-
1
-
-
0025903619
-
A rapid in vitro assay for HIV DNA integration
-
10.1093/nar/19.10.2729 1:CAS:528:DyaK3MXksVaqsL0%3D 2041748
-
R Craigie K Mizuuchi FD Bushman A Engelman 1991 A rapid in vitro assay for HIV DNA integration Nucleic Acids Res 19 2729 2734 10.1093/nar/19.10.2729 1:CAS:528:DyaK3MXksVaqsL0%3D 2041748
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 2729-2734
-
-
Craigie, R.1
Mizuuchi, K.2
Bushman, F.D.3
Engelman, A.4
-
2
-
-
0031434606
-
Molecular mechanisms in retrovirus DNA integration
-
DOI 10.1016/S0166-3542(97)00046-6, PII S0166354297000466
-
E Asante-Appiah AM Skalka 1997 Molecular mechanisms in retrovirus DNA integration Antiviral Res 36 139 156 10.1016/S0166-3542(97)00046-6 1:CAS:528:DyaK2sXnvVSgtL4%3D 9477115 (Pubitemid 28031997)
-
(1997)
Antiviral Research
, vol.36
, Issue.3
, pp. 139-156
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
3
-
-
14944374558
-
Integrase inhibitors to treat HIV/AIDS
-
DOI 10.1038/nrd1660
-
Y Pommier AA Johnson C Marchand 2005 Integrase inhibitors to treat HIV/AIDS Nat Rev Drug Discov 4 236 248 10.1038/nrd1660 1:CAS:528: DC%2BD2MXhslSns70%3D 15729361 (Pubitemid 40372557)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.3
, pp. 236-248
-
-
Pommier, Y.1
Johnson, A.A.2
Marchand, C.3
-
5
-
-
0026437577
-
Crystal structure of a Src-homology 3 (SH3) domain
-
10.1038/359851a0 1:CAS:528:DyaK38XmsVOgu7w%3D 1279434
-
A Musacchio M Noble R Pauptit R Wierenga M Saraste 1992 Crystal structure of a Src-homology 3 (SH3) domain Nature 359 851 855 10.1038/359851a0 1:CAS:528:DyaK38XmsVOgu7w%3D 1279434
-
(1992)
Nature
, vol.359
, pp. 851-855
-
-
Musacchio, A.1
Noble, M.2
Pauptit, R.3
Wierenga, R.4
Saraste, M.5
-
6
-
-
0026649557
-
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
-
1:CAS:528:DyaK3sXivFWq 1404595
-
A Engelman R Craigie 1992 Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro J Virol 66 6361 6369 1:CAS:528:DyaK3sXivFWq 1404595
-
(1992)
J Virol
, vol.66
, pp. 6361-6369
-
-
Engelman, A.1
Craigie, R.2
-
7
-
-
0026719238
-
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases
-
1:STN:280:DyaK383js1Kjug%3D%3D 1314954
-
J Kulkosky KS Jones RA Katz JP Mack AM Skalka 1992 Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases Mol Cell Biol 12 2331 2338 1:STN:280:DyaK383js1Kjug%3D%3D 1314954
-
(1992)
Mol Cell Biol
, vol.12
, pp. 2331-2338
-
-
Kulkosky, J.1
Jones, K.S.2
Katz, R.A.3
MacK, J.P.4
Skalka, A.M.5
-
8
-
-
0027470432
-
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro
-
1:CAS:528:DyaK3sXhvVGjsr0%3D 8420982
-
AD Leavitt L Shiue HE Varmus 1993 Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro J Biol Chem 268 2113 2119 1:CAS:528:DyaK3sXhvVGjsr0%3D 8420982
-
(1993)
J Biol Chem
, vol.268
, pp. 2113-2119
-
-
Leavitt, A.D.1
Shiue, L.2
Varmus, H.E.3
-
9
-
-
0028584269
-
Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
-
10.1126/science.7801124 1:CAS:528:DyaK2MXisl2lurY%3D 7801124
-
F Dyda AB Hickman TM Jenkins A Engelman R Craigie DR Davies 1994 Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases Science 266 1981 1986 10.1126/science.7801124 1:CAS:528:DyaK2MXisl2lurY%3D 7801124
-
(1994)
Science
, vol.266
, pp. 1981-1986
-
-
Dyda, F.1
Hickman, A.B.2
