A novel method for the determination of biliary clearance in humans

AAPS Journal

Volumn 6, Issue 4, 2004, Pages

  Ghibellini, Guilia ^a   Johnson, Brendan M ^a   Kowalsky, Richard J ^a,b   Heizer, William D ^b   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Biliary clearance; Biliary excretion; Gallbladder; Oroenteric tube; Tc 99m mebrofenin

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; MEBROFENIN TC 99M; XENOBIOTIC AGENT; IMINO ACID; TECHNETIUM COMPLEX; TECHNETIUM TC 99M MEBROFENIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; BLOOD SAMPLING; CATHETER; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG UPTAKE; DUODENUM; FEMALE; GALLBLADDER CONTRACTION; HEPATOBILIARY SYSTEM; HUMAN; HUMAN EXPERIMENT; LIVER BLOOD FLOW; MALE; MATHEMATICAL COMPUTING; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SCINTILLATION CAMERA; URINALYSIS; BILE; CATHETERIZATION; CLINICAL TRIAL; GALLBLADDER; INSTRUMENTATION; METABOLISM; METHODOLOGY;

ADULT; BILE; CATHETERIZATION; FEMALE; GALLBLADDER; HUMANS; IMINO ACIDS; MALE; ORGANOTECHNETIUM COMPOUNDS;

EID: 33646664459     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj060433     Document Type: Article

References (24)

1. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46:3-26.
2. Fleck C, Braunlich H. Factors determining the relationship between renal and hepatic excretion of xenobiotics. Arzneimittelforschung. 1990;40:942-946.
3. US Food and Drug Administration Center for Drug Evaluation and Research. Guidance for Industry: In Vivo Drug Metabolism/Drug Interaction Studies-Study Design, Data Analysis, and Recommendations for Dosing and Labeling Drug. Rockville, MD: FDA Information Branch; November 1999.
4. Liu X, Chism JP, LeCluyse EL, Brouwer KR, Brouwer KL. Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab Dispos. 1999;27:637-644.
5. Acocella G, Mattiussi R, Nicolis FB, Pallanza R, Tenconi LT. Biliary excretion of antibiotics in man. Gut. 1968;9:536-545.
6. Westphal JF, Brogard JM, Caro-Sampara F, et al. Assessment of biliary excretion of piperacillin-tazobactam in humans. Antimicrob Agents Chemother. 1997;41:1636-1640.
7. Lorenz D, Lucker PW, Mennicke WH, Wetzelsberger N. Pharmacokinetic studies with silymarin in human serum and bile. Methods Find Exp Clin Pharmacol. 1984;6:655-661.
8. Brookman LJ, Rolan PE, Benjamin IS, et al. Pharmacokinetics of valsartan in patients with liver disease. Clin Pharmacol Ther. 1997;62:272-278.
9. Strasberg SM, Harvey PR, Hofmann AF. Bile sampling, processing and analysis in clinical studies. Hepatology. 1990;12:176S-180S; discussion 180S-182S.
10. Ryde M, Gustavsson S. Biliary excretion of olsalazine sodium in humans. Eur J Drug Metab Pharmacokinet. 1987;12:17-24.
11. Gundert-Remy U, Frohnapfel F, Jourdan W, Weber E, Stiehl A. Estimation of biliary excretion of ureidopenicillins in healthy volunteers using marker dilution technique. Br J Clin Pharmacol. 1982;13:795-801.
12. Caldwell JH, Cline CT. Biliary excretion of digoxin in man. Clin Pharmacol Ther. 1976;19:410-415.
13. Keitel V, Nies AT, Brom M, Hummel-Eisenbeiss J, Spring H, Keppler D. A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). Am J Physiol Gastrointest Liver Physiol. 2003;284:G165-G174.
14. Lecureur V, Courtois A, Payen L, Verhnet L, Guillouzo A, Fardel O. Expression and regulation of hepatic drug and bile acid transporters. Toxicology. 2000;153:203-219.
15. Simons FE, Watson WTA, Minuk GY, Simons KJ. Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis. J Clin Pharmacol. 1993;33:949-954.
16. Lanzini A, Pigozzi MG, Wuhrer A, et al. Quantitative measurement of biliary excretion and of gall bladder concentration of drugs under physiological conditions in man. Gut. 1989;30:104-109.
17. Ziessman HA, Muenz LR, Agarwal AK, ZaZa AA. Normal values for sincalide cholescintigraphy: comparison of two methods. Radiology. 2001;221:404-410.
18. Ziessman HA. Cholecystokinin cholescintigraphy: clinical indications and proper methodology. Radiol Clin North Am. 2001;39:997-1006.
19. Jazrawi RP. Review article: measurement of gall-bladder motor function in health and disease. Aliment Pharmacol Ther. 2000;14:27-31.
20. Lanzini A, Jazrawi RP, Northfield TC. Simultaneous quantitative measurements of absolute gallbladder storage and emptying during fasting and eating in humans. Gastroenterology. 1987;92:852-861.
21. Choletec [package insert]. Princeton, NJ: Bracco Diagnostic Inc; 1994.
22. Krishnamurthy S, Krishnamurthy GT. Technetium-99m-iminodiacetic acid organic anions: review of biokinetics and clinical application in hepatology. Hepatology. 1999;9:139-153.
23. Gibaldi MP, Perrier D. Pharmacokinetics. New York, NY: Marcel Dekker Inc; 1982.
24. Daniel GB, Bahr A, Dykes JA, DeNovo R, Young K, Smith GT. Hepatic extraction efficiency and excretion rate of Technetium-99m-mebrofenin in dogs. J Nuclear Med. 1996;37:1846-1849.