Pulmonary drug delivery: Medicines for inhalation

Handbook of Experimental Pharmacology

Volumn 197, Issue , 2010, Pages 171-192

  Henning, Andreas ^b   Hein, Stephanie ^b   Schneider, Marc ^b   Bur, Michael ^b   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b NONE

Author keywords

Aerosol deposition; Inhalation vaccination; Macrophage clearance; Mucociliary clearance; Telomerase inhibition

Indexed keywords

ANTIINFLAMMATORY AGENT; BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CHITOSAN; CYCLOSPORIN A; DILAUROYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPHTHERIA VACCINE; FLUOROURACIL; FORMOTEROL; INFLUENZA VACCINE; ISONIAZID; LACTOSE; LIPOSOME; MACROGOL; MEASLES VACCINE; PHOSPHATIDYLETHANOLAMINE; PLASMID DNA; POLYGLACTIN; POLYLACTIC ACID; PROPELLANT; PYRAZINAMIDE; RIFAMPICIN; SALBUTAMOL; SALMETEROL; TACROLIMUS; TERBUTALINE SULFATE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNINDEXED DRUG; DRUG;

ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED DRUG RELEASE; CYSTIC FIBROSIS; DIPHTHERIA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG HALF LIFE; DRUG RESEARCH; DRUG TARGETING; DRY POWDER; HUMAN; INFLUENZA; LIVER TOXICITY; LUNG CLEARANCE; LUNG SQUAMOUS CELL CARCINOMA; LUNG STRUCTURE; LUNG TUBERCULOSIS; MEAN RESIDENCE TIME; MEASLES; METERED DOSE INHALER; MUCOCILIARY CLEARANCE; NEBULIZATION; NEPHROTOXICITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; REVIEW; SUSTAINED DRUG RELEASE; AEROSOL; ANIMAL; GENE THERAPY; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; METHODOLOGY;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; DRUG DELIVERY SYSTEMS; GENE THERAPY; HUMANS; LUNG; PHARMACEUTICAL PREPARATIONS;

EID: 77953247048     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-00477-3_6     Document Type: Review

References (111)