Jenkins, T.M.3
Engelman, A.4
Craigie, R.5
Davies, D.R.6
-
10
-
-
0029643858
-
The catalytic domain of avian sarcoma virus integrase: Conformation of the active-site residues in the presence of divalent cations
-
10.1016/S0969-2126(96)00012-3 1:CAS:528:DyaK28XnvVGqsA%3D%3D 8805516
-
G Bujacz M Jaskolski J Alexandratos A Wlodawer G Merkel RA Katz AM Skalka 1996 The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations Structure 4 89 96 10.1016/S0969-2126(96)00012-3 1:CAS:528:DyaK28XnvVGqsA%3D%3D 8805516
-
(1996)
Structure
, vol.4
, pp. 89-96
-
-
Bujacz, G.1
Jaskolski, M.2
Alexandratos, J.3
Wlodawer, A.4
Merkel, G.5
Katz, R.A.6
Skalka, A.M.7
-
11
-
-
0025908083
-
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
-
10.1126/science.1707186 1:CAS:528:DyaK3MXlslyju7g%3D 1707186
-
JF Davies Z Hostomska Z Hostomsky SR Jordan DA Matthews 1991 Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase Science 252 88 95 10.1126/science.1707186 1:CAS:528:DyaK3MXlslyju7g%3D 1707186
-
(1991)
Science
, vol.252
, pp. 88-95
-
-
Davies, J.F.1
Hostomska, Z.2
Hostomsky, Z.3
Jordan, S.R.4
Matthews, D.A.5
-
12
-
-
0027377121
-
2+-binding site
-
DOI 10.1002/prot.340170402
-
K Katayanagi M Okumura K Morikawa 1993 Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution: proof for a single Mg(2+)-binding site Proteins 17 337 346 10.1002/prot.340170402 1:CAS:528:DyaK2cXlt1ylsro%3D 8108376 (Pubitemid 23358543)
-
(1993)
Proteins: Structure, Function and Genetics
, vol.17
, Issue.4
, pp. 337-346
-
-
Katayanagi, K.1
Okumura, M.2
Morikawa, K.3
-
13
-
-
0034681278
-
X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)-an initial glance of the viral DNA binding platform
-
10.1006/jmbi.1999.3451 1:CAS:528:DC%2BD3cXps1Gluw%3D%3D 10669606
-
Z Chen Y Yan S Munshi Y Li J Zugay-Murphy B Xu M Witmer P Felock A Wolfe V Sardana EA Emini D Hazuda LC Kuo 2000 X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)-an initial glance of the viral DNA binding platform J Mol Biol 296 521 533 10.1006/jmbi.1999.3451 1:CAS:528:DC%2BD3cXps1Gluw%3D%3D 10669606
-
(2000)
J Mol Biol
, vol.296
, pp. 521-533
-
-
Chen, Z.1
Yan, Y.2
Munshi, S.3
Li, Y.4
Zugay-Murphy, J.5
Xu, B.6
Witmer, M.7
Felock, P.8
Wolfe, A.9
Sardana, V.10
Emini, E.A.11
Hazuda, D.12
Kuo, L.C.13
-
14
-
-
0037126629
-
Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein
-
DOI 10.1093/emboj/20.24.7333
-
JY Wang H Ling W Yang R Craigie 2001 Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein EMBO J 20 7333 7343 10.1093/emboj/20.24.7333 1:CAS:528:DC%2BD38XpsF2q 11743009 (Pubitemid 34062324)
-
(2001)
EMBO Journal
, vol.20
, Issue.24
, pp. 7333-7343
-
-
Wang, J.-Y.1
Ling, H.2
Yang, W.3
Craigie, R.4
-
15
-
-
13044295993
-
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
-
10.1073/pnas.96.23.13040 1:CAS:528:DyaK1MXns1GmsrY%3D 10557269
-
Y Goldgur R Craigie GH Cohen T Fujiwara T Yoshinaga T Fujishita H Sugimoto T Endo H Murai DR Davies 1999 Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design Proc Natl Acad Sci USA 96 13040 13043 10.1073/pnas.96.23.13040 1:CAS:528:DyaK1MXns1GmsrY%3D 10557269
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13040-13043
-
-
Goldgur, Y.1
Craigie, R.2
Cohen, G.H.3
Fujiwara, T.4
