Synergy of IL-23 and Th17 cytokines: New light on inflammatory bowel disease

Neurochemical Research

Volumn 35, Issue 6, 2010, Pages 940-946

  Shen, Wei ^a   Durum, Scott K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

IL 17A; IL 17F; IL 22; IL 23; Inflammatory bowel disease (IBD)

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 23; STAT3 PROTEIN;

ADAPTIVE IMMUNITY; COLON MUCOSA; CONFERENCE PAPER; CYTOKINE PRODUCTION; ENTERITIS; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE; TH17 CELL;

ADAPTIVE IMMUNITY; ANIMALS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; INTESTINAL MUCOSA; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

ANIMALIA;

EID: 77953231189     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-0091-9     Document Type: Conference Paper

References (48)

1. RJ Xavier DK Podolsky 2007 Unravelling the pathogenesis of inflammatory bowel disease Nature 448 427 434 10.1038/nature06005 1:CAS:528: DC%2BD2sXotFajurs%3D 17653185 (Pubitemid 47123518)
2. CO Elson Y Cong CT Weaver, et al. 2007 Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice Gastroenterology 132 2359 2370 10.1053/j.gastro.2007.03.104 1:CAS:528:DC%2BD2sXnvFOhtb8%3D 17570211 (Pubitemid 46890867)
3. S Hue P Ahern S Buonocore, et al. 2006 Interleukin-23 drives innate and T cell-mediated intestinal inflammation J Exp Med 203 2473 2483 10.1084/jem.20061099 1:CAS:528:DC%2BD28XhtFGqtL7I 17030949 (Pubitemid 44664617)
4. HH Uhlig BS McKenzie S Hue, et al. 2006 Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology Immunity 25 309 318 10.1016/j.immuni.2006.05.017 1:CAS:528:DC%2BD28XpvVGjsrk%3D 16919486
5. D Yen J Cheung H Scheerens, et al. 2006 IL-23 is essential for T cell mediated colitis and promotes inflammation via IL-17 and IL-6 J Clin Invest 116 1310 1316 10.1172/JCI21404 1:CAS:528:DC%2BD28XksVWns78%3D 16670770
6. RH Duerr KD Taylor SR Brant, et al. 2006 A genome-wide association study identifies IL23R as an inflammatory bowel disease gene Science 314 1461 1463 10.1126/science.1135245 1:CAS:528:DC%2BD28Xht1CntrjF 17068223 (Pubitemid 44871953)
7. NJ Wilson K Boniface JR Chan, et al. 2007 Cytokine profile and function of human interleukin 17-producing helper T cells Nat Immunol 8 950 957 10.1038/ni1497 1:CAS:528:DC%2BD2sXptlSku7o%3D 17676044 (Pubitemid 47300009)
8. M Veldhoen RJ Hocking CJ Atkins, et al. 2006 TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 2 179 189 10.1016/j.immuni.2006.01.001 1:CAS:528:DC%2BD28XitVOks7s%3D 16473830 (Pubitemid 43214587)
9. M Veldhoen RJ Hocking RA Flavell, et al. 2006 Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease Nat Immunol 7 1151 1156 10.1038/ni1391 1:CAS:528:DC%2BD28XhtV2gsrbN 16998492 (Pubitemid 44594310)
10. E Volpe N Servant R Zollinger, et al. 2008 Critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses Nat Immunol 9 650 657 10.1038/ni.1613 1:CAS:528:DC%2BD1cXmtVWqurc%3D 18454150 (Pubitemid 351712635)
11. A Izcue JL Coombes F Powrie 2006 Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation Immunol Rev 212 256 271 10.1111/j.0105-2896.2006.00423.x 1:CAS:528:DC%2BD28XpvFegtLk%3D 16903919 (Pubitemid 44116713)
12. MT Abreu M Fukata M Arditi 2005 TLR signalingin the gut in health and disease J Immunol 174 4453 4460 1:CAS:528:DC%2BD2MXivFKisbo%3D 15814663