1. Abu-Dahab R, Schafer UF, Lehr C-M (2001) Lectin-functionalized liposomes for pulmonary drug delivery: effect of nebulization on stability and bioadhesion. Eur J Pharm Sci 14:37-46
2. Aiache JM (1990) Aerosol therapy in France. J Aerosol Med 3:85-120
3. Albertine KH, Williams MC, Hyde DM (2000) Anatomy and development of the respiratory tract. In: Murray JF, Nadel JA (eds) Textbook of respiratory medicine. W.B. Saunders CBS Educ. and Professional Publ, New York, NY, pp 3-33
4. Allen TM, Hansen C (1991) Pharmacokinetics of stealth versus conventional liposomes: effect of dose. BBA Biomembranes 1068:133-141
5. Amidi M, Pellikaan HC, Hirschberg H, de Boer AH, Crommelin DJA, Hennink WE, Kersten G, Jiskoot W (2007) Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs. Vaccine 25:6818-6829
6. Amorij JP, Saluja V, Petersen AH, Hinrichs WLJ, Huckriede A, Frijlink HW (2007) Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice. Vaccine 25:8707-8717
7. Anabousi S, Bakowsky U, Schneider M, Huwer H, Lehr CM, Ehrhardt C (2006a) In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci 29:367-374
8. Anabousi S, Kleemann E, Bakowsky U, Kissel T, Schmehl T, Gessler T, Seeger W, Lehr CM, Ehrhardt G (2006b) Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. J Nanosci Nanotechnol 6:3010-3016
9. Arya V, Coowanitwong I, Brugos B, Kim WS, Singh R, Hochhaus G (2006) Pulmonary targeting of sustained release formulation of budesonide in neonatal rats. J Drug Target 14:680-686
10. Bailey MR, Ansoborlo E, Guilmette RA, Paquet F (2007) Updating the ICRP human respiratory tract model. Radiat Prot Dosim 127:31-34
11. Bechtold-Peters K, Luessen H (eds) (2007) Pulmonary drug delivery - basics, applications and opportunities for small molecules and biopharmaceutics. Editio Cantor Verlag, Aulendorf, Germany.
12. Beisner J, Dong M, Taetz S, Piotrowska K, Kleideiter E, Friedel G, Schaefer U, Lehr CM, Klotz U, Mürdter TE (2008) Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2'-O-methyl-RNA. J Pharm Sci 98:1765-1774
13. Bennet C (1654) Theatri tabidorum vestibulum: seu exercitationes dianoeticae cum historiis et experimentis demonstratives. Newcomb, London, pp 1-126
14. Bennett JV, De Castro JF, Valdespino-Gomez JL, De Lourdes Garcia-Garcia M, Islas-Romero R, Echaniz-Aviles G, Jimenez-Corona A, Sepulveda-Amor J (2002) Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican school children. Bull World Health Organ 80:806-812
15. Bennett WD, Scheuch G, Zeman KL, Brown JS, Kim C, Heyder J, Stahlhofen W (1999) Regional deposition and retention of particles in shallow, inhaled boluses: effect of lung volume. J Appl Physiol 86:168-173
16. Bhattarai SR, Kim SY, Jang KY, Yi HK, Lee YH, Bhattarai N, Nam SY, Lee DY, Kim HY, Hwang PH (2007) Amphiphilic triblock copolymer poly(p-dioxanone-co- L-lactide)-block-poly(ethylene glycol), enhancement of gene expression and inhibition of lung metastasis by aerosol delivery. Gene Ther 14:476-483
17. Bivas-Benita M, Ottenhoff THM, Junginger HE, Borchard G (2005) Pulmonary DNA vaccination: concepts, possibilities and perspectives. J Control Release 107:1-29
18. Bivas-Benita M, Van Meijgaarden KE, Franken KLMC, Junginger HE, Borchard G, Ottenhoff THM, Geluk A (2004) Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis. Vaccine 22:1609-1615
19. Booker R (2005) Do patients think that dry powder inhalers can be used interchangeably? Int J Clin Prac 59:30-32
20. Brand P, Friemel I, Meyer T, Schulz H, Heyder J, Huinger K (2000) Total deposition of therapeutic particles during spontaneous and controlled inhalations. J Pharm Sci 89:724-731
21. Brown JS, Bennett WD (2004) Deposition of coarse particles in cystic fibrosis: model predictions versus experimental results. J Aerosol Med 17:239-248
22. Brueck A, Abu-Dahab R, Borchard G, Schaefer UF, Lehr CM (2001) Lectin-functionalized liposomes for pulmonary drug delivery: interaction with human alveolar epithelial cells. J Drug Target 9:241-251
23. Burger JL, Cape SP, Braun CS, McAdams DH, Best JA, Bhagwat P, Pathak P, Rebits LG, Sievers RE (2008) Stabilizing formulations for inhalable powders of live-attenuated measles virus vaccine. J Aerosol Med 21:1-10
24. Chen T, Wang Z, Wang R, Lu T, WangW(2007) Polyethylenimine - DNA solid particles for gene delivery. J Drug Target 15:714-720
25. Chiou H, Chan HK, Heng D, Prud'homme RK, Raper JA (2008) A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. J Aerosol Sci 39:500-509
26. Chono S, Tanino T, Seki T, Morimoto K (2008) Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for treatment of respiratory intracellular parasitic infections. J Control Release 127: 50-58
