Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers

International Journal of Pharmaceutics

Volumn 181, Issue 1, 1999, Pages 1-9

  Saari, Marisanna ^a   Vidgren, Mika T ^b   Koskinen, Matti O ^a   Turjanmaa, Väinö M H ^a   Nieminen, Markku M ^c  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

99mTechnetium; Aerosol; Dilauroylphophatidylcholine (DLPC); Dipalmitoylphophatidylcholine (DPPC); Liposome; Nebulizer

Indexed keywords

BECLOMETASONE DIPROPIONATE; DILAUROYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; LUNG SURFACTANT; TECHNETIUM 99M;

ADULT; AEROSOL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; FEMALE; HUMAN; HUMAN CELL; INHALATIONAL DRUG ADMINISTRATION; MALE; NEBULIZER; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCINTIGRAPHY;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ADMINISTRATION, INHALATION; ADULT; AEROSOLS; ANTI-ASTHMATIC AGENTS; BECLOMETHASONE; CROSS-OVER STUDIES; DRUG CARRIERS; FEMALE; HUMANS; LIPOSOMES; LUNG; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; ORGANOTECHNETIUM COMPOUNDS; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 0032924188     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00398-6     Document Type: Article

References (27)

1. 99mTc-DTPA in the human respiratory tract. Int. J. Pharm. 102:1994;159-165.
2. Barratt M.G., Tusel N.S., Ryman B.E. The labelling of liposomal membranes with radioactive technetium. Gregoridiadis G. Liposome Technology. II:1983;93-106 CRC Press, Boca Raton, FL.
3. Bjermer L., Larsson L. Obstructive symptoms in athletes: is it asthma and what to do about it? Respir. Med. 90:1996;1-3.
4. Farr S.J., Kellaway I.W., Parry-Jones D.R., Woolfrey S.G. 99m-Technetium as a marker of liposomal deposition and clearance in the human lung. Int. J. Pharm. 26:1985;303-316.
5. Gilbert B.E., Six H.R., Wilson S.S., Wyde P.R., Knight V. Small particle aerosols of enviroxime-containing liposomes. Antiviral Res. 9:1988;355-365.
6. Hennes H.M., Lee M.B., Rimm A.A., Shapiro D.L. Surfactant replacement therapy in respiratory distress syndrome. Meta-analysis of clinical trials of single-dose surfactant extracts. Am. J. Dis. Child. 145:1991;102-104.
7. Knight C.M., Gilbert B.E., Waldrep J.C., Black M.B., Knight W.L., Eschenbacher W.L. Inhalation of a corticosteroid-liposome preparation by normal subjects causes no adverse effects. Am. Rev. Respir. Dis. 4:1994;220.
8. Macey D.J., Marshall R. Absolute quantitation of radiotracer uptake in the lungs using a gamma camera. J. Nucl. Med. 23:1982;731-735.
9. McCalden T.A., Abra R.M. Bronchodilator efficacy of liposome formulations of metaproterenol sulfate in the anesthetised guinea pig. J. Liposome Res. 1:1989;211-222.
10. Meisner D., Pringle J., Mesei M. Liposomal pulmonary delivery I. J. Microencapsulation. 6:1989;379-387.
11. Mihalko P.J., Schreier H., Abra R.M. Liposomes: as a pulmonary perspective. Gregoriadis G. Liposomes as Drug Carriers. 1988;679-694 Wiley, Chichester.
12. Morley C. Surfactant treatment for premature babies - a review of clinical trials. Arch. Dis. Child. 66:1991;445-450.
13. Myers M.A., Thomas D.A., Straub L., Soucy D.W., Niven R.W., Kaltenbach M., Hood C.I., Schreier H., Gonsales-Rothi R.J. Pulmonary effects of chronic exposure to liposome aerosol in mice. Exp. Lung Res. 19:1993;1-19.
14. Nieminen M.M., Holli H., Lahdensuo A., Muittari A., Karvonen J. Aerosol deposition in automatic dosimeter nebulization. Eur. J. Respir. Dis. 71:1987;145-152.
15. Nieminen M.M., Lahdensuo A., Kellomäki L., Karvonen J., Muittari A. Methacholine bronchial challenge using dosimeter with controlled tidal breathing. Thorax. 43:1988;896-900.
16. Nieminen M.M., Moilanen E., Nyholm J.-E., Koskinen M.O., Karvonen J.I., Metsä-Ketelä T.I., Vapaatalo H. Platelet-activating factor impairs tracheobronchial transport and increases plasma leukotriene. Eur. Respir. J. 4:1991;561-570.
17. Saari S.M., Vidgren M.T., Koskinen M.O., Turjanmaa V.M.H., Waldrep J.C., Nieminen M.M. Regional lung deposition and clearance of 99m-Tc-labelled Bec-DLPC liposomes in mild and severe asthma. Chest. 113:1998;1573-1579.
18. Smaldone G.C., Perry R.J., Bennett W.D., Messina M.S., Swang J., Ilowite J. Interpretation of '24 hour lung retention' in studies of mucociliary clearance. J. Aerosol Med. 1:1988;11-20.
19. Smaldone G.C., Walser L., Perry R.J., Ilowite J.S., Bennett W.D., Greco M. Generation and administration of aerosols for medical and physiological research studies. J. Aerosol Med. 2:1989;81-87.
20. Stahlhofen W., Gebhart J., Heyder J. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 4:1980;385-398.
21. Sue-Chu M., Larsson L., Bjermer L. Prevalence of asthma in young cross-country skiers in central Scandinavia: differences between Norway and Sweden. Respir. Med. 90(2):1996;99-105.
22. Thomas D.A., Myers M.A., Wichert B., Shreier H., Gonsales-Roth R.J. Acute effects of liposome aerosol inhalation on pulmonary function in healthy volunteers. Chest. 99:1991;1268-1270.
23. 99mtechnetium labelled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers. Int. J. Pharm. 115:1995;209-216.
24. Waldrep J.C., Keyhani K., Black M., Knight V. Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol. Chest. 105:1994;106-110.
25. Waldrep J.C., Scherer P.W., Hess G.D., Black M., Knight V. Nebulized glucocorticoids in liposomes: aerosol characteristics and human dose estimates. J. Aerosol Med. 7:1994;135-144.
26. Waldrep J.C., Gilbert B.E., Knight B.N., Black M.B., Scherer P.W., Knight V., Eschenbacher W. Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Chest. 111:1997;316-323.
27. Wright J.M., Clemets J.A. Metabolism and turnover of lung surfactant. Am. Rev. Respir. Dis. 135:1987;426-444.