Mitochondrial functions and aging

Gene

Volumn 286, Issue 1, 2002, Pages 65-71

  Osiewacz, Heinz D ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Aging; Mitochondrial DNA instabilities; Oxidative stress; Podospora anserina; Remodeling

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHAPERONE; COPPER; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

AGING; ASCOMYCETES; BINDING AFFINITY; BIOAVAILABILITY; CELL ORGANELLE; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONFERENCE PAPER; ENVIRONMENT; GENETIC CODE; HOMEOSTASIS; LIFESPAN; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION; MOLECULAR INTERACTION; MUTANT; NONHUMAN; PODOSPORA ANSERINA; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; WILD TYPE;

ASCOMYCOTA; DNA, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; MYCELIUM; OXIDATIVE STRESS;

PODOSPORA ANSERINA;

EID: 0037029072     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(01)00804-6     Document Type: Conference Paper

References (80)

1. Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment
2. Identification and characterization of PaMTH1, a putative O-methyltransferase accumulating during senescence of Podospora anserina cultures
3. Molecular control of copper homeostasis in filamentous fungi: Increased expression of a metallothionein gene during aging of Podospora anserina
4. Mitochondrial DNA amplification in senescent cultures of Podospora anserina
5. Does senescence in Podospora anserina result from instability of the mitochondrial genome?
6. GRISEA, a copper-modulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae
7. Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea
8. Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina
9. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina
10. Copper resistance mechanisms in bacteria and fungi
11. Role of mitochondrial DNA mutations in disease and aging
12. Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract
13. Mitochondrial DNA from Podospora anserina. II. Properties of mutant DNA and multimeric circular DNA from senescent cultures
14. Mechanisms to protect against copper toxicity
15. The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake
16. A causal link between respiration and senescence in Podospora anserina
17. Genetic control of aging: The mobile intron model
18. Genes inhibiting senescence in the ascomycete Podospora anserina
19. Prevention of senescence in the ascomycete Podospora anserina by the antibiotic tiamulin
20. Senescence in fungi
21. Reverse transcriptase activity of an intron encoded polypeptide
22. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein
23. Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase
24. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae
25. ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene
26. A theory based on free radical and radiation chemistry
27. The aging process
28. Aging and oxidative stress
29. Cox11p is required for stable formation of the Cu(B) and magnesium centers of cytochrome c oxidase
30. Contribution of various classes of defective mitochondrial DNA molecules to senescence in Podospora anserina
31. Intramolecular cross-overs generate deleted mitochondrial DNA molecules in Podospora anserina
32. Mutations in genes encoding the mitochondrial outer membrane proteins Tom70 and Mdm 10 of Podospora anserina modify the spectrum of mitochondrial DNA rearrangements associated with cellular death
33. The yeast transcription factor Mac1 binds to DNA in a modular fashion
34. Metabolic control and gene dysregulation in yeast aging
35. MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast
36. Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue
37. PaGrg1, a glucose-repressible gene of Podospora anserina that is differentially expressed during lifespan
38. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
39. A widespread transposable element masks expression of a yeast copper transport gene
40. A 1100-bp sequence of mitochondria DNA is involved in senescence process in Podospora: Study of senescent and mutant cultures
41. Plasmid-like DNA is part of mitochondrial DNA in Podospora anserina
42. The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina
43. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway
44. A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe
45. RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus
46. Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae
47. Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease
48. Mitochondrial copper metabolism in yeast: Interaction between Sco1p and Cox2p
49. Reversion of a long-living, undifferentiated mutant of Podospora anserina by copper
50. Notion de longevite et nature cytoplasmique du determinant de la senescence chez quelques champignons
51. Mitochondrial class I introns encode proteins related to the reverse transcriptases of retroviruses
52. Molecular analysis of aging processes in fungi
53. Aging and genetic instabilities
54. Cellular copper homeostasis, mitochondrial DNA instabilities, and lifespan control in the filamentous fungus Podospora anserina
55. The mitochondrial plasmid of Podospora anserina: A mobile intron of a mitochondrial gene
56. The role of mitochondrial DNA rearrangements in aging and human diseases
57. Mitochondrial-nuclear interactions and lifespan control in fungi
58. GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence
59. Metabolism and aging in the filamentous fungus Podospora anserina
60. Mitochondrial DNA rearrangements are correlated with a delayed amplification of the mobile intron (plDNA) in a long-lived mutant of Podospora anserina
61. Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae
62. The phenoloxidases of the ascomycete Podospora anserina. XIII. Action and interaction of genes controlling the formation of laccase
63. Sur l'impossibilite d'obtenir la multiplication vegetative ininterrompue et illemite de l'ascomycete Podospora anserina
64. Extrachromosomal mutants from Podospora anserina: Permanent vegetative growth in spite of multiple recombination events in the mitochondrial genome
65. Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors rtg1p and rtg3p
66. Transposition of a group II intron
67. Cytosolic ribosomal mutations that abolish accumulation of circular intron in the mitochondria without preventing senescence of Podospora anserina
68. Cell degeneration in the model system Podospora anserina
69. Evidence for plasmid like DNA in a filamentous fungus, the ascomycete Podospora anserina
70. Replication and expression of a bacterial-mitochondrial hybrid plasmid in the fungus Podospora anserina
71. A fraction of yeast Cu/Zn superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria: A physical role for SOD1 in guarding against mitochondrial oxidative damage
72. Inhibitors of mitochondrial function prevent senescence in the ascomycete Podospora anserina
73. Chromosomal and extrachromosomal control of senescence in the ascomycete Podospora anserina
74. A sequence of mitochondrial DNA is associated with the onset of senescence in a fungus
75. Structure and function of the plant alternative oxidase: Its putative role in the oxygen defence mechanism
76. Diseases of mitochondrial DNA
77. Mitochondrial diseases in man and mouse
78. Metal-ion regulation of gene expression in yeast
79. Metal ion stress in yeast
80. hCTR1: A human gene for copper uptake identified by complementation in yeast