27. Cruz PE, Mueller C, Flotte TR (2007) The promise of gene therapy for the treatment of a-1 antitrypsin deficiency. Pharmacogenomics 8:1191-1198
28. de Swart RL, Li Calsi C, Quirk AV, van Amerongen G, Nodelman V, Alcock R, Yuksel S, Ward GH, Hardy JG, Vos H, Witham CL, Grainger CI, Kuiken T, Greenspan BJ, Gard TG, Osterhaus ADME (2007) Measles vaccination of macaques by dry powder inhalation. Vaccine 25:1183-1190
29. Deol P, Khuller GK (1997) Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice. BBA-Gen Subjects 1334:161-172
30. Deol P, Khuller GK, Joshi K (1997) Therapeutic efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice. Antimicrob Agents Chemother 41:1211-1214
31. Dessanges JF (2001) A history of nebulization. J Aerosol Med 14:65-71
32. Desseyn JL, Aubert JP, Porchet N, Laine A (2000) Evolution of the large secreted gel-forming mucins. Mol Biol Evol 17:1175-1184
33. Dhand R (2005) Aerosol plumes: slow and steady wins the race. J Aerosol Med 18:261-263
34. Dilraj A, Sukhoo R, Cutts FT, Bennett JV (2007) Aerosol and subcutaneous measles vaccine: measles antibody responses 6 years after re-vaccination. Vaccine 25:4170-4174
35. Dolovich MA, MacIntyre NR, Anderson PJ, Camargo CA Jr, Chew N, Cole CH, Dhand R, Fink JB, Gross NJ, Hess DR, Hickey AJ, Kim CS, Martonen TB, Pierson DJ, Rubin BK, Smaldone GC (2000) Consensus statement: aerosols and delivery devices. Respir Care 45:589-596
36. Eager R, Harle L, Nemunaitis JJ (2007) Lung cancer vaccines. Curr Gene Ther 7:469-484
37. El-Aneed A (2004) An overview of current delivery systems in cancer gene therapy. J Control Release 94:1-14
38. Forbes B, Ehrhardt C (2005) Human respiratory epithelial cell culture for drug delivery applications. Eur J Pharma Biopharm 60:193-205
39. Gaber NN, Darwis Y, Peh KK, Tan YTF (2006) Characterization of polymeric micelles for pulmonary delivery of beclomethasone dipropionate. J Nanosci Nanotechnol 6:3095-3101
40. Garcia-Contreras L, Fiegel J, Telko MJ, Elbert K, Hawi A, Thomas M, VerBerkmoes J, Germishuizen WA, Fourie PB, Hickey AJ, Edwards DA (2007) Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother 51:2830-2836
41. Garmise RJ, Staats HF, Hickey AJ (2007) Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech 8:81
42. Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555-1560
43. Gilbert BE, Knight C, Alvarez FG, Waldrep JC, Rodarte JR, Knight V, Eschenbacher WL (1997) Tolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosol. Am J Respir Crit Care Med 156:1789-1793
44. Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, Hawkins M, O'Shaughnessy J (2005) Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 23:7794-7803
45. Groneberg DA, Witt C, Wagner U, Chung KF, Fischer A (2003) Fundamentals of pulmonary drug delivery. Respir Med 97:382-387
46. Heyder J (1981) Mechanisms of aerosol particle deposition. Chest 80:820-823
47. Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W (1986) Deposition of particles in the human respiratory tract in the size range 0.005-15 mm. J Aerosol Sci 17:811-825.
48. Heyder J, Svartengren MU (2002) Basic principles of particle behavior in the human respiratory tract. In: Bisgaard H, O'Callaghan C, Smaldone GC (eds) Drug delivery to the lung. New York, Marcel Dekker, pp 21-45
49. Hirota K, Hasegawa T, Hinata H, Ito F, Inagawa H, Kochi C, Soma GI, Makino K, Terada H (2007) Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages. J Control Release 119:69-76
50. Hitzman CJ, Elmquist WF, Wattenberg LW, Wiedmann TS (2006a) Development of a respirable, sustained release microcarrier for 5-fluorouracil I: In vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. J Pharm Sci 95:1114-1126
51. Hitzman CJ, Elmquist WF, Wiedmann TS (2006b) Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles. J Pharm Sci 95:1127-1143
52. Hitzman CJ, Wattenberg LW, Wiedmann TS (2006c) Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles. J Pharm Sci 95:1196-1211
53. Hiyama K, Hiyama E, Ishioka S, Yamakido M, Inai K, Gazdar AF, Piatyszek MA, Shay JW (1995) Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 87:895-902
54. Hobson P, Barnfield C, Barnes A, Klavinskis LS (2003) Mucosal immunization with DNA vaccines. Methods 31:217-224
55. Hochrainer D, Holz H, Kreher C, Scaffidi L, Spallek M, Wachtel H (2005) Comparison of the aerosol velocity and spray duration of Respimat1 Soft MistTM inhaler and pressurized metered dose inhalers. J Aerosol Med 18:273-282
56. Howard KA, Rahbek UL, Liu X, Damgaard CK, Glud SZ, Andersen MØ, Hovgaard MB, Schmitz A, Nyengaard JR, Besenbacher F, Kjems J (2006) RNA Interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol Ther 14:476-484