Yoshinaga, T.5
Fujishita, T.6
Sugimoto, H.7
Endo, T.8
Murai, H.9
Davies, D.R.10
-
16
-
-
17144425757
-
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
-
DOI 10.1093/nar/gki346
-
JG Renisio S Cosquer I Cherrak S El Antri O Mauffret S Fermandjian 2005 Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase Nucleic Acids Res 33 1970 1981 10.1093/nar/gki346 1:CAS:528: DC%2BD2MXjtlensbY%3D 15814814 (Pubitemid 41748341)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.6
, pp. 1970-1981
-
-
Renisio, J.-G.1
Cosquer, S.2
Cherrak, I.3
El Antri, S.4
Mauffret, O.5
Fermandjian, S.6
-
17
-
-
0037827778
-
Strategy to discriminate between high and low affinity bindings of human immunodeficiency virus, type 1 integrase to viral DNA
-
DOI 10.1074/jbc.M211711200
-
L Zargarian MS Benleumi JG Renisio H Merad RG Maroun F Wieber O Mauffret H Porumb F Troalen S Fermandjian 2003 Strategy to discriminate between high and low affinity bindings of human immunodeficiency virus, type 1 integrase to viral DNA J Biol Chem 278 19966 19973 10.1074/jbc.M211711200 1:CAS:528: DC%2BD3sXktVaqtb0%3D 12626494 (Pubitemid 36799188)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.22
, pp. 19966-19973
-
-
Zargarian, L.1
Benleumi, M.S.2
Renisio, J.-G.3
Merad, H.4
Maroun, R.G.5
Wieber, F.6
Mauffret, O.7
Porumb, H.8
Troalen, F.9
Fermandjian, S.10
-
18
-
-
0037130159
-
Structure activity of 3-Aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors
-
DOI 10.1021/jm020037p
-
GC Pais X Zhang C Marchand N Neamati K Cowansage ES Svarovskaia VK Pathak Y Tang M Nicklaus Y Pommier TR Burke Jr 2002 Structure activity of 3-aryl-1, 3-diketo-containing compounds as HIV-1 integrase inhibitors J Med Chem 45 3184 3194 10.1021/jm020037p 1:CAS:528:DC%2BD38Xkt1Clt74%3D 12109903 (Pubitemid 34774270)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.15
, pp. 3184-3194
-
-
Pais, G.C.G.1
Zhang, X.2
Marchand, C.3
Neamati, N.4
Cowansage, K.5
Svarovskaia, E.S.6
Pathak, V.K.7
Tang, Y.8
Nicklaus, M.9
Pommier, Y.10
Burke Jr., T.R.11
-
19
-
-
0037463757
-
Azido-containing aryl β-diketo acid HIV-1 integrase inhibitors
-
DOI 10.1016/S0960-894X(03)00059-3
-
X Zhang GC Pais ES Svarovskaia C Marchand AA Johnson RG Karki MC Nicklaus VK Pathak Y Pommier TR Burke 2003 Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors Bioorg Med Chem Lett 13 1215 1219 10.1016/S0960-894X(03) 00059-3 1:CAS:528:DC%2BD3sXitFGktrc%3D 12643946 (Pubitemid 36331834)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.6
, pp. 1215-1219
-
-
Zhang, X.1
Pais, G.C.G.2
Svarovskaia, E.S.3
Marchand, C.4
Johnson, A.A.5
Karki, R.G.6
Nicklaus, M.C.7
Pathak, V.K.8
Pommier, Y.9
Burke Jr., T.R.10
-
20
-
-
0041353616
-
Metal-dependent inhibition of HIV-1 integrase by β-diketo acids and resistance of the soluble double-mutant (F185K/C280S)
-
DOI 10.1124/mol.64.3.600
-
C Marchand AA Johnson RG Karki GC Pais X Zhang K Cowansage TA Patel MC Nicklaus TR Burke Jr Y Pommier 2003 Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185 K/C280S) Mol Pharmacol 64 600 609 10.1124/mol.64.3.600 1:CAS:528: DC%2BD3sXmvFaiu7s%3D 12920196 (Pubitemid 37048563)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.3
, pp. 600-609
-
-
Marchand, C.1
Johnson, A.A.2