13. H Hamada T Hiroi Y Nishiyama, et al. 2002 Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine J Immunol 168 57 64 1:CAS:528:DC%2BD38Xht1GisQ%3D%3D 11751946
14. RD Newberry RG Lorenz 2005 Organizing a mucosal defense Immunol Rev 206 6 21 10.1111/j.0105-2896.2005.00282.x 1:CAS:528:DC%2BD2MXhtVWjsb7L 16048539 (Pubitemid 41105160)
15. B Oppmann R Lesley B Blom, et al. 2000 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715 725 10.1016/S1074-7613(00)00070-4 1:CAS:528:DC%2BD3cXovV2ht7c%3D 11114383
16. PP Ahern A Izcue KJ Maloy, et al. 2008 The interleukin-23 axis in intestinal inflammation Immunol Rev 226 147 159 10.1111/j.1600-065X.2008.00705.x 19161422
17. C Parham M Chirica J Timans, et al. 2002 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 5699 5708 1:CAS:528:DC%2BD38XktFCrtrw%3D 12023369
18. MC Kullberg D Jankovic CG Feng, et al. 2006 IL-23 plays a key role in Helicobacter hepaticus-induced T celldependent colitis J Exp Med 203 2485 2494 10.1084/jem.20061082 1:CAS:528:DC%2BD28XhtFGqtL7J 17030948 (Pubitemid 44664618)
19. C Becker H Dornhoff C Neufert, et al. 2006 IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis J Immunol 177 2760 2764 1:CAS:528:DC%2BD28Xot1equ7s%3D 16920909
20. C Dong 2008 TH17 cells in development: an updated view of their molecular identity and genetic programming Nat Rev Immunol 8 337 348 10.1038/nri2295 1:CAS:528:DC%2BD1cXltFejsb0%3D 18408735 (Pubitemid 351595217)
21. R Nurieva XO Yang G Martinez, et al. 2007 Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 480 483 10.1038/nature05969 1:CAS:528:DC%2BD2sXotFajur8%3D 17581589 (Pubitemid 47123514)
22. H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 967 974 10.1038/ni1488 1:CAS:528:DC%2BD2sXptlSkurw%3D 17581537 (Pubitemid 47300011)
23. IR Williams 2006 CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis Ann NY Acad Sci 1072 52 61 10.1196/annals.1326.036 1:CAS:528:DC%2BD28XhtVOjurjK 17057190 (Pubitemid 44448443)
24. MM Fort J Cheung D Yen, et al. 2001 IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo Immunity 15 985 995 10.1016/S1074- 7613(01)00243-6 1:CAS:528:DC%2BD38Xhsl2ksA%3D%3D 11754819 (Pubitemid 34075378)
25. Z Yao WC Fanslow MF Seldin, et al. 1995 Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor Immunity 3 811 821 10.1016/1074-7613(95)90070-5 1:CAS:528:DyaK28XhtF2gsw%3D%3D 8777726 (Pubitemid 26091152)
26. D Toy D Kugler M Wolfson, et al. 2006 Cutting edge: Interleukin-17 signals through a heteromeric receptor complex J Immunol 177 36 39 1:CAS:528:DC%2BD28XlvV2ntrc%3D 16785495
27. H Park Z Li XO Yang, et al. 2005 A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin-17 Nat Immunol 6 1133 1141 10.1038/ni1261 1:CAS:528:DC%2BD2MXhtFamsb%2FO 16200068 (Pubitemid 41541791)
28. I Reiko K Masakazu S Masaharu, et al. 2008 Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice Biochem Biophys Res Commun 377 12 16 10.1016/j.bbrc.2008.09.019
29. Z Zhang M Zheng J Bindas, et al. 2006 Critical role of IL-17 receptor signaling in acute TNBS-induced colitis, Inflamm Bowel Dis 12 382 388 10.1097/01.MIB.0000218764.06959.91
30. W O'Connor Jr M Kamanaka CJ Booth, et al. 2009 A protective function for interleukin 17A in T cell-mediated intestinal inflammation Nat Immunol 10 603 609 10.1038/ni.1736 19448631