57. Iacono AT, Smaldone GC, Keenan RJ, Diot P, Dauber JH, Zeevi A, Burckart GJ, Griffith BP (1997) Dose-related reversal of acute lung rejection by aerosolized cyclosporine. Am J Respir Crit Care Med 155:1690-1698
58. ICRP (1994) Human respiratory tract model for radiological protection. Ann ICRP 24:1-120
59. Issa MM, Köping-Höggård M, Tømmeraas K, Vårum KM, Christensen BE, Strand SP, Artursson P (2006) Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. J Control Release 115:103-112
60. Jaspart S, Bertholet P, Piel G, Dogne JM, Delattre L, Evrard B (2007) Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 65:47-56
61. Kleemann E, Dailey LA, Abdelhady HG, Gessler T, Schmehl T, Roberts CJ, Davies MC, Seeger W, Kissel T (2004) Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: Investigations of the complex structure and stability during air-jet and ultrasonic nebulization. J Control Release 100:437-450
62. Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T (2005) Nanocarriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release 109:299-316
63. Köping-Höggård M, Varum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, Artursson P (2004) Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 11:1441-1452
64. Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang YY, Cone R, Hanes J (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci USA 104:1482-1487
65. Learoyd TP, Burrows JL, French E, Seville PC (2008) Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur J Pharm Biopharm 68:224-234
66. Lehr C-M, Bouwstra JA, Schacht EH, Junginger HE (1992) In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 78:43-48
67. Lentz YK, Anchordoquy TJ, Lengsfeld CS (2006) Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Med 19:372-384
68. Letsou GV, Safi HJ, Reardon MJ, Ergenoglu M, Li Z, Klonaris CN, Baldwin JC, Gilbert BE, Waldrep JC (1999) Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression. Ann Thorac Surg 68:2044-2048
69. Li HY, Birchall J (2006) Chitosan-modified dry powder formulations for pulmonary gene delivery. Pharm Res 23:941-950
70. LiCalsi C, Maniaci MJ, Christensen T, Phillips E, Ward GH, Witham C (2001) A powder formulation of measles vaccine for aerosol delivery. Vaccine 19:2629-2636
71. Lu D, Hickey AJ (2007) Pulmonary vaccine delivery. Expert Rev Vaccines 6:213-226
72. Möller W, Haüßinger K, Kreyling WG, Scheuch G (2005) Particle clearance from the human respiratory tract. Atemw-Lungenkrkh 31:342-351
73. Mudge J (1778) A radical and expeditious cure for a recent catarrhous cough. Allen, London, pp 1-252
74. Murphy SL, High KA (2008) Gene therapy for haemophilia. Br J Haematol 140:479-487
75. Nafee N, Taetz S, Schneider M, Schaefer UF, Lehr CM (2007) Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine 3:173-183
76. O'Riordan TG, Iacono A, Keenan RJ, Duncan SR, Burckart GJ, Griffith BP, Smaldone GC (1995) Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am J Respir Crit Care Med 151:516-521
77. Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839
78. Pandey R, Sharma A, Zahoor A, Sharma S, Khuller GK, Prasad B (2003) Poly (DL-lactide-coglycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 52:981-986
79. Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67-74
80. Perkins W, Weers J, Meers P (2005) An inhalation formulation of liposomal cisplatin (SLITTM Cisplatin) for treatment of lung cancer [abstract]. In: Conference Vancouver: Lipids, Liposomes & Biomembranes Pilcer G, Sebti T, Amighi K (2006) Formulation and characterization of lipid-coated tobramycin particles for dry powder inhalation. Pharm Res 23:931-940
81. Pitcairn G, Reader S, Pavia D, Newman S (2005) Deposition of corticosteroid aerosol in the human lung by Respimat1 Soft MistTM inhaler compared to deposition by metered dose inhaler or by Turbuhaler1 dry powder inhaler. J Aerosol Med 18:264-272
82. Ravi Kumar MNV, Bakowsky U, Lehr CM (2004) Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials 25:1771-1777
83. Read RC, Naylor SC, Potter CW, Bond J, Jabbal-Gill I, Fisher A, Illum L, Jennings R (2005) Effective nasal influenza vaccine delivery using chitosan. Vaccine 23:4367-4374
84. Saari M, Vidgren MT, Koskinen MO, Turjanmaa VMH, Nieminen MM (1999) Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers. Int J Pharm 181:1-9
85. Sanders M (2007) Inhalation therapy: an historical review. Prim Care Respir J 16:71-81
86. Sanna V, Kirschvink N, Gustin P, Gavini E, Roland I, Delattre L, Evrard B (2004) Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration. AAPS PharmSciTech 5(2):27