Karki, R.G.3
Pais, G.C.G.4
Zhang, X.5
Cowansage, K.6
Patel, T.A.7
Nicklaus, M.C.8
Burke Jr., T.R.9
Pommier, Y.10
-
21
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
DOI 10.1073/pnas.092056199
-
JA Grobler K Stillmock B Hu M Witmer P Felock AS Espeseth A Wolfe M Egbertson M Bourgeois J Melamed JS Wai S Young J Vacca DJ Hazuda 2002 Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes Proc Natl Acad Sci USA 99 6661 6666 10.1073/pnas.092056199 1:CAS:528:DC%2BD38XjvFCrs78%3D 11997448 (Pubitemid 34526189)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.10
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
Witmer, M.4
Felock, P.5
Espeseth, A.S.6
Wolfe, A.7
Egbertson, M.8
Bourgeois, M.9
Melamed, J.10
Wai, J.S.11
Young, S.12
Vacca, J.13
Hazuda, D.J.14
-
22
-
-
0026608073
-
Environment affects amino acid preference for secondary structure
-
10.1073/pnas.89.10.4462 1:CAS:528:DyaK38Xlt1Kltbw%3D 1584778
-
L Zhong WC Johnson Jr 1992 Environment affects amino acid preference for secondary structure Proc Natl Acad Sci USA 89 4462 4465 10.1073/pnas.89.10.4462 1:CAS:528:DyaK38Xlt1Kltbw%3D 1584778
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4462-4465
-
-
Zhong, L.1
Johnson Jr., W.C.2
-
23
-
-
58149474162
-
An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF
-
10.1371/journal.pone.0004081 19119323
-
H Merad H Porumb L Zargarian B Rene Z Hobaika RG Maroun O Mauffret S Fermandjian 2009 An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF PLoS One 4 e4081 10.1371/journal.pone. 0004081 19119323
-
(2009)
PLoS One
, vol.4
, pp. 4081
-
-
Merad, H.1
Porumb, H.2
Zargarian, L.3
Rene, B.4
Hobaika, Z.5
Maroun, R.G.6
Mauffret, O.7
Fermandjian, S.8
-
24
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
DOI 10.1126/science.287.5453.646
-
DJ Hazuda P Felock M Witmer A Wolfe K Stillmock JA Grobler A Espeseth L Gabryelski W Schleif C Blau MD Miller 2000 Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells Science 287 646 650 10.1126/science.287.5453.646 1:CAS:528:DC%2BD3cXovVyjtQ%3D%3D 10649997 (Pubitemid 30070911)
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
25
-
-
34447263572
-
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
-
1:CAS:528:DC%2BD2sXos1Khtro%3D 17668566
-
M Lataillade J Chiarella MJ Kozal 2007 Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance Antivir Ther 12 563 570 1:CAS:528:DC%2BD2sXos1Khtro%3D 17668566
-
(2007)
Antivir Ther
, vol.12
, pp. 563-570
-
-
Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
-
26
-
-
52749086245
-
Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors
-
10.1186/1742-4690-5-74 18687142
-
SY Rhee TF Liu M Kiuchi R Zioni RJ Gifford SP Holmes RW Shafer 2008 Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors Retrovirology 5 74 10.1186/1742-4690-5-74 18687142
-
(2008)
Retrovirology
, vol.5
, pp. 74
-
-
Rhee, S.Y.1
Liu, T.F.2
Kiuchi, M.3
Zioni, R.4
Gifford, R.J.5
Holmes, S.P.6
Shafer, R.W.7
-
27
-
-
37549010982
-
Les différents classes des molécules inhibant lintegrase du VIH1
-
P Cotelle C Queffélec 2007 Les différents classes des molécules inhibant lintegrase du VIH1 Virologie 11 163 173
-
(2007)
Virologie
, vol.11
, pp. 163-173
-
-
Cotelle, P.1
Queffélec, C.2
|