Drug. Dev. Ind. Pharm. 25:1999;651-657.
6. Melia C.D. Hydrophilic matrix sustained release systems based on polysaccharide carriers. Crit. Rev. Ther. Drug Carrier Syst. 8:1991;391-421.
7. Rama Prasad Y.V., Krishnaiah Y.S., Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J. Control. Release. 51:1998;281-287.
8. Sinha V.R., Kumria R. Colonic drug delivery: prodrug approach. Pharm. Res. 18:2001a;557-564.
9. Sinha V.R., Kumria R. Polysaccharides for colon specific drug delivery. Int. J. Pharm. 224:2001b;19-38.
10. Sinha V.R., Kumria R. Binders for colon specific drug delivery: an in vitro evaluation. Int. J. Pharm. 249:2002;23-31.
11. Sujja-areevath J., Munday D.L., Cox P.J., Khan K.N. Relationship between swelling, erosion and drug release in hydrophilic natural gum mini-matrix formulations. Eur. J. Pharm. Sci. 6:1998;207-217.
12. Talukdar M.M., Kinget K. Swelling and drug release behaviour of xanthan gum matrix tablets. Drug Dev. Ind. Pharm. 120:1995;63-72.
13. Vilivalam V.D., Illum L., Iqbal K. Starch capsules: an alternative system for oral drug delivery. Pharm. Sci. Tech. Today. 3:2000;64-69.
14. Wong D., Larrabeo S., Clifford K., Tremblay J., Friend D.R. USP dissolution Apparatus III (reciprocating cylinder) for screening of guar-based colonic delivery formulation. J. Control. Release. 47:1997;173-179.