87. Scheuch G, Fischer A (2008) Improved entry into the airways. Manuf Chem Aerosol News 79:39-40
88. Scheuch G, Siekmeier R (2007) Novel approaches to enhance pulmonary delivery of proteins and peptides. J Physiol Pharmacol 58:615-625
89. Scheuch G, Zimlich WC, Siekmeier R (2007) Biophysical parameters determining pulmonary drug delivery. In: Bechthold-Peters K, Luessen H (eds) Pulmonary drug delivery: basiscs, applications, and opportunities for small molecules and biopharmaceutics. Editio Cantor Verlag, Aulendorf, pp 46-54
90. Selting K, Waldrep JC, Reinero C, Branson K, Gustafson D, Kim DY, Henry C, Owen N, Madsen R, Dhand R (2008) Feasibility and safety of targeted cisplatin delivery to a select lung lobe in dogs via the AeroProbe1. J Aerosol Med Pulm Drug Deliv 21:255-268
91. Serra-Batlles J, Plaza V, Badiola C, Morejon E, Bardagi S, Brotons B, Cabello F, Castillo JA, Hermida JA, Lopez-Vinas A, Marin JM, Tabar A (2002) Patient perception and acceptability of multidose dry powder inhalers: a randomized crossover comparison of Diskus/Accuhaler with Turbuhaler. J Aerosol Med 15:59-64
92. Sharma A, Sharma S, Khuller GK (2004) Lectin-functionalized poly (lactide-co-glycolide) nanoparticles as oral/aerosolized antitubercular drug carriers for treatment of tuberculosis. J Antimicrob Chemother 54:761-766
93. Shay JW, Wright WE (2006) Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 5:577-584
94. Sibille Y, Reynolds HY (1990) Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141:471-501
95. Sinswat P, Overhoff KA, McConville JT, Johnston KP, Williams III RO (2008) Nebulization of nanoparticulate amorphous or crystalline tacrolimus - single-dose pharmacokinetics study in mice. Eur J Pharm Biopharm 69:1057-1066
96. Smith DJ, Bot S, Dellamary L, Bot A (2003) Evaluation of novel aerosol formulations designed for mucosal vaccination against influenza virus. Vaccine 21:2805-2812
97. Sueblinvong V, Suratt BT, Weiss DJ (2007) Novel therapies for the treatment of cystic fibrosis: new developments in gene and stem cell therapy. Clin Chest Med 28:361-379
98. Taetz S, Nafee N, Beisner J, Piotrowska K, Baldes C, Mürdter TE, Huwer H, Schneider M, Schaefer UF, Klotz U, Lehr CM (2009) The influence of chitosan content in cationic chitosan/ PLGA nanoparticles on the delivery efficiency of antisense 20-O-methyl-RNA directed against telomerase in lung cancer cells. Eur J Pharm Biopharm 72:358-369
99. Tagalakis AD, McAnulty RJ, Devaney J, Bottoms SE, Wong JB, Elbs M, Writer MJ, Hailes HC, Tabor AB, O'Callaghan C, Jaffe A, Hart SL (2008) A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer. Mol Ther 16:907-915
100. Tahara K, Yamamoto H, Takeuchi H, Kawashima Y (2007) Development of gene delivery system using PLGA nanospheres. Yakugaku Zasshi 127:1541-1548
101. Takenaga M, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Disratthakit A, Doi N (2008) Lipid microsphere formulation containing rifampicin targets alveolar macrophages. Drug Deliv 15:169-175
102. Thornton DJ, Rousseau K, McGuckin MA (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70:459-486
103. Tschernig T, Pabst R (2000) Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology 68:1-8
104. Ventura CA, Tommasini S, Crupi E, Giannone I, Cardile V, Musumeci T, Puglisi G (2008) Chitosan microspheres for intrapulmonary administration of moxifloxacin: interaction with biomembrane models and in vitro permeation studies. Eur J Pharm Biopharm 68:235-244
105. Weibel ER (ed) (1963) Morphometry of the human lung. Academic Press, New York
106. Weibel ER (1979) Morphometry of the human lung: the state of the art after two decades. Clin Respir Physiol 15:999-1013
107. Welch MJ, Nelson HS, Shapiro G, Bensch GW, Sokol WN, Smith JA, Parasuraman BM (2004) Comparison of patient preference and ease of teaching inhaler technique for Pulmicort Turbuhaler1 versus pressurized metered-dose inhalers. J Aerosol Med 17:129-139
108. WHO (2008) http://www.who.int/tb/publications/global-report/2008/summary/ en/index.html.
109. Wijagkanalan W, Kawakami S, Takenaga M, Igarashi R, Yamashita F, HashidaM(2008) Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats. J Control Release 125:121-130
110. Wittgen BPH, Kunst PWA, Van Der Born K, Van Wijk AW, Perkins W, Pilkiewicz FG, Perez-Soler R, Nicholson S, Peters GJ, Postmus PE (2007) Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung. Clin Cancer Res 13:2414-2421
111. Zaru M, Mourtas S, Klepetsanis P, Fadda AM, Antimisiaris SG (2007) Liposomes for drug delivery to the lungs by nebulization. Eur J Pharm Biopharm 67:655-666