Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, w-selenoconotoxin GVIA

Biochemistry

Volumn 49, Issue 12, 2010, Pages 2741-2752

  Gowd, Konkallu Hanumae ^a   Yarotskyy, Viktor ^c   Elmslie, Keith S ^c   Skalicky, Jack J ^b   Olivera, Baldomero M ^a   Bulaj, Grzegorz ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; BIOACTIVE CONFORMATION; BIOACTIVE PEPTIDES; CALCIUM CHANNELS; CHEMICAL SYNTHESIS; CONOTOXINS; DISELENIDE BRIDGES; EFFICIENT SYNTHESIS; FUNCTIONAL ACTIVITIES; GENERAL APPROACH; GLUTATHIONES; IN-VITRO; IN-VIVO; LARGE GROUPS; LOOP SIZE; OXIDATIVE FOLDING; SELENOCYSTEINE; SELENOPEPTIDES; SITE-SPECIFIC; WILD TYPES;

AMINO ACIDS; ANIMALS; CALCIUM; CALCIUM ALLOYS; ORGANIC ACIDS; PEPTIDES; SELENIUM COMPOUNDS;

SYNTHESIS (CHEMICAL);

CALCIUM CHANNEL N TYPE; CONOTOXIN; CYSTINE; DISELENIDE; DISULFIDE; GLUTATHIONE; OMEGA SELENOCONOTOXIN; SELENIDE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; BIOLOGICAL ACTIVITY; CONFORMATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; SYNTHESIS;

ANIMALS; CYSTINE; DISULFIDES; MICE; MODELS, CHEMICAL; OMEGA-CONOTOXIN GVIA; OMEGA-CONOTOXINS; OXIDATION-REDUCTION; PEPTIDES; PROTEIN FOLDING; SODIUM SELENITE;

ANIMALIA;

EID: 77949820036     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902137c     Document Type: Article

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