COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells

International Immunopharmacology

Volumn 10, Issue 7, 2010, Pages 760-768

  Jung, In Duk ^a   Jeong, Young Il ^a   Lee, Chang Min ^a   Noh, Kyung Tae ^a   Jeong, Soo Kyung ^a   Chun, Sung Hak ^a   Choi, Oksoon Hong ^b   Park, Won Sun ^c   Han, Jin ^d   Shin, Yong Kyoo ^e   Kim, Han Wool ^f   Yun, Cheol Heui ^f   Park, Yeong Min ^a  

^a National Research Laboratory of Dendritic Cell Differentiation and Regulation   (South Korea)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Kangwon National University   (South Korea)

^d Inje University College of Medicine   (South Korea)

^e Chung Ang University   (South Korea)

^f Seoul National University   (South Korea)

Author keywords

Curcumin; Cyclooxygenase; Dendritic cells; Indoleamine 2,3 dioxygenase

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CURCUMIN; CYCLOOXYGENASE 2; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROSTAGLANDIN E2; PROTEIN P70; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; GENE EXPRESSION REGULATION; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, DIFFERENTIATION; BONE MARROW; CELL DIFFERENTIATION; CELLS, CULTURED; CURCUMIN; CYCLOOXYGENASE 2; CYTOKINES; DENDRITIC CELLS; DINOPROSTONE; IMMUNOMODULATION; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 77953229722     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.04.006     Document Type: Article

References (42)

1. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu Rev Immunol 21 (2003) 685-711
2. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
3. Randolph G.J., Angeli V., and Swartz M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 5 (2005) 617-628
4. Mellor A.L., and Munn D.H. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?. Immunol Today 20 (1999) 469-473
5. Jung I.D., Lee C.M., Jeong Y.I., Lee J.S., Park W.S., Han J., et al. Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells. FEBS Lett 581 (2007) 1449-1456
6. Mellor A.L., and Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4 (2004) 762-774
7. Hwu P., Du M.X., Lapointe R., Do M., Taylor M.W., and Young H.A. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 164 (2000) 3596-3599
8. Munn D.H., Zhou M., Attwood J.T., Bondarev I., Conway S.J., Marshall B., et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281 (1998) 1191-1193
9. Mellor A. Indoleamine 2,3 dioxygenase and regulation of T cell immunity. Biochem Biophys Res Commun 338 (2005) 20-24
10. Ueno A., Cho S., Cheng L., Wang J., Hou S., Nakano H., et al. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56 (2007) 1686-1693
11. Munn D.H., Shafizadeh E., Attwood J.T., Bondarev I., Pashine A., and Mellor A.L. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 189 (1999) 1363-1372
12. Jeong Y.I., Kim S.W., Jung I.D., Lee J.S., Chang J.H., Lee C.M., et al. Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase C{delta}-STAT1 signaling pathway in interferon-{gamma}-stimulated murine dendritic cells. J Biol Chem 284 (2009) 3700-3708
13. +CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol 37 (2007) 3054-3062
14. Stoner G.D., and Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl 22 (1995) 169-180
15. Khar A., Ali A.M., Pardhasaradhi B.V., Begum Z., and Anjum R. Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells. FEBS Lett 445 (1999) 165-168
16. Huang M.T., Lou Y.R., Ma W., Newmark H.L., Reuhl K.R., and Conney A.H. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res 54 (1994) 5841-5847
17. Kim G.Y., Kim K.H., Lee S.H., Yoon M.S., Lee H.J., Moon D.O., et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 174 (2005) 8116-8124
18. Thomas S.R., Salahifar H., Mashima R., Hunt N.H., Richardson D.R., and Stocker R. Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate. J Immunol 166 (2001) 6332-6340
19. Lee H.J., Jeong Y.I., Lee T.H., Jung I.D., Lee J.S., Lee C.M., et al. Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Biochem Pharmacol 73 (2007) 1412-1421
20. Jeong Y.I., Jung I.D., Lee J.S., Lee C.M., Lee J.D., and Park Y.M. (-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets. Biochem Biophys Res Commun 354 (2007) 1004-1009
21. Kim S.I., Jeong Y.I., Jung I.D., Lee J.S., Lee C.M., Yoon M.S., et al. p-Coumaric acid inhibits indoleamine 2, 3-dioxygenase expression in murine dendritic cells. Int Immunopharmacol 7 (2007) 805-815
22. Stan S.D., Kar S., Stoner G.D., and Singh S.V. Bioactive food components and cancer risk reduction. J Cell Biochem 104 (2008) 339-356
23. Dubois R.N., Abramson S.B., Crofford L., Gupta R.A., Simon L.S., Van De Putte L.B., et al. Cyclooxygenase in biology and disease. FASEB J 12 (1998) 1063-1073
24. Smith W.L., DeWitt D.L., and Garavito R.M. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69 (2000) 145-182
25. Weber W.M., Hunsaker L.A., Gonzales A.M., Heynekamp J.J., Orlando R.A., Deck L.M., et al. TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. Biochem Pharmacol 72 (2006) 928-940
26. Kang G., Kong P.J., Yuh Y.J., Lim S.Y., Yim S.V., Chun W., et al. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells. J Pharmacol Sci 94 (2004) 325-328
27. Hong J., Bose M., Ju J., Ryu J.H., Chen X., Sang S., et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 25 (2004) 1671-1679
28. Basu G.D., Tinder T.L., Bradley J.M., Tu T., Hattrup C.L., Pockaj B.A., et al. Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. J Immunol 177 (2006) 2391-2402
29. Tilley S.L., Coffman T.M., and Koller B.H. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Investig 108 (2001) 15-23
30. Kunkel S.L., Spengler M., May M.A., Spengler R., Larrick J., and Remick D. Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J Biol Chem 263 (1988) 5380-5384
31. Mellor A.L., Sivakumar J., Chandler P., Smith K., Molina H., Mao D., et al. Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2 (2001) 64-68
32. Hwang S.L., Chung N.P., Chan J.K., and Lin C.L. Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines. Cell Res 15 (2005) 167-175
33. Arrighi J.F., Rebsamen M., Rousset F., Kindler V., and Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol 166 (2001) 3837-3845
34. Munn D.H., and Mellor A.L. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J Clin Investig 117 (2007)
35. Phipps R.P., Stein S.H., and Roper R.L. A new view of prostaglandin E regulation of the immune response. Immunol Today 12 (1991) 349-352
36. Harizi H., Juzan M., Grosset C., Rashedi M., and Gualde N. Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigen-presenting cells. Cell Immunol 209 (2001) 19-28
37. Groux H., Bigler M., de Vries J.E., and Roncarolo M.G. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J Immunol 160 (1998) 3188-3193
38. Igietseme J.U., Ananaba G.A., Bolier J., Bowers S., Moore T., Belay T., et al. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. J Immunol 164 (2000) 4212-4219
39. Park J.W., Choi Y.J., Suh S.I., and Kwon T.K. Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cells. Biochem Biophys Res Commun 286 (2001) 721-725
40. Kim S.Y., Ahn B.H., Min K.J., Lee Y.H., Joe E.H., and Min D.S. Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. J Biol Chem 279 (2004) 38125-38133
41. Harizi H., Juzan M., Pitard V., Moreau J.F., and Gualde N. Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 168 (2002) 2255-2263
42. Jung I.D., Lee M.G., Chang J.H., Lee J.S., Jeong Y.I., Lee C.M., et al. Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock. J Immunol 182 (2009) 3146-3154