31. A Ogawa A Andoh Y Araki, et al. 2004 Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice Clin Immunol 110 55 62 10.1016/j.clim.2003.09.013 1:CAS:528:DC%2BD2cXhtV2hur4%3D 14962796 (Pubitemid 38177420)
32. CL Langrish Y Chen WM Blumenschein, et al. 2005 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233 240 10.1084/jem.20041257 1:CAS:528:DC%2BD2MXot12mtA%3D%3D 15657292 (Pubitemid 40189432)
33. SH Chang C Dong 2007 A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses Cell Res 17 435 440 17452998
34. RE Kuestner DW Taft A Haran, et al. 2007 Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F J Immunol 179 5462 5473 1:CAS:528:DC%2BD2sXhtFWitrfP 17911633
35. X Wolk S Kunz E Witte, et al. 2004 IL-22 increases the innate immunity of tissues Immunity 21 241 254 10.1016/j.immuni.2004.07.007 1:CAS:528: DC%2BD2cXnsVKlt7k%3D 15308104 (Pubitemid 39094053)
36. H17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Nature 445 648 651 10.1038/nature05505 1:CAS:528:DC%2BD2sXhtlOrtLk%3D 17187052 (Pubitemid 46232884)
37. H17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis J Immunol 179 8098 8104 1:CAS:528:DC%2BD2sXhtlyitrbN 18056351
38. X Sugimoto A Ogawa E Mizoguchi, et al. 2008 IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis J Clin Invest 118 534 544 1:CAS:528:DC%2BD1cXhsFOmsr8%3D 18172556
39. X Zheng PA Valdez DM Danilenko, et al. 2008 Interleukin 22 mediates early host defense against attaching and effacing bacterial pathogens Nat Med 14 282 289 10.1038/nm1720 1:CAS:528:DC%2BD1cXivFOrtLw%3D 18264109 (Pubitemid 351347912)
40. + cells Nat Immunol 10 83 91 10.1038/ni.1684 1:CAS:528:DC%2BD1cXhsVWhu7bO 19029903
41. K Malmberg H Ljunggren 2009 Spotlight on IL-22-producing NK cell receptor expressing mucosal lymphocytes Nat Immunol 10 11 12 10.1038/ni0109-11 1:CAS:528:DC%2BD1cXhsFSmur%2FL 19088733
42. A Izcue S Hue S Buonocore, et al. 2008 Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis Immunity 28 559 570 10.1016/j.immuni.2008.02.019 1:CAS:528:DC%2BD1cXkvV2itL4%3D 18400195 (Pubitemid 351467043)
43. C Sutton C Brereton B Keogh, et al. 2006 A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis J Exp Med 203 1685 1691 10.1084/jem.20060285 1:CAS:528:DC%2BD28XntVCgs78%3D 16818675 (Pubitemid 44036274)
44. XO Yang SH Chang H Park, et al. 2008 Regulation of inflammatory responses by IL-17F J Exp Med 205 1063 1075 10.1084/jem.20071978 1:CAS:528: DC%2BD1cXlvFWrsrc%3D 18411338 (Pubitemid 351679682)
45. T Korn E Bettelli W Gao, et al. 2007 IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Nature 448 484 487 10.1038/nature05970 1:CAS:528:DC%2BD2sXotFajurw%3D 17581588 (Pubitemid 47123515)
46. Z Chen A Laurence Y Kanno, et al. 2006 Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells Proc Natl Acad Sci USA 103 8137 8142 10.1073/pnas.0600666103 1:CAS:528:DC%2BD28Xlt1Cht7Y%3D 16698929 (Pubitemid 43801065)
47. II Ivanov BS McKenzie L Zhou, et al. 2006 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 10.1016/j.cell.2006.07.035 1:CAS:528: DC%2BD28XhtVCnsrrE 16990136 (Pubitemid 44380299)
48. L Zhou JE Lopes MM Chong, et al. 2008 TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function Nature 453 236 240 10.1038/nature06878 1:CAS:528:DC%2BD1cXls12msL4%3D 18368049 (Pubitemid 351667978)